Mitochondrial DNA D-loop as a new target of Saporin 6 nuclease activity

Toxicon

Volumn 45, Issue 4, 2005, Pages 475-480

  Gasperi Campani, Anna ^a   Brognara, Irene ^a   Baiocchi, Daniela ^a   Roncuzzi, Laura ^a,b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

Author keywords

DNase activity; Mitochondrial DNA; N glycosidase activity; Ribosome inactivating protein; Ribotoxin Saporin 6

Indexed keywords

MITOCHONDRIAL DNA; SAPORIN;

ARTICLE; ENZYME ACTIVITY; HUMAN; MITOCHONDRION; PRIORITY JOURNAL;

BACTERIA (MICROORGANISMS); EUKARYOTA; SAPONARIA OFFICINALIS;

EID: 13944280312     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2004.12.007     Document Type: Article

References (32)

1. S. Anderson, A.T. Bankier, B.G. Barrel, M.H.L. De Bruijn, A.R. Coulson, J. Drouin, I.C. Eperon, D.P. Nierlich, B.A. Roe, F. Sanger, P.H. Schreier, A.J.H. Smith, R. Staden, and I.G. Young Sequence and organisation of the human mitochondrial genome Nature 290 1981 457 465
2. S. Bagga, D. Seth, and J.K. Batra The cytotoxic activity of ribosome-inactivating protein saporin-6 is attributed to its rRNA N-glycosidase and internucleosomal DNA fragmentation activities J. Biol. Chem. 278 2003 4813 4820
3. S. Bagga, M.V. Hosur, and J.K. Batra Cytotoxicity of ribosome- inactivating protein saporin is not mediated through α2-macroglobulin receptor FEBS Lett. 541 2003 16 20
4. L. Barbieri, M.G. Battelli, and F. Stirpe Ribosome-inactivating proteins from plants Biochim. Biophys. Acta 1154 1993 237 282
5. L. Barbieri, P. Valbonesi, E. Bonora, P. Gorini, A. Bolognesi, and F. Stirpe Polynucleotide:adenosine glycosidase activity of ribosome-inactivating proteins: effect on DNA, RNA and Poly (A) Nucleic Acids Res. 25 1997 518 522
6. L. Barbieri, P. Valbonesi, F. Righi, G. Zuccheri, F. Monti, P. Gorini, B. Samorì, and F. Stirpe Polynucleotide: adenosine glycosidase is the sole activity of ribosome-inactivating proteins on DNA Biochem. J. 128 2000 883 889
7. L. Barbieri, P. Valbonesi, M. Govoni, A. Pession, and F. Stirpe Polynucleotide:adenosine glycosidase activity of saporin-L1: effect on various forms of mammalian DNA Biochim. Biophys. Acta 1480 2000 258 266
8. P.J. Day, J.M. Lord, and L.M. Roberts The deoxyribonuclease activity attributed to ribosome-inactivating proteins is due to contamination Eur. J. Biochem. 258 1998 540 545
9. Y. Endo, K. Tsurugi, and J.M. Lambert The site of action of six different ribosome-inactivating proteins from plants on eukaryotic ribosomes: the RNA N-glycosidase activity of the proteins Biochem. Biophys. Res. Commun. 150 1988 1032 1036
10. J.M. Ferreras, L. Barbieri, T. Girbes, M.G. Battelli, M.A. Rojo, F.J. Arias, M.A. Rocher, F. Soriano, E. Mendez, and F. Stirpe Distribution and properties of major ribosome-inactivating proteins (28 S rRNA N-glycosidases) of the plant Saponaria officinalis L (Caryophyllaceae) Biochim. Biophys. Acta 1216 1993 31 42
11. A. Gasperi-Campani, and L. Roncuzzi Modificazione del DNA superavvolto da parte delle proteine vegetali inattivanti i ribosomi Tumori 75 1989 130
12. A. Gasperi-Campani, L. Barbieri, M.G. Battelli, and F. Stirpe On the distribution of ribosome-inactivating proteins amongst plants J. Nat. Prod. 48 1985 446 454
13. A. Gasperi-Campani, G. Zauli, L. Roncuzzi, L. Valvassori, L. Vitale, L. Gaggioli, and G.P. Bagnara Differential activity of Saporin 6 on normal and leukemic hemopoietic cells Exp. Hematol. 17 1989 755 759
14. A. Gasperi-Campani, W. Zoli, A.L. Volpi, L. Roncuzzi, and D. Amadori Inhibition of growth of breast cancer cells in vitro by the ribosome- inactivating protein Saporin 6 Anticancer Res. 11 1991 1007 1012
15. A. Gasperi-Campani, A.R. Musa, and L. Roncuzzi Diverse activity of the sc-RIP Saporin 6 on primary and metastatic melanoma cells in vitro Melanoma Res. 3 1993 363 367
16. A. Gasperi-Campani, L. Roncuzzi, W. Zoli, and D. Amadori Saporin 6 and Lonidamine in primary cell cultures from human breast carcinomas: a synergistic effect Anticancer Drug Des. 12 1997 91 98
17. W.J. He, and W.Y. Liu Cinnamomin: a multifunctional type II ribosome-inactivating protein Int. J. Biochem. Cell. Biol. 35 2003 1021 1027
18. J.K. Lodge, W.K. Kaniewski, and N.E. Tumer Broad-spectrum virus resistance in transgenic plants expressing pokeweed antiviral protein Proc. Natl Acad. Sci. USA 90 1993 7089 7093
19. K. Nielsen, and R.S. Boston Ribosome-inactivating proteins: a plant perspective Annu. Rev. Physiol. Plant Mol. Biol. 52 2001 785 816
20. E. Nicolas, J.M. Beggs, B.M. Haltiwanger, and T.F. Taraschi Direct evidence for the deoxyribonuclease activity of the plant ribosome-inactivating protein Gelonin FEBS Lett. 406 1997 162 164
21. E. Nicolas, I.D. Goodyer, and T.F. Taraschi An additional mechanism of ribosome-inactivating protein cytotoxicity: degradation of extrachromosomal DNA Biochem. J. 327 1997 413 417
22. R.J. Kreitman, and I. Pastan Immunotoxins for targeted cancer therapy Adv. Drug Deliv. Rev. 31 1998 53 88
23. W.J. Peumans, Q. Hao, and E.J. Van Damme Ribosome-inactivating proteins from plants: more than RNA N-glycosidases? FASEB J. 15 2001 1493 1506
24. L. Roncuzzi, and A. Gasperi-Campani DNA-nuclease activity of the single-chain ribosome-inactivating proteins dianthin 30, saporin 6 and gelonin FEBS Lett. 392 1996 16 20
25. L. Roncuzzi, W. Zoli, P. Bajorko, and A. Gasperi-Campani In vitro potentiation by Lonidamine of the sc-RIP Saporin 6 effect in a human metastatic breast cancer cell line Anticancer Res. 15 1995 773 776
26. L. Roncuzzi, I. Brognara, S. Cocchi, W. Zoli, and A. Gasperi-Campani Loss of heterozygosity at pseudoautosomal regions in human breast cancer and association with negative hormonal phenotype Cancer Genet. Cytogenet. 135 2002 173 176
27. E. Sbisà, F. Tanzariello, A. Reyes, G. Pesole, and C. Saccone Mammalian mitochondrial D-loop region structural analysis: identification of new conserved sequences and their functional evolutionary implications Gene 205 1997 125 140
28. C.P. Selitrennikoff Antifungal proteins Appl. Environ. Microbiol. 67 2001 2883 2894
29. G. Singh, S.M. Sharkey, and R. Moorehead Mitochondrial DNA damage by anticancer agents Pharmacol. Ther. 54 1992 217 230
30. E.M. Southern Detection of specific sequences among DNA fragments separated by gel electrophoresis J. Mol. Biol. 98 1975 503 517
31. N.E. Tumer, D.J. Hwang, and M. Bonness C-terminal deletion mutant of pokeweed antiviral protein inhibits viral infection but does not depurinate host ribosomes Proc. Natl Acad. Sci. USA 94 1997 3866 3871
32. P. Wang, and N.E. Tumer Pokeweed antiviral protein cleaves double-stranded supercoiled DNA using the same active site required to depurinate rRNA Nucleic Acids Res. 27 1999 1900 1905