Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1

Toxicology in Vitro

Volumn 27, Issue 1, 2013, Pages 220-231

  Daniels Wells, Tracy R ^a   Helguera, Gustavo ^a   Rodríguez, José A ^a,b   Leoh, Lai Sum ^a   Erb, Michael A ^a   Diamante, Graciel ^a   Casero, David ^a,b   Pellegrini, Matteo ^a,b   Martínez Maza, Otoniel ^a,c   Penichet, Manuel L ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Immunotoxin; Oxidative stress; Ribosome inactivating protein; Saporin; Transferrin receptor 1

Indexed keywords

ACETYLCYSTEINE; ANTIBODY AVIDIN FUSION PROTEIN; CASPASE; CD71 ANTIGEN; DNA; HYBRID PROTEIN; SAPORIN; UNCLASSIFIED DRUG;

ARTICLE; BIOTINYLATION; CANCER CELL CULTURE; CELL ASSAY; CELL DEATH; CELL NUCLEUS; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DNA DAMAGE; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG TARGETING; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PROTEIN SYNTHESIS INHIBITION; TRANSCRIPTION REGULATION;

ANIMALS; ANTIGENS, CD; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; AVIDIN; CELL DEATH; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION PROFILING; HUMANS; IMMUNOGLOBULIN G; MICE; NEOPLASMS; RECEPTORS, TRANSFERRIN; RECOMBINANT FUSION PROTEINS; RIBOSOME INACTIVATING PROTEINS, TYPE 1;

EID: 84869427890     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2012.10.006     Document Type: Article

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