메뉴 건너뛰기




Volumn 49, Issue 3-4, 2011, Pages 185-193

1H NMR metabolomics identification of markers of hypoxia-induced metabolic shifts in a breast cancer model system

Author keywords

1H NMR spectroscopy; Breast cancer; Chemometrics; Glycolysis; Hypoxia; Metabolomics; OPLS DA; Tumor xenograft

Indexed keywords

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER MODEL; CONTROLLED STUDY; ENERGY METABOLISM; HUMAN; HUMAN CELL; HYPOXIA; MALE; METABOLOMICS; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; TUMOR XENOGRAFT;

EID: 79958766576     PISSN: 09252738     EISSN: 15735001     Source Type: Journal    
DOI: 10.1007/s10858-011-9486-4     Document Type: Article
Times cited : (57)

References (28)
  • 1
    • 0038699591 scopus 로고    scopus 로고
    • High-throughput classification of yeast mutants for functional genomics using metabolic footprinting
    • DOI 10.1038/nbt823
    • Allen J, Davey H, Broadhurst D, Heald J, Rowland J, Oliver S, Kell D (2003) High-throughput classification of yeast mutants for functional genomics using metabolic footprinting. Nat Biotechnol 21:692-696 (Pubitemid 36638098)
    • (2003) Nature Biotechnology , vol.21 , Issue.6 , pp. 692-696
    • Allen, J.1    Davey, H.M.2    Broadhurst, D.3    Heald, J.K.4    Rowland, J.J.5    Oliver, S.G.6    Kell, D.B.7
  • 2
    • 66049119129 scopus 로고    scopus 로고
    • The lysyl oxidase inhibitor, beta-aminopropionitrile, diminishes the metastatic colonization potential of circulating breast cancer cells
    • Bondareva A, Downey CM, Ayres F, Liu W, Boyd SK, Hallgrimsson B, Jirik FR (2009) The lysyl oxidase inhibitor, beta-aminopropionitrile, diminishes the metastatic colonization potential of circulating breast cancer cells. PLoS ONE 4:e5620
    • (2009) PLoS ONE , vol.4
    • Bondareva, A.1    Downey, C.M.2    Ayres, F.3    Liu, W.4    Boyd, S.K.5    Hallgrimsson, B.6    Jirik, F.R.7
  • 3
    • 38449098514 scopus 로고    scopus 로고
    • Leveraging latent information in NMR spectra for robust predictive models
    • Chang D, Weljie AM, Newton J (2007) Leveraging latent information in NMR spectra for robust predictive models. Pac Symp Biocomput 12:115-126
    • (2007) Pac Symp Biocomput , vol.12 , pp. 115-126
    • Chang, D.1    Weljie, A.M.2    Newton, J.3
  • 4
    • 34447564234 scopus 로고    scopus 로고
    • Metabolomics: Available results, current research projects in breast cancer, and future applications
    • DOI 10.1200/JCO.2006.09.7550
    • Claudino WM, Quattrone A, Biganzoli L, Pestrin M, Bertini I, Di Leo A (2007) Metabolomics: available results, current research projects in breast cancer, and future applications. J Clin Oncol 25:2840-2846 (Pubitemid 47123194)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.19 , pp. 2840-2846
    • Claudino, W.M.1    Quattrone, A.2    Biganzoli, L.3    Pestrin, M.4    Bertini, I.5    Di, L.A.6
  • 5
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB (2008) The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 7:11-20
    • (2008) Cell Metab , vol.7 , pp. 11-20
    • DeBerardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 9
    • 67449085093 scopus 로고    scopus 로고
    • 1H NMR-based metabonomics in the study of metabolic profiling of human hepatocellular carcinoma and liver cirrhosis
    • 1H NMR-based metabonomics in the study of metabolic profiling of human hepatocellular carcinoma and liver cirrhosis. Cancer Sci 100:782-785
    • (2009) Cancer Sci , vol.100 , pp. 782-785
    • Gao, H.1    Lu, Q.2    Liu, X.3    Cong, H.4    Zhao, L.5    Wang, H.6    Lin, D.7
  • 10
    • 0036468251 scopus 로고    scopus 로고
    • Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild-type tumors and tumors deficient in hypoxia-inducible factor-1beta (HIF-1beta): Evidence of an anabolic role for the HIF-1 pathway
    • Griffiths JR, McSheehy PM, Robinson SP, Troy H, Chung YL, Leek RD, Williams KJ, Stratford IJ, Harris AL, Stubbs M (2002) Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild-type tumors and tumors deficient in hypoxia-inducible factor-1beta (HIF-1beta): evidence of an anabolic role for the HIF-1 pathway. Cancer Res 62:688-695 (Pubitemid 34126942)
    • (2002) Cancer Research , vol.62 , Issue.3 , pp. 688-695
    • Griffiths, J.R.1    McSheehy, P.M.J.2    Robinson, S.P.3    Troy, H.4    Chung, Y.-L.5    Leek, R.D.6    Williams, K.J.7    Stratford, I.J.8    Harris, A.L.9    Stubbs, M.10
  • 11
    • 0016423016 scopus 로고
    • The formation of 2-hydroxybutyric acid in experimental animals
    • Landaas S (1975) The formation of 2-hydroxybutyric acid in experimental animals. Clin Chim Acta 58:23-32
    • (1975) Clin Chim Acta , vol.58 , pp. 23-32
    • Landaas, S.1
  • 13
    • 0036818507 scopus 로고    scopus 로고
    • Pyruvate reverses metabolic effects produced by hypoxia in glioma and hepatoma cell cultures
    • DOI 10.1016/S0300-9084(02)00008-1, PII S0300908402000081
    • Perrin A, Roudier E, Duborjal H, Bachelet C, Riva-Lavieille C, Leverve X, Massarelli R (2002) Pyruvate reverses metabolic effects produced by hypoxia in glioma and hepatoma cell cultures. Biochimie 84:1003-1011 (Pubitemid 36040533)
    • (2002) Biochimie , vol.84 , Issue.10 , pp. 1003-1011
    • Perrin, A.1    Roudier, E.2    Duborjal, H.3    Bachelet, C.4    Riva-Lavieille, C.5    Leverve, X.6    Massarelli, R.7
  • 15
    • 57449097020 scopus 로고    scopus 로고
    • Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
    • Sonveaux P, Végran F, Schroeder T, Wergin MC et al (2008) Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest 118:3930-3942
    • (2008) J Clin Invest , vol.118 , pp. 3930-3942
    • Sonveaux, P.1    Végran, F.2    Schroeder, T.3    Wergin, M.C.4
  • 16
    • 33646917296 scopus 로고    scopus 로고
    • The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism
    • DOI 10.1074/jbc.M511397200
    • Ullah MS, Davies AJ, Halestrap AP (2006) The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. J Biol Chem 281:9030-9037 (Pubitemid 43864615)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.14 , pp. 9030-9037
    • Ullah, M.S.1    Davies, A.J.2    Halestrap, A.P.3
  • 18
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O (1956) On the origin of cancer cells. Science 123:309-314
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 19
    • 70449527373 scopus 로고    scopus 로고
    • Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing
    • Webb JD, Coleman ML, Pugh CW (2009) Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing. Cell Mol Life Sci 66:3539-3554
    • (2009) Cell Mol Life Sci , vol.66 , pp. 3539-3554
    • Webb, J.D.1    Coleman, M.L.2    Pugh, C.W.3
  • 21
    • 77957110143 scopus 로고    scopus 로고
    • Hypoxia-induced metabolic shifts in cancer cells: Moving beyond the Warburg effect
    • Weljie AM, Jirik FR (2010) Hypoxia-induced metabolic shifts in cancer cells: moving beyond the Warburg effect. Int J Biochem cell biol
    • (2010) Int J Biochem Cell Biol
    • Weljie, A.M.1    Jirik, F.R.2
  • 23
    • 57449118489 scopus 로고    scopus 로고
    • Evaluating low-intensity unknown signals in quantitative proton NMR mixture analysis
    • Weljie AM, Newton J, Jirik FR, Vogel HJ (2008) Evaluating low-intensity unknown signals in quantitative proton NMR mixture analysis. Anal Chem 80:8956-8965
    • (2008) Anal Chem , vol.80 , pp. 8956-8965
    • Weljie, A.M.1    Newton, J.2    Jirik, F.R.3    Vogel, H.J.4
  • 24
    • 44949127039 scopus 로고    scopus 로고
    • PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer
    • DOI 10.1038/sj.bjc.6604356, PII 6604356
    • Wigfield SM, Winter SC, Giatromanolaki A, Taylor J, Koukourakis ML, Harris AL (2008) PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer. Br J Cancer 98:1975-1984 (Pubitemid 351821556)
    • (2008) British Journal of Cancer , vol.98 , Issue.12 , pp. 1975-1984
    • Wigfield, S.M.1    Winter, S.C.2    Giatromanolaki, A.3    Taylor, J.4    Koukourakis, M.L.5    Harris, A.L.6
  • 27
    • 54549089738 scopus 로고    scopus 로고
    • Hypoxia signalling through mTOR and the unfolded protein response in cancer
    • Wouters B, Koritzinsky M (2008) Hypoxia signalling through mTOR and the unfolded protein response in cancer. Nat Rev Cancer 8:851-864
    • (2008) Nat Rev Cancer , vol.8 , pp. 851-864
    • Wouters, B.1    Koritzinsky, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.