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Volumn 7, Issue 11, 2012, Pages

Involvement of Kv1.5 Protein in Oxidative Vascular Endothelial Cell Injury

Author keywords

[No Author keywords available]

Indexed keywords

(2 ISOPROPYL 5 METHYLCYCLOHEXY)DIPHENYLPHOSPHINE OXIDE; ANGIOTENSIN II; ANTIOXIDANT; COMPLEMENTARY DNA; OXIDIZED LOW DENSITY LIPOPROTEIN; POTASSIUM CHANNEL KV1.5; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2;

EID: 84869824775     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0049758     Document Type: Article
Times cited : (22)

References (48)
  • 1
    • 6344285417 scopus 로고    scopus 로고
    • Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology
    • Li JM, Shah AM, (2004) Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology. Am J Physiol Regul Integr Comp Physiol 287: R1014-1030.
    • (2004) Am J Physiol Regul Integr Comp Physiol , vol.287
    • Li, J.M.1    Shah, A.M.2
  • 2
    • 69349088394 scopus 로고    scopus 로고
    • A novel marine compound xyloketal B protects against oxidized LDL-induced cell injury in vitro
    • Chen WL, Qian Y, Meng WF, Pang JY, Lin YC, et al. (2009) A novel marine compound xyloketal B protects against oxidized LDL-induced cell injury in vitro. Biochem Pharmacol 78: 941-950.
    • (2009) Biochem Pharmacol , vol.78 , pp. 941-950
    • Chen, W.L.1    Qian, Y.2    Meng, W.F.3    Pang, J.Y.4    Lin, Y.C.5
  • 3
    • 33644543347 scopus 로고    scopus 로고
    • Impact of oxidized low density lipoprotein on vascular cells
    • Galle J, Hansen-Hagge T, Wanner C, Seibold S, (2006) Impact of oxidized low density lipoprotein on vascular cells. Atherosclerosis 185: 219-226.
    • (2006) Atherosclerosis , vol.185 , pp. 219-226
    • Galle, J.1    Hansen-Hagge, T.2    Wanner, C.3    Seibold, S.4
  • 4
    • 41949104144 scopus 로고    scopus 로고
    • Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction
    • Doughan AK, Harrison DG, Dikalov SI, (2008) Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction. Circ Res 102: 488-496.
    • (2008) Circ Res , vol.102 , pp. 488-496
    • Doughan, A.K.1    Harrison, D.G.2    Dikalov, S.I.3
  • 5
    • 0035814745 scopus 로고    scopus 로고
    • Estrogen prevents oxidative stress-induced endothelial cell apoptosis in rats
    • Sudoh N, Toba K, Akishita M, Ako J, Hashimoto M, et al. (2001) Estrogen prevents oxidative stress-induced endothelial cell apoptosis in rats. Circulation 103: 724-729.
    • (2001) Circulation , vol.103 , pp. 724-729
    • Sudoh, N.1    Toba, K.2    Akishita, M.3    Ako, J.4    Hashimoto, M.5
  • 6
    • 0031003283 scopus 로고    scopus 로고
    • Antisense oligodeoxynucleotides directed against Kv1.5 mRNA specifically inhibit ultrarapid delayed rectifier K+ current in cultured adult human atrial myocytes
    • Feng J, Wible B, Li GR, Wang Z, Nattel S, (1997) Antisense oligodeoxynucleotides directed against Kv1.5 mRNA specifically inhibit ultrarapid delayed rectifier K+ current in cultured adult human atrial myocytes. Circ Res 80: 572-579.
    • (1997) Circ Res , vol.80 , pp. 572-579
    • Feng, J.1    Wible, B.2    Li, G.R.3    Wang, Z.4    Nattel, S.5
  • 7
    • 67650215357 scopus 로고    scopus 로고
    • Antiarrhythmic drug-induced internalization of the atrial-specific k+ channel kv1.5
    • Schumacher SM, McEwen DP, Zhang L, Arendt KL, Van Genderen KM, et al. (2009) Antiarrhythmic drug-induced internalization of the atrial-specific k+ channel kv1.5. Circ Res 104: 1390-1398.
    • (2009) Circ Res , vol.104 , pp. 1390-1398
    • Schumacher, S.M.1    McEwen, D.P.2    Zhang, L.3    Arendt, K.L.4    Van Genderen, K.M.5
  • 8
    • 39149109618 scopus 로고    scopus 로고
    • Atrial-selective approaches for the treatment of atrial fibrillation
    • Ehrlich JR, Biliczki P, Hohnloser SH, Nattel S, (2008) Atrial-selective approaches for the treatment of atrial fibrillation. J Am Coll Cardiol 51: 787-792.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 787-792
    • Ehrlich, J.R.1    Biliczki, P.2    Hohnloser, S.H.3    Nattel, S.4
  • 9
    • 73449119314 scopus 로고    scopus 로고
    • Voltage-gated potassium channels as therapeutic targets
    • Wulff H, Castle NA, Pardo LA, (2009) Voltage-gated potassium channels as therapeutic targets. Nat Rev Drug Discov 8: 982-1001.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 982-1001
    • Wulff, H.1    Castle, N.A.2    Pardo, L.A.3
  • 10
    • 33646766140 scopus 로고    scopus 로고
    • Novel, potent inhibitors of human Kv1.5 K+ channels and ultrarapidly activating delayed rectifier potassium current
    • Lagrutta A, Wang J, Fermini B, Salata JJ, (2006) Novel, potent inhibitors of human Kv1.5 K+ channels and ultrarapidly activating delayed rectifier potassium current. J Pharmacol Exp Ther 317: 1054-1063.
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 1054-1063
    • Lagrutta, A.1    Wang, J.2    Fermini, B.3    Salata, J.J.4
  • 11
    • 33750689149 scopus 로고    scopus 로고
    • Discovery and in vitro/in vivo studies of tetrazole derivatives as Kv1.5 blockers
    • Wu S, Fluxe A, Sheffer J, Janusz JM, Blass BE, et al. (2006) Discovery and in vitro/in vivo studies of tetrazole derivatives as Kv1.5 blockers. Bioorg Med Chem Lett 16: 6213-6218.
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 6213-6218
    • Wu, S.1    Fluxe, A.2    Sheffer, J.3    Janusz, J.M.4    Blass, B.E.5
  • 12
    • 34247252024 scopus 로고    scopus 로고
    • In vitro and in vivo effects of the atrial selective antiarrhythmic compound AVE1231
    • Wirth KJ, Brendel J, Steinmeyer K, Linz DK, Rutten H, et al. (2007) In vitro and in vivo effects of the atrial selective antiarrhythmic compound AVE1231. J Cardiovasc Pharmacol 49: 197-206.
    • (2007) J Cardiovasc Pharmacol , vol.49 , pp. 197-206
    • Wirth, K.J.1    Brendel, J.2    Steinmeyer, K.3    Linz, D.K.4    Rutten, H.5
  • 13
    • 9644270197 scopus 로고    scopus 로고
    • Hypoxic pulmonary vasoconstriction: redox regulation of O2-sensitive K+ channels by a mitochondrial O2-sensor in resistance artery smooth muscle cells
    • Michelakis ED, Thebaud B, Weir EK, Archer SL, (2004) Hypoxic pulmonary vasoconstriction: redox regulation of O2-sensitive K+ channels by a mitochondrial O2-sensor in resistance artery smooth muscle cells. J Mol Cell Cardiol 37: 1119-1136.
    • (2004) J Mol Cell Cardiol , vol.37 , pp. 1119-1136
    • Michelakis, E.D.1    Thebaud, B.2    Weir, E.K.3    Archer, S.L.4
  • 14
    • 39149106144 scopus 로고    scopus 로고
    • Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer
    • Archer SL, Gomberg-Maitland M, Maitland ML, Rich S, Garcia JG, et al. (2008) Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer. Am J Physiol Heart Circ Physiol 294: H570-578.
    • (2008) Am J Physiol Heart Circ Physiol , vol.294
    • Archer, S.L.1    Gomberg-Maitland, M.2    Maitland, M.L.3    Rich, S.4    Garcia, J.G.5
  • 16
    • 6344257102 scopus 로고    scopus 로고
    • Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis
    • McMurtry MS, Bonnet S, Wu X, Dyck JR, Haromy A, et al. (2004) Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis. Circ Res 95: 830-840.
    • (2004) Circ Res , vol.95 , pp. 830-840
    • McMurtry, M.S.1    Bonnet, S.2    Wu, X.3    Dyck, J.R.4    Haromy, A.5
  • 17
    • 33846002728 scopus 로고    scopus 로고
    • A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
    • Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C, et al. (2007) A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 11: 37-51.
    • (2007) Cancer Cell , vol.11 , pp. 37-51
    • Bonnet, S.1    Archer, S.L.2    Allalunis-Turner, J.3    Haromy, A.4    Beaulieu, C.5
  • 18
    • 79953686516 scopus 로고    scopus 로고
    • New perspectives for the treatment of pulmonary hypertension
    • Baliga RS, MacAllister RJ, Hobbs AJ, (2011) New perspectives for the treatment of pulmonary hypertension. Br J Pharmacol 163: 125-140.
    • (2011) Br J Pharmacol , vol.163 , pp. 125-140
    • Baliga, R.S.1    MacAllister, R.J.2    Hobbs, A.J.3
  • 19
    • 0033667705 scopus 로고    scopus 로고
    • Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production
    • Arsenijevic D, Onuma H, Pecqueur C, Raimbault S, Manning BS, et al. (2000) Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet 26: 435-439.
    • (2000) Nat Genet , vol.26 , pp. 435-439
    • Arsenijevic, D.1    Onuma, H.2    Pecqueur, C.3    Raimbault, S.4    Manning, B.S.5
  • 21
    • 71849114477 scopus 로고    scopus 로고
    • Marine compound Xyloketal B protects PC12 cells against OGD-induced cell damage
    • Zhao J, Li L, Ling C, Li J, Pang JY, et al. (2009) Marine compound Xyloketal B protects PC12 cells against OGD-induced cell damage. Brain Res 1302: 240-247.
    • (2009) Brain Res , vol.1302 , pp. 240-247
    • Zhao, J.1    Li, L.2    Ling, C.3    Li, J.4    Pang, J.Y.5
  • 22
    • 31144478800 scopus 로고    scopus 로고
    • In vivo cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker, (2-Isopropyl-5-methylcyclohexyl) diphenylphosphine oxide, in rat and nonhuman primate
    • Regan CP, Wallace AA, Cresswell HK, Atkins CL, Lynch JJ Jr, (2006) In vivo cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker, (2-Isopropyl-5-methylcyclohexyl) diphenylphosphine oxide, in rat and nonhuman primate. J Pharmacol Exp Ther 316: 727-732.
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 727-732
    • Regan, C.P.1    Wallace, A.A.2    Cresswell, H.K.3    Atkins, C.L.4    Lynch Jr., J.J.5
  • 23
    • 0036936265 scopus 로고    scopus 로고
    • NAD(P)H oxidase-derived reactive oxygen species as mediators of angiotensin II signaling
    • Hanna IR, Taniyama Y, Szocs K, Rocic P, Griendling KK, (2002) NAD(P)H oxidase-derived reactive oxygen species as mediators of angiotensin II signaling. Antioxid Redox Signal 4: 899-914.
    • (2002) Antioxid Redox Signal , vol.4 , pp. 899-914
    • Hanna, I.R.1    Taniyama, Y.2    Szocs, K.3    Rocic, P.4    Griendling, K.K.5
  • 24
    • 4444333896 scopus 로고    scopus 로고
    • Reactive oxygen species and angiotensin II signaling in vascular cells - implications in cardiovascular disease
    • Touyz RM, (2004) Reactive oxygen species and angiotensin II signaling in vascular cells - implications in cardiovascular disease. Braz J Med Biol Res 37: 1263-1273.
    • (2004) Braz J Med Biol Res , vol.37 , pp. 1263-1273
    • Touyz, R.M.1
  • 25
    • 0030817798 scopus 로고    scopus 로고
    • Angiotensin II induces apoptosis of human endothelial cells. Protective effect of nitric oxide
    • Dimmeler S, Rippmann V, Weiland U, Haendeler J, Zeiher AM, (1997) Angiotensin II induces apoptosis of human endothelial cells. Protective effect of nitric oxide. Circ Res 81: 970-976.
    • (1997) Circ Res , vol.81 , pp. 970-976
    • Dimmeler, S.1    Rippmann, V.2    Weiland, U.3    Haendeler, J.4    Zeiher, A.M.5
  • 26
    • 74149088771 scopus 로고    scopus 로고
    • Palmitate attenuates myocardial contractility through augmentation of repolarizing Kv currents
    • Haim TE, Wang W, Flagg TP, Tones MA, Bahinski A, et al. (2010) Palmitate attenuates myocardial contractility through augmentation of repolarizing Kv currents. J Mol Cell Cardiol 48: 395-405.
    • (2010) J Mol Cell Cardiol , vol.48 , pp. 395-405
    • Haim, T.E.1    Wang, W.2    Flagg, T.P.3    Tones, M.A.4    Bahinski, A.5
  • 28
    • 84856745984 scopus 로고    scopus 로고
    • Pterostilbene protects vascular endothelial cells against oxidized low-density lipoprotein-induced apoptosis in vitro and in vivo
    • Zhang L, Zhou G, Song W, Tan X, Guo Y, et al. (2012) Pterostilbene protects vascular endothelial cells against oxidized low-density lipoprotein-induced apoptosis in vitro and in vivo. Apoptosis 17: 25-36.
    • (2012) Apoptosis , vol.17 , pp. 25-36
    • Zhang, L.1    Zhou, G.2    Song, W.3    Tan, X.4    Guo, Y.5
  • 29
    • 27744502501 scopus 로고    scopus 로고
    • In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide
    • Stump GL, Wallace AA, Regan CP, Lynch JJ Jr, (2005) In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide. J Pharmacol Exp Ther 315: 1362-1367.
    • (2005) J Pharmacol Exp Ther , vol.315 , pp. 1362-1367
    • Stump, G.L.1    Wallace, A.A.2    Regan, C.P.3    Lynch Jr., J.J.4
  • 30
    • 33947162483 scopus 로고    scopus 로고
    • Potent free radical scavenger, edaravone, suppresses oxidative stress-induced endothelial damage and early atherosclerosis
    • Xi H, Akishita M, Nagai K, Yu W, Hasegawa H, et al. (2007) Potent free radical scavenger, edaravone, suppresses oxidative stress-induced endothelial damage and early atherosclerosis. Atherosclerosis 191: 281-289.
    • (2007) Atherosclerosis , vol.191 , pp. 281-289
    • Xi, H.1    Akishita, M.2    Nagai, K.3    Yu, W.4    Hasegawa, H.5
  • 31
    • 0031918474 scopus 로고    scopus 로고
    • Regulation of cardiac Kv1.5 K+ channel expression by cardiac fibroblasts and mechanical load in cultured newborn rat ventricular myocytes
    • Guo W, Kamiya K, Kada K, Kodama I, Toyama J, (1998) Regulation of cardiac Kv1.5 K+ channel expression by cardiac fibroblasts and mechanical load in cultured newborn rat ventricular myocytes. J Mol Cell Cardiol 30: 157-166.
    • (1998) J Mol Cell Cardiol , vol.30 , pp. 157-166
    • Guo, W.1    Kamiya, K.2    Kada, K.3    Kodama, I.4    Toyama, J.5
  • 32
    • 0037308146 scopus 로고    scopus 로고
    • Effects of irbesartan on cloned potassium channels involved in human cardiac repolarization
    • Moreno I, Caballero R, Gonzalez T, Arias C, Valenzuela C, et al. (2003) Effects of irbesartan on cloned potassium channels involved in human cardiac repolarization. J Pharmacol Exp Ther 304: 862-873.
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 862-873
    • Moreno, I.1    Caballero, R.2    Gonzalez, T.3    Arias, C.4    Valenzuela, C.5
  • 33
    • 1242297561 scopus 로고    scopus 로고
    • Role of caspases in Ox-LDL-induced apoptotic cascade in human coronary artery endothelial cells
    • Chen J, Mehta JL, Haider N, Zhang X, Narula J, et al. (2004) Role of caspases in Ox-LDL-induced apoptotic cascade in human coronary artery endothelial cells. Circ Res 94: 370-376.
    • (2004) Circ Res , vol.94 , pp. 370-376
    • Chen, J.1    Mehta, J.L.2    Haider, N.3    Zhang, X.4    Narula, J.5
  • 34
    • 1242342768 scopus 로고    scopus 로고
    • Apoptosis of vascular cells by oxidized LDL: involvement of caspases and LOX-1 and its implication in atherosclerotic plaque rupture
    • Kume N, Kita T, (2004) Apoptosis of vascular cells by oxidized LDL: involvement of caspases and LOX-1 and its implication in atherosclerotic plaque rupture. Circ Res 94: 269-270.
    • (2004) Circ Res , vol.94 , pp. 269-270
    • Kume, N.1    Kita, T.2
  • 35
    • 60749137151 scopus 로고    scopus 로고
    • NADPH oxidase-dependent signaling in endothelial cells: role in physiology and pathophysiology
    • Frey RS, Ushio-Fukai M, Malik AB, (2009) NADPH oxidase-dependent signaling in endothelial cells: role in physiology and pathophysiology. Antioxid Redox Signal 11: 791-810.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 791-810
    • Frey, R.S.1    Ushio-Fukai, M.2    Malik, A.B.3
  • 36
    • 63449141267 scopus 로고    scopus 로고
    • Reduced antioxidant capacity and diet-induced atherosclerosis in uncoupling protein-2-deficient mice
    • Moukdar F, Robidoux J, Lyght O, Pi J, Daniel KW, et al. (2009) Reduced antioxidant capacity and diet-induced atherosclerosis in uncoupling protein-2-deficient mice. J Lipid Res 50: 59-70.
    • (2009) J Lipid Res , vol.50 , pp. 59-70
    • Moukdar, F.1    Robidoux, J.2    Lyght, O.3    Pi, J.4    Daniel, K.W.5
  • 37
    • 73649108218 scopus 로고    scopus 로고
    • Effects of extensively oxidized low-density lipoprotein on mitochondrial function and reactive oxygen species in porcine aortic endothelial cells
    • Roy Chowdhury SK, Sangle GV, Xie X, Stelmack GL, Halayko AJ, et al. (2009) Effects of extensively oxidized low-density lipoprotein on mitochondrial function and reactive oxygen species in porcine aortic endothelial cells. Am J Physiol Endocrinol Metab 298: E89-98.
    • (2009) Am J Physiol Endocrinol Metab , vol.298
    • Roy Chowdhury, S.K.1    Sangle, G.V.2    Xie, X.3    Stelmack, G.L.4    Halayko, A.J.5
  • 38
    • 28844506068 scopus 로고    scopus 로고
    • Cell signalling by oxidized lipids and the role of reactive oxygen species in the endothelium
    • Zmijewski JW, Landar A, Watanabe N, Dickinson DA, Noguchi N, et al. (2005) Cell signalling by oxidized lipids and the role of reactive oxygen species in the endothelium. Biochem Soc Trans 33: 1385-1389.
    • (2005) Biochem Soc Trans , vol.33 , pp. 1385-1389
    • Zmijewski, J.W.1    Landar, A.2    Watanabe, N.3    Dickinson, D.A.4    Noguchi, N.5
  • 39
    • 76249124669 scopus 로고    scopus 로고
    • The emerging role of cardiovascular risk factor-induced mitochondrial dysfunction in atherogenesis
    • Puddu P, Puddu GM, Cravero E, De Pascalis S, Muscari A, (2009) The emerging role of cardiovascular risk factor-induced mitochondrial dysfunction in atherogenesis. J Biomed Sci 16: 112.
    • (2009) J Biomed Sci , vol.16 , pp. 112
    • Puddu, P.1    Puddu, G.M.2    Cravero, E.3    De Pascalis, S.4    Muscari, A.5
  • 40
    • 0042526012 scopus 로고    scopus 로고
    • Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes
    • Teshima Y, Akao M, Jones SP, Marban E, (2003) Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes. Circ Res 93: 192-200.
    • (2003) Circ Res , vol.93 , pp. 192-200
    • Teshima, Y.1    Akao, M.2    Jones, S.P.3    Marban, E.4
  • 41
    • 70349778265 scopus 로고    scopus 로고
    • Detection of uncoupling protein-2 (UCP2) as a mitochondrial modulator of apoptosis
    • Derdak Z, Garcia TA, Baffy G, (2009) Detection of uncoupling protein-2 (UCP2) as a mitochondrial modulator of apoptosis. Methods Mol Biol 559: 205-217.
    • (2009) Methods Mol Biol , vol.559 , pp. 205-217
    • Derdak, Z.1    Garcia, T.A.2    Baffy, G.3
  • 42
    • 84860758607 scopus 로고    scopus 로고
    • Uncoupling protein-2 protects endothelial function in diet-induced obese mice
    • Tian XY, Wong WT, Xu A, Lu Y, Zhang Y, et al. (2012) Uncoupling protein-2 protects endothelial function in diet-induced obese mice. Circ Res 110: 1211-1216.
    • (2012) Circ Res , vol.110 , pp. 1211-1216
    • Tian, X.Y.1    Wong, W.T.2    Xu, A.3    Lu, Y.4    Zhang, Y.5
  • 43
    • 20444437554 scopus 로고    scopus 로고
    • Effects of recombinant adenovirus-mediated uncoupling protein 2 overexpression on endothelial function and apoptosis
    • Lee KU, Lee IK, Han J, Song DK, Kim YM, et al. (2005) Effects of recombinant adenovirus-mediated uncoupling protein 2 overexpression on endothelial function and apoptosis. Circ Res 96: 1200-1207.
    • (2005) Circ Res , vol.96 , pp. 1200-1207
    • Lee, K.U.1    Lee, I.K.2    Han, J.3    Song, D.K.4    Kim, Y.M.5
  • 44
    • 80052848190 scopus 로고    scopus 로고
    • Cellular model of Warburg effect identifies tumor promoting function of UCP2 in breast cancer and its suppression by genipin
    • Ayyasamy V, Owens KM, Desouki MM, Liang P, Bakin A, et al. (2011) Cellular model of Warburg effect identifies tumor promoting function of UCP2 in breast cancer and its suppression by genipin. PLoS One 6: e24792.
    • (2011) PLoS One , vol.6
    • Ayyasamy, V.1    Owens, K.M.2    Desouki, M.M.3    Liang, P.4    Bakin, A.5
  • 45
    • 79956265753 scopus 로고    scopus 로고
    • Negative regulation of UCP2 by TGFbeta signaling characterizes low and intermediate-grade primary breast cancer
    • Sayeed A, Meng Z, Luciani G, Chen LC, Bennington JL, et al. (2010) Negative regulation of UCP2 by TGFbeta signaling characterizes low and intermediate-grade primary breast cancer. Cell Death Dis 1: e53.
    • (2010) Cell Death Dis , vol.1
    • Sayeed, A.1    Meng, Z.2    Luciani, G.3    Chen, L.C.4    Bennington, J.L.5
  • 46
    • 33645221439 scopus 로고    scopus 로고
    • Smad4-expression is decreased in breast cancer tissues: a retrospective study
    • Stuelten CH, Buck MB, Dippon J, Roberts AB, Fritz P, et al. (2006) Smad4-expression is decreased in breast cancer tissues: a retrospective study. BMC Cancer 6: 25.
    • (2006) BMC Cancer , vol.6 , pp. 25
    • Stuelten, C.H.1    Buck, M.B.2    Dippon, J.3    Roberts, A.B.4    Fritz, P.5
  • 47
    • 79451475323 scopus 로고    scopus 로고
    • Atrial fibrillation induces myocardial fibrosis through angiotensin II type 1 receptor-specific Arkadia-mediated downregulation of Smad7
    • He X, Gao X, Peng L, Wang S, Zhu Y, et al. (2011) Atrial fibrillation induces myocardial fibrosis through angiotensin II type 1 receptor-specific Arkadia-mediated downregulation of Smad7. Circ Res 108: 164-175.
    • (2011) Circ Res , vol.108 , pp. 164-175
    • He, X.1    Gao, X.2    Peng, L.3    Wang, S.4    Zhu, Y.5
  • 48
    • 17744377430 scopus 로고    scopus 로고
    • Oxidized LDL activates PAI-1 transcription through autocrine activation of TGF-beta signaling in mesangial cells
    • Song CY, Kim BC, Hong HK, Lee HS, (2005) Oxidized LDL activates PAI-1 transcription through autocrine activation of TGF-beta signaling in mesangial cells. Kidney Int 67: 1743-1752.
    • (2005) Kidney Int , vol.67 , pp. 1743-1752
    • Song, C.Y.1    Kim, B.C.2    Hong, H.K.3    Lee, H.S.4


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