Insights into avian influenza virus pathogenicity, the hemagglutinin precursor HA0 of subtype H16 has an alpha-helix structure in its cleavage site with inefficient HA1/HA2 cleavage

Journal of Virology

Volumn 86, Issue 23, 2012, Pages 12861-12870

  Lu, Xishan ^a,b   Shi, Yi ^b   Gao, Feng ^c   Xiao, Haixia ^d   Wang, Ming ^a   Qi, Jianxun ^b   Gao, George F ^a,b,d,e  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b INSTITUTE OF MICROBIOLOGY   (China)

^c INSTITUTE OF BIOPHYSICS   (China)

^d Tianjin Airport Economic Area   (China)

^e INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE; TRYPSIN; VIRUS HEMAGGLUTININ;

ALPHA HELIX; ARTICLE; AVIAN INFLUENZA VIRUS; BINDING SITE; CONTROLLED STUDY; CROSS REACTION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; HYDROPHOBICITY; IN VITRO STUDY; MOLECULAR PHYLOGENY; NONHUMAN; PH MEASUREMENT; PHYLOGENETIC TREE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; RECEPTOR BINDING; RESIDUE ANALYSIS; SEQUENCE ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; VIRUS VIRULENCE;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CLONING, MOLECULAR; CRYSTALLIZATION; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; HYDROGEN-ION CONCENTRATION; INFLUENZA A VIRUS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOTHS; PROTEIN STRUCTURE, SECONDARY; TRYPSIN;

AVES; AVIAN INFLUENZA VIRUS; INFLUENZA A VIRUS; ORTHOMYXOVIRIDAE;

EID: 84869210338     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01606-12     Document Type: Article

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