Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 22, 2012, Pages 6962-6966

  Parhi, Ajit ^a   Lu, Songfeng ^a   Kelley, Cody ^b   Kaul, Malvika ^c   Pilch, Daniel S ^c   Lavoie, Edmond J ^b  

^a TAXIS Pharmaceuticals Inc   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Antibacterial; Dibenzo a,g quinolizinium; Enterococcus faecalis; FtsZ targeting; Staphylococcus aureus

Indexed keywords

12 BIPHENYLDIBENZO[A,G]QUINOLIZIN 7 IUM DERIVATIVE; 2 BIPHENYLDIBENZO[A,G]QUINOLIZIN 7 IUM DERIVATIVE; 8 METHYLDIBENZO[A,G]QUINOLIZIN 7 IUM DERIVATIVE; ANTIINFECTIVE AGENT; BIPHENYL; DIBENZO[A,G]QUINOLIZIN 7 IUM DERIVATIVE; FTSZ PROTEIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG POTENCY; DRUG STRUCTURE; ENTEROCOCCUS FAECALIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; POLYMERIZATION; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BERBERINE; CYTOSKELETAL PROTEINS; ENTEROCOCCUS FAECALIS; MICROBIAL SENSITIVITY TESTS; QUINOLIZINES; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); ENTEROCOCCUS FAECALIS; STAPHYLOCOCCUS AUREUS;

EID: 84867876580     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.123     Document Type: Article

References (25)

1. H.L. Leavis, R.J.L. Willems, J. Top, E. Spalburg, E.M. Mascini, A.C. Fluit, A. Hoepelman, A.J. de Neeling, and M.J.M. Bonten Emerg. Infect. Dis. 9 2003 1108
2. R.M. Klevens, M.A. Morrison, J. Nadle, S. Petit, K. Gershman, S. Ray, L.H. Harrison, R. Lynfield, G. Dumyati, J.M. Townes, A.S. Craig, E.R. Zell, G.E. Fosheim, L.K. McDougal, R.B. Carey, and S.K. Fridkin J. Am. Med. Assoc. 298 2007 1763
3. S.G. Addinall, and B. Holland J. Mol. Biol. 318 2002 219
4. W. Margolin Nat. Rev. Mol. Cell Biol. 6 2005 862
5. S.G. Addinall, E. Bi, and J. Lutkenhaus J. Bacteriol. 178 1996 3877
6. M.G. Pinho, and J. Errington Mol. Microbiol. 50 2003 871
7. J. Lutkenhaus, and S.G. Addinall Annu. Rev. Biochem. 66 1997 93
8. J. Lowe, F. van den Entm, and L.A. Amos Annu. Rev. Biophys. Biomol. Struct. 33 2004 177
9. R.L. Lock, and E.J. Harry Nat. Rev. 7 2008 324
10. S. Kapoor, and D. Panda Expert Opin. Ther. Targets 13 2009 1037
11. M.H. Foss, Y.-J. Eun, and D.B. Weibel Biochemistry 50 2011 7719
12. C. Schaffner-Barbero, M. Martin-Fontecha, P. Chacon, and J.M. Andreu ACS Chem. Biol. 7 2012 269
13. D.N. Margalit, L. Romberg, R.B. Mets, A.M. Hebert, T.J. Mitchision, M.W. Kirschner, and D. RayChaudhuri Proc. Natl. Acad. Sci. U.S.A. 101 2004 11821
14. J.M. Andreu, C. Schaffner-Barbero, S. Huecas, D. Alonso, M.L. Lopez-Rodriguez, L.B. Ruiz-Avila, R. Núñez-Ramírez, O. Llorca, and A.J. Martín-Galiano J. Biol. Chem. 285 2010 14239
15. T.K. Beuria, M.K. Santra, and D. Panda Biochemistry 44 2005 16584
16. P.N. Domadia, A. Bhunia, J. Sivaraman, S. Swarup, and D. Dasgupta Biochemistry 47 2008 3225
17. D.J. Haydon, J.M. Bennett, D. Brown, I. Collins, G. Galbraith, P. Lancett, R. Macdonald, N.R. Stokes, P.K. Chauhan, J.K. Sutariya, N. Nayal, A. Srivastava, J. Beanland, R. Hall, V. Henstock, C. Noula, C. Rockley, and L. Czaplewski J. Med. Chem. 53 2010 3927
18. D.J. Haydon, N.R. Stokes, R. Ure, G. Galbraith, J.M. Bennett, D.R. Brown, P.J. Baker, V.V. Barynin, D.W. Rice, S.E. Sedelnikova, J.R. Heal, J.M. Sheridan, S.T. Aiwale, P.K. Chauhan, A. Srivastava, A. Taneja, I. Collins, J. Errington, and L.G. Czaplewski Science 321 2008 1673
19. K. Kumar, D. Awasthi, S.Y. Lee, I. Zanardi, B. Ruzsicska, S. Knudson, P.J. Tonge, R.A. Slayden, and I. Ojima J. Med. Chem. 54 2011 374
20. T. Läppchen, A.F. Hartog, V.A. Pinas, G.J. Koomen, and T. den Blaauwen Biochemistry 44 2005 7879
21. S. Urgaonkar, H.S. La Pierre, I. Meir, H. Lund, D. RayChaudhuri, and J.T. Shaw Org. Lett. 7 2005 5609
22. A.R. Ball, G. Casadei, S. Samosorn, J.B. Bremner, F.M. Ausubel, T.I. Moy, and K. Lewis ACS Chem. Biol. 1 2006 594
23. J.M. Boberek, J. Stach, and L. Good PLoS One 5 2010 e13745
24. K. Iwasa, M. Kamigauchi, M. Ueki, and M. Taniguchi Eur. J. Med. Chem. 31 1996 469
25. CLSI Methods for dilution antimicrobial sucseptibility tests for bacteria that grow aerobically; approved standard-eighth edition; Clinical and Laboratory Standards Institute: Wayne, PA, 2009.