Glutamine suppresses airway neutrophilia by blocking cytosolic phospholipase A2 via an induction of MAPK phosphatase-1

Journal of Immunology

Volumn 189, Issue 11, 2012, Pages 5139-5146

  Lee, Chang Hoon ^a   Kim, Hae Kyoung ^a   Kim, June Mo ^a   Ayush, Otgonzaya ^a   Im, Suhn Young ^b   Oh, Dae Kyu ^c   Lee, Hern Ku ^a  

^a Chonbuk National University Medical School   (South Korea)

^b Chonnam National University   (South Korea)

^c Gachon University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; CYTOSOLIC PHOSPHOLIPASE A2; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; GLUTAMINE; KERATINOCYTE DERIVED CHEMOKINE; LEUKOTRIENE B4; MACROPHAGE INFLAMMATORY PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; SMALL INTERFERING RNA;

AIRWAY NEUTROPHILIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MECHANISM; FEMALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NEUTROPHILIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RESPIRATORY TRACT DISEASE; RNA INTERFERENCE;

ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; CYTOSOL; DUAL SPECIFICITY PHOSPHATASE 1; FEMALE; GENE EXPRESSION REGULATION; GLUTAMINE; INFLAMMATION; LEUKOTRIENE B4; MICE; MICE, INBRED BALB C; NEUTROPHILS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOLIPASES A2; PHOSPHORYLATION; RESPIRATORY SYSTEM; SIGNAL TRANSDUCTION;

EID: 84869834944     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1201599     Document Type: Article

References (48)

1. Barnes, P. J. 1998. Efficacy of inhaled corticosteroids in asthma. J. Allergy Clin. Immunol. 102: 531-538.
2. Burke, C., C. K. Power, A. Norris, A. Condez, B. Schmekel, and L. W. Poulter. 1992. Lung function and immunopathological changes after inhaled corticosteroid therapy in asthma. Eur. Respir. J. 5: 73-79.
3. Djukanović, R., J. W. Wilson, K. M. Britten, S. J. Wilson, A. F. Walls, W. R. Roche, P. H. Howarth, and S. T. Holgate. 1992. Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am. Rev. Respir. Dis. 145: 669-674.
4. Jeffery, P. K., R. W. Godfrey, E. Adelroth, F. Nelson, A. Rogers, and S. A. Johansson. 1992. Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma. A quantitative light and electron microscopic study. Am. Rev. Respir. Dis. 145: 890-899.
5. Laitinen, L. A., A. Laitinen, and T. Haahtela. 1992. A comparative study of the effects of an inhaled corticosteroid, budesonide, and a beta 2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: a randomized, double-blind, parallel-group controlled trial. J. Allergy Clin. Immunol. 90: 32-42.
6. Bhagat, R. G., and M. M. Grunstein. 1985. Effect of corticosteroids on bronchial responsiveness to methacholine in asthmatic children. Am. Rev. Respir. Dis. 131: 902-906. (Pubitemid 15065923)
7. Chakir, J., Q. Hamid, M. Bossé, L. P. Boulet, and M. Laviolette. 2002. Bronchial inflammation in corticosteroid-sensitive and corticosteroid-resistant asthma at baseline and on oral corticosteroid treatment. Clin. Exp. Allergy 32: 578-582. (Pubitemid 34429578)
8. Bentley, A. M., Q. Hamid, D. S. Robinson, E. Schotman, Q. Meng, B. Assoufi, A. B. Kay, and S. R. Durham. 1996. Prednisolone treatment in asthma. Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa. Am. J. Respir. Crit. Care Med. 153: 551-556.
9. Hauber, H. P., M. Gotfried, K. Newman, R. Danda, R. J. Servi, P. Christodoulopoulos, and Q. Hamid. 2003. Effect of HFA-flunisolide on peripheral lung inflammation in asthma. J. Allergy Clin. Immunol. 112: 58-63. (Pubitemid 36819807)
10. Nguyen, L. T., S. Lim, T. Oates, and K. F. Chung. 2005. Increase in airway neutrophils after oral but not inhaled corticosteroid therapy in mild asthma. Respir. Med. 99: 200-207. (Pubitemid 40104275)
11. Fukakusa, M., C. Bergeron, M. K. Tulic, P. O. Fiset, O. Al Dewachi, M. Laviolette, Q. Hamid, and J. Chakir. 2005. Oral corticosteroids decrease eosinophil and CC chemokine expression but increase neutrophil, IL-8, and IFN-gamma-inducible protein 10 expression in asthmatic airway mucosa. J. Allergy Clin. Immunol. 115: 280-286. (Pubitemid 40215090)
12. Barnes, P. J. 2007. New molecular targets for the treatment of neutrophilic diseases. J. Allergy Clin. Immunol. 119: 1055-1062; quiz 1063-1064.
13. Häussinger, D. 1998. Hepatic glutamine transport and metabolism. Adv. Enzymol. Relat. Areas Mol. Biol. 72: 43-86.
14. Fox, R. E., I. B. Hopkins, E. T. Cabacungan, and J. T. Tildon. 1996. The role of glutamine and other alternate substrates as energy sources in the fetal rat lung type II cell. Pediatr. Res. 40: 135-141. (Pubitemid 26196612)
15. Encarnación, S., J. Calderón, A. S. Gelbard, A. J. Cooper, and J. Mora. 1998. Glutamine biosynthesis and the utilization of succinate and glutamine by Rhizobium etli and Sinorhizobium meliloti. Microbiology 144: 2629-2638. (Pubitemid 28457173)
16. Newsholme, E. A., B. Crabtree, and M. S. Ardawi. 1985. Glutamine metabolism in lymphocytes: its biochemical, physiological and clinical importance. Q. J. Exp. Physiol. 70: 473-489. (Pubitemid 16255147)
17. Wischmeyer, P. E., M. Kahana, R. Wolfson, H. Ren, M. M. Musch, and E. B. Chang. 2001. Glutamine reduces cytokine release, organ damage, and mortality in a rat model of endotoxemia. Shock 16: 398-402. (Pubitemid 33598218)
18. Griffiths, R. D., C. Jones, and T. E. Palmer. 1997. Six-month outcome of critically ill patients given glutamine-supplemented parenteral nutrition. Nutrition 13: 295-302.
19. Kim, Y. S., G. Y. Kim, J. H. Kim, H. J. You, Y. M. Park, H. K. Lee, H. C. Yu, S. M. Chung, Z. W. Jin, H. M. Ko, and B. H. Cho. 2006. Glutamine inhibits lipopolysaccharide-induced cytoplasmic phospholipase A2 activation and protects against endotoxin shock in mouse. Shock 25: 290-294.
20. Ko, H. M., S. H. Oh, H. S. Bang, N. I. Kang, B. H. Cho, S. Y. Im, and H. K. Lee. 2009. Glutamine protects mice from lethal endotoxic shock via a rapid induction of MAPK phosphatase-1. J. Immunol. 182: 7957-7962.
21. Ko, H. M., N. I. Kang, Y. S. Kim, Y. M. Lee, Z. W. Jin, Y. J. Jung, S. Y. Im, J. H. Kim, Y. H. Shin, B. H. Cho, and H. K. Lee. 2008. Glutamine preferentially inhibits T-helper type 2 cell-mediated airway inflammation and late airway hyperresponsiveness through the inhibition of cytosolic phospholipase A(2) activity in a murine asthma model. Clin. Exp. Allergy 38: 357-364.
22. Lee, Y. M., N. I. Kang, and H. K. Lee. 2007. Dexamethasone does not inhibit airway CXC chemokine expression and neutrophilia in a murine model of asthma. Immune Netw. 7: 18-25.
23. Choi, I. W., Y. S. Sun-Kim, H. M. Kim, S. Y. Ko, J. H. Im, H. J. Kim, Y. C. You, J. H. Lee, Y. M. Lee, Park, and H. K. Lee. 2005. TNF-alpha induces the late-phase airway hyperresponsiveness and airway inflammation through cytosolic phospholipase A(2) activation. J. Allergy Clin. Immunol. 116: 537-543.
24. Diab, A., H. Abdalla, H. L. Li, F. D. Shi, J. Zhu, B. Höjberg, L. Lindquist, B. Wretlind, M. Bakhiet, and H. Link. 1999. Neutralization of macrophage inflammatory protein 2 (MIP-2) and MIP-1alpha attenuates neutrophil recruitment in the central nervous system during experimental bacterial meningitis. Infect. Immun. 67: 2590-2601. (Pubitemid 29200523)
25. Oquendo, P., J. Alberta, D. Z. Wen, J. L. Graycar, R. Derynck, and C. D. Stiles. 1989. The platelet-derived growth factor-inducible KC gene encodes a secretory protein related to platelet alpha-granule proteins. J. Biol. Chem. 264: 4133-4137. (Pubitemid 19072306)
26. Walz, A., P. Schmutz, C. Mueller, and S. Schnyder-Candrian. 1997. Regulation and function of the CXC chemokine ENA-78 in monocytes and its role in disease. J. Leukoc. Biol. 62: 604-611. (Pubitemid 27519771)
27. Samuelsson, B., S. E. Dahlén, J. A. Lindgren, C. A. Rouzer, and C. N. Serhan. 1987. Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science 237: 1171-1176. (Pubitemid 17131222)
28. Kramer, R. M., and J. D. Sharp. 1995. Recent insights into the structure, function and biology of cPLA2. Agents Actions Suppl. 46: 65-76.
29. Yokomizo, T., T. Izumi, and T. Shimizu. 2001. Leukotriene B4: metabolism and signal transduction. Arch. Biochem. Biophys. 385: 231-241.
30. Su, B., and M. Karin. 1996. Mitogen-activated protein kinase cascades and regulation of gene expression. Curr. Opin. Immunol. 8: 402-411. (Pubitemid 26229663)
31. Nagase, T., N. Uozumi, S. Ishii, K. Kume, T. Izumi, Y. Ouchi, and T. Shimizu. 2000. Acute lung injury by sepsis and acid aspiration: a key role for cytosolic phospholipase A2. Nat. Immunol. 1: 42-46.
32. Meliton, A. Y., N. M. Munoz, X. Zhu, and A. R. Leff. 2008. Attenuated translocation of group IVa phospholipase A2 and up-regulated annexin-1 synthesis by glucocorticoid blocks beta 2-integrin adhesion in neutrophils. J. Leukoc. Biol. 83: 344-351. (Pubitemid 351225615)
33. Wilton, D. C. 2005. Phospholipases A2: structure and function. Eur. J. Lipid Sci. Technol. 107: 193-205.
34. Niknami, M., M. Patel, P. K. Witting, and Q. Dong. 2009. Molecules in focus: cytosolic phospholipase A2-alpha. Int. J. Biochem. Cell Biol. 41: 994-997.
35. Ghosh, M., D. E. Tucker, S. A. Burchett, and C. C. Leslie. 2006. Properties of the Group IV phospholipase A2 family. Prog. Lipid Res. 45: 487-510.
36. Misra-Press, A., C. S. Rim, H. Yao, M. S. Roberson, and P. J. Stork. 1995. A novel mitogen-activated protein kinase phosphatase. Structure, expression, and regulation. J. Biol. Chem. 270: 14587-14596.
37. Sun, H., C. H. Charles, L. F. Lau, and N. K. Tonks. 1993. MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell 75: 487-493. (Pubitemid 23335074)
38. Franklin, C. C., and A. S. Kraft. 1997. Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells. J. Biol. Chem. 272: 16917-16923. (Pubitemid 27289792)
39. Hammer, M., J. Mages, H. Dietrich, A. Servatius, N. Howells, A.C. Cato, and R. Lang. 2006. Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock. J. Exp. Med. 203: 15-20. (Pubitemid 43139639)
40. Abraham, S. M., T. Lawrence, A. Kleiman, P. Warden, M. Medghalchi, J. Tuckermann, J. Saklatvala, and A. R. Clark. 2006. Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1. J. Exp. Med. 203: 1883-1889. (Pubitemid 44188463)
41. Hammer, M., J. Mages, H. Dietrich, F. Schmitz, F. Striebel, P. J. Murray, H. Wagner, and R. Lang. 2005. Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10. Eur. J. Immunol. 35: 2991-3001. (Pubitemid 41555095)
42. Xiao, Y. Q., K. Malcolm, G. S. Worthen, S. Gardai, W. P. Schiemann, V. A. Fadok, D. L. Bratton, and P. M. Henson. 2002. Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-beta. J. Biol. Chem. 277: 14884-14893. (Pubitemid 34952562)
43. Fabre, J. E., J. L. Goulet, E. Riche, M. Nguyen, K. Coggins, S. Offenbacher, and B. H. Koller. 2002. Transcellular biosynthesis contributes to the production of leukotrienes during inflammatory responses in vivo. J. Clin. Invest. 109: 1373-1380. (Pubitemid 34546902)
44. Hellings, P. W., A. Kasran, Z. Liu, P. Vandekerckhove, A. Wuyts, L. Overbergh, C. Mathieu, and J. L. Ceuppens. 2003. Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma. Am. J. Respir. Cell Mol. Biol. 28: 42-50. (Pubitemid 36017049)
45. Oda, N., P. B. Canelos, D. M. Essayan, B. A. Plunkett, A. C. Myers, and S. K. Huang. 2005. Interleukin-17F induces pulmonary neutrophilia and amplifies antigen-induced allergic response. Am. J. Respir. Crit. Care Med. 171:12-18. (Pubitemid 40051689)
46. Brondello, J. M., J. Pouysségur, and F. R. McKenzie. 1999. Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation. Science 286: 2514-2517.
47. Novak, F., D. K. Heyland, A. Avenell, J. W. Drover, and X. Su. 2002. Glutamine supplementation in serious illness: a systematic review of the evidence. Crit. Care Med. 30: 2022-2029.
48. Wischmeyer, P. E., J. Lynch, J. Liedel, R. Wolfson, J. Riehm, L. Gottlieb, and M. Kahana. 2001. Glutamine administration reduces Gram-negative bacteremia in severely burned patients: a prospective, randomized, double-blind trial versus isonitrogenous control. Crit. Care Med. 29: 2075-2080. (Pubitemid 33063533)