The impairment of insulin signaling in Alzheimer's disease

IUBMB Life

Volumn 64, Issue 12, 2012, Pages 951-957

  Candeias, Emanuel ^a   Duarte, Ana I ^a   Carvalho, Cristina ^a,b   Correia, Sõnia C ^a,b   Cardoso, Susana ^a,b   Santos, Renato X ^a,b   Plácido, Ana I ^a,c   Perry, George ^d   Moreira, Paula I ^a,c  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF COIMBRA   (Portugal)

^d The University of Texas at San Antonio   (United States)

Author keywords

aging; Alzheimer's disease; insulin signaling; type 2 diabetes

Indexed keywords

COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; COPPER ZINC SUPEROXIDE DISMUTASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIN DEPENDENT KINASE 5; CYTOCHROME C; FORKHEAD TRANSCRIPTION FACTOR; GAMMA SECRETASE; GLUCOSE TRANSPORTER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INSULINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROOPIOMELANOCORTIN; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN TYROSINE PHOSPHATASE 1B; RECEPTOR; SOMATOMEDIN C; TAU PROTEIN; TYROSINE KINASE RECEPTOR;

AGING; ALZHEIMER DISEASE; APOPTOSIS; AUTONOMIC NEUROPATHY; AUTOPHOSPHORYLATION; BLOOD BRAIN BARRIER; BRAIN DISEASE; CARDIOVASCULAR DISEASE; CELL DEATH; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; COGNITIVE DEFECT; DISEASE ASSOCIATION; ELECTROENCEPHALOGRAM; GLUCONEOGENESIS; GLUCOSE BRAIN LEVEL; GLUCOSE TRANSPORT; HIPPOCAMPUS; HUMAN; HYPERINSULINEMIA; HYPOGLYCEMIA; HYPOTHALAMUS; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; KIDNEY DISEASE; LONG TERM POTENTIATION; MEMORY CONSOLIDATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NERVOUS SYSTEM; NEUROBLAST; NEUROIMAGING; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OLFACTORY BULB; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PERIPHERAL NEUROPATHY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RETINOPATHY; REVIEW; RISK FACTOR; SEDENTARY LIFESTYLE; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

AGING; ALZHEIMER DISEASE; BRAIN; DIABETES MELLITUS; GENE EXPRESSION; GLUCOSE; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR I; MITOCHONDRIA; NEURONS; RECEPTOR, IGF TYPE 1; RISK FACTORS; SIGNAL TRANSDUCTION;

EID: 84870197271     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.1098     Document Type: Review

References (52)

1. Correia, S. C., Santos, R. X., Carvalho, C., Cardoso, S., Candeias, E., et al. (2012) Insulin signaling, glucose metabolism and mitochondria: major players in Alzheimer's disease and diabetes interrelation. Brain Res. 1441, 64-78.
2. Cummings, J. L., (2004) Alzheimer's disease. N. Engl. J. Med. 351, 56-67.
3. Alzheimer's Association (2012) Alzheimer's disease facts and figures. Alzheimer Dement. 8, 131-168.
4. Brody, H., (2011) Alzheimer's disease. Nature 475 (7355), S1. doi: 10.1038/475S1a.
5. Cunnane, S., Nugent, S., Roy, M., Courchesne-Loyer, A., Croteau, E., et al. (2011) Brain fuel metabolism, aging and Alzheimer's disease. Nutrition 27, 3-20.
6. McGowan, E., Eriksen, J., and, Hutton, M., (2006) A decade of modeling Alzheimer's disease in transgenic mice. Trends Genet. 22, 281-289.
7. Selkoe, D. J., (2001) Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid β-protein. J. Alzheimers Dis. 3, 75-80.
8. Fita, I. G., Enciu, A., and, Stanoiu, B. P., (2011) New insights on Alzheimer's disease diagnostic. Rom. J. Morphol. Embryol. 52, 975-979.
9. Moreira P. I., (2012) Alzheimer's disease and diabetes: an integrative view of the role of mitochondria, oxidative stress, and insulin. J. Alzheimers Dis. 30, 199-215.
10. Moreira, P. I., Duarte, A. I., Santos, M. S., Rego, A. C., and, Oliveira, C. R., (2009) An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease. J. Alzheimers Dis. 16, 741-761.
11. Duarte, A. I., Moreira, P. I., and, Oliveira, C. R., (2012) Insulin in central nervous system: more than just a peripheral hormone. J. Aging Res. 2012, 1-21.
12. Schulingkamp, R. J., Pagano, T. C., Hung, D., and, Raffa, R. B., (2000) Insulin receptors and insulin action in the brain: review and clinical implications. Neurosci. Biobehav. Rev. 24, 855-872.
13. van der Heide, L. P., Ramakers, G. M., and, Smidt, M. P., (2006) Insulin signaling in the central nervous system: learning to survive. Prog. Neurobiol. 79, 205-221. (Pubitemid 44331498)
14. Cole, A. R., Astell, A., Green, C., and, Sutherland, C., (2007) Molecular connexions between dementia and diabetes. Neurosci. Behav. Rev. 31, 1046-1063. (Pubitemid 47332620)
15. Plum, L., Schubert, M., and, Brüning, J. C., (2005) The role of insulin receptor signaling in the brain. Trends Endrocrinol. Metab. 16, 59-65. (Pubitemid 40270851)
16. Gasparini, L., Netzer, W. J., Greengard, P., and, Xu, H., (2002) Does insulin dysfunction play a role in Alzheimer's disease? Trends Pharmacol Sci. 23, 288-293. (Pubitemid 34655735)
17. Bosco, D., Fava, A., Plastine, M., Montalcine, T., and, Pujia, A., (2011) Possible implications of insulin resistance and glucose metabolism in Alzheimer's disease pathogenesis. J. Cell Mol. Med. 15, 1807-1821.
18. McNay, E. C., and, Recknagel, A. K., (2011) Brain insulin signaling: a key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes. Neurobiol. Learn. Mem. 96, 432-442.
19. Li, L., and, Holscher, C., (2007) Common pathological processes in Alzheimer disease and type 2 diabetes: a review. Brain Res. Rev. 56, 384-402. (Pubitemid 350166529)
20. Kim, B., and, Feldman, E. L., (2012) Insulin resistance in the nervous system. Trends Endocrinol. Metab. 23, 133-141.
21. Lizcano, J. M., and, Alessi, D. R., (2002) The insulin signaling pathway. Curr. Biol. 12, 236-238.
22. Fang, X., Yu, S. X., Lu, Y., Bast, R. C., Woodgett, J. R., et al. (2000) Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc. Natl. Acad. Sci. USA 97, 11960-11965.
23. Heras-Sandoval, D., Avila-Muñoz, E., and, Arias, C., (2011) The phosphatidylinositol 3-kinase/mTor pathway as a therapeutic target for brain aging and neurodegeneration. Pharmaceuticals 4, 1070-1087.
24. Maier, M., Seabrook, T. J., and, Lemere, C. A., (2005) Developing novel immunogens for an effective, safe Alzheimer's disease vaccine. Neurodegener. Dis. 2, 267-272. (Pubitemid 43805911)
25. Correia, S. C., Santos, R. X., Perry, G., Zhu, X., Moreira, P. I., et al. (2011) Insulin-resistant brain state: the culprit in sporadic Alzheimer's disease? Ageing Res. Rev. 10, 264-273.
26. Anderton, B. H., (2002) Ageing of the brain. Mech. Ageing Dev. 123, 811-817. (Pubitemid 34178493)
27. Brewer, G. J., (2010) Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories. Exp. Gerontol. 45, 173-179.
28. Fulop, T., Larbi, A., and, Douziech, N., (2003) Insulin receptor and ageing. Pathol. Biol. 51, 574-580. (Pubitemid 37466376)
29. Muller, A. P., Fernandez, A. M., Haas, C., Zimmer, E., Portela, L. V., et al. (2012) Reduced brain insulin-like growth factor I function during aging. Mol. Cell Neurosci. 49, 9-12.
30. Burns, J. M., Honea, R. A., Vidoni, E. D., Hutfles, L. J., Brooks, W. M., et al. (2012) Insulin is differentially related to cognitive decline and atrophy in Alzheimer's disease and aging. Biochim Biophys Acta 1822, 333-339.
31. Bishop, N., Lu, T., and, Yankner, B. A., (2010) Neural mechanisms of ageing and cognitive decline. Nature 464, 529-535.
32. Harries, L. W., Fellows, A. D., Pilling, L. C., Hernandez, D., Singleton, A., et al. (2012) Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations. Mech. Ageing Dev. 133, 556-562.
33. Parella, E., and, Longo, V. D., (2010) Insulin/IGF-1 and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain. ScientificWorldJournal 10, 161-177.
34. de la Monte, S. M., (2009) Insulin resistance and Alzheimer's disease. BMB Rep. 31, 475-481.
35. Moloney, A. M., Griffin, R. J., Timmons, S., O'Connor, R., Ravid, R., et al. (2010) Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signaling. Neurobiol. Aging 31, 224-243.
36. Sims-Robinson, C., Kim, B., Rosko, A., and, Feldman, E. L., (2010) How does diabetes accelerate Alzheimer's disease pathology? Nat. Rev. Neurol. 6, 551-559.
37. Zhao, Z., Xiang, Z., Haroutunian, V., Buxbaum, J. D., Stetka, B., et al. (2007) Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease. Neurobiol. Aging 28, 824-830. (Pubitemid 46589743)
38. Bomfim, T. R., Forny-Germano, L., Sathler, L. B., Brito-Moreira, J., Houzel, J. C., et al. (2012) An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Aβ oligomers. J. Clin. Invest. 122, 1339-1353.
39. Talbot, K., Wang, H. Y., Kazi, H., Han, L. Y., Bakshi, K. P., et al. (2012) Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J. Clin. Invest. 122, 1316-1338.
40. Moreira, P. I., Cardoso, S. M., Pereira, C. M., Santos, M. S., and, Oliveira, C. R., (2009) Mitochondria as a therapeutic target in Alzheimer's disease and diabetes. CNS Neurol. Disord. Drug Targets 8, 492-511.
41. Biessels, G. J., van der Heide, L. P., Kamal, A., Bleys, R. L. A. W., and, Gispen, W. H., (2002) Ageing and diabetes: implications for brain function. Eur. J. Pharmacol. 441, 1-14. (Pubitemid 34465684)
42. Roriz-Filho, J. S., Sá-Roriz, T. M., Rosset, I., Camozzato, A. L., Santos, A. C., et al. (2009) (Pre)diabetes, brain aging and cognition. Biochim. Biophys. Acta 1792, 432-443.
43. Reijmer, Y. D., van den Berg, E., Ruis, C., Kappelle, L. J., and, Biessels, G. J., (2010) Cognitive dysfunction in patients with type 2 diabetes. Diabetes Metab. Res. Rev. 26, 507-519.
44. Ristow, M., (2004) Neurodegenerative disorders associated with diabetes mellitus. J. Mol. Med. 82, 510-529. (Pubitemid 39149861)
45. Wiwanitkit, V., (2008) Diabetes type 3: a brief review. Diabetes Metab. Syndr. Clin. Res. Rev. 2, 223-226.
46. Zhao, W., and, Townsend, M., (2009) Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease. Biochim. Biophys. Acta 1792, 482-496.
47. Ott, A., Stolk, R. P., van Harskamp, F., Pols, H. A., Hofman, A., et al. (1999) Diabetes mellitus and the risk of dementia: the Rotterdam study. Neurology 53, 1937-1942.
48. Liu, Y., Liu, F., Grundke-Igbal, I., Igbal, K., and, Gong, C. X., (2011) Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes. J. Pathol. 225, 54-62.
49. Jolivalt, C. G., Hurford, R., Lee, C. A., Dumaop, W., Rockenstein, E., et al. (2010) Type 1 diabetes exaggerates features of Alzhmeir's disease in APP transgenic mice. Exp. Neurol. 223, 422-431.
50. Carvalho, C., Cardoso, S., Correia, S. C., Santos, R. X., Baldeiras, I., et al. (2012) Metabolic alterations induced by sucrose intake and Alzheimer's disease promote similar brain mitochondrial abnormalities. Diabetes 61, 1234-1242.
51. Devi, L., Alldred, M. J., Ginsberg, S. D., and, Ohno, M., (2012) Mechanisms underlying insulin deficiency-induced acceleration of β-amyloidosis in a mouse model of Alzheimer's disease. PLoS One 7, e32792.
52. Son, S. M., Song, H., Byun, J., Park, K. S., Jang, H. C., et al. (2012) Altered APP processing in insulin-resistant conditions is mediated by autophagosome accumulation via the inhibition of mammalian target of rapamycin pathway. Diabetes (in press).