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Volumn , Issue , 2011, Pages 64-77

Resistance to azole fungicides in Mycosphaerella graminicola: Mechanisms and management

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EID: 84869131010     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter
Times cited : (10)

References (61)
  • 1
    • 77954887528 scopus 로고    scopus 로고
    • Progress in understanding molecular mechanisms and evolution of resistance to succinate dehydrogenase inhibiting (SDHI) fungicides in phytopathogenic fungi
    • Avenot, H.F. and Michailides, T.J. (2010) Progress in understanding molecular mechanisms and evolution of resistance to succinate dehydrogenase inhibiting (SDHI) fungicides in phytopathogenic fungi. Crop Protection 29, 643-651.
    • (2010) Crop Protection , vol.29 , pp. 643-651
    • Avenot, H.F.1    Michailides, T.J.2
  • 2
    • 70350083572 scopus 로고    scopus 로고
    • Expression of genes encoding efflux proteins in Mycosphaerella graminicola isolates with sensitive or reduced triazole sensitivity phenotypes
    • In: Dehne, H.W., Deising, H.B., Gisi, U., Kuck, K.H., Russell, P.E. and Lyr, H. (eds), Deutsche Phytomedizinische Gesellschaft, Braunschweig, Germany
    • Bean, T.P., Cools, H.J., Lucas, J.A. and Fraaije, B.A. (2008) Expression of genes encoding efflux proteins in Mycosphaerella graminicola isolates with sensitive or reduced triazole sensitivity phenotypes. In: Dehne, H.W., Deising, H.B., Gisi, U., Kuck, K.H., Russell, P.E. and Lyr, H. (eds) Modern Fungicides and Antifungal Compounds V: Proceedings 15th International Reinhardsbrunn Symposium on Modern Fungicides and Antifungal Compounds, 2007. Deutsche Phytomedizinische Gesellschaft, Braunschweig, Germany, pp. 93-99.
    • (2008) Modern Fungicides and Antifungal Compounds V: Proceedings 15th International Reinhardsbrunn Symposium on Modern Fungicides and Antifungal Compounds, 2007 , pp. 93-99
    • Bean, T.P.1    Cools, H.J.2    Lucas, J.A.3    Fraaije, B.A.4
  • 3
    • 67649207960 scopus 로고    scopus 로고
    • Sterol content analysis suggests altered eburicol 14α-demethylase (CYP51) activity in isolates of Mycosphaerella graminicola adapted to azole fungicides
    • Bean, T.P., Cools, H.J., Lucas, J.A., Hawkins, N.D., Ward, J.L., Shaw, M.W., et al. (2009) Sterol content analysis suggests altered eburicol 14α-demethylase (CYP51) activity in isolates of Mycosphaerella graminicola adapted to azole fungicides. FEMS Microbiology Letters 296, 266-273.
    • (2009) FEMS Microbiology Letters , vol.296 , pp. 266-273
    • Bean, T.P.1    Cools, H.J.2    Lucas, J.A.3    Hawkins, N.D.4    Ward, J.L.5    Shaw, M.W.6
  • 4
    • 0004643230 scopus 로고    scopus 로고
    • Fungicide resistance in crop pathogens: how can it be managed
    • 2nd revised edition. Croplife International, Brussels
    • Brent, K.J. and Hollomon, D.W. (2007) Fungicide resistance in crop pathogens: how can it be managed. FRAC Monograph No.2, 2nd revised edition. Croplife International, Brussels.
    • (2007) FRAC Monograph , vol.2
    • Brent, K.J.1    Hollomon, D.W.2
  • 5
    • 42249102435 scopus 로고    scopus 로고
    • Evolution of the CYP51 gene in Mycosphaerella graminicola: evidence for intragenic recombination and selective replacement
    • Brunner, P.C., Stefanato, F.L. and McDonald, B.A. (2008) Evolution of the CYP51 gene in Mycosphaerella graminicola: evidence for intragenic recombination and selective replacement. Molecular Plant Pathology 9, 305-316.
    • (2008) Molecular Plant Pathology , vol.9 , pp. 305-316
    • Brunner, P.C.1    Stefanato, F.L.2    McDonald, B.A.3
  • 7
    • 84862231813 scopus 로고    scopus 로고
    • Sensitivity of Cyp51 genotypes to DMI fungicides in Mycosphaerella graminicola
    • In: Dehne, H.W., Gisi, U., Kuck, K.H., Russell, P.E. and Lyr, H. (eds), DPG Seebsterverlag, Braunschweig, Germany
    • Chassot, C., Hugelshofer, U., Sierotzki, H. and Gisi, U. (2008) Sensitivity of Cyp51 genotypes to DMI fungicides in Mycosphaerella graminicola. In: Dehne, H.W., Gisi, U., Kuck, K.H., Russell, P.E. and Lyr, H. (eds) Modern Fungicides and Antifungal Compounds V. DPG Seebsterverlag, Braunschweig, Germany, pp. 129-136.
    • (2008) Modern Fungicides and Antifungal Compounds V , pp. 129-136
    • Chassot, C.1    Hugelshofer, U.2    Sierotzki, H.3    Gisi, U.4
  • 8
    • 2542494102 scopus 로고    scopus 로고
    • Application of realtime quantitative PCR to molecular analysis of Candida albicans strains exhibiting reduced susceptibility to azoles
    • Chau, A.S., Mendrick, C.A., Sabatelli, F.J., Loebenberg, D. and McNicholas, P.M. (2004) Application of realtime quantitative PCR to molecular analysis of Candida albicans strains exhibiting reduced susceptibility to azoles. Antimicrobial Agents and Chemotherapy 48, 2124-2131.
    • (2004) Antimicrobial Agents and Chemotherapy , vol.48 , pp. 2124-2131
    • Chau, A.S.1    Mendrick, C.A.2    Sabatelli, F.J.3    Loebenberg, D.4    McNicholas, P.M.5
  • 9
    • 34247323902 scopus 로고    scopus 로고
    • Septoria tritici and azole performance. Fungicide resistance: are we winning the battle but losing the war?
    • Clark, W.S. (2006) Septoria tritici and azole performance. Fungicide resistance: are we winning the battle but losing the war? Aspects of Applied Biology 78, 127-132.
    • (2006) Aspects of Applied Biology , vol.78 , pp. 127-132
    • Clark, W.S.1
  • 10
    • 46849118811 scopus 로고    scopus 로고
    • Spotlight: are azole fungicides losing ground against Septoria wheat disease? Resistance mechanisms in Mycosphaerella graminicola
    • Cools, H.J. and Fraaije, B.A. (2008) Spotlight: are azole fungicides losing ground against Septoria wheat disease? Resistance mechanisms in Mycosphaerella graminicola. Pest Management Science 64, 681-684.
    • (2008) Pest Management Science , vol.64 , pp. 681-684
    • Cools, H.J.1    Fraaije, B.A.2
  • 12
    • 34247352000 scopus 로고    scopus 로고
    • Molecular mechanisms correlated with changes in triazole sensitivity in isolates of Mycosphaerella graminicola
    • In, Glasgow, 31 October-2 November 2005. BCPC, Alton, UK
    • Cools, H.J., Fraaije, B.A. and Lucas, J.A. (2005b) Molecular mechanisms correlated with changes in triazole sensitivity in isolates of Mycosphaerella graminicola. In: Proceedings BCPC International Congress-Crop Science and Technology, Glasgow, 31 October-2 November 2005. BCPC, Alton, UK, pp. 267-274.
    • (2005) Proceedings BCPC International Congress-Crop Science and Technology , pp. 267-274
    • Cools, H.J.1    Fraaije, B.A.2    Lucas, J.A.3
  • 13
    • 34548136160 scopus 로고    scopus 로고
    • Transcriptome profiling of the response of Mycosphaerella graminicola isolates to an azole fungicide using cDNA microarrays
    • Cools, H.J., Fraaije, B.A., Bean T.P., Antoniw, J. and Lucas J.A. (2007) Transcriptome profiling of the response of Mycosphaerella graminicola isolates to an azole fungicide using cDNA microarrays. Molecular Plant Pathology 8, 639-651.
    • (2007) Molecular Plant Pathology , vol.8 , pp. 639-651
    • Cools, H.J.1    Fraaije, B.A.2    Bean, T.P.3    Antoniw, J.4    Lucas, J.A.5
  • 14
    • 77951593696 scopus 로고    scopus 로고
    • Heterologous expression of mutated eburicol 14α-demethylase (CYP51) proteins of Mycosphaerella graminicola to assess effects on azole fungicide sensitivity and intrinsic protein function
    • Cools, H.J., Parker, J.E., Kelly, D.E., Lucas, J.A., Fraaije, B.A. and Kelly, S.L. (2010) Heterologous expression of mutated eburicol 14α-demethylase (CYP51) proteins of Mycosphaerella graminicola to assess effects on azole fungicide sensitivity and intrinsic protein function. Applied Environmental Microbiology 76, 2866-2872.
    • (2010) Applied Environmental Microbiology , vol.76 , pp. 2866-2872
    • Cools, H.J.1    Parker, J.E.2    Kelly, D.E.3    Lucas, J.A.4    Fraaije, B.A.5    Kelly, S.L.6
  • 15
    • 79958294577 scopus 로고    scopus 로고
    • Impact of recently emerged sterol 14α-demethylase (CYP51) variants of Mycosphaerella graminicola on azole fungicide sensitivity
    • Cools, H.J., Mullins, J.G.L., Fraaije, B.A., Parker, J.E., Kelly, D.E., Lucas, J.A., et al. (2011) Impact of recently emerged sterol 14α-demethylase (CYP51) variants of Mycosphaerella graminicola on azole fungicide sensitivity. Applied and Environmental Microbiology 77, 3830-3837.
    • (2011) Applied and Environmental Microbiology , vol.77 , pp. 3830-3837
    • Cools, H.J.1    Mullins, J.G.L.2    Fraaije, B.A.3    Parker, J.E.4    Kelly, D.E.5    Lucas, J.A.6
  • 16
    • 0042544006 scopus 로고    scopus 로고
    • A mutation in the sterol 14α-demethylase gene in Uncinular necator that correlates with resistance to sterol biosynthesis inhibitors
    • Delye, C., Laigret, F. and Corio-Costet, M.F. (1997) A mutation in the sterol 14α-demethylase gene in Uncinular necator that correlates with resistance to sterol biosynthesis inhibitors. Applied Environmental Microbiology 63, 2966-2970.
    • (1997) Applied Environmental Microbiology , vol.63 , pp. 2966-2970
    • Delye, C.1    Laigret, F.2    Corio-Costet, M.F.3
  • 17
    • 0032428659 scopus 로고    scopus 로고
    • PCR cloning and detection of point mutations in the eburicol 14α-demethylase (CYP51) gene from Erysiphe graminis f. sp. hordei, a 'recalcitrant' fungus
    • Delye, C., Bousset, L. and Corio-Costet, M.F. (1998) PCR cloning and detection of point mutations in the eburicol 14α-demethylase (CYP51) gene from Erysiphe graminis f. sp. hordei, a 'recalcitrant' fungus. Current Genetics 34, 399-403.
    • (1998) Current Genetics , vol.34 , pp. 399-403
    • Delye, C.1    Bousset, L.2    Corio-Costet, M.F.3
  • 18
    • 0032880113 scopus 로고    scopus 로고
    • Multiple amino acid substitutions in lanosterol 14α-demethylase contribute to azole resistance in Candida albicans
    • Favre, B., Didmon, M. and Ryder, N.S. (1999) Multiple amino acid substitutions in lanosterol 14α-demethylase contribute to azole resistance in Candida albicans. Microbiology 145, 2715-2725.
    • (1999) Microbiology , vol.145 , pp. 2715-2725
    • Favre, B.1    Didmon, M.2    Ryder, N.S.3
  • 19
    • 22844435164 scopus 로고    scopus 로고
    • The ergosterol biosynthesis pathway, transporter genes, and azole resistance in Aspergillus fumigatus
    • Ferreira, M.E.D., Colombo, A.L., Paulsen, I., Ren, Q., Wortman, J., Huang, J., et al. (2005) The ergosterol biosynthesis pathway, transporter genes, and azole resistance in Aspergillus fumigatus. Medical Mycology 43, S313-S319.
    • (2005) Medical Mycology , vol.43
    • Ferreira, M.E.D.1    Colombo, A.L.2    Paulsen, I.3    Ren, Q.4    Wortman, J.5    Huang, J.6
  • 20
    • 22744436048 scopus 로고    scopus 로고
    • The role of ascospores in further spread of QoI-resistant cytochrome b alleles (G143A) in field populations of Mycosphaerella graminicola
    • Fraaije, B.A., Cools, H.J., Fountaine, J., Lovell, D.J., Motteram, J., West, J.S., et al. (2005) The role of ascospores in further spread of QoI-resistant cytochrome b alleles (G143A) in field populations of Mycosphaerella graminicola. Phytopathology 95, 933-941.
    • (2005) Phytopathology , vol.95 , pp. 933-941
    • Fraaije, B.A.1    Cools, H.J.2    Fountaine, J.3    Lovell, D.J.4    Motteram, J.5    West, J.S.6
  • 21
    • 34247334689 scopus 로고    scopus 로고
    • A novel substitution I381V in the sterol 14α-demethylase (CYP51) of Mycosphaerella graminicola is differentially selected by azole fungicides
    • Fraaije, B.A., Cools, H.J., Kim, S.-H., Motteram, J., Clark, W.S. and Lucas, J.A. (2007) A novel substitution I381V in the sterol 14α-demethylase (CYP51) of Mycosphaerella graminicola is differentially selected by azole fungicides. Molecular Plant Pathology 8, 245-254.
    • (2007) Molecular Plant Pathology , vol.8 , pp. 245-254
    • Fraaije, B.A.1    Cools, H.J.2    Kim, S.-H.3    Motteram, J.4    Clark, W.S.5    Lucas, J.A.6
  • 22
    • 84980198840 scopus 로고
    • Laboratory studies on benzimidazole resistance in Septoria tritici
    • Griffin, M.J. and Fisher, N. (1985) Laboratory studies on benzimidazole resistance in Septoria tritici. EPPO Bulletin 15, 505-511.
    • (1985) EPPO Bulletin , vol.15 , pp. 505-511
    • Griffin, M.J.1    Fisher, N.2
  • 23
    • 0033857187 scopus 로고    scopus 로고
    • Tandem repeat of a transcriptional enhancer upstream of the sterol 14 alpha-demethylase gene (CYP51) in Penicillium digitatum
    • Hamamoto, H., Hasegawa, K., Nakaune, R., Lee, Y.J., Makizumi, Y., Akutsu, K., et al. (2000) Tandem repeat of a transcriptional enhancer upstream of the sterol 14 alpha-demethylase gene (CYP51) in Penicillium digitatum. Applied and Environmental Microbiology 66, 3421-3426.
    • (2000) Applied and Environmental Microbiology , vol.66 , pp. 3421-3426
    • Hamamoto, H.1    Hasegawa, K.2    Nakaune, R.3    Lee, Y.J.4    Makizumi, Y.5    Akutsu, K.6
  • 24
    • 0034888383 scopus 로고    scopus 로고
    • Factors affecting diseases of winter wheat in England and Wales, 1989-98
    • Hardwick, N.V., Jones, D.R. and Royle, D.J. (2001) Factors affecting diseases of winter wheat in England and Wales, 1989-98. Plant Pathology 50, 453-462.
    • (2001) Plant Pathology , vol.50 , pp. 453-462
    • Hardwick, N.V.1    Jones, D.R.2    Royle, D.J.3
  • 25
    • 12544249126 scopus 로고    scopus 로고
    • Maintaining the effectiveness of DMI fungicides in cereal disease control strategies
    • HGCA, London
    • Hollomon, D., Cooke, L. and Locke, T. (2002) Maintaining the effectiveness of DMI fungicides in cereal disease control strategies. HGCA Project Report 275. HGCA, London.
    • (2002) HGCA Project Report , vol.275
    • Hollomon, D.1    Cooke, L.2    Locke, T.3
  • 27
    • 0037197022 scopus 로고    scopus 로고
    • Antifungal drug resistance of pathogenic fungi
    • Kontoyiannis, D.P. and Lewis, R.E. (2002) Antifungal drug resistance of pathogenic fungi. The Lancet 359, 1135-1144.
    • (2002) The Lancet , vol.359 , pp. 1135-1144
    • Kontoyiannis, D.P.1    Lewis, R.E.2
  • 29
    • 76249100348 scopus 로고    scopus 로고
    • Crystal structures of Trypanosoma brucei sterol 14α-demethylase and implications for selective treatment of human infections
    • Lepesheva, G.I., Park, H.W., Hargrove, T.Y., Vanhollebeke, B., Wawrzak, Z., Harp, J.M., et al. (2010) Crystal structures of Trypanosoma brucei sterol 14α-demethylase and implications for selective treatment of human infections. Journal of Biological Chemistry 284, 1773-1780.
    • (2010) Journal of Biological Chemistry , vol.284 , pp. 1773-1780
    • Lepesheva, G.I.1    Park, H.W.2    Hargrove, T.Y.3    Vanhollebeke, B.4    Wawrzak, Z.5    Harp, J.M.6
  • 30
    • 78650235983 scopus 로고    scopus 로고
    • Multiple mechanisms account for resistance to sterol 14 alpha-demethylation inhibitors in field isolates of Mycosphaerella graminicola
    • Leroux, P. and Walker, A.S. (2011) Multiple mechanisms account for resistance to sterol 14 alpha-demethylation inhibitors in field isolates of Mycosphaerella graminicola. Pest Management Science 67, 44-59.
    • (2011) Pest Management Science , vol.67 , pp. 44-59
    • Leroux, P.1    Walker, A.S.2
  • 31
    • 34347402859 scopus 로고    scopus 로고
    • Mutations in the cyp51 gene correlated with changes in sensitivity to sterol 14α-demethylation inhibitors in field isolates of Mycosphaerella graminicola
    • Leroux, P., Albertini, C., Gautier, A., Gredt, M. and Walker, A.S. (2007) Mutations in the cyp51 gene correlated with changes in sensitivity to sterol 14α-demethylation inhibitors in field isolates of Mycosphaerella graminicola. Pest Management Science 63, 688-699.
    • (2007) Pest Management Science , vol.63 , pp. 688-699
    • Leroux, P.1    Albertini, C.2    Gautier, A.3    Gredt, M.4    Walker, A.S.5
  • 33
    • 70350081660 scopus 로고    scopus 로고
    • QoI resistance in Mycosphaerella graminicola: What have we learned so far?
    • In: Dehne, H.W., Deising, H.B., Gisi, U., Kuck, K.-H., Russell, P. and Lyr, H. (eds), DPG Spectrum Phytomedizin, Braunschweig, Germany, Chapter 9
    • Lucas, J.A. and Fraaije, B.A. (2008) QoI resistance in Mycosphaerella graminicola: What have we learned so far? In: Dehne, H.W., Deising, H.B., Gisi, U., Kuck, K.-H., Russell, P. and Lyr, H. (eds) Modern Fungicides and Antifungal Compounds V. DPG Spectrum Phytomedizin, Braunschweig, Germany, Chapter 9, pp. 71-77.
    • (2008) Modern Fungicides and Antifungal Compounds V , pp. 71-77
    • Lucas, J.A.1    Fraaije, B.A.2
  • 34
    • 38349146447 scopus 로고    scopus 로고
    • The cytochrome p450 lanosterol 14 alpha-demethylase gene is a demethylation inhibitor fungicide resistance determinant in Monilinia fructicola field isolates from Georgia
    • Luo, C.X. and Schnabel, G. (2008) The cytochrome p450 lanosterol 14 alpha-demethylase gene is a demethylation inhibitor fungicide resistance determinant in Monilinia fructicola field isolates from Georgia. Applied and Environmental Microbiology 74, 359-366.
    • (2008) Applied and Environmental Microbiology , vol.74 , pp. 359-366
    • Luo, C.X.1    Schnabel, G.2
  • 35
    • 33646119664 scopus 로고    scopus 로고
    • Overexpression of the 14 alpha-demethylase target gene (CYP51) mediates fungicide resistance in Blumeriella jaapii
    • Ma, Z.H., Proffer, T.J., Jacobs, J.L. and Sundin, G.W. (2006) Overexpression of the 14 alpha-demethylase target gene (CYP51) mediates fungicide resistance in Blumeriella jaapii. Applied and Environmental Microbiology 72, 2581-2585.
    • (2006) Applied and Environmental Microbiology , vol.72 , pp. 2581-2585
    • Ma, Z.H.1    Proffer, T.J.2    Jacobs, J.L.3    Sundin, G.W.4
  • 36
    • 0032826408 scopus 로고    scopus 로고
    • Contribution of mutations in the cytochrome P450 14α-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans
    • Marichal, P., Koymans, L., Willemsens, S., Bellens, D., Verhasselt, P., Luyten, W., et al. (1999) Contribution of mutations in the cytochrome P450 14α-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans. Microbiology 145, 2701-2713.
    • (1999) Microbiology , vol.145 , pp. 2701-2713
    • Marichal, P.1    Koymans, L.2    Willemsens, S.3    Bellens, D.4    Verhasselt, P.5    Luyten, W.6
  • 37
    • 33750932129 scopus 로고    scopus 로고
    • Effects of fungicide dose and mixtures on selection for triazole resistance in Mycosphaerella graminicola under field conditions
    • Mavroeidi, V.I. and Shaw, M.W. (2006) Effects of fungicide dose and mixtures on selection for triazole resistance in Mycosphaerella graminicola under field conditions. Plant Pathology 55, 715-725.
    • (2006) Plant Pathology , vol.55 , pp. 715-725
    • Mavroeidi, V.I.1    Shaw, M.W.2
  • 38
    • 34250223076 scopus 로고    scopus 로고
    • A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations
    • Mellado, E., Garcia-Effron, G., Alcazar-Fuoli, L., Melchers, W.J.G., Verweij, P.E., Cuenca-Estrella, A., et al. (2007) A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations. Antimicrobial Agents and Chemotherapy 51, 1897-1904.
    • (2007) Antimicrobial Agents and Chemotherapy , vol.51 , pp. 1897-1904
    • Mellado, E.1    Garcia-Effron, G.2    Alcazar-Fuoli, L.3    Melchers, W.J.G.4    Verweij, P.E.5    Cuenca-Estrella, A.6
  • 39
    • 0033788395 scopus 로고    scopus 로고
    • The effect of dose and mobility on the strength of selection for DMI fungicide resistance in inoculated field experiments
    • Metcalfe, R.J., Shaw, M.W. and Russel, P.E. (2000) The effect of dose and mobility on the strength of selection for DMI fungicide resistance in inoculated field experiments. Plant Pathology 49, 546-557.
    • (2000) Plant Pathology , vol.49 , pp. 546-557
    • Metcalfe, R.J.1    Shaw, M.W.2    Russel, P.E.3
  • 40
    • 77749291956 scopus 로고    scopus 로고
    • Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature
    • Morio, F., Loge, C., Besse, B., Hennequin, C. and Le Pape, P. (2010) Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature. Diagnostic Microbiology and Infectious Diseases 66, 373-384.
    • (2010) Diagnostic Microbiology and Infectious Diseases , vol.66 , pp. 373-384
    • Morio, F.1    Loge, C.2    Besse, B.3    Hennequin, C.4    Le Pape, P.5
  • 41
    • 0034812585 scopus 로고    scopus 로고
    • Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virusinfected patients
    • Perea, S., Lopez-Ribot, J.L., Kirkpatrick, W.R., McAtee, R.K., Santillan, R.A., Martinez, M., et al. (2001) Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virusinfected patients. Antimicrobial Agents Chemotherapy 45, 2676-2684.
    • (2001) Antimicrobial Agents Chemotherapy , vol.45 , pp. 2676-2684
    • Perea, S.1    Lopez-Ribot, J.L.2    Kirkpatrick, W.R.3    McAtee, R.K.4    Santillan, R.A.5    Martinez, M.6
  • 42
    • 0035853108 scopus 로고    scopus 로고
    • Crystal structure of cytochrome P450 14alpha-sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors
    • Podust, L.M., Poulos, T.L. and Waterman, M.R. (2001) Crystal structure of cytochrome P450 14alpha-sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors. Proceedings of the National Academy of Sciences USA 98, 3068-3073.
    • (2001) Proceedings of the National Academy of Sciences USA , vol.98 , pp. 3068-3073
    • Podust, L.M.1    Poulos, T.L.2    Waterman, M.R.3
  • 45
    • 0028793725 scopus 로고
    • Mechanisms of resistance to azole antifungals in Candida albicans from AIDS patients involves specific multidrug resistance transporters
    • Sanglard, D., Kuchler, K., Ischer, F., Pagani, J.L., Monod, M. and Bille, J. (1995) Mechanisms of resistance to azole antifungals in Candida albicans from AIDS patients involves specific multidrug resistance transporters. Antimicrobial Agents Chemotherapy 39, 2378-2386.
    • (1995) Antimicrobial Agents Chemotherapy , vol.39 , pp. 2378-2386
    • Sanglard, D.1    Kuchler, K.2    Ischer, F.3    Pagani, J.L.4    Monod, M.5    Bille, J.6
  • 46
    • 0031047670 scopus 로고    scopus 로고
    • Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene
    • Sanglard, D., Ischer, F., Monod, M. and Bille, J. (1997) Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 143, 405-416.
    • (1997) Microbiology , vol.143 , pp. 405-416
    • Sanglard, D.1    Ischer, F.2    Monod, M.3    Bille, J.4
  • 47
    • 0031938057 scopus 로고    scopus 로고
    • Amino acid substitutions in the cytochrome P450 lanosterol 14α-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to antifungal agents
    • Sanglard, D., Ischer, F., Koymans, L. and Billie, J. (1998) Amino acid substitutions in the cytochrome P450 lanosterol 14α-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to antifungal agents. Antimicrobial Agents Chemotherapy 42, 241-253.
    • (1998) Antimicrobial Agents Chemotherapy , vol.42 , pp. 241-253
    • Sanglard, D.1    Ischer, F.2    Koymans, L.3    Billie, J.4
  • 48
    • 0035130833 scopus 로고    scopus 로고
    • The 14 alpha-demethylase (CYP51A1) gene is overexpressed in Venturia inaequalis strains resistant to myclobutanil
    • Schnabel, G. and Jones, A.L. (2000) The 14 alpha-demethylase (CYP51A1) gene is overexpressed in Venturia inaequalis strains resistant to myclobutanil. Phytopathology 91, 102-110.
    • (2000) Phytopathology , vol.91 , pp. 102-110
    • Schnabel, G.1    Jones, A.L.2
  • 51
    • 53249105343 scopus 로고    scopus 로고
    • Frequency of different CYP51-haplotypes of Mycosphaerella graminicola and their impact on epoxiconazole-sensitivity and-field efficacy
    • Stammler, G., Carstensen, M., Koch, A., Semar, M., Strobel, D. and Schlehuber, S. (2008) Frequency of different CYP51-haplotypes of Mycosphaerella graminicola and their impact on epoxiconazole-sensitivity and-field efficacy. Crop Protection 27, 1448-1456.
    • (2008) Crop Protection , vol.27 , pp. 1448-1456
    • Stammler, G.1    Carstensen, M.2    Koch, A.3    Semar, M.4    Strobel, D.5    Schlehuber, S.6
  • 52
    • 69249222646 scopus 로고    scopus 로고
    • Role of the Y134F mutation in cyp51 and overexpression of cyp51 in the sensitivity response of Puccinia triticina to epoxiconazole
    • Stammler, G., Cordero, J., Koch, A., Semar, M. and Schlehuber, S. (2009) Role of the Y134F mutation in cyp51 and overexpression of cyp51 in the sensitivity response of Puccinia triticina to epoxiconazole. Crop Protection 28, 891-897.
    • (2009) Crop Protection , vol.28 , pp. 891-897
    • Stammler, G.1    Cordero, J.2    Koch, A.3    Semar, M.4    Schlehuber, S.5
  • 53
    • 0036620221 scopus 로고    scopus 로고
    • Activity of azole fungicides and ABC transporter modulators on Mycosphaerella graminicola
    • Stergiopoulos, I. and De Waard, M.A. (2002) Activity of azole fungicides and ABC transporter modulators on Mycosphaerella graminicola. Journal of Phytopathology 150, 313-320.
    • (2002) Journal of Phytopathology , vol.150 , pp. 313-320
    • Stergiopoulos, I.1    De Waard, M.A.2
  • 54
    • 0042905955 scopus 로고    scopus 로고
    • The ABC transporter MgAtr4 is a virulence factor of Mycosphaerella graminicola that affects colonisation of substomatal cavities in wheat leaves
    • Stergiopoulos, I., Zwiers, L.-H. and De Waard, M.A. (2003a) The ABC transporter MgAtr4 is a virulence factor of Mycosphaerella graminicola that affects colonisation of substomatal cavities in wheat leaves. Molecular Plant Microbe Interactions 16, 689-698.
    • (2003) Molecular Plant Microbe Interactions , vol.16 , pp. 689-698
    • Stergiopoulos, I.1    Zwiers, L.-H.2    De Waard, M.A.3
  • 55
    • 0345303947 scopus 로고    scopus 로고
    • Multiple mechanisms account for variation in base-line sensitivity to azole fungicides in field isolates of Mycosphaerella graminicola
    • Stergiopoulos, I., Van Nistelrooy, J.G.M., Kema, G.H.J. and De Waard, M.A. (2003b) Multiple mechanisms account for variation in base-line sensitivity to azole fungicides in field isolates of Mycosphaerella graminicola. Pest Management Science 59, 1333-1343.
    • (2003) Pest Management Science , vol.59 , pp. 1333-1343
    • Stergiopoulos, I.1    Van Nistelrooy, J.G.M.2    Kema, G.H.J.3    De Waard, M.A.4
  • 56
    • 77950023120 scopus 로고    scopus 로고
    • Structural basis of human CYP51 inhibition by antifungal azoles
    • Strushkevich, H., Usanov, S.A. and Park, H.-W. (2010) Structural basis of human CYP51 inhibition by antifungal azoles. Journal of Molecular Biology 397, 1067-1078.
    • (2010) Journal of Molecular Biology , vol.397 , pp. 1067-1078
    • Strushkevich, H.1    Usanov, S.A.2    Park, H.-W.3
  • 57
    • 0030757227 scopus 로고    scopus 로고
    • Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus
    • White, T. (1997) Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus. Antimicrobial Agents Chemotherapy 41, 1482-1487.
    • (1997) Antimicrobial Agents Chemotherapy , vol.41 , pp. 1482-1487
    • White, T.1
  • 58
    • 41149159789 scopus 로고    scopus 로고
    • Susceptibility of clinical isolates of Candida species to fluconazole and detection of Candida albicans ERG11 mutations
    • Xu, Y.H., Chen, L.M. and Li, C.Y. (2008) Susceptibility of clinical isolates of Candida species to fluconazole and detection of Candida albicans ERG11 mutations. Journal of Antimicrobial Chemotherapy 61, 798-804.
    • (2008) Journal of Antimicrobial Chemotherapy , vol.61 , pp. 798-804
    • Xu, Y.H.1    Chen, L.M.2    Li, C.Y.3
  • 59
    • 33745238361 scopus 로고    scopus 로고
    • Selection for increased cyproconazole tolerance in Mycosphaerella graminicola through local adaptation and response to host resistance
    • Zhan, J., Stefanato, F. and McDonald, B.A. (2006) Selection for increased cyproconazole tolerance in Mycosphaerella graminicola through local adaptation and response to host resistance. Molecular Plant Pathology 7, 259-268.
    • (2006) Molecular Plant Pathology , vol.7 , pp. 259-268
    • Zhan, J.1    Stefanato, F.2    McDonald, B.A.3
  • 61
    • 0042661008 scopus 로고    scopus 로고
    • ABC transporters of the wheat pathogen Mycosphaerella graminicola function as protectants against biotic and xenobiotic toxic compounds
    • Zwiers, L.-H., Stergiopoulos, I., Gielkens, M.M.C., Goodall, S.D. and De Waard, M.A. (2003) ABC transporters of the wheat pathogen Mycosphaerella graminicola function as protectants against biotic and xenobiotic toxic compounds. Molecular Genetics and Genomics 269, 499-507.
    • (2003) Molecular Genetics and Genomics , vol.269 , pp. 499-507
    • Zwiers, L.-H.1    Stergiopoulos, I.2    Gielkens, M.M.C.3    Goodall, S.D.4    De Waard, M.A.5


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