How can a chemical element elicit complex immunopathology? Lessons from mercury-induced autoimmunity

Trends in Immunology

Volumn 30, Issue 10, 2009, Pages 502-509

  Schiraldi, Michael ^a   Monestier, Marc ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; H2 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MERCURY; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR BETA 2; T LYMPHOCYTE RECEPTOR BETA CHAIN; UNCLASSIFIED DRUG;

ALLELE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; B LYMPHOCYTE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL DEATH; DISEASE COURSE; GENE EXPRESSION; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HEAVY METAL POISONING; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IMMUNOPATHOLOGY; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; NEPHROTOXICITY; PATHOPHYSIOLOGY; REVIEW; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; AUTOIMMUNE DISEASES; B-LYMPHOCYTES; DISEASE MODELS, ANIMAL; DOGS; HUMANS; MERCURY; RATS; T-LYMPHOCYTES;

EID: 70349560009     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2009.07.005     Document Type: Review

References (109)

1. Barr R.D., et al. Nephrotic syndrome in adult Africans in Nairobi. Br. Med. J. 2 (1972) 131-134
2. Silva I., et al. Mercury exposure, malaria, and serum antinuclear/antinucleolar antibodies in Amazon populations in Brazil: a cross-sectional study. Environ. Health 3 (2004) 11
3. Bernard A.M., et al. Search for anti-laminin antibodies in the serum of workers exposed to cadmium, mercury vapor and lead. Int. Arch. Occup. Environ. Health 59 (1987) 303-309
4. Clarkson T.W., et al. Mechanisms of mercury deposition in the body. Am. J. Ind. Med. 50 (2007) 757-764
5. Risher J.F., and De Rosa C.T. Inorganic: the other mercury. J. Environ. Health 70 (2009) 9-16
6. Turk J.L., and Baker H. Nephrotic syndrome due to ammoniated mercury. Br. J. Dermatol. 80 (1968) 623-624
7. Soo Y.O.Y., et al. A whitened face woman with nephrotic syndrome. Am. J. Kidney Dis. 41 (2003) 250-253
8. Tang H.L., et al. Minimal change disease following exposure to mercury-containing skin lightening cream. Hong Kong Med. J. 12 (2006) 316-318
9. Albert D., et al. Wegener's granulomatosis: Possible role of environmental agents in its pathogenesis. Arthritis Rheum. 51 (2004) 656-664
10. Moszczynski P., et al. Lymphocytes, T and NK cells, in men occupationally exposed to mercury vapours. Int. J. Occup. Med. Environ. Health 8 (1995) 49-56
11. Lauwerys R., et al. Anti-laminin antibodies in workers exposed to mercury vapour. Toxicol. Lett. 17 (1983) 113-116
12. Arnett F.C., et al. Urinary mercury levels in patients with autoantibodies to U3-RNP (fibrillarin). J. Rheumatol. 27 (2000) 405-410
13. Kindas-Mugge I. Human autoantibodies against a nucleolar protein. Biochem. Biophys. Res. Commun. 163 (1989) 1119-1127
14. Frank C.A., et al. Autoantibodies to fibrillarin in systemic sclerosis (scleroderma). An immunogenetic, serologic, and clinical analysis. Arthritis Rheum. 39 (1996) 1151-1160
15. Hultman P., et al. Selective induction of anti-fibrillarin autoantibodies by silver nitrate in mice. Clin. Exp. Immunol. 92 (1994) 285-291
16. Hultman P., et al. Genetic susceptibility to silver-induced anti-fibrillarin autoantibodies in mice. Clin. Immunol. Immunopathol. 77 (1995) 291-297
17. Havarinasab S., et al. Gold causes genetically determined autoimmune and immunostimulatory responses in mice. Clin. Exp. Immunol. 150 (2007) 179-188
18. Aminzadeh K.K., and Mahyar E. Dental amalgam and multiple sclerosis: A systematic review and meta-analysis. J. Public Health Dent. 67 (2007) 64-66
19. Prochazkova J., et al. The beneficial effect of amalgam replacement on health in patients with autoimmunity. Neuro. Endocrinol. Lett. 25 (2004) 211-218
20. Cooper G.S., et al. Occupational risk factors for the development of systemic lupus erythematosus. J. Rheumatol. 31 (2004) 1928-1933
21. Grandjean P., et al. Placebo response in environmental disease: Chelation Therapy of Patients With Symptoms Attributed to Amalgam illings. J. Occup. Environ. Med. 39 (1997) 707-714
22. 2 in the Brown Norway rat. Annales d'immunologie 129 C(6) (1978) 777-792
23. Vas J., and Monestier M. Immunology of mercury. Ann. NY. Acad. Sci. 1143 (2008) 240-267
24. Aten J., et al. Susceptibility to the induction of either autoimmunity or immunosuppression by mercuric chloride is related to the major histocompatibility complex class II haplotype. Eur. J. Immunol. 21 (1991) 611-616
25. Druet P., et al. Mercury-induced autoimmune glomerulonephritis in animals. Contrib. Nephrol. 61 (1988) 120-130
26. Bariety J., et al. Glomerulonephritis with gamma- and beta-1C-globulin deposits induced in rats by mercuric chloride. Am. J. Pathol. 65 (1971) 293-302
27. Pusey C.D., et al. Kinetics and pathogenicity of autoantibodies induced by mercuric chloride in the brown Norway rat. Clin. Exp. Immunol. 81 (1990) 76-82
28. Marriott J.B., et al. Anti-phospholipid antibodies in the mercuric chloride treated Brown Norway rat. J. Autoimmun. 7 (1994) 457-467
29. + T cells revealed by in vivo depletion studies. Eur. J. Immunol. 21 (1991) 2105-2109
30. Bowman C., et al. Autoregulation of autoantibody synthesis in mercuric chloride nephritis in the Brown Norway rat I. A role for T suppressor cells. Eur. J. Immunol. 14 (1984) 464-470
31. Castedo M., et al. Mercury-induced autoreactive anti-class II T cell line protects from experimental autoimmune encephalomyelitis by the bias of CD8+ antiergotypic cells in Lewis rats. J. Exp. Med. 177 (1993) 881-889
32. Pelletier L., et al. Role of CD8+ T cells in mercury-induced autoimmunity or immunosuppression in the rat. Scand. J. Immunol. 31 (1990) 65-74
33. Bagentose L.M., et al. Murine mercury-induced autoimmunity: a model of chemically related autoimmunity in humans. Immunol. Res. 20 (1999) 67-78
34. d congenic mice. Clin. Immunol. Immunopathol. 68 (1993) 9-20
35. Pollard K.M., et al. Immunology and genetics of induced systemic autoimmunity. Autoimmun. Rev. 4 (2005) 282-288
36. S mice. J. Immunol. 152 (1994) 667-675
37. Hultman P., et al. Murine susceptibility to mercury: I. Autoantibody profiles and systemic immune deposits in inbred, congenic, and intra-H-2 recombinant strains. Clin. Immunol. Immunopathol. 65 (1992) 98-109
38. Hultman P., et al. Murine genotype influences the specificity, magnitude and persistence of murine mercury-induced autoimmunity. J. Autoimmun. 9 (1996) 139-149
39. Abedi-Valugerdi M., et al. Mercury-induced renal immune complex deposits in young (NZB × NZW)F1 mice: characterization of antibodies/autoantibodies. Clin. Exp. Immunol. 110 (1997) 86-91
40. Pollard K.M., et al. Lupus-prone mice as models to study xenobiotic-induced acceleration of systemic autoimmunity. Environ. health perspect. 107 (1999) 729-735
41. Via C.S., et al. Low-dose exposure to inorganic mercury accelerates disease and mortality in acquired murine lupus. Environ. health perspect. 111 (2003) 1273-1277
42. Ilback N.G., et al. Effects of methyl mercury on cytokines, inflammation and virus clearance in a common infection (Coxsackie B3 myocarditis). Toxicol. Lett. 89 (1996) 19-28
43. Ilback N.G., et al. Trace element distribution in heart tissue sections studied by nuclear microscopy is changed in coxsackie virus B3 myocarditis in methyl mercury-exposed mice. Biol. Trace Elem. Res. 78 (2000) 131-147
44. Clarkson T.W. The three modern faces of mercury. Environ. Health Perspect. 110 (2002) 11-23
45. Clarkson T.W., et al. The toxicology of mercury-current exposures and clinical manifestations. N. Engl. J. Med. 342 (2003) 1731-1737
46. Agency for Toxic Substances and Disease Registry [ATSDR] (1999) Toxicological profile for mercury. Atlanta, Georgia: Centers for Disease Control TP93/10
47. Custodio H.M., et al. Genetic influences on the retention of inorganic mercury. Arch. Environ. Occupat. Health 60 (2005) 17-23
48. Engstrom K.S., et al. Genetic variation in glutathione-related genes and body burden of methylmercury. Environ. health perspect. 116 (2008) 734-739
49. Goldman M., et al. TH2 cells in systemic autoimmunity: insights from allogeneic diseases and chemically-induced autoimmunity. Immunol. Today 12 (1991) 223-227
50. Druet E., et al. Mercuric chloride-induced anti-glomerular basement membrane antibodies in the rat: genetic control. Eur. J. Immunol. 7 (1977) 348-351
51. Robinson C.J., et al. Mercuric chloride-, gold sodium thiomalate-, and D-penicillamine-induced antinuclear antibodies in mice. Toxicol. Appl. Pharmacol. 86 (1986) 159-169
52. 2-induced antinucleolar autoantibodies. Eur. J. Immunol. 19 (1989) 2257-2261
53. f mice. Clin. Exp. Immunol. 131 (2003) 405-414
54. 2-treated mice. Clin. Immunol. Immunopathol. 84 (1997) 328-337
55. 2-induced autoimmunity in haplotype-heterozygous mice is an intrinsic property of B cells. J. Immunol. 161 (1998) 1778-1785
56. Nygard N.R., et al. Mixed haplotypes and autoimmunity. Immunol. Today 14 (1993) 53-56
57. Short P., et al. Requirement of H-2 heterozygosity for autoimmunity in (NZB × NZW)F1 hybrid mice. Eur. J. Immunol. 16 (1986) 1631-1633
58. Stiller-Winkler R., et al. Immunopathological signs in mice treated with mercury compounds - I. Identification by the popliteal lymph node assay of responder and nonreponder strains. Int. J. Immunopharmacol. 10 (1988) 475-484
59. Oram P.D., et al. The formation constants of mercury(II)-glutathione complexes. Chem. Res. Toxicol. 9 (1996) 709-712
60. Passow H., et al. The general pharmacology of the heavy metals. Pharmacol. Rev. 13 (1961) 185-224
61. Nakashima I., et al. Redox mechanism as alternative to ligand binding for receptor activation delivering disregulated cellular signals. J. Immunol. 152 (1994) 1064-1071
62. McCabe M.J., et al. Low and nontoxic levels of ionic mercury interfere with the regulation of cell growth in the WEHI-231 B-Cell lymphoma. Scand. J.Immunol. 50 (1999) 233-241
63. Pollard K.M., and Landberg G.P. The in vitro proliferation of murine lymphocytes to mercuric chloride is restricted to mature T cells and is interleukin 1 dependent. Int. Immunopharmacol. 1 (2001) 581-593
64. 2 on murine lymphocytes. I. Preferable activation of CD4+ T cells in a responder. J. Immunol. 154 (1995) 3138-3146
65. 2 on murine lymphocytes. II. Selective activation of T cells expressing certain vβ TCR. Int. Immunol. 8 (1996) 1729-1736
66. Cederbrant K., and Hultman P. Characterization of mercuric mercury-induced lymphoblasts from patients with mercury allergy and from healthy subjects. Clin. Exp. Immunol. 121 (2007) 23-30
67. Hultman P., et al. Murine mercury-induced autoimmunity: The role of T-helper cells. J. Autoimmun. 8 (1995) 809-823
68. Johansson U., et al. Effects of the murine genotype on T Cell activation and cytokine production in murine mercury-induced autoimmunity. J. Autoimmun. 10 (1997) 347-355
69. Layland L.E., et al. Drug-induced autoantibody formation in mice: triggering by primed CD4+CD25- T cells, prevention by primed CD4 + CD25+ T cells. Eur. J. Immunol. 34 (2004) 36-46
70. Kubicka-Muranyi M., et al. Mercuric-chloride-induced autoimmunity in mice involves up-regulated presentation by spleen cells of altered and unaltered nucleolar self antigen. Int. Arch. Allergy Immunol. 108 (1995) 1-10
71. Johansson U., et al. The genotype determines the B cell response in mercury-treated mice. Int. Arch. Allergy Immunol. 16 (1998) 295-305
72. Prigent P., et al. Mercuric chloride, a chemical responsible for T helper cell (Th)2-mediated autoimmunity in Brown Norway rats, directly triggers T cells to produce interleukin-4. J. Clin. Invest. 96 (1995) 1484-1489
73. Mackay F., et al. B cells and the BAFF/APRIL axis: fast-forward on autoimmunity and signaling. Curr. Opin. Immunol. 19 (2007) 327-336
74. Zheng Y., et al. A role for B Cell-activating factor of the TNF family in chemically induced autoimmunity. J. Immunol. 175 (2005) 6163-6168
75. Bagenstose L.M., et al. B7-1 and B7-2 co-stimulatory molecules are required for mercury-induced autoimmunity. Clin. Exp. Immunol. 127 (2002) 12-19
76. Zheng Y., et al. ICOS-B7 homologous protein interactions are necessary for mercury-induced autoimmunity. J. Immunol. 174 (2005) 3117-3121
77. Vinay D.S., et al. Amelioration of mercury-induced autoimmunity by 4-1BB. J. Immunol. 177 (2006) 5708-5717
78. Zheng Y., and Monestier M. Inhibitory signal override increases susceptibility to mercury-induced autoimmunity. J. Immunol. 171 (2003) 1596-1601
79. van Vliet E., et al. MHC control of IL-4-dependent enhancement of B cell Ia expression and Ig class switching in mice treated with mercuric chloride. Int. Arch. Allergy Immunol. 101 (1993) 392-401
80. Gillespie K.M., et al. Th1/Th2 cytokine gene expression after mercuric chloride in susceptible and resistant rat strains. Eur. J. Immunol. 26 (1996) 2388-2392
81. Mathieson P.W., and Gillespie K.M. Cloning of a partial cDNA for rat interleukin-12 (IL-12) and analysis of IL-12 expression in vivo. Scand. J. Immunol. 44 (1996) 11-14
82. Kono D.H., et al. The prototypic Th2 autoimmunity induced by mercury is dependent on IFNγ and not Th1/Th2 imbalance. J. Immunol. 161 (1998) 234-240
83. Oliveira D.B., et al. Compounds that induce autoimmunity in the Brown Norway rat sensitize mast cells for mediator release and interleukin-4 expression. Eur. J. Immunol. 25 (1995) 2259-2264
84. Hu H., et al. Thiol compounds inhibit mercury-induced immunological and immunopathological alterations in susceptible mice. Clin. Exp. Immunol. 107 (1997) 68-75
85. Baggett J.M., and Berndt W.O. The effect of depletion of nonprotein sulfhydryls by diethyl maleate plus buthionine sulfoximine on renal uptake of mercury in the rat. Toxicol. Appl. Pharmacol. 83 (1986) 556-562
86. Peterson J.D., et al. Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 3071-3076
87. van der Meide P.H., et al. Mercuric chloride down-regulates T cell interferon-gamma production in Brown Norway but not in Lewis rats: role of glutathione. Eur. J. Immunol. 23 (1993) 675-681
88. Woods J.S., and Ellis M.E. Up-regulation of glutathione synthesis in rat kidney by methyl mercury: Relationship to mercury-induced oxidative stress. Biochem. Pharmacol. 50 (1995) 1719-1724
89. Shenker B.J., et al. Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes. IV. Alterations in cellular glutathione content. Immunopharmacol. Immunotoxicol. 15 (1993) 273-290
90. Bagenstose L.M., et al. Mercury-induced autoimmunity in the absence of IL-4. Clin. Exp. Immunol. 114 (1998) 9-12
91. Whitekus M.J., et al. Protection against CD95-mediated apoptosis by inorganic mercury in Jurkat T cells. J. Immunol. 162 (1999) 7162-7170
92. Ziemba S.E., et al. Inorganic mercury dissociates preassembled Fas/CD95 receptor oligomers in T lymphocytes. Toxicol. Appl. Pharmacol. 206 (2005) 334-342
93. Watanabe-Fukunaga R., et al. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356 (1992) 314-317
94. Zhang J., et al. Impaired Fas signaling pathway involved in defective T cell apoptosis in autoimmune murine arthritis. J. Immunol. 166 (2001) 4981-4986
95. Martin D.A., et al. Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia. Proc. Natl.l Acad. Sci. U.S.A. 96 (1999) 4552-4557
96. Pollard K.M., et al. The autoimmunity-inducing xenobiotic mercury interacts with the autoantigen fibrillarin and modifies its molecular and antigenic properties. J. Immunol. 158 (1997) 3521-3528
97. Chen M., et al. Subcellular recruitment of fibrillarin to nucleoplasmic proteasomes: Implications for processing of a nucleolar autoantigen. Mol. Biol. Cell 13 (2002) 3576-3587
98. Kubicka-Muranyi M., et al. Murine systemic autoimmune disease induced by mercuric chloride: T helper cells reacting to self proteins. Int. Arch. Allergy Appl. Immunol. 109 (1996) 11-20
99. Pollard K.M., et al. Proteolytic cleavage of a self-antigen following xenobiotic-induced cell death produces a fragment with novel immunogenic properties. J. Immunol. 165 (2000) 2263-2270
100. Albert M.L., et al. Immature dendritic cells phagocytose apoptotic cells via αVβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J. Exp. Med. 188 (1998) 1359-1368
101. Guermonprez P., et al. ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells. Nature 425 (2003) 397-402
102. Malnati M.S., et al. Processing pathways for presentation of cytosolic antigen to MHC class II-restricted T cells. Nature 357 (1992) 702-704
103. Munz C., et al. Human CD4+ T lymphocytes consistently respond to the latent Epstein-Barr virus nuclear antigen EBNA1. J. Exp. Med. 191 (2000) 1649-1660
104. Chen M., and Mikecz A. Xenobiotic-induced recruitment of autoantigens to nuclear proteasomes suggests a role for altered antigen processing in scleroderma. Ann. N. Y. Acad. Sci. 1051 (2005) 382-389
105. Brkljacic J., et al. Interaction of rat renal glucocorticoid receptor with Hsp90 and Hsp70 upon stress provoked by mercury. J. Appl. Toxicol. 27 (2007) 43-50
106. Goering P.L., et al. Mercury induces regional and cell-specific stress protein expression in rat kidney. Toxicol. Sci. 53 (2000) 447-457
107. Goering P.L., et al. Relationship between stress protein induction in rat kidney by mercuric chloride and nephrotoxicity. Toxicol. Appl. Pharmacol. 113 (1992) 184-191
108. Bauman J.W., et al. Production of metallothionein and heat-shock proteins in response to metals. Fundam. Appl. Toxicol. 21 (1993) 15-22
109. Schuhmann D., et al. Adverse immune reactions to gold. I. Chronic treatment with an Au(I) drug sensitizes mouse T cells no to Au(I), but to Au(III) and induces autoantibody formation. J. Immunol. 145 (1990) 2132-2139