CYP2D6 mediates 4-hydroxylation of clonidine in vitro: Implication for pregnancy-induced changes in clonidine clearance

Drug Metabolism and Disposition

Volumn 38, Issue 9, 2010, Pages 1393-1396

  Claessens, Adam J ^a   Risler, Linda J ^c   Eyal, Sara ^a   Shen, Danny D ^a,c   Easterling, Thomas R ^b   Hebert, Mary F ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYCLONIDINE; CLONIDINE; COMPLEMENTARY DNA; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; DRUG METABOLITE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME MECHANISM; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY CLEARANCE; LIVER MICROSOME; PREGNANCY; PRIORITY JOURNAL;

ADRENERGIC ALPHA-AGONISTS; CHROMATOGRAPHY, LIQUID; CLONIDINE; CYTOCHROME P-450 CYP2D6; FEMALE; HUMANS; HYDROXYLATION; MASS SPECTROMETRY; MICROSOMES, LIVER; PREGNANCY;

EID: 77955989948     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.110.033878     Document Type: Article

References (11)

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