Measurement of hypoxia in vivo using a 2-nitromidazole (NITP)

Advances in Experimental Medicine and Biology

Volumn 428, Issue , 1997, Pages 61-67

  Hodgkiss, R J ^a  

^a MOUNT VERNON HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPARASITIC AGENT; NICOTINAMIDE; NITROIMIDAZOLE; SUPEROXIDE;

BREAST CARCINOMA; CANCER RESEARCH; CELL CYCLE; CELL METABOLISM; CONFERENCE PAPER; DNA SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HYPOXIA; OXYGEN DIFFUSION; OXYGEN TRANSPORT; PRIORITY JOURNAL; SPECIES DIFFERENTIATION; TUMOR CELL CULTURE; VASCULARIZATION;

EID: 0031423899     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-5399-1_10     Document Type: Conference Paper

References (12)

1. Aboagye, E.O., Lewis, A.D., Johnson, A., Workman, P., Tracy, M. and Huxham, I.M., 1995. The novel fluorinated 2-nitroimidazole hypoxia probe SR-4554: reductive metabolism and semi-quantitative localisation in human ovarian cancer multicellular spheroids as measured by electron energy loss spectroscopic analysis. Br. J. Cancer. 72, 312-318.
2. Arteel, G.E., Thurman, R.G., Yates, J.M., Raleigh, J.A., 1995. Evidence that hypoxia markers detect oxygen gradients in liver: pimonidazole and retrograde perfusion of rat liver. Br. J. Cancer, 72, 889-895.
3. Biskupiak, J.E., Grierson, J.R., Rasey, J.E., Martin, G.V. and Krohn, K.A., 1991. Synthesis of an (iodovinyl)misonidazole derivative for hypoxia imaging. J. Med. Chem., 34, 2165-2168.
4. Chaplin, D.J., Durand, R.E. and Olive, P.L., 1986. Acute hypoxia in tumours: implications for modifiers of radiation effects. Int. J. Radiat. Oncol. Biol. Phys., 12, 1279-1282.
5. Hodgkiss, R.J. and Wardman, P., 1992. The measurement of hypoxia in tumours. Br. J. Radial., Suppl. 24, 105-110.
6. Hodgkiss, R.J., Parrick, J., Porssa, M. and Stratford, M.R.L., 1994. Bioreductive markers for hypoxic cells: 2-nitroimidazoles with biotinylated 1-substituents. J. Med. Chem., 37, 4352-4356.
7. A. Long, J. Parrick and R.J. Hodgkiss, 1991. An efficient procedure for the 1-alkylation of 2-nitroimidazoles and the synthesis of a probe for hypoxia in solid tumours. Synthesis, 9, 709-713.
8. Rumscy, W.L., Patel, B. and Linder, K.E., 1995. Effect of graded hypoxia on retention of technetium-99m-nitroheterocycle in perfused rat heart. J. Nucl. Med., 36, 632-636.
9. Stewart, F.A., Denekamp, J. and Randhawa, V.S., 1982. Skin sensitisation by misonidazole: a demonstration of uniform mild hypoxia. Br. J. Cancer, 45, 869-877.
10. Wardman, P. and Clarke, E.D., 1976. Oxygen inhibition of nitroreductase electron transfer from nitro radical-anions to oxygen. Biochem.. Biophys. Res. Com. 69, 942-949.
11. Webster, L., 1994. Hypoxia and proliferation in murine tumour models. PhD Thesis University of London Faculty of Science.
12. Webster, L., Hodgkiss, R.J. and Wilson, G.D., 1995. Simultaneous triple staining for hypoxia, proliferation and DNA content in solid murine tumors. Cytometry. 21, 344-351.