In vitro antioxidant effects of aloe barbadensis miller extracts and the potential role of these extracts as antidiabetic and antilipidemic agents on streptozotocin-induced type 2 diabetic model rats

Molecules

Volumn 17, Issue 11, 2012, Pages 12851-12867

  Moniruzzaman, Mohammed ^a,b,c   Rokeya, Begum ^a   Ahmed, Sohel ^c   Bhowmik, Amrita ^a   Khalil, Md Ibrahim ^b,c   Gan, Siew Hua ^b  

^a Bangladesh Institute of Research and Rehabilitation in Diabetes Endocrine and Metabolic Disorders   (Bangladesh)

^b SCHOOL OF MEDICAL SCIENCES   (Malaysia)

^c JAHANGIRNAGAR UNIVERSITY   (Bangladesh)

Author keywords

Aloe vera; Antidiabetic; Antioxidants; DPPH; FRAP; Streptozotocin induced diabetic rats

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 2,2-DIPHENYL-1-PICRYLHYDRAZYL; ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; BIPHENYL DERIVATIVE; CHOLESTEROL; FREE RADICAL; HIGH DENSITY LIPOPROTEIN; INSULIN; LOW DENSITY LIPOPROTEIN; MALONALDEHYDE; PICRIC ACID; PLANT EXTRACT; SCAVENGER; STREPTOZOCIN; TRIACYLGLYCEROL;

ALOE; ANIMAL; ARTICLE; BLOOD; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DRUG EFFECT; ERYTHROCYTE; EXPERIMENTAL DIABETES MELLITUS; FEMALE; GLUCOSE BLOOD LEVEL; ISOLATION AND PURIFICATION; LONG EVANS RAT; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PLANT LEAF; RAT;

ALOE; ANIMALS; BIPHENYL COMPOUNDS; BLOOD GLUCOSE; CHOLESTEROL; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; ERYTHROCYTES; FEMALE; FREE RADICAL SCAVENGERS; FREE RADICALS; HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; INSULIN; LIPOPROTEINS, HDL; LIPOPROTEINS, LDL; MALONDIALDEHYDE; PICRATES; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, LONG-EVANS; STREPTOZOCIN; TRIGLYCERIDES;

EID: 84870202615     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules171112851     Document Type: Article

References (64)

1. Wild, H.; Roglic, G.; Green, A.; Sicree, R.; King, H. Global prevalence of diabetes, estimates for the year 2000 and projections for 2030. Diabetes Care 2004, 27, 1047-1053.
2. Lenhard, J.M.; Gottschalk, W.K. Preclinical developments in type 2 diabetes. Adv. Drug Deliv. Rev. 2002, 54, 1199-1212.
3. Bailey, C.J.; Day, C. Traditional plant medicines as treatment for diabetes. Diabetes Care 1989, 12, 553-564.
4. Habeeb, F.; Shakir, E.; Bradbury, F.; Cameron, P.; Taravati, M.R.; Drummond, A.J.; Gray, A.I.; Ferro, V.A. Screening methods used to determine the anti-microbial properties of Aloe vera inner gel. Methods 2007, 42, 315-320.
5. Hamman, J.H. Composition and applications of Aloe vera leaf gel. Molecules 2008, 13, 1599-1616.
6. Vogler, B.; Ernst, E. Aloe vera: A systematic review of its clinical effectiveness. Br. J. Gen. Pract. 1999, 49, 823-828.
7. Choonhakarn, C.; Busaracome, P.; Sripanidkulchai, B.; Sarakarn, P. A prospective, randomized clinical trial comparing topical Aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis. J. Eur. Acad. Dermatol. Venereol. 2010, 24, 168-172.
8. Grindlay, D.; Reynolds, T. The Aloe vera phenomenon: A review of the propertiesand modern uses of the leaf parenchyma gel. J. Ethnopharmacol. 1986, 16, 117-151.
9. Chithra, P.; Sajithlal, G.B.; Chandrakasan, G. Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats. Mol. Cell. Biochem. 1998, 181, 71-76.
10. Rajendran, A.; Narayanan, V.; Gnanavel, I. Study on the evaluation of therapeutic efficacy of Aloe vera sap in diabetes and treating wounds and inflammation in animals. J. Appl. Sci. Res. 2007, 3, 1434-1436.
11. Heggers, J.; Kucukcelebi, A. Beneficial effect of Aloe on wound healing in an excisional wound model. J. Altern. Complement. Med. 1996, 2, 271-277.
12. Hart, L.; Nibbering, P.H.; Barselaar, M.T.V.D. Effects of low molecular constituents from Aloe vera gel on oxidative metabolism and cytotoxic and bactericidal activities of human neutrophils. Int. J. Immunopharmacol. 1990, 12, 427-434.
13. Lee, C.K.; Han, S.S.; Mo, Y.K.; Kim, R.S.; Chung, M.H.; Park, Y.I.; Lee, S.K.; Kim, Y.S. Prevention of ultraviolet radiation-induced suppression of accessory cell function of langerhans cells by Aloe vera gel components. Immunopharmacology 1999, 37, 153-162.
14. Sabeh, F.; Wright, T.; Norton, S.J. Purification and characterization of glutathione peroxidase and isozymes of superoxide dismutase from Aloe vera plant. Enzyme Protein 1993, 47, 92-98.
15. Giugliano, D.; Ceriello, A.; Paolisso, G. Oxidative stress and diabetic vascular complications. Diabetes Care 1996, 19, 257-267.
16. Rajasekaran, S.; Sivagnanam, K.; Subramanian, S. Antioxidant effect of Aloe vera gel extract in streptozotocin-induced diabetes in rats. Pharmacol. Rep. 2005, 57, 90-96.
17. Ajabnoor, M.A. Effect of aloes on blood glucose levels in normal and alloxan diabetic mice. J. Ethnopharmacol. 1990, 28, 215-220.
18. Asbun, J.; Villarreal, F.J. The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy. J. Am. Coll. Cardiol. 2006, 47, 693-700.
19. Poitout, V.; Robertson, R.P. Minireview: Secondary beta-cell failure in type 2 diabetes - A convergence of glucotoxicity and lipotoxicity. Endocrinology 2002, 143, 339-342.
20. Rajasekaran, S.; Ravi, K.; Sivagnanam, K.; Subramanian, S. Beneficial effects of Aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes. Clin. Exp. Pharmacol. Physiol. 2006, 33, 232-237.
21. Ross, R.; Glomset, J.A. The pathogenesis of atherosclerosis. N. Engl. J. Med. 1976, 295, 369-377.
22. Kim, K.; Kim, H.; Kwon, J.; Lee, S.; Kong, H.; Im, S.A.; Lee, Y.H.; Lee, Y.R.; Oh, ST.; Jo, T.H. Study on the hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a mouse model of niddm. Phytomedicine 2009, 16, 856-863.
23. Tanaka, M.; Misawa, E.; Ito, Y.; Habara, N.; Nomaguchi, K.; Yamada, M.; Toida, T.; Hayasawa, H.; Takase, M.; Inagaki, M.; et al. Identification of five phytosterols from Aloe vera gel as anti-diabetic compounds. Biol. Pharm. Bull. 2006, 29, 1418-1422.
24. Abuelgasim, A.I.; Osman, M.K.M.; Elmahdi, B. Study on the effects of Aloe vera (elsabar) ethanolic extract on blood glucose level in wister albino rats. J. Appl. Sci. Res. 2008, 43, 1841-1845.
25. Beppu, H.; Shimpo, K.; Chihara, T.; Kaneko, T.; Tamai, I.; Yamaji, S.; Ozaki, S.; Kuzuya, H.; Sonoda, S. Study of antidiabetic activity of dietary administration of Aloe arborescens Miller components on multiple low-dose streptozotocin-induced diabetes in mice: Investigation on hypoglycemic action and systemic absorption dynamics of Aloe components. J. Ethnopharmacol. 2006, 103, 468-477.
26. Botes, L.; Westhuizen, F.H.V.; Loots, D.T. Phytochemical contents and antioxidant capacities of two Aloe greatheadii var. Davyana extracts. Molecules 2008, 13, 2169-2180.
27. Hu, Y.; Xu, J.; Hu, Q. Evaluation of antioxidant potential of Aloe vera (Aloe barbadensis Miller) extracts. J. Agric. Food Chem. 2003, 51, 7788-7791.
28. Miladi, S.; Damak, M. In vitro antioxidant activities of Aloe vera leaf skin extracts. Journal de la Société Chimique de Tunisie 2008, 10, 101-109.
29. Sultana, B.; Anwar, F.; Ashraf, M. Effect of extraction solvent/technique on the antioxidant activity of selected medicinal plant extracts. Molecules 2009, 14, 2167-2180.
30. Agarwal, P.O. Prevention of atheromatous heart disease. Angiology 1985, 36, 485-492.
31. Beppu, H.T.; Koike, K.; Shimpo, T.; Chihara, M.; Hoshino, C.I.; Kuzuya, H. Radical-scavenging effects of Aoe arborescens Miller on prevention of pancreatic islet β-cell destruction in rats. J. Ethnopharmacol. 2003, 89, 37-45.
32. Reynolds, T.; Dweck, A.C. Aloe vera leaf gel: A review update. J. Ethnopharmacol. 1999, 68, 3-37.
33. Cao, H.; Hininger-Favier, I.; Kelly, M.A.; Benaraba, R.; Dawson, H.D.; Coves, S.; Roussel, A.M.; Anderson, R.A. Green tea polyphenol extract regulates the expression of genes involved in glucose uptake and insulin signalling in rats fed a high fructose diet. J. Agric. Food Chem. 2007, 55, 6372-6378.
34. Johnston, K.; Sharp, P.; Clifford, M.; Morgan, L. Dietary polyphenols decrease glucose uptake by human intestinal caco-2 cells. FEBS Lett. 2005, 579, 1653-1657.
35. Beretta, G.; Granata, P.; Ferrero, M.; Orioli, M.; Facino, R.M. Standardization of antioxidant properties of honey by a combination of spectrophotometric/fluorimetric assays and chemometrics. Anal. Chim. Acta 2005, 533, 185-191.
36. Saritha, V.; Anilakumar, K.R.; Khanum, F. Antioxidant and antibacterial activity of Aloe vera gel extracts. Int. J. Pharm. Biol. Arch. 2010, 1, 376-384.
37. Rajasekaran, S.; Sivagnanam, K.; Ravi, K.; Subramanian, S. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. J. Med. Food 2004, 7, 61-66.
38. Noor, A.; Gunasekaran, S.; Manickam, A.; Vijayalakshmi, M. Antidiabetic activity of Aloe vera and histology of organs in streptozotocin induced diabetic rats. Curr. Sci. 2008, 94, 1070-1076.
39. Akinmoladun, A.C.; Akinloye, O. Prevention of the onset of hyperglycaemia by extracts of Aloe barbadensis in rabbits treated with alloxan. Afr. J. Biotechnol. 2007, 6, 1028-1230.
40. Mohamed, A.; Abdel-Aziz, A.; El-Sherbiny, E.; Mors, R. Anti-diabetic effect of Aloe vera juice and evaluation of thyroid function in female diabetic rats. Biosci. Res. 2009, 6, 28-34.
41. Yki-Jarvinen, H.; Mott, D.; Young, A.A.; Stone, K.; Bogardus, C. Regulation of glycogen synthase and phosphorylase activities by glucose and insulin in human skeletal muscle. J. Clin. Invest. 1987, 80, 95-100.
42. Groop, L.; Otheo-Melander, M. New insights into impaired muscle glycogen synthesis. PLoS Med. 2008, 5, e25.
43. Gadi, R.; Samehe, F.F. Dyslipideia in type 2 diabetes mellitus. Curr. Diab. Rep. 2007, 7, 228-234.
44. Group, U.K.P.D.S. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: Ukpds 38. Br. Med. J. 1998, 317, 703-713.
45. Burk, R.F. Glutathione dependent protection by rats liver microsomal protein against lipid peroxidation. Biochim. Biophys. Acta 1983, 75, 21-28.
46. Kaplowitz, N.; Ookhtems, M.; Ty, A. The regulation of hepatic glutathione. Annu. Rev. Pharmacol. Toxicol. 1995, 25, 715-744.
47. Baynes, J.W. Role of Oxidative Stress in Development of Complications in Diabetes. Diabetes 1991, 40, 405-412.
48. Miyaka, Y.; Yamamoto, K.; Tsujiihara, N.; Osawa, T. Protective effects of lemon flavonoids on oxidative stress in diabetes rats. Lipids 1998, 33, 689-697.
49. Bonner-Weir, S.; Trend, D.F.; Honey, R.N.; Weir, G.C. Responses of neonatal rat islets to streptozotocin: Limited β-cell regeneration and hyperglycemia. Diabetes 1981, 30, 64-69.
50. Ali, L.; Azad Khan, A.K.; Mamun, M.I.R.; Mosihuzzaman, M.; Nahar, N.; Nur-E-Alam, M.; Rokeya, B. Studies on hypoglycemic effects fruit pulp, seed and whole plant of momordica charantia on normal and diabetic model rats. Planta Med. 1993, 59, 408-412.
51. Singleton, V.L.; Orthofer, R.; Lamuela-Raventos, R.M. Analysis of total phenols and other oxidation substrates and antioxidant by means of Folin-ciocalteu reagent. Meth. Enzymol. 1999, 299, 152-178.
52. Zhishen, J.; Mengcheng, T.; Jianming, W. The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Food Chem. 1999, 64, 555-559.
53. Ferreira, I.C.F.R.; Aires, E.; Barreira, J.C.M.; Estevinho, L.M. Antioxidant activity of portuguese honey samples: Different contributions of the entire honey and phenolic extract. Food Chem. 2009, 114, 1438-1443.
54. Hatano, T.; Kagawa, H.; Yashura, T.; Okuda, T. Two new flavonoids and other constituents in licorice root: Their relative astringency and radical scavenging effects. Chem. Pharm. Bull. (Tokyo) 1988, 36, 2090-2097.
55. Benzie, I.F.F.; Strain, J.J. The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": The FRAP assay. Anal. Biochem. 1996, 239, 70-76.
56. Trinder, P. Glucose GOD-PAP method enzymatic colorimetric method. Ann. Clin. Biochem. 1969, 6, 24-27.
57. Kratzsch, J.; Ackermann, W.; Leliacker, H.; Berch, W.; Keller, E. A sensitive sandwich enzyme immunoassay for measurement of insulin on microtitre plates. Exp. Clin. Endocrinol. 1990, 95, 229-236.
58. Vries, J.V. Two methods for the determination of glycogen in liver. Biochem. J. 1954, 57, 410-416.
59. Allain, C.C.; Poon, L.; Chan, S.G.; Richmond, W.; Fu, P. Enzymatic determination of total serum cholesterol. Clin. Chem. 1974, 20, 470-475.
60. Fossati, P.; Prencipe, L. Serum triglyceride determined colourimatrically with an enzyme that produce hydrogen peroxide. Clin. Chem. 1982, 28, 2077-2080.
61. Nagy, G.; Kim, J.H.; Pang, Z.P.; Matti, U.; Rettig, J.; Sudhof, T.C.; Sorensen, J.B. Different effects on fast exocytosis induced by synaptotagmin 1 and 2 isoforms and abundance but not by phosphorylation. J. Neurosci. 2006, 26, 632-643.
62. Van Kampen, E.J.; Zijlstra, W.G. Standardization of hemoglobinometry. II. The hemoglobincyanide method. Clin. Chim. Acta 1961, 6, 538-544.
63. Srour, M.A.; Bilto, Y.Y.; Juma, M.; Irhimeh, M.R. Exposure of human erythrocytes to oxygen radicalscauses loss of deformability, increased osmotic fragility lipid peroxidation and protein degradation. Clin. Haemorheol. Microcirc. 2000, 23, 13-21.
64. Ellman, G.L. Determination of sulfhydryl group. Arch. Biochem. Biophys. 1959, 82, 70-74.