Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects

Cancer Letters

Volumn 201, Issue 2, 2003, Pages 133-137

  Akihisa, Toshihiro ^a   Tokuda, Harukuni ^b   Ukiya, Motohiko ^a   Iizuka, Masao ^a   Schneider, Stefan ^a   Ogasawara, Kazuya ^c   Mukainaka, Teruo ^b   Iwatsuki, Kenji ^d   Suzuki, Takashi ^a   Nishino, Hoyoku ^b  

^a NIHON UNIVERSITY   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c Japan Bio Sci Laboratory Co Ltd   (Japan)

^d K Lab for Intell Med Remote Serv   (Japan)

Author keywords

Angelica keiskei; Antitumor initiator; Antitumor promoter; Chalcones; Chemopreventive effects; Coumarins; Epstein Barr virus; Flavanones; Umbelliferae

Indexed keywords

2 (4 CARBOXYPHENYL) 4,4,5,5 TETRAMETHYLIMIDAZOLIN 1 OXYL 3 OXIDE; 3' HYDROXYCOLUMBIANADIN; 3' SENECIOYL KHELLACTONE; 4 HYDROXYDERRICIN; 4' O GERANYLNARINGENIN; 4' SENECIOYL KHELLACTONE; 5 PENTADECYLRESORCINOL; ANGELICA KEISKEI EXTRACT; BETA CAROTENE; CHALCONE DERIVATIVE; COUMARIN DERIVATIVE; EPSTEIN BARR VIRUS ANTIGEN; FALCARINDIOL; FLAVANONE DERIVATIVE; GLYCYRRHIZIC ACID; ISOBAVACHALCONE; ISOLASERPITIN; LASEPITIN; METHYL 2 HYDROXYIMINO 5 NITRO 6 METHOXY 3 HEXEMIDE; MUNDULEAFLAVANONE A; NITRIC OXIDE DONOR; PHORBOL 13 ACETATE 12 MYRISTATE; PLANT EXTRACT; PROSTRATOL F; PTERYXIN; SELENIDIN; UNCLASSIFIED DRUG; XANTHOANGELOL; XANTHOANGELOL F; XANTHOANGELOL H;

ANGELICA KEISKEI; ARTICLE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; LIVER CELL; MEDICINAL PLANT; PRIORITY JOURNAL; PROTEIN ISOLATION; RAJI CELL; SCREENING TEST;

ANGELICA KEISKEI; APIACEAE; HUMAN HERPESVIRUS 4;

EID: 0242321147     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(03)00466-X     Document Type: Article

References (18)

1. Baba K., Taniguchi M., Nakata K. Studies on Angelica keiskei ashitaba. Foods Food Ingredients J. Jpn. 178:1998;52-60.
2. Kozawa M., Morita N., Baba K., Hata H. Chemical components of the roots of Angelica keiskei KOIDZUMI. II. The structure of chalcone derivatives. Yakugaku Zasshi. 98:1978;210-214.
3. Baba K., Kido T., Yoneda Y., Taniguchi M., Kozawa M. Chemical components of Angelika keiskei KOIDZUMI (V) Components of the fruits, and comparison of coumarins and chalcones in the fruits, roots and the leaves. Syoyakugaku Zasshi. 44:1990;235-239.
4. Baba K., Nakata K., Taniguchi M., Kido T., Kozawa M. Chalcones from Angelica keiskei. Phytochemistry. 29:1990;3907-3910.
5. Nakata K., Taniguchi M., Baba K. Three chalcones from Angelica keiskei. Nat. Med. 53:1999;329-332.
6. Okuyama T., Takata M., Takayasu J., Hasegawa T., Tokuda H., Nishino A., Nishino H., Iwashima A. Anti-tumor-promotion by principles obtained from Angelica keiskei. Planta Med. 57:1991;242-246.
7. Iinuma M., Ohyama M., Tanaka T. Two flavanones from roots of Sophora leachiana. Phytochemistry. 38:1995;539-543.
8. Swager T.M., Cardellina J.H. II. Coumarins from Musineon divaricatum. Phytochemistry. 24:1985;805-813.
9. Chen I.S., Chang C.T., Sheen W.S., Teng C.M., Tsai I.L., Duh C.Y., Ko F.N. Coumarins and antiplatelet aggregation constituents from Formosan Peucedanum japonicum. Phytochemistry. 41:1996;525-530.
10. Baba K., Hamasaki T., Tabata Y., Kozawa M., Honda Y., Tabata M. Chemical studies on Chinese crude drug 'She Chuang Zi'. Syoyakugaku Zasshi. 39:1985;282-290.
11. Venkata Rao E., Sridhar P., Prasad R. Two prenylated flavanones from Mundulea suberosa. Phytochemistry. 46:1997;1221-1274.
12. Satoh A., Narita Y., Endo N., Nishimura H. Potent allelochemical falcalindiol from Glehnia littoralisF. Schm. Biosci. Biotech. Biochem. 60:1996;152-153.
13. Ahsan M., Armstrong J.A., Gibbons S., Gray A.I., Waterman P.G. Novel O-prenylated flavonoids from two varieties of Boronia coerulescens. Phytochemistry. 37:1994;259-266.
14. Ridley D.D., Ritchie E., Taylor W.C. Chemical studies of the Proteaceae II. Some further constituents of Grevillea robusta A. Cunn.; Experiments on the synthesis of 5-n-tridecylresorcinol (grevillol) and related substances. Aust. J. Chem. 21:1968;2079-2988.
15. Takaishi Y., Ujita K., Tokuda H., Nishino H., Iwashima A., Fujita T. Inhibitory effects of dihydroagarofuran sesquiterpenes on Epstein-Barr virus activation. Cancer Lett. 65:1992;19-26.
16. Tokuda H., Kuchide M., Okuda M., Mukainaka T., Nobukuni Y., Takayasu J., Nishino H. Chemopreventive activity of antioxidants on nitric oxide donors induced mouse skin carcinogenesis. Proc. Am. Assoc. Cancer Res. #5674:2002;1145.
17. Murakami A., Ohigashi H., Koshimizu K. Anti-tumor promotion with food phytochemicals: A strategy for cancer chemoprevention. Biosci. Biotech. Biochem. 60:1996;1-8.
18. Ito Y., Tokuda H., Ohigashi H., Koshimizu K. Distribution and characterization of environmental promoter substances as assay by synergistic Epstein-Barr virus-activating system. Fujiki H., et al. Cellular Interactions by Environmental Tumor Promoters. 1984;125-137 VNU Science Press, Utrecht.