Interleukin-18 receptor signaling is not required for autoantibody production and end-organ disease in murine lupus

Arthritis and Rheumatism

Volumn 52, Issue 3, 2005, Pages 984-986

  Lin, Ling ^a   Peng, Stanford L ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; COMPLEMENTARY DNA; INTERLEUKIN 12; INTERLEUKIN 18 RECEPTOR; RECOMBINANT INTERLEUKIN 18;

ALLELE; ANTIBODY PRODUCTION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUTOIMMUNITY; BACKCROSSING; BACTERIAL FLORA; CHROMOSOME 1; CONGENIC STRAIN; CORRELATION ANALYSIS; DISEASE ACTIVITY; DISEASE EXACERBATION; DISEASE SEVERITY; GENE EXPRESSION; GENE LOCATION; GENE LOCUS; GLOMERULONEPHRITIS; HOMOZYGOTE; IMMUNE COMPLEX DISEASE; INFLAMMATION; KNOCKOUT MOUSE; LUPUS ERYTHEMATOSUS NEPHRITIS; LYMPHOCYTE PROLIFERATION; MORTALITY; MOUSE STRAIN; NONHUMAN; PATHOGENESIS; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN TARGETING; PROTEINURIA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; AUTOANTIBODIES; HUMANS; INTERLEUKIN-18 RECEPTOR ALPHA SUBUNIT; KIDNEY DISEASES; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, INBRED MRL LPR; MODELS, ANIMAL; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-18; SIGNAL TRANSDUCTION;

EID: 14944350431     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.20961     Document Type: Article

References (23)

1. Wong CK, Li EK, Ho CY, Lam CW. Elevation of plasma interleukin-18 concentration is correlated with disease activity in systemic lupus erythematosus. Rheumatology (Oxford) 2000;39: 1078-81.
2. Neumann D, del Giudice E, Ciaramella A, Boraschi D, Bossu P. Lymphocytes from autoimmune MRL lpr/lpr mice are hyperresponsive to IL-18 and overexpress the IL-18 receptor accessory chain. J Immunol 2001;166:3757-62.
3. Amerio P, Frezzolini A, Abeni D, Teofoli P, Girardelli CR, de Pita O, et al. Increased IL-18 in patients with systemic lupus erythematosus: relations with Th-1, Th-2, pro-inflammatory cytokines and disease activity: IL-18 is a marker of disease activity but does not correlate with pro-inflammatory cytokines. Clin Exp Rheumatol 2002;20:535-8.
4. Robak E, Robak T, Wozniacka A, Zak-Prelich M, Sysa-Jedrzejowska A, Stepien H. Proinflammatory interferon-γ-inducing monokines (interleukin-12, interleukin-18, interleukin-15): serum profile in patients with systemic lupus erythematosus. Eur Cytokine Net 2002;13:364-8.
5. lpr mice with autoimmune lupus nephritis. Arthritis Rheum 2002;46:3083-95.
6. Wong CK, Ho CY, Li EK, Tam LS, Lam CW. Elevated production of interleukin-18 is associated with renal disease in patients with systemic lupus erythematosus. Clin Exp Immunol 2002;130:345-51.
7. Shlomchik MJ, Craft JE, Mamula MJ. From T to B and back again: positive feedback in systemic autoimmune disease. Nat Rev Immunol 2001;1:147-53.
8. Esfandiari E, McInnes IB, Lindop G, Huang FP, Field M, Komai-Koma M, et al. A proinflammatory role of IL-18 in the development of spontaneous autoimmune disease. J Immunol 2001;167:5338-47.
9. lpr mice. J Immunol 2004;173:5312-8.
10. Kelly JA, Moser KL, Harley JB. The genetics of systemic lupus erythematosus: putting the pieces together. Genes Immun 2002;3 Suppl 1:871-85.
11. Hoshino K, Tsutsui H, Kawai T, Takeda K, Nakanishi K, Takeda Y, et al. Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor. J Immunol 1999;162:5041-4.
12. Gu L, Weinreb A, Wang XP, Zack DJ, Qiao JH, Weisbart R, et al. Genetic determinants of autoimmune disease and coronary vasculitis in the MRL-lpr/lpr mouse model of systemic lupus erythematosus. J Immunol 1998;161:6999-7006.
13. Nishihara M, Terada M, Kamogawa J, Ohashi Y, Mori S, Nakatsuru S. et al. Genetic basis of autoimmune sialadenitis in MRL/lpr lupus-prone mice: additive and hierarchical properties of polygenic inheritance. Arthritis Rheum 1999;42:2616-23.
14. lpr mice. J Clin Invest 1998;101:696-702.
15. Watson ML, Rao JK, Gilkeson GS, Ruiz P, Eicher EM, Pisetsky DS, et al. Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci. J Exp Med 1992;176:1645-56.
16. Hron JD, Peng SL. Type I interferon protects against murine lupus. J Immunol 2004;173:2134-42.
17. Isenberg DA, Katz D, le Page S, Knight B, Tucker L, Maddison P, et al. Independent analysis of the 16/6 idiotype lupus model: a role for an environmental factor? J Immunol 1991;147:4172-7.
18. Leiter EH, Serreze DV, Prochazka M. The genetics and epidemiology of diabetes in NOD mice. Immunol Today 1990;11:147-9.
19. Bygrave AE, Rose KL, Cortes-Hernandez J, Warren J, Rigby RJ, Cook HT, et al. Spontaneous autoimmunity in 129 and C57BL/6 mice: implications for autoimmunity described in gene-targeted mice. PLoS Biol 2004;2:E243.
20. Bossu P, Neumann D, del Giudice E, Ciaramella A, Gloaguen I, Fantuzzi G, et al. IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease. Proc Natl Acad Sci U S A 2003;100:14181-6.
21. Peng SL. Experimental use of murine lupus models. Methods Mol Med 2004;102:227-72.
22. Lauwerys BR, Renauld JC, Houssiau FA. Inhibition of in vitro immunoglobulin production by IL-12 in murine chronic graft-vs.-host disease: synergism with IL-18. Eur J Immunol 1998;28: 2017-24.
23. Izui S, Lambert PH, Fournie GJ, Turler H, Miescher PA. Features of systemic lupus erythematosus in mice injected with bacterial lipopolysaccharides: identification of circulating DNA and renal localization of DNA-anti-DNA complexes. J Exp Med 1977;145: 1115-30.