Human prion protein mutants with deleted and inserted octarepeats undergo different pathways to trigger cell apoptosis

Journal of Molecular Neuroscience

Volumn 43, Issue 3, 2011, Pages 225-234

  Xu, Kun ^a,b   Wang, Xin ^b   Shi, Qi ^b   Chen, Cao ^b   Tian, Chan ^b   Li, Xiao Li ^b   Zhou, Rui Min ^b   Chu, Yong Lie ^a   Dong, Xiao Ping ^b  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

Apoptosis; Endoplasmic reticulum; Endoplasmic reticulum stress; Octarepeats sequence; Prion protein

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; CASPASE; CYTOCHROME C; GLUCOSE REGULATED PROTEIN 94; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MESSENGER RNA; MUTANT PROTEIN; PLASMID DNA; PRION PROTEIN; PROCASPASE 12; PROCASPASE 3; PROTEIN BCL 2; PROTEIN PRECURSOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

APOPTOSIS; ARTICLE; CELL ASSAY; CELL DISRUPTION; CELL LINE; CELL MEMBRANE; CELL STIMULATION; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INDEL MUTATION; MITOCHONDRION; NEUROBLASTOMA CELL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; RECOMBINANT PLASMID; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; WILD TYPE;

APOPTOSIS; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; HEAT-SHOCK PROTEINS; HUMANS; MITOCHONDRIA; MUTANT PROTEINS; PRIONS; PRPSC PROTEINS; RECOMBINANT PROTEINS; REPETITIVE SEQUENCES, AMINO ACID;

EID: 79954424574     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-010-9387-0     Document Type: Article

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