Repression of hepatobiliary transporters and differential regulation of classic and alternative bile acid pathways in mice during pregnancy

Toxicological Sciences

Volumn 130, Issue 2, 2012, Pages 257-268

  Aleksunes, Lauren M ^a,b,c   Yeager, Ronnie L ^a,d   Wen, Xia ^b,c   Cui, Julia Yue ^a   Klaassen, Curtis D ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c RUTGERS UNIVERSITY   (United States)

^d ABBOTT LABORATORIES   (United States)

Author keywords

Bile acids; Liver; Mice; Nuclear receptors; Pregnancy; Transporter

Indexed keywords

BILE ACID; BREAST CANCER RESISTANCE PROTEIN; CHOLESTEROL 7ALPHA MONOOXYGENASE; CONSTITUTIVE ANDROSTANE RECEPTOR; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; LIVER X RECEPTOR; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 6; ORGANIC CATION TRANSPORTER 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PREGNANE X RECEPTOR; PROGESTERONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE ACID METABOLISM; BILE ACID SYNTHESIS; BIRTH; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; FEMALE; GESTATIONAL AGE; HEPATOBILIARY SYSTEM; IMMUNOFLUORESCENCE TEST; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; PREGNANCY; PROTEIN EXPRESSION; REGULATORY MECHANISM; WESTERN BLOTTING;

ANIMALS; BILE ACIDS AND SALTS; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; BODY WEIGHT; DOWN-REGULATION; ESTRADIOL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GESTATIONAL AGE; LACTATION; LIVER; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, INBRED C57BL; ORGAN SIZE; PARTURITION; PREGNANCY; PROGESTERONE; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

MUS;

EID: 84869468705     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs248     Document Type: Article

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