Induction of apoptosis through tubulin inhibition in human cancer cells by new chromene-based chalcones

Pharmaceutical Biology

Volumn 50, Issue 12, 2012, Pages 1551-1560

  Aryapour, Hassan ^a   Riazi, Gholam Hossein ^b   Ahmadian, Shahin ^b   Foroumadi, Alireza ^c   Mahdavi, Majid ^d   Emami, Saeed ^e  

^a GOLESTAN UNIVERSITY   (Iran)

^b UNIVERSITY OF TEHRAN   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d UNIVERSITY OF TABRIZ   (Iran)

^e MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Cytotoxic; K562; Microtubules; SK N MC

Indexed keywords

3 (6 CHLORO 2H CHROMEN 3 YL) 1 (3,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; ANTINEOPLASTIC AGENT; CHALCONE DERIVATIVE; CHROMENE DERIVATIVE; COLCHICINE; DNA; TUBULIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL ASSAY; CELL CYCLE ARREST; CELL STRAIN K 562; CELL STRAIN SK N MC; CELL STRUCTURE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IC 50; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; INHIBITION KINETICS; MICROTUBULE ASSEMBLY; MITOSIS SPINDLE; PROTEIN CONFORMATION; SPECTROSCOPY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOPYRANS; CELL SHAPE; CHALCONES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; K562 CELLS; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, FLUORESCENCE; MICROTUBULES; MOLECULAR STRUCTURE; SPECTROMETRY, FLUORESCENCE; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUBULIN MODULATORS;

EID: 84869427826     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2012.695799     Document Type: Article

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