Ribosome inactivating protein saporin induces apoptosis through mitochondrial cascade, independent of translation inhibition

International Journal of Biochemistry and Cell Biology

Volumn 40, Issue 12, 2008, Pages 2880-2888

  Sikriwal, Deepa ^a   Ghosh, Paroma ^a   Batra, Janendra K ^a  

^a NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

Author keywords

Ribosome; Ricin; RIP; Toxin; Translation

Indexed keywords

ANISOMYCIN; CASPASE 3; CASPASE 9; CYTOCHROME C; GLYCOSIDASE; RIBOSOME INACTIVATING PROTEIN; SAPORIN;

APOPTOSIS; ARTICLE; CELL STRAIN U937; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRION; PROTEIN SYNTHESIS INHIBITION; RIBOSOME; SIGNAL TRANSDUCTION; TRANSLATION REGULATION;

ANNEXIN A5; ANTIGENS, CD95; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CYTOCHROMES C; HUMANS; KINETICS; MITOCHONDRIA; MUTATION; PLANT PROTEINS; PROTEIN BIOSYNTHESIS; PROTEIN SYNTHESIS INHIBITORS; RIBOSOME INACTIVATING PROTEINS, TYPE 1; RIBOSOMES; RICIN; SAPONARIA; U937 CELLS;

EUKARYOTA; SAPONARIA; SAPONARIA OFFICINALIS;

EID: 51249107532     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2008.06.004     Document Type: Article

References (30)

1. Adams J.M. Ways of dying: multiple pathways to apoptosis. Genes Dev 17 (2003) 2481-2495
2. 2-macroglobulin receptor. FEBS Lett 541 (2003) 16-20
3. Bagga S., Seth D., and Batra J.K. The cytotoxic activity of ribosome-inactivating protein saporin-6 is attributed to its rRNA N-glycosidase and internucleosomal DNA fragmentation activities. J Biol Chem 278 (2003) 4813-4820
4. Bergamaschi G., Perfetti V., Tonon L., Novella A., Lucotti C., Danova M., et al. Saporin, a ribosome-inactivating protein used to prepare immunotoxins induces cell death via apoptosis. Br J Haematol 93 (1996) 789-794
5. Bolognesi A., Tazzari P.L., Olivieri F., Polito L., Falini B., and Stirpe F. Induction of apoptosis by ribosome-inactivating proteins and related immunotoxins. Int J Cancer 68 (1996) 349-355
6. Brigotti M., Alfieri R., Sestili P., Bonelli M., Petronini P.G., Guidarelli A., et al. Damage to nuclear DNA induced by Shiga toxin 1 and ricin in human endothelial cells. FASEB J 16 (2002) 365-372
7. Cheng-Yun J., Dong-Oh M., Yung H.C., Jae-Dong L., and Gi-Young K. Bcl-2 and Caspase-3 are major regulators in Agaricus blazei-induced human leukemic U937 cell apoptosis through dephoshorylation of Akt. Biol Pharm Bull 30 (2007) 1432-1437
8. Fuji J., Matsui T., Heatherly D.P., Schlegel K.H., Lobo P.I., Yutsudo T., et al. Rapid apoptosis induced by shiga toxin in Hela cells. Infect Immun 71 (2003) 2724-2735
9. Ghosh P., and Batra J.K. The differential catalytic activity of ribosome inactivating protein saporin 5 and 6 is due to a single substitution at position 162. Biochem J 400 (2006) 99-104
10. 2+-dependent proteases and protein kinase C. J Cell Biochem 81 (2001) 583-593
11. Kageyama A., Kusano I., Tamura T., Oda T., and Muramatsu T. Comparision of the apoptosis-inducing abilities of various protein synthesis inhibitors in U937 cells. Biosci Biotechnol Biochem 66 (2002) 835-839
12. Keppler-Hafkemeyer A., Brinkmann U., and Pastan I. Role of caspases in immunotoxin-induced apoptosis of cancer cells. Biochemistry 37 (1998) 16934-16942
13. Kochi S.K., and Collier R.J. DNA fragmentation and cytolysis in U937 cells treated with Diphtheria toxin or other inhibitors of protein synthesis. Exp Cell Res 208 (1993) 296-302
14. Komatsu N., Oda T., and Muramatsu T. Involvement of both caspase-like proteases and serine preteases in apoptotic cell death induced by ricin, modeccin, diphtheria toxin, and Pseudomonas exotoxin. J Biochem 124 (1998) 1038-1044
15. Lawen A. Apoptosis-an introduction. BioEssays 25 (2003) 888-896
16. Li H., Zhu H., Xu C.J., and Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94 (1998) 491-501
17. 2+-calpain and caspase-mitochondria-dependent pathways. J Biol Chem 275 (2000) 39702-39709
18. Maianski N.A., Roos D., and Kuijpers T.W. Bid truncation, bid/bax targeting to the mitochondria, and caspase activation associated with neutrophil apoptosis are inhibited by granulocyte colony-stimulating factor. J Immunol 172 (2004) 7024-7030
19. Matsumoto Y., Hayakawa A., Tamada Y., Mori H., and Ohashi M. Upregulated expression of Fas antigen on cultured human keratinocytes with induction of apoptosis by cisplatin. Arch Dermatol Res 288 (1996) 267-269
20. Micheau O., Solary E., Hammann A., Martin F., and Dimanche-Boitrel M.T. Sensitization of cancer cells treated with cytotoxic drugs to fas-mediated cytotoxicity. J Natl Cancer Inst 89 (1997) 783-789
21. Nagata S. Apoptotic DNA fragmentation. Exp Cell Res 256 (2000) 12-18
22. Narayanan S., Surolia A., and Karande A.A. Ribosome inactivating proteins and apoptosis. Biochem J 377 (2004) 233-240
23. Olmo N., Turnay J., De Buitrago G.G., De Silanes I.L., Gavilanes J.G., and Lizarbe M.A. Cytotoxic mechanism of the ribotoxin α-sarcin. Eur J Biochem 268 (2001) 2113-2123
24. Savill J.S., Wyllie A.H., Henson I.E., Walport M.J., Henson P.M., and Haslett C. Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages. J Clin Invest 83 (1989) 865-875
25. Shih S.F., Wu Y.H., Hung C.H., Yang H.Y., and Lin J.Y. Abrin triggers cell death by inactivating a thiol-specific antioxidant protein. J Biol Chem 276 (2001) 21870-21877
26. Stirpe F., Gasperi-Campani A., Barbieri L., Falasca A., Abbondaza A., and Stevens W.A. Ribosome-inactivating proteins from seeds of Saponaria officinalis L. (soapwort), of Agrostemma githago L. (corn cockle) and of Asparagus officinalis L. (asparagus), and from the latex of Hura crepitians L. (sandbox tree). Biochem J 216 (1983) 617-625
27. Stirpe F., Bailey S., Miller S.P., and Bodley J.W. Modification of ribosomal RNA by ribosome-inactivating proteins from plants. Nucl Acids Res 16 (1988) 1349-1357
28. Suzuki A., Doi H., Matsuzawa F., Aikawa S., Takiguchi K., Kawano H., et al. Bcl-2 antiapoptotic protein mediates verotoxin II induced cell death: possible association between bcl-2 and tissue failure by E. coli 0157:H7. Genes Dev 14 (2000) 1734-1740
29. Wu Y.H., Shih S.F., and Lin J.Y. A study of the intracellular routing of cytotoxic ribonucleases. J Biol Chem 279 (2004) 19264-19275
30. Zhang C.Y., Gong Y., Ma H., An C., and Chen D. Reactive oxygen species involved in tricosanthin-induced apoptosis of human choriocarcinima cells. Biochem J 355 (2001) 653-661