-
1
-
-
0035048096
-
Cytokine therapy for metastatic renal cell carcinoma
-
Bukowski RM. Cytokine therapy for metastatic renal cell carcinoma. Semin Urol Oncol 2001; 19: 148-54
-
(2001)
Semin Urol Oncol
, vol.19
, pp. 148-154
-
-
Bukowski, R.M.1
-
2
-
-
0018304899
-
Induction of a fibrin-gel investment: An early event in line 10 hepatocarcinoma growth mediated by tumor-secreted products
-
Dvorak HF, Orenstein NS, Carvalho AC et al. Induction of a fibrin-gel investment: an early event in line 10 hepatocarcinoma growth mediated by tumor-secreted products. J Immunol 1979; 122: 166-74
-
(1979)
J Immunol
, vol.122
, pp. 166-174
-
-
Dvorak, H.F.1
Orenstein, N.S.2
Carvalho, A.C.3
-
3
-
-
0029004025
-
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis
-
Dvorak HF, Brown LF, Detmar M, Dvorak AM. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 1995; 146: 1029-39
-
(1995)
Am J Pathol
, vol.146
, pp. 1029-1039
-
-
Dvorak, H.F.1
Brown, L.F.2
Detmar, M.3
Dvorak, A.M.4
-
4
-
-
0031039243
-
The biology of vascular endothelial growth factor
-
Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev 1997; 18: 4-25
-
(1997)
Endocr Rev
, vol.18
, pp. 4-25
-
-
Ferrara, N.1
Davis-Smyth, T.2
-
5
-
-
0032952010
-
Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
-
Benjamin LE, Golijanin D, Itin A, Pode D, Keshet E. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 1999; 103: 159-65
-
(1999)
J Clin Invest
, vol.103
, pp. 159-165
-
-
Benjamin, L.E.1
Golijanin, D.2
Itin, A.3
Pode, D.4
Keshet, E.5
-
6
-
-
0030999445
-
Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells
-
Watanabe Y, Lee SW, Detmar M, Ajioka I, Dvorak HF. Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells. Oncogene 1997; 14: 2025-32
-
(1997)
Oncogene
, vol.14
, pp. 2025-2032
-
-
Watanabe, Y.1
Lee, S.W.2
Detmar, M.3
Ajioka, I.4
Dvorak, H.F.5
-
7
-
-
0036842215
-
Vascular permeability factor/vascular endothelial growth factor, a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
-
Dvorak HF. Vascular permeability factor/vascular endothelial growth factor, a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 2002; 20: 4368-80
-
(2002)
J Clin Oncol
, vol.20
, pp. 4368-4380
-
-
Dvorak, H.F.1
-
8
-
-
0027240519
-
Identification of the von Hippel-Lindau disease tumor suppressor gene
-
Latif F, Tory K, Gnarra J et al. Identification of the von Hippel-Lindau disease tumor suppressor gene. Science 1993; 260: 1317-20
-
(1993)
Science
, vol.260
, pp. 1317-1320
-
-
Latif, F.1
Tory, K.2
Gnarra, J.3
-
9
-
-
14644415949
-
Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma
-
Rini BI, Small EJ. Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma. J Clin Oncol 2005; 23: 1028-43
-
(2005)
J Clin Oncol
, vol.23
, pp. 1028-1043
-
-
Rini, B.I.1
Small, E.J.2
-
10
-
-
0029147430
-
Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C
-
Kibel A, Iliopoulos O, DeCaprio JA, Kaelin WG Jr. Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C. Science 1995; 269: 1444-6
-
(1995)
Science
, vol.269
, pp. 1444-1446
-
-
Kibel, A.1
Iliopoulos, O.2
Decaprio, J.A.3
Kaelin Jr., W.G.4
-
11
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, Wiesener MS, Chang GW et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999; 399: 271-5
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
-
12
-
-
0034682783
-
Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
-
Cockman ME, Masson N, Mole DR et al. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J Biol Chem 2000; 275: 25733-41
-
(2000)
J Biol Chem
, vol.275
, pp. 25733-25741
-
-
Cockman, M.E.1
Masson, N.2
Mole, D.R.3
-
13
-
-
0029785321
-
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein
-
Iliopoulos O, Levy AP, Jiang C, Kaelin WG Jr, Goldberg MA. Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proc Natl Acad Sci USA 1996; 93: 10595-9
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 10595-10599
-
-
Iliopoulos, O.1
Levy, A.P.2
Jiang, C.3
Kaelin Jr., W.G.4
Goldberg, M.A.5
-
14
-
-
0029785838
-
Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene
-
Gnarra JR, Zhou S, Merrill MJ et al. Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene. Proc Natl Acad Sci USA 1996; 93: 10589-94
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 10589-10594
-
-
Gnarra, J.R.1
Zhou, S.2
Merrill, M.J.3
-
15
-
-
0025050735
-
Oxygen tension regulates the expression of the platelet-derived grown factor-B chain gene in human endothelial cells
-
Kourembanas S, Hannan RL, Faller DV. Oxygen tension regulates the expression of the platelet-derived grown factor-B chain gene in human endothelial cells. J Clin Invest 1990; 86: 670-4
-
(1990)
J Clin Invest
, vol.86
, pp. 670-674
-
-
Kourembanas, S.1
Hannan, R.L.2
Faller, D.V.3
-
16
-
-
0030856731
-
Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
-
Presta LG, Chen H, O'Connor SJ et al. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res 1997; 57: 4593-9
-
(1997)
Cancer Res
, vol.57
, pp. 4593-4599
-
-
Presta, L.G.1
Chen, H.2
O'Connor, S.J.3
-
17
-
-
0042343801
-
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
-
Yang JC, Haworth L, Sherry RM et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003; 349: 427-34
-
(2003)
N Engl J Med
, vol.349
, pp. 427-434
-
-
Yang, J.C.1
Haworth, L.2
Sherry, R.M.3
-
18
-
-
0036138580
-
Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
-
Motzer RJ, Bacik J, Murphy BA, Russo P, Mazumdar M. Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol 2002; 20: 289-96
-
(2002)
J Clin Oncol
, vol.20
, pp. 289-296
-
-
Motzer, R.J.1
Bacik, J.2
Murphy, B.A.3
Russo, P.4
Mazumdar, M.5
-
19
-
-
0031964099
-
Transforming growth factor alpha is a target for the von Nippel-Lindau tumor suppressor
-
Knebelmann B, Ananth S, Cohen HT, Sukhatme VP. Transforming growth factor alpha is a target for the von Nippel-Lindau tumor suppressor. Cancer Res 1998; 58: 226-31
-
(1998)
Cancer Res
, vol.58
, pp. 226-231
-
-
Knebelmann, B.1
Ananth, S.2
Cohen, H.T.3
Sukhatme, V.P.4
-
20
-
-
0242581718
-
Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL (-/-) renal cell carcinoma cells
-
Gunaratnam L, Morley M, Franovic A et al. Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL (-/-) renal cell carcinoma cells. J Biol Chem 2003; 278: 44966-74
-
(2003)
J Biol Chem
, vol.278
, pp. 44966-44974
-
-
Gunaratnam, L.1
Morley, M.2
Franovic, A.3
-
21
-
-
0035852630
-
Role of transforming growth factor-alpha in von Hippel-Lindau (VHL) (-/-) clear cell renal carcinoma cell proliferation: A possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis
-
de Paulsen N, Brychzy A, Fournier MC et al. Role of transforming growth factor-alpha in von Hippel-Lindau (VHL) (-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis. Proc Natl Acad Sci USA 2001; 98: 1387-92
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 1387-1392
-
-
De Paulsen, N.1
Brychzy, A.2
Fournier, M.C.3
-
22
-
-
12444251187
-
Phase II trial of antiepidermal growth factor receptor antibody C225 in patients with advanced renal cell carcinoma
-
Motzer RJ, Amato R, Todd M et al. Phase II trial of antiepidermal growth factor receptor antibody C225 in patients with advanced renal cell carcinoma. Invest New Drugs 2003; 21: 99-101
-
(2003)
Invest New Drugs
, vol.21
, pp. 99-101
-
-
Motzer, R.J.1
Amato, R.2
Todd, M.3
-
23
-
-
0035394833
-
Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: A role for altered tumor angiogenesis
-
Viloria-Petit A, Crombet T, Jothy S et al. Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesis. Cancer Res 2001; 61: 5090-101
-
(2001)
Cancer Res
, vol.61
, pp. 5090-5101
-
-
Viloria-Petit, A.1
Crombet, T.2
Jothy, S.3
-
24
-
-
7944224125
-
Phase II trial of bevacizumab and erlotinib in patients with metastatic renal carcinoma (RCC). ASCO Proceedings
-
Hainsworth JD, Sosman JA, Spigel DR et al. Phase II trial of bevacizumab and erlotinib in patients with metastatic renal carcinoma (RCC). ASCO Proceedings. J Clin Oncol 2004; 23: A4502
-
(2004)
J Clin Oncol
, vol.23
-
-
Hainsworth, J.D.1
Sosman, J.A.2
Spigel, D.R.3
-
25
-
-
12244301581
-
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
-
Mendel DB, Laird AD, Xin X et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 2003; 9: 327-37
-
(2003)
Clin Cancer Res
, vol.9
, pp. 327-337
-
-
Mendel, D.B.1
Laird, A.D.2
Xin, X.3
-
26
-
-
9744226669
-
SU 011248, a novel tyrosine kinase inhibitor, shows anti-tumor activity in second-line therapy for patients with metastatic renal cell carcinoma. Results of a phase II trial. ASCO Proceedings
-
Motzer RJ, Rini BI, Michaelson MD et al. SU 011248, a novel tyrosine kinase inhibitor, shows anti-tumor activity in second-line therapy for patients with metastatic renal cell carcinoma. Results of a phase II trial. ASCO Proceedings. J Clin Oncol 2004; 23: A4500
-
(2004)
J Clin Oncol
, vol.23
-
-
Motzer, R.J.1
Rini, B.I.2
Michaelson, M.D.3
-
28
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm SM, Carter C, Tang L et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004; 64: 7099-109
-
(2004)
Cancer Res
, vol.64
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
-
29
-
-
4644276593
-
Preliminary antitumor actvity of BAY 43, 43-9006 in metastatic renal cell carcinoma and other advanced refractory solid tumors in a phase II randomized discontinuation trial (RDT). ASCO Proceedings
-
Ratain MJ, Flaherty KT, Stadler WM. et al. Preliminary antitumor actvity of BAY 43, 43-9006 in metastatic renal cell carcinoma and other advanced refractory solid tumors in a phase II randomized discontinuation trial (RDT). ASCO Proceedings. J Clin Oncol 2004; 23: A4501
-
(2004)
J Clin Oncol
, vol.23
-
-
Ratain, M.J.1
Flaherty, K.T.2
Stadler, W.M.3
-
30
-
-
1942470411
-
A randomized phase III trial of interferon-alpha or interferon-alpha plus anti-vascular endothelial growth factor antibody (bevacizumab) in metastatic renal cell carcinoma
-
Rini BI, Halabi S, Taylor J, Small EJ, Schilsky RL and the Cancer and Leukemia Group B 90206. A randomized phase III trial of interferon-alpha or interferon-alpha plus anti-vascular endothelial growth factor antibody (bevacizumab) in metastatic renal cell carcinoma. Clin Cancer Res 2004; 10: 2584-6
-
(2004)
Clin Cancer Res
, vol.10
, pp. 2584-2586
-
-
Rini, B.I.1
Halabi, S.2
Taylor, J.3
Small, E.J.4
Schilsky, R.L.5
-
31
-
-
0035934596
-
Radical nephrectomy plus interferon-alfa-based immunotherapy compared with interferon alfa alone in metastatic renal-cell carcinoma: A randomised trial
-
Mickisch GH, Garin A, van Poppel H, de Prijck L, Sylvester R. Radical nephrectomy plus interferon-alfa-based immunotherapy compared with interferon alfa alone in metastatic renal-cell carcinoma: a randomised trial. Lancet 2001; 358: 966-70
-
(2001)
Lancet
, vol.358
, pp. 966-970
-
-
Mickisch, G.H.1
Garin, A.2
Van Poppel, H.3
De Prijck, L.4
Sylvester, R.5
-
32
-
-
0035818877
-
Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer
-
Flanigan RC, Salmon SE, Blumenstein BA et al. Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer. N Engl J Med 2001; 345: 1655-9
-
(2001)
N Engl J Med
, vol.345
, pp. 1655-1659
-
-
Flanigan, R.C.1
Salmon, S.E.2
Blumenstein, B.A.3
-
33
-
-
0029842830
-
Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells
-
Gabrilovich DI, Chen HL, Girgis KR et al. Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat Med 1996; 2: 1096-103
-
(1996)
Nat Med
, vol.2
, pp. 1096-1103
-
-
Gabrilovich, D.I.1
Chen, H.L.2
Girgis, K.R.3
-
34
-
-
0032741283
-
Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function
-
Gabrilovich DI, Ishida T, Nadaf S, Ohm JE, Carbone DP. Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. Clin Cancer Res 1999; 5: 2963-70
-
(1999)
Clin Cancer Res
, vol.5
, pp. 2963-2970
-
-
Gabrilovich, D.I.1
Ishida, T.2
Nadaf, S.3
Ohm, J.E.4
Carbone, D.P.5
|