A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization

Journal of Medicinal Chemistry

Volumn 55, Issue 22, 2012, Pages 10160-10176

  Kaul, Malvika ^a   Parhi, Ajit K ^b   Zhang, Yongzheng ^b   Lavoie, Edmond J ^c   Tuske, Steve ^d   Arnold, Eddy ^d   Kerrigan, John E ^e   Pilch, Daniel S ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b TAXIS Pharmaceuticals Inc   (United States)

^c RUTGERS UNIVERSITY   (United States)

^d RUTGERS UNIVERSITY   (United States)

^e RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [[4' (TERT BUTYL)(1,1' BIPHENYL) 3 YL]METHYL]GUANIDINE; AMIKACIN; AMPICILLIN; CLINDAMYCIN; ERYTHROMYCIN; FTSZ PROTEIN; GUANIDINE DERIVATIVE; METHYL GROUP; NEOMYCIN; OXACILLIN; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL CELL WALL; BACTERICIDAL ACTIVITY; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; IN VITRO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PROTEIN POLYMERIZATION; PROTEIN TARGETING; VANCOMYCIN RESISTANT ENTEROCOCCUS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BIPHENYL COMPOUNDS; CYTOSKELETAL PROTEINS; DRUG RESISTANCE, MULTIPLE; ENTEROCOCCUS; GUANIDINES; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; POLYMERIZATION; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; VANCOMYCIN RESISTANCE;

EID: 84870051438     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3012728     Document Type: Article

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