Pharmacokinetics and pharmacodynamics of phase II drug metabolizing/ antioxidant enzymes gene response by anticancer agent sulforaphane in rat lymphocytes

Molecular Pharmaceutics

Volumn 9, Issue 10, 2012, Pages 2819-2827

  Wang, Hu ^a   Khor, Tin Oo ^a   Yang, Qian ^b   Huang, Ying ^a   Wu, Tien Yuan ^a   Saw, Constance Lay Lay ^a   Lin, Wen ^a   Androulakis, Ioannis P ^b,c   Kong, Ah Ng Tony ^a  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; COMPLEMENTARY DNA; DRUG METABOLIZING ENZYME; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A6; GLUTATHIONE PEROXIDASE 1; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE T1; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); RNA; SULFORAPHANE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR MAF; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BOOTSTRAPPING; CENTRIFUGE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG ANALYSIS; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETOXIFICATION; DRUG DISTRIBUTION; DRUG HALF LIFE; GENE EXPRESSION; GENE TARGETING; LIQUID CHROMATOGRAPHY; LYMPHOCYTE; MALE; MASS SPECTROMETRY; MEAN RESIDENCE TIME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; STEADY STATE;

EID: 84870207759     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300130k     Document Type: Article

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