-
1
-
-
0038699591
-
High-throughput classification of yeast mutants for functional genomics using metabolic footprinting
-
DOI 10.1038/nbt823
-
Allen J, Davey H, Broadhurst D, Heald J, Rowland J, Oliver S, Kell D (2003) High-throughput classification of yeast mutants for functional genomics using metabolic footprinting. Nat Biotechnol 21:692-696 (Pubitemid 36638098)
-
(2003)
Nature Biotechnology
, vol.21
, Issue.6
, pp. 692-696
-
-
Allen, J.1
Davey, H.M.2
Broadhurst, D.3
Heald, J.K.4
Rowland, J.J.5
Oliver, S.G.6
Kell, D.B.7
-
2
-
-
66049119129
-
The lysyl oxidase inhibitor, beta-aminopropionitrile, diminishes the metastatic colonization potential of circulating breast cancer cells
-
Bondareva A, Downey CM, Ayres F, Liu W, Boyd SK, Hallgrimsson B, Jirik FR (2009) The lysyl oxidase inhibitor, beta-aminopropionitrile, diminishes the metastatic colonization potential of circulating breast cancer cells. PLoS ONE 4:e5620
-
(2009)
PLoS ONE
, vol.4
-
-
Bondareva, A.1
Downey, C.M.2
Ayres, F.3
Liu, W.4
Boyd, S.K.5
Hallgrimsson, B.6
Jirik, F.R.7
-
3
-
-
38449098514
-
Leveraging latent information in NMR spectra for robust predictive models
-
Chang D, Weljie AM, Newton J (2007) Leveraging latent information in NMR spectra for robust predictive models. Pac Symp Biocomput 12:115-126
-
(2007)
Pac Symp Biocomput
, vol.12
, pp. 115-126
-
-
Chang, D.1
Weljie, A.M.2
Newton, J.3
-
4
-
-
34447564234
-
Metabolomics: Available results, current research projects in breast cancer, and future applications
-
DOI 10.1200/JCO.2006.09.7550
-
Claudino WM, Quattrone A, Biganzoli L, Pestrin M, Bertini I, Di Leo A (2007) Metabolomics: available results, current research projects in breast cancer, and future applications. J Clin Oncol 25:2840-2846 (Pubitemid 47123194)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.19
, pp. 2840-2846
-
-
Claudino, W.M.1
Quattrone, A.2
Biganzoli, L.3
Pestrin, M.4
Bertini, I.5
Di, L.A.6
-
6
-
-
63449101035
-
Metabolic footprinting study of white spruce somatic embryogenesis using NMR spectroscopy
-
Dowlatabadi R, Weljie AM, Thorpe TA, Yeung EC, Vogel HJ (2009) Metabolic footprinting study of white spruce somatic embryogenesis using NMR spectroscopy. Plant Physiol Biochem 47:343-350
-
(2009)
Plant Physiol Biochem
, vol.47
, pp. 343-350
-
-
Dowlatabadi, R.1
Weljie, A.M.2
Thorpe, T.A.3
Yeung, E.C.4
Vogel, H.J.5
-
8
-
-
33646365644
-
Lysyl oxidase is essential for hypoxia-induced metastasis
-
Erler JT, Bennewith KL, Nicolau M, Dornhöfer N, Kong C, Le Q, Chi JA, Jeffrey SS, Giaccia AJ (2006) Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 440:1222-1226
-
(2006)
Nature
, vol.440
, pp. 1222-1226
-
-
Erler, J.T.1
Bennewith, K.L.2
Nicolau, M.3
Dornhöfer, N.4
Kong, C.5
Le, Q.6
Chi, J.A.7
Jeffrey, S.S.8
Giaccia, A.J.9
-
9
-
-
67449085093
-
1H NMR-based metabonomics in the study of metabolic profiling of human hepatocellular carcinoma and liver cirrhosis
-
1H NMR-based metabonomics in the study of metabolic profiling of human hepatocellular carcinoma and liver cirrhosis. Cancer Sci 100:782-785
-
(2009)
Cancer Sci
, vol.100
, pp. 782-785
-
-
Gao, H.1
Lu, Q.2
Liu, X.3
Cong, H.4
Zhao, L.5
Wang, H.6
Lin, D.7
-
10
-
-
0036468251
-
Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild-type tumors and tumors deficient in hypoxia-inducible factor-1beta (HIF-1beta): Evidence of an anabolic role for the HIF-1 pathway
-
Griffiths JR, McSheehy PM, Robinson SP, Troy H, Chung YL, Leek RD, Williams KJ, Stratford IJ, Harris AL, Stubbs M (2002) Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild-type tumors and tumors deficient in hypoxia-inducible factor-1beta (HIF-1beta): evidence of an anabolic role for the HIF-1 pathway. Cancer Res 62:688-695 (Pubitemid 34126942)
-
(2002)
Cancer Research
, vol.62
, Issue.3
, pp. 688-695
-
-
Griffiths, J.R.1
McSheehy, P.M.J.2
Robinson, S.P.3
Troy, H.4
Chung, Y.-L.5
Leek, R.D.6
Williams, K.J.7
Stratford, I.J.8
Harris, A.L.9
Stubbs, M.10
-
11
-
-
0016423016
-
The formation of 2-hydroxybutyric acid in experimental animals
-
Landaas S (1975) The formation of 2-hydroxybutyric acid in experimental animals. Clin Chim Acta 58:23-32
-
(1975)
Clin Chim Acta
, vol.58
, pp. 23-32
-
-
Landaas, S.1
-
12
-
-
0037444362
-
Contemporary issues in toxicology: The role of metabonomics in toxicology and its evaluation by the COMET project
-
DOI 10.1016/S0041-008X(02)00079-0
-
Lindon JC, Nicholson JK, Holmes E, Antti H et al (2003) Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project. Toxicol Appl Pharmacol 187:137-146 (Pubitemid 36349345)
-
(2003)
Toxicology and Applied Pharmacology
, vol.187
, Issue.3
, pp. 137-146
-
-
Lindon, J.C.1
Nicholson, J.K.2
Holmes, E.3
Antti, H.4
Bollard, M.E.5
Keun, H.6
Beckonert, O.7
Ebbels, T.M.8
Reily, M.D.9
Robertson, D.10
Stevens, G.J.11
Luke, P.12
Breau, A.P.13
Cantor, G.H.14
Bible, R.H.15
Niederhauser, U.16
Senn, H.17
Schlotterbeck, G.18
Sidelmann, U.G.19
Laursen, S.M.20
Tymiak, A.21
Car, B.D.22
Lehman-McKeeman, L.23
Colet, J.-M.24
Loukaci, A.25
Thomas, C.26
more..
-
13
-
-
0036818507
-
Pyruvate reverses metabolic effects produced by hypoxia in glioma and hepatoma cell cultures
-
DOI 10.1016/S0300-9084(02)00008-1, PII S0300908402000081
-
Perrin A, Roudier E, Duborjal H, Bachelet C, Riva-Lavieille C, Leverve X, Massarelli R (2002) Pyruvate reverses metabolic effects produced by hypoxia in glioma and hepatoma cell cultures. Biochimie 84:1003-1011 (Pubitemid 36040533)
-
(2002)
Biochimie
, vol.84
, Issue.10
, pp. 1003-1011
-
-
Perrin, A.1
Roudier, E.2
Duborjal, H.3
Bachelet, C.4
Riva-Lavieille, C.5
Leverve, X.6
Massarelli, R.7
-
15
-
-
57449097020
-
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
-
Sonveaux P, Végran F, Schroeder T, Wergin MC et al (2008) Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest 118:3930-3942
-
(2008)
J Clin Invest
, vol.118
, pp. 3930-3942
-
-
Sonveaux, P.1
Végran, F.2
Schroeder, T.3
Wergin, M.C.4
-
16
-
-
33646917296
-
The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism
-
DOI 10.1074/jbc.M511397200
-
Ullah MS, Davies AJ, Halestrap AP (2006) The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. J Biol Chem 281:9030-9037 (Pubitemid 43864615)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.14
, pp. 9030-9037
-
-
Ullah, M.S.1
Davies, A.J.2
Halestrap, A.P.3
-
17
-
-
0035501326
-
Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model
-
Walenta S, Snyder S, Haroon ZA, Braun RD, Amin K, Brizel D, Mueller-Klieser W, Chance B, Dewhirst MW (2001) Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model. Int J Radiat Oncol Biol Phys 51:840-848
-
(2001)
Int J Radiat Oncol Biol Phys
, vol.51
, pp. 840-848
-
-
Walenta, S.1
Snyder, S.2
Haroon, Z.A.3
Braun, R.D.4
Amin, K.5
Brizel, D.6
Mueller-Klieser, W.7
Chance, B.8
Dewhirst, M.W.9
-
18
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O (1956) On the origin of cancer cells. Science 123:309-314
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
19
-
-
70449527373
-
Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing
-
Webb JD, Coleman ML, Pugh CW (2009) Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing. Cell Mol Life Sci 66:3539-3554
-
(2009)
Cell Mol Life Sci
, vol.66
, pp. 3539-3554
-
-
Webb, J.D.1
Coleman, M.L.2
Pugh, C.W.3
-
20
-
-
34948910696
-
1H NMR spectroscopy
-
DOI 10.1021/pr070123j
-
Weljie A, Dowlatabadi R, Miller B, Vogel H, Jirik F (2007) An inflammatory arthritis-associated metabolite biomarker pattern revealed by 1H NMR spectroscopy. J Proteome Res 6:3456-3464 (Pubitemid 47522736)
-
(2007)
Journal of Proteome Research
, vol.6
, Issue.9
, pp. 3456-3464
-
-
Weljie, A.M.1
Dowlatabadi, R.2
Miller, B.J.3
Vogel, H.J.4
Jirik, F.R.5
-
21
-
-
77957110143
-
Hypoxia-induced metabolic shifts in cancer cells: Moving beyond the Warburg effect
-
Weljie AM, Jirik FR (2010) Hypoxia-induced metabolic shifts in cancer cells: moving beyond the Warburg effect. Int J Biochem cell biol
-
(2010)
Int J Biochem Cell Biol
-
-
Weljie, A.M.1
Jirik, F.R.2
-
23
-
-
57449118489
-
Evaluating low-intensity unknown signals in quantitative proton NMR mixture analysis
-
Weljie AM, Newton J, Jirik FR, Vogel HJ (2008) Evaluating low-intensity unknown signals in quantitative proton NMR mixture analysis. Anal Chem 80:8956-8965
-
(2008)
Anal Chem
, vol.80
, pp. 8956-8965
-
-
Weljie, A.M.1
Newton, J.2
Jirik, F.R.3
Vogel, H.J.4
-
24
-
-
44949127039
-
PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer
-
DOI 10.1038/sj.bjc.6604356, PII 6604356
-
Wigfield SM, Winter SC, Giatromanolaki A, Taylor J, Koukourakis ML, Harris AL (2008) PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer. Br J Cancer 98:1975-1984 (Pubitemid 351821556)
-
(2008)
British Journal of Cancer
, vol.98
, Issue.12
, pp. 1975-1984
-
-
Wigfield, S.M.1
Winter, S.C.2
Giatromanolaki, A.3
Taylor, J.4
Koukourakis, M.L.5
Harris, A.L.6
-
25
-
-
41149120242
-
Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models
-
DOI 10.1021/ac0713510
-
Wiklund S, Johansson E, Sjöström L, Mellerowicz EJ, Edlund U, Shockcor JP, Gottfries J, Moritz T, Trygg J (2008) Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models. Anal Chem 80:115-122 (Pubitemid 351448411)
-
(2008)
Analytical Chemistry
, vol.80
, Issue.1
, pp. 115-122
-
-
Wiklund, S.1
Johansson, E.2
Sjostrom, L.3
Mellerowicz, E.J.4
Edlund, U.5
Shockcor, J.P.6
Gottfries, J.7
Moritz, T.8
Trygg, J.9
-
26
-
-
33846088138
-
HMDB: The human metabolome database
-
DOI 10.1093/nar/gkl923
-
Wishart DS, Tzur D, Knox C, Eisner R et al (2007) HMDB: the Human Metabolome Database. Nucleic Acids Res 35:D521-D526 (Pubitemid 46056263)
-
(2007)
Nucleic Acids Research
, vol.35
, Issue.SUPPL. 1
-
-
Wishart, D.S.1
Tzur, D.2
Knox, C.3
Eisner, R.4
Guo, A.C.5
Young, N.6
Cheng, D.7
Jewell, K.8
Arndt, D.9
Sawhney, S.10
Fung, C.11
Nikolai, L.12
Lewis, M.13
Coutouly, M.-A.14
Forsythe, I.15
Tang, P.16
Shrivastava, S.17
Jeroncic, K.18
Stothard, P.19
Amegbey, G.20
Block, D.21
Hau, D.D.22
Wagner, J.23
Miniaci, J.24
Clements, M.25
Gebremedhin, M.26
Guo, N.27
Zhang, Y.28
Duggan, G.E.29
MacInnis, G.D.30
Weljie, A.M.31
Dowlatabadi, R.32
Bamforth, F.33
Clive, D.34
Greiner, R.35
Li, L.36
Marrie, T.37
Sykes, B.D.38
Vogel, H.J.39
Querengesser, L.40
more..
-
27
-
-
54549089738
-
Hypoxia signalling through mTOR and the unfolded protein response in cancer
-
Wouters B, Koritzinsky M (2008) Hypoxia signalling through mTOR and the unfolded protein response in cancer. Nat Rev Cancer 8:851-864
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 851-864
-
-
Wouters, B.1
Koritzinsky, M.2
-
28
-
-
43649104579
-
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
-
Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, Gonzalez FJ, Semenza GL (2008) Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem 283:10892-10903
-
(2008)
J Biol Chem
, vol.283
, pp. 10892-10903
-
-
Zhang, H.1
Bosch-Marce, M.2
Shimoda, L.A.3
Tan, Y.S.4
Baek, J.H.5
Wesley, J.B.6
Gonzalez, F.J.7
Semenza, G.L.8
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