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Volumn 5, Issue 6, 2012, Pages 763-771

Understanding the hypoxic niche of multiple myeloma: Therapeutic implications and contributions of mouse models

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; PIMONIDAZOLE; VASCULOTROPIN RECEPTOR;

EID: 84870020416     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.008961     Document Type: Note
Times cited : (54)

References (115)
  • 2
    • 79952717247 scopus 로고    scopus 로고
    • Oncogenomics to target myeloma in the bone marrow microenvironment
    • Anderson, K. C. (2011). Oncogenomics to target myeloma in the bone marrow microenvironment. Clin. Cancer Res. 17, 1225-1233.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 1225-1233
    • Anderson, K.C.1
  • 3
    • 0034584607 scopus 로고    scopus 로고
    • The 5TMM series: A useful in vivo mouse model of human multiple myeloma
    • Asosingh, K., Radl, J., Van Riet, I., Van Camp, B. and Vanderkerken, K. (2000). The 5TMM series: a useful in vivo mouse model of human multiple myeloma. Hematol. J. 1, 351-356.
    • (2000) Hematol. J. , vol.1 , pp. 351-356
    • Asosingh, K.1    Radl, J.2    Van Riet, I.3    Van Camp, B.4    Vanderkerken, K.5
  • 6
    • 66149150580 scopus 로고    scopus 로고
    • CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy
    • Azab, A. K., Runnels, J. M., Pitsillides, C., Moreau, A. S., Azab, F., Leleu, X., Jia, X., Wright, R., Ospina, B., Carlson, A. L. et al. (2009). CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy. Blood 113, 4341-4351.
    • (2009) Blood , vol.113 , pp. 4341-4351
    • Azab, A.K.1    Runnels, J.M.2    Pitsillides, C.3    Moreau, A.S.4    Azab, F.5    Leleu, X.6    Jia, X.7    Wright, R.8    Ospina, B.9    Carlson, A.L.10
  • 7
    • 84862506605 scopus 로고    scopus 로고
    • Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features
    • Azab, A. K., Hu, J., Quang, P., Azab, F., Pitsillides, C., Awwad, R., Thompson, B., Maiso, P., Sun, J. D., Hart, C. P. et al. (2012). Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features. Blood 119, 5782-5794.
    • (2012) Blood , vol.119 , pp. 5782-5794
    • Azab, A.K.1    Hu, J.2    Quang, P.3    Azab, F.4    Pitsillides, C.5    Awwad, R.6    Thompson, B.7    Maiso, P.8    Sun, J.D.9    Hart, C.P.10
  • 10
    • 82255167669 scopus 로고    scopus 로고
    • Targeting hypoxic tumour cells to overcome metastasis
    • Bennewith, K. L. and Dedhar, S. (2011). Targeting hypoxic tumour cells to overcome metastasis. BMC Cancer 11, 504.
    • (2011) BMC Cancer , vol.11 , pp. 504
    • Bennewith, K.L.1    Dedhar, S.2
  • 11
    • 79954436115 scopus 로고    scopus 로고
    • A unique three-dimensional SCID-polymeric scaffold (SCID-synth-hu) model for in vivo expansion of human primary multiple myeloma cells
    • Calimeri, T., Battista, E., Conforti, F., Neri, P., Di Martino, M. T., Rossi, M., Foresta, U., Piro, E., Ferrara, F., Amorosi, A. et al. (2011). A unique three-dimensional SCID-polymeric scaffold (SCID-synth-hu) model for in vivo expansion of human primary multiple myeloma cells. Leukemia 25, 707-711.
    • (2011) Leukemia , vol.25 , pp. 707-711
    • Calimeri, T.1    Battista, E.2    Conforti, F.3    Neri, P.4    Di Martino, M.T.5    Rossi, M.6    Foresta, U.7    Piro, E.8    Ferrara, F.9    Amorosi, A.10
  • 13
    • 0031839633 scopus 로고    scopus 로고
    • Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma
    • Chesi, M., Bergsagel, P. L., Shonukan, O. O., Martelli, M. L., Brents, L. A., Chen, T., Schröck, E., Ried, T. and Kuehl, W. M. (1998). Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma. Blood 91, 4457-4463. (Pubitemid 28270291)
    • (1998) Blood , vol.91 , Issue.12 , pp. 4457-4463
    • Chesi, M.1    Bergsagel, P.L.2    Shonukan, O.O.3    Martelli, M.L.4    Brents, L.A.5    Chen, T.6    Schrock, E.7    Ried, T.8    Kuehl, W.M.9
  • 19
    • 78149468597 scopus 로고    scopus 로고
    • Low bone marrow oxygen tension and hypoxia-inducible factor-1a overexpression characterize patients with multiple myeloma: Role on the transcriptional and proangiogenic profiles of CD138(+) cells
    • Colla, S., Storti, P., Donofrio, G., Todoerti, K., Bolzoni, M., Lazzaretti, M., Abeltino, M., Ippolito, L., Neri, A., Ribatti, D. et al. (2010). Low bone marrow oxygen tension and hypoxia-inducible factor-1a overexpression characterize patients with multiple myeloma: role on the transcriptional and proangiogenic profiles of CD138(+) cells. Leukemia 24, 1967-1970.
    • (2010) Leukemia , vol.24 , pp. 1967-1970
    • Colla, S.1    Storti, P.2    Donofrio, G.3    Todoerti, K.4    Bolzoni, M.5    Lazzaretti, M.6    Abeltino, M.7    Ippolito, L.8    Neri, A.9    Ribatti, D.10
  • 20
    • 0031058592 scopus 로고    scopus 로고
    • Measurement of tumor oxygenation: A comparison between polarographic needle electrodes and a time-resolved luminescence-based optical sensor
    • DOI 10.2307/3579340
    • Collingridge, D. R., Young, W. K., Vojnovic, B., Wardman, P., Lynch, E. M., Hill, S. A. and Chaplin, D. J. (1997). Measurement of tumor oxygenation: a comparison between polarographic needle electrodes and a time-resolved luminescence-based optical sensor. Radiat. Res. 147, 329-334. (Pubitemid 27114389)
    • (1997) Radiation Research , vol.147 , Issue.3 , pp. 329-334
    • Collingridge, D.R.1    Young, W.K.2    Vojnovic, B.3    Wardman, P.4    Lynch, E.M.5    Hill, S.A.6    Chaplin, D.J.7
  • 21
    • 0031929644 scopus 로고    scopus 로고
    • Technetium-99m-labeled HL91 to identify tumor hypoxia: Correlation with fluorine-18-FDG
    • Cook, G. J., Houston, S., Barrington, S. F. and Fogelman, I. (1998). Technetium-99m-labeled HL91 to identify tumor hypoxia: correlation with fluorine-18-FDG. J. Nucl. Med. 39, 99-103. (Pubitemid 28063179)
    • (1998) Journal of Nuclear Medicine , vol.39 , Issue.1 , pp. 99-103
    • Cook, G.J.R.1    Houston, S.2    Barrington, S.F.3    Fogelman, I.4
  • 22
    • 85047692887 scopus 로고    scopus 로고
    • Expansion of human SCID-repopulating cells under hypoxic conditions
    • DOI 10.1172/JCI200317669
    • Danet, G. H., Pan, Y., Luongo, J. L., Bonnet, D. A. and Simon, M. C. (2003). Expansion of human SCID-repopulating cells under hypoxic conditions. J. Clin. Invest. 112, 126-135. (Pubitemid 38056384)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.1 , pp. 126-135
    • Danet, G.H.1    Pan, Y.2    Luongo, J.L.3    Bonnet, D.A.4    Simon, M.C.5
  • 24
    • 83455238248 scopus 로고    scopus 로고
    • Animal models: Towards a myeloma mouse
    • DeWeerdt, S. (2011). Animal models: Towards a myeloma mouse. Nature 480, S38-S39.
    • (2011) Nature , vol.480
    • DeWeerdt, S.1
  • 25
    • 0024226847 scopus 로고
    • Cryospectrophotometric determination of tumor intravascular oxyhemoglobin saturations: Dependence on vascular geometry and tumor growth
    • Fenton, B. M., Rofstad, E. K., Degner, F. L. and Sutherland, R. M. (1988). Cryospectrophotometric determination of tumor intravascular oxyhemoglobin saturations: dependence on vascular geometry and tumor growth. J. Natl. Cancer Inst. 80, 1612-1619. (Pubitemid 19006810)
    • (1988) Journal of the National Cancer Institute , vol.80 , Issue.20 , pp. 1612-1619
    • Fenton, B.M.1    Rofstad, E.K.2    Degner, F.L.3    Sutherland, R.M.4
  • 26
    • 70549107720 scopus 로고    scopus 로고
    • A murine model of myeloma that allows genetic manipulation of the host microenvironment
    • Fowler, J. A., Mundy, G. R., Lwin, S. T., Lynch, C. C. and Edwards, C. M. (2009). A murine model of myeloma that allows genetic manipulation of the host microenvironment. Dis. Model. Mech. 2, 604-611.
    • (2009) Dis. Model. Mech. , vol.2 , pp. 604-611
    • Fowler, J.A.1    Mundy, G.R.2    Lwin, S.T.3    Lynch, C.C.4    Edwards, C.M.5
  • 27
    • 80455174743 scopus 로고    scopus 로고
    • Investigation on tumor hypoxia in resectable primary prostate cancer as demonstrated by 18F-FAZA PET/CT utilizing multimodality fusion techniques
    • Garcia-Parra, R., Wood, D., Shah, R. B., Siddiqui, J., Hussain, H., Park, H., Desmond, T., Meyer, C. and Piert, M. (2011). Investigation on tumor hypoxia in resectable primary prostate cancer as demonstrated by 18F-FAZA PET/CT utilizing multimodality fusion techniques. Eur. J. Nucl. Med. Mol. Imaging 38, 1816-1823.
    • (2011) Eur. J. Nucl. Med. Mol. Imaging , vol.38 , pp. 1816-1823
    • Garcia-Parra, R.1    Wood, D.2    Shah, R.B.3    Siddiqui, J.4    Hussain, H.5    Park, H.6    Desmond, T.7    Meyer, C.8    Piert, M.9
  • 28
    • 0030977162 scopus 로고    scopus 로고
    • A murine model of human myeloma bone disease
    • DOI 10.1016/S8756-3282(97)00056-2, PII S8756328297000562
    • Garrett, I. R., Dallas, S., Radl, J. and Mundy, G. R. (1997). A murine model of human myeloma bone disease. Bone 20, 515-520. (Pubitemid 27270464)
    • (1997) Bone , vol.20 , Issue.6 , pp. 515-520
    • Garrett, I.R.1    Dallas, S.2    Radl, J.3    Mundy, G.R.4
  • 30
    • 33646596927 scopus 로고    scopus 로고
    • Synergistic activity of the proteasome inhibitor PS-341 with non-myeloablative 153-Sm-EDTMP skeletally targeted radiotherapy in an orthotopic model of multiple myeloma
    • DOI 10.1182/blood-2005-09-3870
    • Goel, A., Dispenzieri, A., Geyer, S. M., Greiner, S., Peng, K. W. and Russell, S. J. (2006). Synergistic activity of the proteasome inhibitor PS-341 with nonmyeloablative 153-Sm-EDTMP skeletally targeted radiotherapy in an orthotopic model of multiple myeloma. Blood 107, 4063-4070. (Pubitemid 43726815)
    • (2006) Blood , vol.107 , Issue.10 , pp. 4063-4070
    • Goel, A.1    Dispenzieri, A.2    Geyer, S.M.3    Greiner, S.4    Peng, K.-W.5    Russell, S.J.6
  • 32
    • 0032780848 scopus 로고    scopus 로고
    • The OxyLite: A fibre-optic oxygen sensor
    • Griffiths, J. R. and Robinson, S. P. (1999). The OxyLite: a fibre-optic oxygen sensor. Br. J. Radiol. 72, 627-630. (Pubitemid 29355605)
    • (1999) British Journal of Radiology , vol.72 , Issue.JUL. , pp. 627-630
    • Griffiths, J.R.1    Robinson, S.P.2
  • 33
    • 34447616779 scopus 로고    scopus 로고
    • Oxygen saturation in the bone marrow of healthy volunteers
    • Harrison, J. S., Rameshwar, P., Chang, V. and Bandari, P. (2002). Oxygen saturation in the bone marrow of healthy volunteers. Blood 99, 394.
    • (2002) Blood , vol.99 , pp. 394
    • Harrison, J.S.1    Rameshwar, P.2    Chang, V.3    Bandari, P.4
  • 34
    • 34547106018 scopus 로고    scopus 로고
    • Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
    • DOI 10.1038/nrc2189, PII NRC2189
    • Hideshima, T., Mitsiades, C., Tonon, G., Richardson, P. G. and Anderson, K. C. (2007). Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat. Rev. Cancer 7, 585-598. (Pubitemid 47106630)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.8 , pp. 585-598
    • Hideshima, T.1    Mitsiades, C.2    Tonon, G.3    Richardson, P.G.4    Anderson, K.C.5
  • 35
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
    • Höckel, M. and Vaupel, P. (2001). Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J. Natl. Cancer Inst. 93, 266-276. (Pubitemid 32219813)
    • (2001) Journal of the National Cancer Institute , vol.93 , Issue.4 , pp. 266-276
    • Hockel, M.1    Vaupel, P.2
  • 36
    • 0026356726 scopus 로고
    • Oxygenation of carcinomas of the uterine cervix: Evaluation by computerized O2 tension measurements
    • Höckel, M., Schlenger, K., Knoop, C. and Vaupel, P. (1991). Oxygenation of carcinomas of the uterine cervix: evaluation by computerized O2 tension measurements. Cancer Res. 51, 6098-6102.
    • (1991) Cancer Res. , vol.51 , pp. 6098-6102
    • Höckel, M.1    Schlenger, K.2    Knoop, C.3    Vaupel, P.4
  • 37
    • 0031423899 scopus 로고    scopus 로고
    • Measurement of hypoxia in vivo using a 2-nitromidazole (NITP)
    • Hodgkiss, R. J., Webster, L. and Wilson, G. D. (1997). Measurement of hypoxia in vivo using a 2-nitroimidazole (NITP). Adv. Exp. Med. Biol. 428, 61-67. (Pubitemid 28127990)
    • (1997) Advances in Experimental Medicine and Biology , vol.428 , pp. 61-67
    • Hodgkiss, R.J.1
  • 38
    • 77951868727 scopus 로고    scopus 로고
    • Effect of a topical vasodilator on tumor hypoxia and tumor oxygen guided radiotherapy using EPR oximetry
    • Hou, H., Abramovic, Z., Lariviere, J. P., Sentjurc, M., Swartz, H. and Khan, N. (2010). Effect of a topical vasodilator on tumor hypoxia and tumor oxygen guided radiotherapy using EPR oximetry. Radiat. Res. 173, 651-658.
    • (2010) Radiat. Res. , vol.173 , pp. 651-658
    • Hou, H.1    Abramovic, Z.2    Lariviere, J.P.3    Sentjurc, M.4    Swartz, H.5    Khan, N.6
  • 42
    • 2442677493 scopus 로고    scopus 로고
    • Carbogen-induced changes in vat mammary tumour oxygenation reported by near infrared spectroscopy
    • Hull, E. L., Conover, D. L. and Foster, T. H. (1999). Carbogen-induced changes in rat mammary tumour oxygenation reported by near infrared spectroscopy. Br. J. Cancer 79, 1709-1716. (Pubitemid 29132293)
    • (1999) British Journal of Cancer , vol.79 , Issue.11-12 , pp. 1709-1716
    • Hull, E.1    Conover, D.L.2    Foster, T.H.3
  • 43
    • 1442285889 scopus 로고    scopus 로고
    • Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma
    • DOI 10.1016/S1535-6108(04)00019-4, PII S1535610804000194
    • Hurt, E. M., Wiestner, A., Rosenwald, A., Shaffer, A. L., Campo, E., Grogan, T., Bergsagel, P. L., Kuehl, W. M. and Staudt, L. M. (2004). Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma. Cancer Cell 5, 191-199. (Pubitemid 38283804)
    • (2004) Cancer Cell , vol.5 , Issue.2 , pp. 191-199
    • Hurt, E.M.1    Wiestner, A.2    Rosenwald, A.3    Shaffer, A.L.4    Campo, E.5    Grogan, T.6    Bergsagel, P.L.7    Kuehl, W.M.8    Staudt, L.M.9
  • 44
    • 0037385313 scopus 로고    scopus 로고
    • Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-I
    • DOI 10.1038/ni907
    • Iwakoshi, N. N., Lee, A. H., Vallabhajosyula, P., Otipoby, K. L., Rajewsky, K. and Glimcher, L. H. (2003). Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat. Immunol. 4, 321-329. (Pubitemid 36432313)
    • (2003) Nature Immunology , vol.4 , Issue.4 , pp. 321-329
    • Iwakoshi, N.N.1    Lee, A.-H.2    Vallabhajosyula, P.3    Otipoby, K.L.4    Rajewsky, K.5    Glimcher, L.H.6
  • 49
    • 38549119024 scopus 로고    scopus 로고
    • Modeling multiple myeloma by AID-dependent conditional activation of MYC
    • Kuehl, W. M. (2008). Modeling multiple myeloma by AID-dependent conditional activation of MYC. Cancer Cell 13, 85-87.
    • (2008) Cancer Cell , vol.13 , pp. 85-87
    • Kuehl, W.M.1
  • 51
    • 42449114035 scopus 로고    scopus 로고
    • Multiple myeloma
    • Kyle, R. A. and Rajkumar, S. V. (2008). Multiple myeloma. Blood 111, 2962-2972.
    • (2008) Blood , vol.111 , pp. 2962-2972
    • Kyle, R.A.1    Rajkumar, S.V.2
  • 54
    • 0035028655 scopus 로고    scopus 로고
    • Cultivation of rat marrow-derived mesenchymal stem cells in reduced oxygen tension: Effects on in vitro and in vivo osteochondrogenesis
    • DOI 10.1002/jcp.1081
    • Lennon, D. P., Edmison, J. M. and Caplan, A. I. (2001). Cultivation of rat marrow-derived mesenchymal stem cells in reduced oxygen tension: effects on in vitro and in vivo osteochondrogenesis. J. Cell. Physiol. 187, 345-355. (Pubitemid 32378359)
    • (2001) Journal of Cellular Physiology , vol.187 , Issue.3 , pp. 345-355
    • Lennon, D.P.1    Edmison, J.M.2    Caplan, A.I.3
  • 56
    • 34547873919 scopus 로고    scopus 로고
    • Hematopoietic progenitor cell mobilization results in hypoxia with increased hypoxia-inducible transcription factor-1α and vascular endothelial growth factor A in bone marrow
    • DOI 10.1634/stemcells.2006-0688
    • Lévesque, J. P., Winkler, I. G., Hendy, J., Williams, B., Helwani, F., Barbier, V., Nowlan, B. and Nilsson, S. K. (2007). Hematopoietic progenitor cell mobilization results in hypoxia with increased hypoxia-inducible transcription factor-1 alpha and vascular endothelial growth factor A in bone marrow. Stem Cells 25, 1954-1965. (Pubitemid 47258173)
    • (2007) Stem Cells , vol.25 , Issue.8 , pp. 1954-1965
    • Levesque, J.-P.1    Winkler, I.G.2    Hendy, J.3    Williams, B.4    Helwani, F.5    Barbier, V.6    Nowlan, B.7    Nilsson, S.K.8
  • 58
    • 78349272461 scopus 로고    scopus 로고
    • HIF-1 and HIF-2 transcription factors - Similar but not identical
    • Loboda, A., Jozkowicz, A. and Dulak, J. (2010). HIF-1 and HIF-2 transcription factors - similar but not identical. Mol. Cells 29, 435-442.
    • (2010) Mol. Cells , vol.29 , pp. 435-442
    • Loboda, A.1    Jozkowicz, A.2    Dulak, J.3
  • 59
    • 60449115552 scopus 로고    scopus 로고
    • The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions
    • Lu, L., Payvandi, F., Wu, L., Zhang, L. H., Hariri, R. J., Man, H. W., Chen, R. S., Muller, G. W., Hughes, C. C., Stirling, D. I. et al. (2009). The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions. Microvasc. Res. 77, 78-86.
    • (2009) Microvasc. Res. , vol.77 , pp. 78-86
    • Lu, L.1    Payvandi, F.2    Wu, L.3    Zhang, L.H.4    Hariri, R.J.5    Man, H.W.6    Chen, R.S.7    Muller, G.W.8    Hughes, C.C.9    Stirling, D.I.10
  • 62
    • 80054022144 scopus 로고    scopus 로고
    • The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma
    • Martin, S. K., Diamond, P., Gronthos, S., Peet, D. J. and Zannettino, A. C. (2011). The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma. Leukemia 25, 1533-1542.
    • (2011) Leukemia , vol.25 , pp. 1533-1542
    • Martin, S.K.1    Diamond, P.2    Gronthos, S.3    Peet, D.J.4    Zannettino, A.C.5
  • 68
    • 79952796286 scopus 로고    scopus 로고
    • 18F-fluromisonidazole PET imaging as a biomarker for the response to 5,6-dimethylxanthenone-4-acetic acid in colorectal xenograft tumors
    • Oehler, C., O'Donoghue, J. A., Russell, J., Zanzonico, P., Lorenzen, S., Ling, C. C. and Carlin, S. (2011). 18F-fluromisonidazole PET imaging as a biomarker for the response to 5,6-dimethylxanthenone-4-acetic acid in colorectal xenograft tumors. J. Nucl. Med. 52, 437-444.
    • (2011) J. Nucl. Med. , vol.52 , pp. 437-444
    • Oehler, C.1    O'Donoghue, J.A.2    Russell, J.3    Zanzonico, P.4    Lorenzen, S.5    Ling, C.C.6    Carlin, S.7
  • 72
    • 14944377039 scopus 로고    scopus 로고
    • Targeting multiple myeloma cells and their bone marrow microenvironment
    • DOI 10.1196/annals.1322.047
    • Pagnucco, G., Cardinale, G. and Gervasi, F. (2004). Targeting multiple myeloma cells and their bone marrow microenvironment. Ann. N. Y. Acad. Sci. 1028, 390-399. (Pubitemid 40361840)
    • (2004) Annals of the New York Academy of Sciences , vol.1028 , pp. 390-399
    • Pagnucco, G.1    Cardinale, G.2    Gervasi, F.3
  • 73
    • 33748938340 scopus 로고    scopus 로고
    • Targeting the PAS-A domain of HIF-1α for development of small molecule inhibitors of HIF-1
    • Park, E. J., Kong, D., Fisher, R., Cardellina, J., Shoemaker, R. H. and Melillo, G. (2006). Targeting the PAS-A domain of HIF-1alpha for development of small molecule inhibitors of HIF-1. Cell Cycle 5, 1847-1853. (Pubitemid 44435329)
    • (2006) Cell Cycle , vol.5 , Issue.16 , pp. 1847-1853
    • Eun, J.P.1    Kong, D.2    Fisher, R.3    Cardellina, J.4    Shoemaker, R.H.5    Melillo, G.6
  • 76
    • 0023150682 scopus 로고
    • Augmentation of in vitro human marrow erythropoiesis under physiological oxygen tensions is mediated by monocytes and T lymphocytes
    • Pennathur-Das, R. and Levitt, L. (1987). Augmentation of in vitro human marrow erythropoiesis under physiological oxygen tensions is mediated by monocytes and T lymphocytes. Blood 69, 899-907. (Pubitemid 17057475)
    • (1987) Blood , vol.69 , Issue.3 , pp. 899-907
    • Pennathur-Das, R.1    Levitt, L.2
  • 77
    • 0034142369 scopus 로고    scopus 로고
    • Myeloma progenitors in the blood of patients with aggressive or minimal disease: Engraftment and self-renewal of primary human myeloma in the bone marrow of NOD SCD mice
    • Pilarski, L. M., Hipperson, G., Seeberger, K., Pruski, E., Coupland, R. W. and Belch, A. R. (2000). Myeloma progenitors in the blood of patients with aggressive or minimal disease: engraftment and self-renewal of primary human myeloma in the bone marrow of NOD SCID mice. Blood 95, 1056-1065. (Pubitemid 30062731)
    • (2000) Blood , vol.95 , Issue.3 , pp. 1056-1065
    • Pilarski, L.M.1    Hipperson, G.2    Seeberger, K.3    Pruski, E.4    Coupland, R.W.5    Belch, A.R.6
  • 78
    • 77953597349 scopus 로고    scopus 로고
    • A therapeutic role for targeting c-Myc/Hif-1-dependent signaling pathways
    • Podar, K. and Anderson, K. C. (2010). A therapeutic role for targeting c-Myc/Hif-1-dependent signaling pathways. Cell Cycle 9, 1722-1728.
    • (2010) Cell Cycle , vol.9 , pp. 1722-1728
    • Podar, K.1    Anderson, K.C.2
  • 79
    • 70350452792 scopus 로고    scopus 로고
    • Targeting the hypoxia-inducible factor (HIF) pathway in cancer
    • Poon, E., Harris, A. L. and Ashcroft, M. (2009). Targeting the hypoxia-inducible factor (HIF) pathway in cancer. Expert Rev. Mol. Med. 11, e26.
    • (2009) Expert Rev. Mol. Med. , vol.11
    • Poon, E.1    Harris, A.L.2    Ashcroft, M.3
  • 80
    • 70350379191 scopus 로고    scopus 로고
    • Intermittent hypoxia-mediated plasticity of acute O2 sensing requires altered red-ox regulation by HIF-1 and HIF-2
    • Prabhakar, N. R., Kumar, G. K. and Nanduri, J. (2009). Intermittent hypoxia-mediated plasticity of acute O2 sensing requires altered red-ox regulation by HIF-1 and HIF-2. Ann. N. Y. Acad. Sci. 1177, 162-168.
    • (2009) Ann. N. Y. Acad. Sci. , vol.1177 , pp. 162-168
    • Prabhakar, N.R.1    Kumar, G.K.2    Nanduri, J.3
  • 81
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: Role of the HIF system
    • DOI 10.1038/nm0603-677
    • Pugh, C. W. and Ratcliffe, P. J. (2003). Regulation of angiogenesis by hypoxia: role of the HIF system. Nat. Med. 9, 677-684. (Pubitemid 36749216)
    • (2003) Nature Medicine , vol.9 , Issue.6 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 82
    • 79955837932 scopus 로고    scopus 로고
    • Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4
    • Rademakers, S. E., Lok, J., van der Kogel, A. J., Bussink, J. and Kaanders, J. H. (2011). Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4. BMC Cancer 11, 167.
    • (2011) BMC Cancer , vol.11 , pp. 167
    • Rademakers, S.E.1    Lok, J.2    Van Der Kogel, A.J.3    Bussink, J.4    Kaanders, J.H.5
  • 83
    • 0018351394 scopus 로고
    • Idiopathic paraproteinemia. II. Transplantation of the paraprotein- producing clone from old to young C57BL/KaLwRij mice
    • Radl, J., De Glopper, E. D., Schuit, H. R. and Zurcher, C. (1979). Idiopathic paraproteinemia. II. Transplantation of the paraprotein-producing clone from old to young C57BL/KaLwRij mice. J. Immunol. 122, 609-613. (Pubitemid 9089221)
    • (1979) Journal of Immunology , vol.122 , Issue.2 , pp. 609-613
    • Radl, J.1    De Glopper, E.2    Schuit, H.R.E.3    Zurcher, C.4
  • 87
    • 33746257305 scopus 로고    scopus 로고
    • Importance of the bone marrow microenvironment in inducing the angiogenic response in multiple myeloma
    • DOI 10.1038/sj.onc.1209456, PII 1209456
    • Ribatti, D., Nico, B. and Vacca, A. (2006). Importance of the bone marrow microenvironment in inducing the angiogenic response in multiple myeloma. Oncogene 25, 4257-4266. (Pubitemid 44100496)
    • (2006) Oncogene , vol.25 , Issue.31 , pp. 4257-4266
    • Ribatti, D.1    Nico, B.2    Vacca, A.3
  • 88
    • 24344443670 scopus 로고    scopus 로고
    • Hypoxia-dependent activation of HIF into a transcriptional regulator
    • DOI 10.1016/j.semcdb.2005.04.001, PII S1084952105000601, Biology of Hypoxia and Myogenesis and Muscle Disease
    • Ruas, J. L. and Poellinger, L. (2005). Hypoxia-dependent activation of HIF into a transcriptional regulator. Semin. Cell Dev. Biol. 16, 514-522. (Pubitemid 41247874)
    • (2005) Seminars in Cell and Developmental Biology , vol.16 , Issue.4-5 , pp. 514-522
    • Ruas, J.L.1    Poellinger, L.2
  • 89
    • 0036710591 scopus 로고    scopus 로고
    • Signal transduction to hypoxia-inducible factor 1
    • Semenza, G. (2002). Signal transduction to hypoxia-inducible factor 1. Biochem. Pharmacol. 64, 993-998.
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 993-998
    • Semenza, G.1
  • 90
    • 0035812772 scopus 로고    scopus 로고
    • HIF-1, O(2), and the 3 PHDs: How animal cells signal hypoxia to the nucleus
    • Semenza, G. L. (2001). HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell 107, 1-3.
    • (2001) Cell , vol.107 , pp. 1-3
    • Semenza, G.L.1
  • 91
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza, G. L. (2003). Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3, 721-732.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 92
    • 42449130564 scopus 로고    scopus 로고
    • Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1
    • Shin, D. H., Chun, Y. S., Lee, D. S., Huang, L. E. and Park, J. W. (2008). Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1. Blood 111, 3131-3136.
    • (2008) Blood , vol.111 , pp. 3131-3136
    • Shin, D.H.1    Chun, Y.S.2    Lee, D.S.3    Huang, L.E.4    Park, J.W.5
  • 94
    • 0017259926 scopus 로고
    • Haematologic adaptation in patients with chronic bronchitis and pulmonary insufficiency
    • Skouby, A. R. (1976). Haematologic adaptation in patients with chronic bronchitis and pulmonary insufficiency. Acta Med. Scand. 199, 185-190.
    • (1976) Acta Med. Scand. , vol.199 , pp. 185-190
    • Skouby, A.R.1
  • 95
    • 0016662489 scopus 로고
    • Thermally induced conformational changes of tobacco mosaic virus and their protein assemblies
    • Taniguchi, M. and Taniguchi, T. (1975). Thermally induced conformational changes of tobacco mosaic virus and their protein assemblies. Biochim. Biophys. Acta 386, 1-17.
    • (1975) Biochim. Biophys. Acta , vol.386 , pp. 1-17
    • Taniguchi, M.1    Taniguchi, T.2
  • 97
    • 0018718153 scopus 로고
    • Observations on long bone medullary pressure in relation to mean arterial blood pressure in the anaesthetized dog
    • Tøndevold, E., Eriksen, J. and Jansen, E. (1979). Observations on long bone medullary pressure in relation to mean arterial blood pressure in the anaesthetized dog. Acta Orthop. Scand. 50, 527-531. (Pubitemid 10211567)
    • (1979) Acta Orthopaedica Scandinavica , vol.50 , Issue.5 , pp. 527-531
    • Tondevold, E.1    Eriksen, J.2    Jansen, E.3
  • 102
    • 0041814539 scopus 로고    scopus 로고
    • Multiple myeloma biology: Lessons from the 5TMM models
    • DOI 10.1034/j.1600-065X.2003.00035.x
    • Vanderkerken, K., Asosingh, K., Croucher, P. and Van Camp, B. (2003). Multiple myeloma biology: lessons from the 5TMM models. Immunol. Rev. 194, 196-206. (Pubitemid 36896125)
    • (2003) Immunological Reviews , vol.194 , pp. 196-206
    • Vanderkerken, K.1    Asosingh, K.2    Croucher, P.3    Van Camp, B.4
  • 103
    • 61849136670 scopus 로고    scopus 로고
    • Prognostic potential of the pre-therapeutic tumor oxygenation status
    • Vaupel, P. (2009). Prognostic potential of the pre-therapeutic tumor oxygenation status. Adv. Exp. Med. Biol. 645, 241-246.
    • (2009) Adv. Exp. Med. Biol. , vol.645 , pp. 241-246
    • Vaupel, P.1
  • 104
    • 0025807618 scopus 로고
    • Oxygenation of human tumors: Evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements
    • Vaupel, P., Schlenger, K., Knoop, C. and Höckel, M. (1991). Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements. Cancer Res. 51, 3316-3322.
    • (1991) Cancer Res. , vol.51 , pp. 3316-3322
    • Vaupel, P.1    Schlenger, K.2    Knoop, C.3    Höckel, M.4
  • 105
    • 79958766576 scopus 로고    scopus 로고
    • (1)H NMR metabolomics identification of markers of hypoxia-induced metabolic shifts in a breast cancer model system
    • Weljie, A. M., Bondareva, A., Zang, P. and Jirik, F. R. (2011). (1)H NMR metabolomics identification of markers of hypoxia-induced metabolic shifts in a breast cancer model system. J. Biomol. NMR 49, 185-193.
    • (2011) J. Biomol. NMR , vol.49 , pp. 185-193
    • Weljie, A.M.1    Bondareva, A.2    Zang, P.3    Jirik, F.R.4
  • 106
    • 4444369682 scopus 로고    scopus 로고
    • Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1α
    • Welsh, S., Williams, R., Kirkpatrick, L., Paine-Murrieta, G. and Powis, G. (2004). Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha. Mol. Cancer Ther. 3, 233-244. (Pubitemid 39193698)
    • (2004) Molecular Cancer Therapeutics , vol.3 , Issue.3 , pp. 233-244
    • Welsh, S.1    Williams, R.2    Kirkpatrick, L.3    Paine-Murrieta, G.4    Powis, G.5
  • 107
    • 33644827383 scopus 로고    scopus 로고
    • Bone-marrow haematopoietic-stem-cell niches
    • DOI 10.1038/nri1779, PII N1779
    • Wilson, A. and Trumpp, A. (2006). Bone-marrow haematopoietic-stem-cell niches. Nat. Rev. Immunol. 6, 93-106. (Pubitemid 43361585)
    • (2006) Nature Reviews Immunology , vol.6 , Issue.2 , pp. 93-106
    • Wilson, A.1    Trumpp, A.2
  • 108
    • 0026724974 scopus 로고
    • Localization of tumors and evaluation of their state of oxygenation by phosphorescence imaging
    • Wilson, D. F. and Cerniglia, G. J. (1992). Localization of tumors and evaluation of their state of oxygenation by phosphorescence imaging. Cancer Res. 52, 3988-3993.
    • (1992) Cancer Res. , vol.52 , pp. 3988-3993
    • Wilson, D.F.1    Cerniglia, G.J.2
  • 109
    • 79957534572 scopus 로고    scopus 로고
    • Targeting hypoxia in cancer therapy
    • Wilson, W. R. and Hay, M. P. (2011). Targeting hypoxia in cancer therapy. Nat. Rev. Cancer 11, 393-410.
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 393-410
    • Wilson, W.R.1    Hay, M.P.2
  • 111
    • 0032532608 scopus 로고    scopus 로고
    • Primary myeloma cells growing in SCID-hu mice: A model for studying the biology and treatment of myeloma and its manifestations
    • Yaccoby, S., Barlogie, B. and Epstein, J. (1998). Primary myeloma cells growing in SCID-hu mice: a model for studying the biology and treatment of myeloma and its manifestations. Blood 92, 2908-2913. (Pubitemid 28469106)
    • (1998) Blood , vol.92 , Issue.8 , pp. 2908-2913
    • Yaccoby, S.1    Barlogie, B.2    Epstein, J.3
  • 112
    • 8844264524 scopus 로고    scopus 로고
    • The SCID-rab model: A novel in vivo system for primary human myeloma demonstrating growth of CD138-expressing malignant cells
    • DOI 10.1038/sj.leu.2403513
    • Yata, K. and Yaccoby, S. (2004). The SCID-rab model: a novel in vivo system for primary human myeloma demonstrating growth of CD138-expressing malignant cells. Leukemia 18, 1891-1897. (Pubitemid 39530021)
    • (2004) Leukemia , vol.18 , Issue.11 , pp. 1891-1897
    • Yata, K.1    Yaccoby, S.2
  • 115
    • 79955571159 scopus 로고    scopus 로고
    • In vivo near-infrared spectroscopy and magnetic resonance imaging monitoring of tumor response to combretastatin A-4-phosphate correlated with therapeutic outcome
    • Zhao, D., Chang, C. H., Kim, J. G., Liu, H. and Mason, R. P. (2011). In vivo near-infrared spectroscopy and magnetic resonance imaging monitoring of tumor response to combretastatin A-4-phosphate correlated with therapeutic outcome. Int. J. Radiat. Oncol. Biol. Phys. 80, 574-581.
    • (2011) Int. J. Radiat. Oncol. Biol. Phys. , vol.80 , pp. 574-581
    • Zhao, D.1    Chang, C.H.2    Kim, J.G.3    Liu, H.4    Mason, R.P.5


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