Mitochondrial control of platelet apoptosis: Effect of cyclosporin a, an inhibitor of the mitochondrial permeability transition pore

Laboratory Investigation

Volumn 89, Issue 4, 2009, Pages 374-384

  Leytin, Valery ^a,b,c,d   Allen, David J ^a   Mutlu, Asuman ^a   Gyulkhandanyan, Armen V ^a   Mykhaylov, Sergiy ^a   Freedman, John ^a,b,c  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b Toronto Platelet Immunobiology Group   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Calpain inhibitor calpeptin; Caspase 3 activation; Cyclosporin A; Mitochondrial inner membrane depolarization; Mitochondrial permeability transition pore; Phosphatidylserine exposure; Platelet shrinkage and microparticle formation

Indexed keywords

APOPTOSIS INHIBITOR; CALCIMYCIN; CALPEPTIN; CASPASE 3; CYCLOSPORIN A; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PHOSPHATIDYLSERINE;

APOPTOSIS; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CELL PROTECTION; CONTROLLED STUDY; CYTOSOL; DEPOLARIZATION; DRUG EFFECT; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PLATELET MICROPARTICLE; PRIORITY JOURNAL; THROMBOCYTE; THROMBOCYTE SHAPE;

APOPTOSIS; BLOOD PLATELETS; CALCIMYCIN; CASPASE 3; CYCLOSPORINE; ENZYME ACTIVATION; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS;

EID: 63449090587     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2009.13     Document Type: Article

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