Stra13 is induced by genotoxic stress and regulates ionizing-radiation-induced apoptosis

EMBO Reports

Volumn 8, Issue 4, 2007, Pages 401-407

  Thin, Tin Htwe ^a   Li, Li ^a   Chung, Teng Kai ^a   Sun, Hong ^a   Taneja, Reshma ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MDM2; PROTEIN NOXA; PROTEIN P53; RETINOIC ACID DERIVATIVE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR STRA13; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; GENOTOXICITY; IN VITRO STUDY; IONIZING RADIATION; MOUSE; NONHUMAN; NUCLEAR EXPORT SIGNAL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; THYMOCYTE; UBIQUITINATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; APOPTOSIS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL NUCLEUS; DNA DAMAGE; HOMEODOMAIN PROTEINS; MICE; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-MDM2; RADIATION, IONIZING; THYMUS GLAND; TRETINOIN; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 34047158745     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/sj.embor.7400912     Document Type: Article

References (27)

1. Boudjelal M, Taneja R, Matsubara S, Bouillet P, Dollé P, Chambon P (1997) Overexpression of Stral 13, a novel retinoic acid-inducible gene of the basic helix-loop-helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells. Genes Dev 11: 2052-2065
2. Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Kontgen F, Adams JM, Strasser A (1999) Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286: 1735-1738
3. Brugarolas J, Chandrasekaran C, Gordon JI, Beach D, Jacks T, Hannon GJ (1995) Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 377: 552-557
4. Chen D, Li M, Luo J, Gu W (2003) Direct interactions between HIF-1α and Mdm2 modulate p53 function. J Biol Chem 278: 13595-13598
5. Dhar M, Taneja R (2001) Cross-regulatory interaction between Stral 3 and USF results in functional antagonism. Oncogene 20: 4750-4756
6. Giaccia AJ, Kastan MB (1998) The complexity of p53 modulation: Emerging patterns from divergent signals. Genes Dev 12: 2973-2983
7. Haupt Y, Maya R, Kazaz A, Oren M (1997) MDM2 promotes the rapid degradation of p53. Nature 387: 296-299
8. Ivanova AV, Ivanov SV, Danilkovitch-Miagkova A, Lerman MI (2001) Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway. J Biol Chem 276:15306-15315
9. Ivanova AV, Ivanov SV, Zhang X, Ivanov VN, Timofeeva OA, Lerman MI (2004) STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets. J Mol Biol 340: 641-653
10. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW (1991) Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51: 6304-6311
11. Knudson CM, Tung KS, Tourtellotte WG, Brown GA, Korsmeyer SJ (1995) Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270: 96-99
12. Ko LJ, Prives C (1996) p53: Puzzle and paradigm. Genes Dev 10: 1054-1072
13. Kubbutat MH, Jones SN, Vousden KH (1997) Regulation of p53 stability by Mdm2. Nature 387: 299-303
14. Lohrum MA, Woods DB, Ludwig RL, Balint E, Vousden KH (2001) C-terminal ubiquitination of p53 contributes to nuclear export, Mol Cell Biol 21: 8521-8532
15. Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T (1993) p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362: 847-849
16. McCurrach ME, Connor TM, Knudson CM, Korsmeyer SJ, Lowe SW (1997) Bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. Proc Natl Acad Sci USA 94: 2345-2349
17. Oren M (1999) Regulation of the p53 tumor suppressor protein. J Biol Chem 274:36031-36034
18. Sato F, Kawamoto T, Fujimoto K, Noshiro M, Honda KK, Honma S, Honma K, Kato Y (2004) Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1. Eur J Biochem 271: 4409-4419
19. Seimiya M et al (2002) Clast5/Stra13 is a negative regulator of B lymphocyte activation. Biochem Biophys Res Commun 292: 121-127
20. Sentman CL, Shutter JR, Hockenberry D, Kanagawa. O, Korsmeyer SJ (1991) Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67: 879-888
21. Sun H, Taneja R (2000) Stra 13 expression is associated with growth arrest and represses transcription through histone deacetylase-dependent and -independent mechanisms. Proc Natl Acad Sci USA 97: 4058-4063
22. Sun H, Lu B, Li RQ, Flavell RA, Taneja R (2001) Defective T cell activation and autoimmune disorder in Stra 13-deficient mice. Nat Immunol 2: 1040-1047
23. Sun H, Li L, Vercherat C, Gulbagci N, Acharjee S, Li J, Chung T-K, Thin TH, Taneja R (2007) Stra 13 regulates satellite cell activation by antagonizing Notch signaling. J Cell Biol (in press)
24. Townsend PA, Scarabelli TM, Davidson SM, Knight RA, Latchman DS, Stephanou A (2004) STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis. J Biol Chem 279: 5811-5820
25. Villunger A, Michalak EM, Coultas L, Mullauer F, Bock G, Ausserlechner MJ, Adams JM, Strasser A (2003) p53- and drug-induced apoptotic responses mediated by BH3-only proteins Puma and Noxa. Science 302:1036-l038
26. Yan C, Lu D, Hai T, Boyd DD (2005) Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination. EMBO J 24: 2425-2435
27. Yun Z, Maecker HL, Johnson RS, Giaccia AJ (2002) Inhibition of PPAR γ2 gene expression by the HIF-1 -regulated gene DEC1/-Stra 13: A mechanism for regulation of adipogenesis by hypoxia. Dev Cell 2: 331-341