Beneficial effect of Aloe on wound healing in an excisional wound model

Journal of Alternative and Complementary Medicine

Volumn 2, Issue 2, 1996, Pages 271-277

  Heggers, John P ^a   Kucukcelebi, Ahmet ^b   Listengarten, Dmitri ^a   Stabenau, Jill ^a   Ko, Francis ^c   Broemeling, Lyle D ^a   Robson, Martin C ^c   Winters, Wendell D ^d  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b Rauf Denktas Caddesi   (Turkey)

^c Bay Pines VA Medical Center   (United States)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOCHLORITE SODIUM; MAFENIDE; TOPICAL ANTIINFECTIVE AGENT;

ALOE; ANIMAL; ARTICLE; COMPARATIVE STUDY; DRUG EFFECT; INJURY; MEDICINAL PLANT; PHYTOTHERAPY; RAT; SKIN; SPRAGUE DAWLEY RAT; WOUND HEALING;

ALOE; ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; MAFENIDE; PHYTOTHERAPY; PLANTS, MEDICINAL; RATS; RATS, SPRAGUE-DAWLEY; SKIN; SODIUM HYPOCHLORITE; WOUND HEALING;

EID: 0030154385     PISSN: 10755535     EISSN: None     Source Type: Journal    
DOI: 10.1089/acm.1996.2.271     Document Type: Article

References (32)

1. Bishop JB, Phillips LG, Mustoe TA, VanderZee AJ, Wiersema L, Roach DE, Heggers JP, Hill DP, Taylor EL, Robson MC. A prospective randomized evaluator-blinded trial of two potential wound healing agents for the treatment of venous stasis ulcers. J Vasc Surg 1992;16:251-257.
2. Bunyan J. The treatment of burns and wounds by the envelope method. Br Med J 1941;2:1-7.
3. Carney DH, Mann R, Redin WR, Pernia SD, Berry D, Heggers JP, Hayward PG, Robson MC, Christie J, Annable C, Fenton JW, II, Glenn KC. Enhancement of incisional wound healing and neovascularization in normal rats by thrombin and synthetic receptor-activating peptides. J Clin Invest 1992;89:1469-1477.
4. Cole HN, Chen KK. Aloe vera in oriental dermatology. Arch Dermatol Syph 1943;47:250.
5. Cotter JL, Fader RC, Lilley C, Herndon DN. Chemical parameters, antimicrobial activities, and tissue toxicity of 0.1 and 0.5% sodium hypochlorite solutions. Antimicrob Agents Chemother 1985;28:118-122.
6. Dakin HD. On the use of certain antiseptic substances. Br Med J 1915a;2:318-320.
7. Dakin HD. The antiseptic action of hypochlorites: The ancient history of the "new antiseptic." Br Med J 1915b;2:809-810.
8. Edlich RF, Custer J, Madden J, et al. Studies in management of the contaminated wound. Am J Surg 1969;118:21-27.
9. Edlich RF, Rodeheaver GT, Thacker JG, Edgerton MT. Technical factors in wound management. In: Dunphy JE, Hunt TK, eds. Fundamentals of wound management in surgery. South Plainfield, NJ: Chirurgecom, 1977;1-83.
10. Fleming A. The action of chemical and physiological antiseptics in a septic wound. Br J Surg 1919;7:99-131.
11. Grindlay D, Reynolds T. The Aloe vera phenomenon; a review of the properties and modern uses. J Ethnopharmacol 1986;16(2/3):117-151.
12. Hayward PG, Hokanson J, Heggers JP, Fiddes J, Klingbeil C, Goeger M, Robson MC. Fibroblast growth factor reverses the bacterial retardation of wound contraction. Am J Surg 1992;1163:288-293.
13. Heggers JP, Robson MC, Zachary LS. Thromboxane inhibitors for the prevention of progressive dermal ischemia due to the thermal injury. JBCR 1985;6:466-468.
14. Heggers JP, Sazy JA, Stenberg BD, McCauley RL, Strock LL, Robson MC, Herndon DN. Bactericidal and wound healing properties of sodium hypochlorite. The 1991 Lindberg Award. J Burn Care Rehab 1991;12:420-424.
15. Heggers JP, Pelley RP, Robson MC. Beneficial effects of Aloe in wound healing. J Phytother Res 1993;7:S48-S52.
16. Hokanson JA, Hayward PG, Carney DH, Phillips LG, Robson MC. A mathematical model for analysis of experimental wound healing data. Wounds 1991;3(6): 213-220.
17. The Holy Bible, King James Version, John, 19:39.
18. Kozol RA, Gillies C, Elgebaly SA. Effects of sodium hypochlorite (Dakin's solution) on cells of the wound module. Arch Surg 1988;123:420-423.
19. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 1970;227:680-685.
20. Leitch IOW, Kucukcelebi A, Robson MC. Inhibition of wound contraction by topical antimicrobials. Aust New Zealand J Surg 1993;63:289-293.
21. Lineaweaver W, McMorris S, Soucy D, Howard R. Cellular and bacterial toxicities of topical antimicrobials. Plas Reconstruc Surg 1985;75:394-396.
22. McCauley RL, Poole B, Heggers JP, Robson MC, Herndon DN. Differential in vitro toxicity of topical antimicrobial agents to human keratinocytes. J Surg Res 1992;52:276-285.
23. Merril CR, Goldman D, Sedman SA, Ebert MH. Ultrasensitive stain for proteins in polyacrylamide gels shows regional variation in cerebrospinal fluid proteins. Science 1981;211:1437-1438.
24. Moncrief JA. Topical antibacterial treatment of the burn wound. In: Artz CP, Moncrief JA, Pruitt BA, Jr., eds. Burns, a team approach. Philadelphia: W.B. Saunders Co., 1979;250-269.
25. Morgan OF, Saner FD, Schlesinger E. Some aspects of the treatment of infected war wounds. Br J Surg 1917;1:425-461.
26. Robson MC, Heggers JP, Hagstrom WJ. Myth, magic, witchcraft or fact? Aloe vera Revisited. JBCR 1982;3:157-163.
27. Robson MC, Phillips LG, Thomason A, Altrock W, Pence PC, Heggers JP, et al. Recombinant human platelet derived growth factor-BB for the treatment of chronic pressure ulcers. Ann Plastic Surg 1992a;29(3):193-201.
28. Robson MC, Phillips LG, Lawrence WT, Bishop JB, Youngerman JS, Hayward PG, Broemeling L, Heggers JP. The safety and effect of topically applied recombinant basic fibroblast growth factor on the healing of chronic pressure sores. Ann Surg 1992b;216:401-408.
29. Sabath LD, Simmons RL, Howard RJ, Canafax DM. Antimicrobial Agents. In: Simmons RL, Howard RJ, eds. Surgical infectious diseases. New York: Appleton-Century-Crofts, 1982;409-412.
30. Winters WD. Lymphocyte stimulation by newly identified Aloe lectinmitogens. Adv New Drug Dev 1991;40:391-397.
31. Winters WD, Bouthet C. Polypeptides of Aloe barbadensis Miller. J Phytother Res 1995;9:395-400.
32. Winters WD, Benavides R, Clouse WJ. Effects of aloe extracts on human normal and tumor cells in vitro. Econ Bot 1981;35:89-95.