Calpain inhibition by calpeptin does not prevent APLT activity reduction in PS-exposing platelets, but calpeptin has independent pro-apoptotic effects

Thrombosis and Haemostasis

Volumn 103, Issue 6, 2010, Pages 1218-1227

  Gwozdz, Adam M ^a   Leung, Roland ^a   Wang, Hong ^a   Bang, K W Annie ^b   Packham, Marian A ^c   Freedman, John ^b,c   Rand, Margaret L ^a,c  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Aminophospholipid translocase; Apoptosis; Calpain; Calpeptin; PS expression

Indexed keywords

ALOXISTATIN; AMINOPHOSPHOLIPID TRANSLOCASE; CALPAIN; CALPEPTIN; CARRIER PROTEIN; COLLAGEN; PADGEM PROTEIN; PHOSPHATIDYLSERINE; THROMBIN; UNCLASSIFIED DRUG; CALCIMYCIN; DIPEPTIDE; PHOSPHOLIPID TRANSFER PROTEIN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; THROMBOCYTE ACTIVATION; ANTAGONISTS AND INHIBITORS; CALCIUM SIGNALING; CELL CULTURE; CELL SEPARATION; DRUG EFFECTS; ENZYME ACTIVATION; IMMUNOLOGY; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; PATHOLOGY; THROMBOCYTE;

APOPTOSIS; BLOOD PLATELETS; CALCIMYCIN; CALCIUM SIGNALING; CALPAIN; CELL SEPARATION; CELLS, CULTURED; DIPEPTIDES; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIAL MEMBRANES; PHOSPHATIDYLSERINES; PHOSPHOLIPID TRANSFER PROTEINS; PLATELET ACTIVATION; THROMBIN;

EID: 77953160439     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH09-08-0557     Document Type: Article

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