-
2
-
-
35148888161
-
Life with oxygen
-
Semenza GL. Life with oxygen. Science 2007;318:62-4.
-
(2007)
Science
, vol.318
, pp. 62-64
-
-
Semenza, G.L.1
-
3
-
-
40949142209
-
The role ofhypoxia-inducible factors in tumorigenesis
-
Rankin EB, Giaccia AJ. The role ofhypoxia-inducible factors in tumorigenesis. Cell Death Differ 2008;15:678-85.
-
(2008)
Cell Death Differ
, vol.15
, pp. 678-685
-
-
Rankin, E.B.1
Giaccia, A.J.2
-
4
-
-
0034050050
-
Loss of PTEN facilitates HIF-1-mediated gene expression
-
Zundel W, Schindler C, Haas-Kogan D, et al. Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev 2000;14:391-6.
-
(2000)
Genes Dev
, vol.14
, pp. 391-396
-
-
Zundel, W.1
Schindler, C.2
Haas-Kogan, D.3
-
5
-
-
34047167041
-
Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway
-
Pollard PJ, Spencer-Dene B, Shukla D, et al. Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway. Cancer Cell 2007;11:311-9.
-
(2007)
Cancer Cell
, vol.11
, pp. 311-319
-
-
Pollard, P.J.1
Spencer-Dene, B.2
Shukla, D.3
-
6
-
-
19944433653
-
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
-
Selak MA, Armour SM, MacKenzie ED, et al. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase. Cancer Cell 2005;7:77-85.
-
(2005)
Cancer Cell
, vol.7
, pp. 77-85
-
-
Selak, M.A.1
Armour, S.M.2
MacKenzie, E.D.3
-
7
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003;3:721-32.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
8
-
-
35048875691
-
Evaluation of HIF-1 inhibitors as anticancer agents
-
Semenza GL. Evaluation of HIF-1 inhibitors as anticancer agents. Drug Discov Today 2007;12:853-9.
-
(2007)
Drug Discov Today
, vol.12
, pp. 853-859
-
-
Semenza, G.L.1
-
9
-
-
17844408765
-
Thrombopoietin enhances expression ofvascular endothelial growth factor (VEGF) in primitive hematopoietic cells through induction of HIF-1α
-
Kirito K, Fox N, Komatsu N, Kaushansky K. Thrombopoietin enhances expression ofvascular endothelial growth factor (VEGF) in primitive hematopoietic cells through induction of HIF-1α. Blood 2005;105:4258-63.
-
(2005)
Blood
, vol.105
, pp. 4258-4263
-
-
Kirito, K.1
Fox, N.2
Komatsu, N.3
Kaushansky, K.4
-
10
-
-
23444449093
-
STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells
-
Jung JE, Lee HG, Cho IH, et al. STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells. FASEB J 2005;19:1296-8.
-
(2005)
FASEB J
, vol.19
, pp. 1296-1298
-
-
Jung, J.E.1
Lee, H.G.2
Cho, I.H.3
-
11
-
-
24644457736
-
Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways
-
Xu Q, Briggs J, Park S, et al. Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways. Oncogene 2005;24:5552-60.
-
(2005)
Oncogene
, vol.24
, pp. 5552-5560
-
-
Xu, Q.1
Briggs, J.2
Park, S.3
-
12
-
-
37049002653
-
Hypoxia up-regulates HIF-1α transcription by involving phosphatidylinositol 3-kinase and nuclear factor κB in pulmonary artery smooth muscle cells
-
Belaiba RS, Bonello S, Zahringer C, et al. Hypoxia up-regulates HIF-1α transcription by involving phosphatidylinositol 3-kinase and nuclear factor κB in pulmonary artery smooth muscle cells. Mol Biol Cell 2007;18:4691-7.
-
(2007)
Mol Biol Cell
, vol.18
, pp. 4691-4697
-
-
Belaiba, R.S.1
Bonello, S.2
Zahringer, C.3
-
13
-
-
44849100198
-
NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1aα
-
Rius J, Guma M, Schachtrup C, et al. NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1aα. Nature 2008;453:807-11.
-
(2008)
Nature
, vol.453
, pp. 807-811
-
-
Rius, J.1
Guma, M.2
Schachtrup, C.3
-
14
-
-
45349097483
-
Regulation ofh ypoxia-inducible factor-1α by NF-κB
-
van Uden P, Kenneth NS, Rocha S. Regulation ofh ypoxia-inducible factor-1α by NF-κB. Biochem J 2008;412:477-84.
-
(2008)
Biochem J
, vol.412
, pp. 477-484
-
-
van Uden, P.1
Kenneth, N.S.2
Rocha, S.3
-
15
-
-
40649089427
-
PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a)
-
Emerling BM, Weinberg F, Liu JL, Mak TW, Chandel NS. PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a). Proc Natl Acad Sci U S A 2008;105:2622-7.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 2622-2627
-
-
Emerling, B.M.1
Weinberg, F.2
Liu, J.L.3
Mak, T.W.4
Chandel, N.S.5
-
16
-
-
42449130564
-
Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1
-
Shin DH, Chun YS, Lee DS, Huang LE, Park JW. Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1. Blood 2008;111:3131-6.
-
(2008)
Blood
, vol.111
, pp. 3131-3136
-
-
Shin, D.H.1
Chun, Y.S.2
Lee, D.S.3
Huang, L.E.4
Park, J.W.5
-
17
-
-
31544436323
-
Antimyeloma activity ofheat shock protein-90 inhibition
-
Mitsiades CS, Mitsiades NS, McMullan CJ, et al. Antimyeloma activity ofheat shock protein-90 inhibition. Blood 2006;107:1092-100.
-
(2006)
Blood
, vol.107
, pp. 1092-1100
-
-
Mitsiades, C.S.1
Mitsiades, N.S.2
McMullan, C.J.3
-
18
-
-
0030910243
-
A distinct function of STAT proteins in erythropoietin signal transduction
-
Kirito K, Uchida M, Yamada M, Miura Y, Komatsu N. A distinct function of STAT proteins in erythropoietin signal transduction. J Biol Chem 1997;272:16507-13.
-
(1997)
J Biol Chem
, vol.272
, pp. 16507-16513
-
-
Kirito, K.1
Uchida, M.2
Yamada, M.3
Miura, Y.4
Komatsu, N.5
-
19
-
-
1642329821
-
Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer
-
Mizukami Y, Li J, Zhang X, Zimmer MA, Iliopoulos O, Chung DC. Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. Cancer Res 2004;64:1765-72.
-
(2004)
Cancer Res
, vol.64
, pp. 1765-1772
-
-
Mizukami, Y.1
Li, J.2
Zhang, X.3
Zimmer, M.A.4
Iliopoulos, O.5
Chung, D.C.6
-
20
-
-
21244497803
-
A tumor-specific gene therapy strategy targeting dysregulation ofthe VHL/HIF pathway in renal cell carcinomas
-
Ogura M, Shibata T, Yi J, et al. A tumor-specific gene therapy strategy targeting dysregulation ofthe VHL/HIF pathway in renal cell carcinomas. Cancer Sci 2005;96:288-94.
-
(2005)
Cancer Sci
, vol.96
, pp. 288-294
-
-
Ogura, M.1
Shibata, T.2
Yi, J.3
-
21
-
-
33847069647
-
Confluence-dependent resistance to doxorubicin in human MDA-MB-231 breast carcinoma cells requires hypoxia-inducible factor-1 activity
-
Fang Y, Sullivan R, Graham CH. Confluence-dependent resistance to doxorubicin in human MDA-MB-231 breast carcinoma cells requires hypoxia-inducible factor-1 activity. Exp Cell Res 2007;313:867-77.
-
(2007)
Exp Cell Res
, vol.313
, pp. 867-877
-
-
Fang, Y.1
Sullivan, R.2
Graham, C.H.3
-
22
-
-
0037064010
-
Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
-
Fukuda R, Hirota K, Fan F, Jung YD, Ellis LM, Semenza GL. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem 2002;277:38205-11.
-
(2002)
J Biol Chem
, vol.277
, pp. 38205-38211
-
-
Fukuda, R.1
Hirota, K.2
Fan, F.3
Jung, Y.D.4
Ellis, L.M.5
Semenza, G.L.6
-
23
-
-
0037008770
-
Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target ofrapa mycin-dependent signaling pathway
-
Treins C, Giorgetti-Peraldi S, Murdaca J, Semenza GL, Van Obberghen E. Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target ofrapa mycin-dependent signaling pathway. J Biol Chem 2002;277:27975-81.
-
(2002)
J Biol Chem
, vol.277
, pp. 27975-27981
-
-
Treins, C.1
Giorgetti-Peraldi, S.2
Murdaca, J.3
Semenza, G.L.4
Van Obberghen, E.5
-
24
-
-
0034667606
-
Insulin-like growth factor I is a dual effector of multiple myeloma cell growth
-
Ge NL, Rudikoff S. Insulin-like growth factor I is a dual effector of multiple myeloma cell growth. Blood 2000;96:2856-61.
-
(2000)
Blood
, vol.96
, pp. 2856-2861
-
-
Ge, N.L.1
Rudikoff, S.2
-
25
-
-
0036625066
-
Insulinlike growth factor-I signaling in multiple myeloma: Downstream elements, functional correlates, and pathway cross-talk
-
Qiang YW, Kopantzev E, Rudikoff S. Insulinlike growth factor-I signaling in multiple myeloma: downstream elements, functional correlates, and pathway cross-talk. Blood 2002;99:4138-46.
-
(2002)
Blood
, vol.99
, pp. 4138-4146
-
-
Qiang, Y.W.1
Kopantzev, E.2
Rudikoff, S.3
-
26
-
-
33748050780
-
Hypoxia-inducible factor-1 inhibition in combination with temozolomide treatment exhibits robust antitumor efficacy in vivo
-
Li L, Lin X, Shoemaker AR, Albert DH, Fesik SW, Shen Y. Hypoxia-inducible factor-1 inhibition in combination with temozolomide treatment exhibits robust antitumor efficacy in vivo. Clin Cancer Res 2006;12:4747-54.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 4747-4754
-
-
Li, L.1
Lin, X.2
Shoemaker, A.R.3
Albert, D.H.4
Fesik, S.W.5
Shen, Y.6
-
27
-
-
54949123005
-
Antisense hypoxia-inducible factor 1α gene therapy enhances the therapeutic efficacy of doxorubicin to combat hepatocellular carcinoma
-
Liu F, Wang P, Jiang X, et al. Antisense hypoxia-inducible factor 1α gene therapy enhances the therapeutic efficacy of doxorubicin to combat hepatocellular carcinoma. Cancer Sci 2008;99:2055-61.
-
(2008)
Cancer Sci
, vol.99
, pp. 2055-2061
-
-
Liu, F.1
Wang, P.2
Jiang, X.3
-
28
-
-
0037158513
-
Activation of NF-κB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: Therapeutic implications
-
Mitsiades CS, Mitsiades N, Poulaki V, et al. Activation of NF-κB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications. Oncogene 2002;21:5673-83.
-
(2002)
Oncogene
, vol.21
, pp. 5673-5683
-
-
Mitsiades, C.S.1
Mitsiades, N.2
Poulaki, V.3
-
29
-
-
40949145602
-
Insulin-like growth factor-I receptor signaling pathway induces resistance to the apoptotic activities of SC H66336 (lonafarnib) through Akt/mammalian target ofrap amycin-mediated increases in survivin expression
-
Oh SH, Jin Q, Kim ES, Khuri FR, Lee HY. Insulin-like growth factor-I receptor signaling pathway induces resistance to the apoptotic activities of SC H66336 (lonafarnib) through Akt/mammalian target ofrap amycin-mediated increases in survivin expression. Clin Cancer Res 2008;14:1581-9.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 1581-1589
-
-
Oh, S.H.1
Jin, Q.2
Kim, E.S.3
Khuri, F.R.4
Lee, H.Y.5
-
30
-
-
0030997680
-
Multiple myeloma cells are protected against dexamethasone-induced apoptosis by insulin-like growth factors
-
Xu F, Gardner A, Tu Y, Michl P, Prager D, Lichtenstein A. Multiple myeloma cells are protected against dexamethasone-induced apoptosis by insulin-like growth factors. Br J Haematol 1997;97:429-40.
-
(1997)
Br J Haematol
, vol.97
, pp. 429-440
-
-
Xu, F.1
Gardner, A.2
Tu, Y.3
Michl, P.4
Prager, D.5
Lichtenstein, A.6
-
31
-
-
12144290914
-
Inhibition ofthe insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors
-
Mitsiades CS, Mitsiades NS, McMullan CJ, et al. Inhibition ofthe insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. Cancer Cell 2004;5:221-30.
-
(2004)
Cancer Cell
, vol.5
, pp. 221-230
-
-
Mitsiades, C.S.1
Mitsiades, N.S.2
McMullan, C.J.3
-
32
-
-
25444523184
-
Echinomycin, a small-molecule inhibitor ofhy poxia-inducible factor-1 DNA-binding activity
-
Kong D, Park EJ, Stephen AG, et al. Echinomycin, a small-molecule inhibitor ofhy poxia-inducible factor-1 DNA-binding activity. Cancer Res 2005;65:9047-55.
-
(2005)
Cancer Res
, vol.65
, pp. 9047-9055
-
-
Kong, D.1
Park, E.J.2
Stephen, A.G.3
-
33
-
-
35448982386
-
Dual effect of echinomycin on hypoxia-inducible factor-1 activity under normoxic and hypoxic conditions
-
Vlaminck B, Toffoli S, Ghislain B, Demazy C, Raes M, Michiels C. Dual effect of echinomycin on hypoxia-inducible factor-1 activity under normoxic and hypoxic conditions. Febs J 2007;274:5533-42.
-
(2007)
Febs J
, vol.274
, pp. 5533-5542
-
-
Vlaminck, B.1
Toffoli, S.2
Ghislain, B.3
Demazy, C.4
Raes, M.5
Michiels, C.6
-
34
-
-
33748742635
-
Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1{α} signal pathways increases resistance to apoptosis by up-regulating survivin gene expression
-
Peng X-H, Karna P, Cao Z, Jiang B-H, Zhou M, Yang L. Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1{α} signal pathways increases resistance to apoptosis by up-regulating survivin gene expression. J Biol Chem 2006;281:25903-14.
-
(2006)
J Biol Chem
, vol.281
, pp. 25903-25914
-
-
Peng, X.-H.1
Karna, P.2
Cao, Z.3
Jiang, B.-H.4
Zhou, M.5
Yang, L.6
-
35
-
-
21244460271
-
Role ofthe hypoxic bone marrow microenvironment in 5T2MM murine myeloma tumor progression
-
Asosingh K, De Raeve H, de Ridder M, et al. Role ofthe hypoxic bone marrow microenvironment in 5T2MM murine myeloma tumor progression. Haematologica 2005;90:810-7.
-
(2005)
Haematologica
, vol.90
, pp. 810-817
-
-
Asosingh, K.1
De Raeve, H.2
de Ridder, M.3
-
36
-
-
39649104151
-
The new tumor-suppressor gene inhibitor ofgrowth family member 4 (ING4) regulates the production ofp roangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 α (HIF-1α) activity: Involvement in myeloma-induced angiogenesis
-
Colla S, Tagliaferri S, Morandi F, et al. The new tumor-suppressor gene inhibitor ofgrowth family member 4 (ING4) regulates the production ofp roangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 α (HIF-1α) activity: involvement in myeloma-induced angiogenesis. Blood 2007;110:4464-75.
-
(2007)
Blood
, vol.110
, pp. 4464-4475
-
-
Colla, S.1
Tagliaferri, S.2
Morandi, F.3
-
37
-
-
0036892647
-
Serum insulinlike growth factor is not elevated in patients with multiple myeloma but is still a prognostic factor
-
Standal T, Borset M, Lenhoff S, et al. Serum insulinlike growth factor is not elevated in patients with multiple myeloma but is still a prognostic factor. Blood 2002;100:3925-9.
-
(2002)
Blood
, vol.100
, pp. 3925-3929
-
-
Standal, T.1
Borset, M.2
Lenhoff, S.3
-
38
-
-
34547225129
-
Metabolic targeting ofhypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy
-
Cairns RA, Papandreou I, Sutphin PD, Denko NC. Metabolic targeting ofhypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy. Proc Natl Acad Sci U S A 2007;104:9445-50.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 9445-9450
-
-
Cairns, R.A.1
Papandreou, I.2
Sutphin, P.D.3
Denko, N.C.4
-
39
-
-
0037973279
-
A phase 2 study of bortezomib in relapsed, refractory myeloma
-
Richardson PG, Barlogie B, Berenson J, et al. A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med 2003;348:2609-17.
-
(2003)
N Engl J Med
, vol.348
, pp. 2609-2617
-
-
Richardson, P.G.1
Barlogie, B.2
Berenson, J.3
-
40
-
-
33847751015
-
Suppression ofthe hypoxia-inducible factor-1 response in cervical carcinoma xenografts by proteasome inhibitors
-
Birle DC, Hedley DW. Suppression ofthe hypoxia-inducible factor-1 response in cervical carcinoma xenografts by proteasome inhibitors. Cancer Res 2007;67:1735-43.
-
(2007)
Cancer Res
, vol.67
, pp. 1735-1743
-
-
Birle, D.C.1
Hedley, D.W.2
-
41
-
-
33746496671
-
Proteasomal inhibition attenuates transcriptional activity ofhypoxia-inducible factor 1 (HIF-1) via specific effect on the HIF-1α C-terminal activation domain
-
Kaluz S, Kaluzova M, Stanbridge EJ. Proteasomal inhibition attenuates transcriptional activity ofhypoxia-inducible factor 1 (HIF-1) via specific effect on the HIF-1α C-terminal activation domain. Mol Cell Biol 2006;26:5895-907.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 5895-5907
-
-
Kaluz, S.1
Kaluzova, M.2
Stanbridge, E.J.3
-
42
-
-
0037119415
-
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 α-degradative pathway
-
Isaacs JS, Jung YJ, Mimnaugh EG, Martinez A, Cuttitta F, Neckers LM. Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 α-degradative pathway. J Biol Chem 2002;277:29936-44.
-
(2002)
J Biol Chem
, vol.277
, pp. 29936-29944
-
-
Isaacs, J.S.1
Jung, Y.J.2
Mimnaugh, E.G.3
Martinez, A.4
Cuttitta, F.5
Neckers, L.M.6
-
43
-
-
33846208233
-
STAT3 and MAPK signaling maintain overexpression ofheat shock proteins 90{α} and {β} in multiple myeloma cells, which critically contribute to tumor-cell survival
-
Chatterjee M, Jain S, Stuhmer T, et al. STAT3 and MAPK signaling maintain overexpression ofheat shock proteins 90{α} and {β} in multiple myeloma cells, which critically contribute to tumor-cell survival. Blood 2007;109:720-8.
-
(2007)
Blood
, vol.109
, pp. 720-728
-
-
Chatterjee, M.1
Jain, S.2
Stuhmer, T.3
-
44
-
-
34247577611
-
Significant impact of survivin on myeloma cell growth
-
Romagnoli M, Trichet V, David C, et al. Significant impact of survivin on myeloma cell growth. Leukemia 2007;21:1070-8.
-
(2007)
Leukemia
, vol.21
, pp. 1070-1078
-
-
Romagnoli, M.1
Trichet, V.2
David, C.3
|