Oral corticosteroids decrease eosinophil and CC chemokine expression but increase neutrophil, IL-8, and IFN-γ-inducible protein 10 expression in asthmatic airway mucosa

Journal of Allergy and Clinical Immunology

Volumn 115, Issue 2, 2005, Pages 280-286

  Fukakusa, Motonori ^a   Bergeron, Celine ^a   Tulic, Meri K ^a   Fiset, Pierre Olivier ^a   Al Dewachi, Oday ^a   Laviolette, Michel ^b   Hamid, Qutayba ^a   Chakir, Jamila ^b  

^a MCGILL UNIVERSITY   (Canada)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

Asthma; Bronchial epithelial cell; Chemokines; Corticosteroids; Eotaxin; IL 8

Indexed keywords

ALPHA CHEMOKINE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA CHEMOKINE; BRONCHODILATING AGENT; CD3 ANTIGEN; CORTICOSTEROID; ELASTASE; EOTAXIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 8; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MAJOR BASIC PROTEIN; MESSENGER RNA; METHYLPREDNISOLONE; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 3; MONOCYTE CHEMOTACTIC PROTEIN 4;

ADULT; ARTICLE; ASTHMA; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE SEVERITY; DRUG EFFECT; ENDOSCOPIC BIOPSY; EOSINOPHIL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; LEUKOCYTE COUNT; MALE; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY TRACT MUCOSA; SUBMUCOSA; T LYMPHOCYTE;

EID: 13444267772     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2004.10.036     Document Type: Article

References (27)

1. P.J. Barnes, K.F. Chung, and C.P. Page Inflammatory mediators of asthma: an update Pharmacol Rev 50 1998 515 596
2. V. Gangur, N.P. Birmingham, and S. Thanesvorakul Chemokines in health and disease Vet Immunol Immunopathol 86 2002 127 136
3. C.E. Rose Jr., S.S. Sung, and S.M. Fu Significant involvement of CCL2 (MCP-1) in inflammatory disorders of the lung Microcirculation 10 2003 273 288
4. E.A. Garcia-Zepeda, C. Combadiere, M.E. Rothenberg, M.N. Sarafi, F. Lavigne, and Q. Hamid Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3 J Immunol 157 1996 5613 5626
5. R.G. Stirling, and K.F. Chung Severe asthma: definition and mechanisms Allergy 56 2001 825 840
6. U. Meyer-Hoffert, D. Lezcano-Meza, J. Bartels, A.R. Montes-Vizuet, J.M. Schroder, and L.M. Teran Th2- and to a lesser extent Th1-type cytokines upregulate the production of both CXC (IL-8 and gro-alpha) and CC (RANTES, eotaxin, eotaxin-2, MCP-3 and MCP-4) chemokines in human airway epithelial cells Int Arch Allergy Immunol 131 2003 264 271
7. A.M. Bentley, Q. Hamid, D.S. Robinson, E. Schotman, Q. Meng, and B. Assoufi Prednisolone treatment in asthma. Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa Am J Respir Crit Care Med 153 1996 551 556
8. H.P. Hauber, M. Gotfried, K. Newman, R. Danda, R.J. Servi, and P. Christodoulopoulos Effect of HFA-flunisolide on peripheral lung inflammation in asthma J Allergy Clin Immunol 112 2003 58 63
9. M. Miyamasu, Y. Misaki, S. Izumi, T. Takaishi, Y. Morita, and H. Nakamura Glucocorticoids inhibit chemokine generation by human eosinophils J Allergy Clin Immunol 101 1998 75 83
10. L.C. Meagher, J.M. Cousin, J.R. Seckl, and C. Haslett Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes J Immunol 156 1996 4422 4428
11. O.J. Kwon, B.T. Au, P.D. Collins, J.N. Baraniuk, I.M. Adcock, and K.F. Chung Inhibition of interleukin-8 expression by dexamethasone in human cultured airway epithelial cells Immunology 81 1994 389 394
12. D. Miotto, P. Christodoulopoulos, R. Olivenstein, R. Taha, L. Cameron, and A. Tsicopoulos Expression of IFN-gamma-inducible protein; monocyte chemotactic proteins 1, 3, and 4; and eotaxin in TH1- and TH2-mediated lung diseases J Allergy Clin Immunol 107 2001 664 670
13. S. Ying, Q. Meng, K. Zeibecoglou, D.S. Robinson, A. Macfarlane, and M. Humbert Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (intrinsic) asthmatics J Immunol 163 1999 6321 6329
14. B. Lamkhioued, P.M. Renzi, S. Abi-Younes, E.A. Garcia-Zepada, Z. Allakhverdi, and O. Ghaffar Increased expression of eotaxin in bronchoalveolar lavage and airways of asthmatics contributes to the chemotaxis of eosinophils to the site of inflammation J Immunol 159 1997 4593 4601
15. L. Greiff, H. Petersen, E. Mattsson, M. Andersson, J.S. Erjefalt, and M. Linden Mucosal output of eotaxin in allergic rhinitis and its attenuation by topical glucocorticosteroid treatment Clin Exp Allergy 31 2001 1321 1327
16. P. Christodoulopoulos, E. Wright, S. Frenkiel, A. Luster, and Q. Hamid Monocyte chemotactic proteins in allergen-induced inflammation in the nasal mucosa: effect of topical corticosteroids J Allergy Clin Immunol 103 1999 1036 1044
17. American Thoracic Society Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, November 1986 Am Rev Respir Dis 136 1987 225 244
18. Workshop summary and guidelines: investigative use of bronchoscopy, lavage, and bronchial biopsies in asthma and other airway diseases J Allergy Clin Immunol 88 1991 808 814
19. Q. Hamid, M. Azzawi, S. Ying, R. Moqbel, A.J. Wardlaw, and C.J. Corrigan Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma J Clin Invest 87 1991 1541 1546
20. Q. Hamid, J. Wharton, G. Terenghi, C.J. Hassall, J. Aimi, and K.M. Taylor Localization of atrial natriuretic peptide mRNA and immunoreactivity in the rat heart and human atrial appendage Proc Natl Acad Sci U S A 84 1987 6760 6764
21. J. Chakir, Q. Hamid, M. Bosse, L.P. Boulet, and M. Laviolette Bronchial inflammation in corticosteroid-sensitive and corticosteroid-resistant asthma at baseline and on oral corticosteroid treatment Clin Exp Allergy 32 2002 578 582
22. S.J. Wilson, A. Wallin, G. Della-Cioppa, T. Sandstrom, and S.T. Holgate Effects of budesonide and formoterol on NF-kappaB, adhesion molecules, and cytokines in asthma Am J Respir Crit Care Med 164 2001 1047 1052
23. D.Y. Leung, and J.W. Bloom Update on glucocorticoid action and resistance J Allergy Clin Immunol 111 2003 3 23
24. A.R. Sousa, S.J. Lane, J.A. Cidlowski, D.Z. Staynov, and T.H. Lee Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor beta-isoform J Allergy Clin Immunol 105 2000 943 950
25. D.Y. Leung, Q. Hamid, A. Vottero, S.J. Szefler, W. Surs, and E. Minshall Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta J Exp Med 186 1997 1567 1574
26. A.R. Sousa, S.J. Lane, J.A. Nakhosteen, T. Yoshimura, T.H. Lee, and R.N. Poston Increased expression of the monocyte chemoattractant protein-1 in bronchial tissue from asthmatic subjects Am J Respir Cell Mol Biol 10 1994 142 147
27. J.L. Pype, L.J. Dupont, P. Menten, E. Van Coillie, G. Opdenakker, and J. Van Damme Expression of monocyte chemotactic protein (MCP)-1, MCP-2, and MCP-3 by human airway smooth-muscle cells. Modulation by corticosteroids and T-helper 2 cytokines Am J Respir Cell Mol Biol 21 1999 528 536