Glutamine reduces cytokine release, organ damage, and mortality in a rat model of endotoxemia

Shock

Volumn 16, Issue 5, 2001, Pages 398-402

  Wischmeyer, Paul E ^a   Kahana, Madelyn ^b   Wolfson, Rachel ^c   Ren, Hongyu ^d   Musch, Mark M ^d   Chang, Eugene B ^d  

^a Clinical Pharmacology ^*  (United States)

^b Psychiatry   (United States)

^c Martin Boyer Laboratories   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

Amino acid; Animal model; Interleukin 1 ; Lipopolysaccharide; Septic shock; Tumor necrosis factor

Indexed keywords

CYTOKINE; GLUTAMINE; INTERLEUKIN 1; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ARTICLE; BLOOD; DISEASE MODEL; ENDOTOXEMIA; ESCHERICHIA COLI; ILEUM; IMMUNOLOGY; LUNG; MALE; PATHOLOGY; RAT; SECRETION; SEPSIS; SPRAGUE DAWLEY RAT; TIME;

ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; ENDOTOXEMIA; ESCHERICHIA COLI; GLUTAMINE; ILEUM; INTERLEUKIN-1; INTERLEUKIN-10; LIPOPOLYSACCHARIDES; LUNG; MALE; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035513751     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-200116050-00014     Document Type: Article

References (21)

1. Glauser MP, Zanetti G, Baumgartner JD, Cohen J: Septic shock: pathogenesis. Lancet 338:732-736, 1991
2. Abraham E: Why immunomodulatory therapies have not worked in sepsis? Intensive Care Med 25:556-566, 1999.
3. Lacey JM, Wilmore DW: Is glutamine a conditional essential amino acid? Nutr Rev 48:297-309, 1990.
4. Newsholme EA, Crabtree B, Ardawi MSM: The role of high rates of glycolysis and glutamine utilization in rapidly dividing cells. Biosci Rep 5:393-400, 1985.
5. Askanazi J, Carpentier YA, Michelsen CB, Elwyn DH, Furst P, Kantrowitz LR, Gump FE, Kinney JM: Muscle and plasma amino acids following injury. Ann Surg 192:78-85, 1980.
6. Ziegler TR, Young LS: Therapeutic effects of specific nutrients. In: Rombeau JL, Rolandelli RH (eds). Clinical Nutrition: Enterai and Tube Feeding, 3rd ed. Philadelphia: WB Saunders, 1997, pp 112-137.
7. Zapata-Sirvent RL, Hansbrough J, Ohara MM, Rice-Asaro M, Nyhan WL: Bacterial translocation in burned mice after administration of various diets including fiber-and glutamine-enriched enterai formulas. Crit Care Med 22: 690-696, 1994.
8. Gianotti L, Alexander JW, Gennari R, Pyles T, Babcock GF: Oral glutamine decreases bacterial translocation and improves survival in experimental gut-origin sepsis. JPEN 19:69-74, 1995.
9. Ziegler TR, Young LS, Benfell K, Scheltinga M, Hortos K, Bye R, Morrow FD, Jacobs DO, Smith RJ, Antin JH, Wilmore DW: Clinical and metabolic efficacy of glutamine supplemented parental nutrition after bone marrow transplantation. Ann Intern Med 116:821-828, 1992.
10. Giffiths RD, Jones C, Palmer TE: Six-month outcome of critically ill patients given glutamine supplemented parenteral nutrition. Nutrition 13:295-302, 1997.
11. Neu J, Roig JC, Meetze WH, Veerman M, Carter C, Millsaps M, Bowling D, Dallas MJ, Sleasman J, Knight T, Auestad N: Enterai glutamine supplementation for very low birth weight infants decreases morbidly. J Pediatr 131:691-699, 1997.
12. Houdijk APJ, Rijnsburger ER, Jansen J, Wesdorp RIC, Weiss JK, McCamish MA, Teerlink T, Meuwissen SGM, Henk JThM, Thijs LG, van Leeuwen PAM: Randomized trial of glutamine-enriched nutrition on infectious morbidity in patients with multiple trauma. Lancet 352:772-776, 1998.
13. Souba WW, Wilmore DW: Postoperative alteration of arteriovenous exchange of amino acids across the gastrointestinal tract. Surgery 94:342-350, 1983.
14. Newsholme EA, Crabtree B, Ardawi MSM: Glutamine metabolism in lymphocytes: its biochemical, physiological, and clinical importance. Q J Exp Physiol 70:473-489, 1985.
15. Souba WW: Interorgan ammonia metabolism in health and disease: a surgeon's view. JPEN 11:569-579, 1987.
16. Denno R, Rounds JD, Faris R, Holejko LB, Wilmore DW: Glutamine-enriched total parenteral nutrition enhances plasma glutathione in the resting state. J Surg Res 61:35-38, 1996.
17. Wischmeyer PE, Musch MW, Madonna MB, Thisted R, Chang EB: Glutamine protects intestinal epithelial cells: role of inducible HSP 70. Am J Physiol 272:G879-G884, 1997.
18. Musch MW, Hayden D, Sugi K, Straus D, Chang EB: Cell-specific induction of hsp72-mediated protection by glutamine against oxidant injury in IEC18 cells. Proc Assoc Amer Physicians 110:136-139, 1998.
19. Deitch EA: Animal models of sepsis and shock: A review and lessons learned. Shock 9:1-11, 1998.
20. Chu EK, Ribeiro SP, Slutsky AS: Heat stress increases survival rates in lipopolysaccharide-stimulated rats. Crit Care Med 25:1727-1732, 1997.
21. Cahill CM, Waterman WR, Xie Y, Auron PE, Calderwood SK: Transcriptional repression of the prointerleukin 1β gene by heat shock factor-1. J Biol Chem 271:17724-17732, 1996.