The GPIIbIIIa antagonist drugs eptifibatide and tirofiban do not induce activation of apoptosis executioner caspase-3 in resting platelets but inhibit caspase-3 activation in platelets stimulated with thrombin or calcium ionophore A23187

Haematologica

Volumn 94, Issue 12, 2009, Pages 1783-1784

  Leytin, Valery ^a,b,c   Mutlu, Asuman ^a   Mykhaylov, Sergiy ^a   Allen, David J ^a   Gyulkhandanyan, Armen V ^a   Freedman, John ^a,b,c  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b Toronto Platelet Immunobiology Group   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Caspase 3; Eptifibatide; GPIIbIIIa antagonists; Platelet apoptosis; Tirofiban

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; CALCIMYCIN; CASPASE 3; EPTIFIBATIDE; FIBRINOGEN; FIBRINOGEN RECEPTOR ANTAGONIST; INTEGRIN; ORBOFIBAN; PROCASPASE 3; PROTEINASE ACTIVATED RECEPTOR; THROMBIN; TIROFIBAN; VON WILLEBRAND FACTOR; XEMILOFIBAN;

ACUTE CORONARY SYNDROME; ANIMAL CELL; APOPTOSIS; CALCIUM MOBILIZATION; CARDIAC PATIENT; CELL NUCLEUS; CONTROLLED STUDY; DRUG EFFECT; FOOD AND DRUG ADMINISTRATION; HEART MUSCLE CELL; HEMOSTASIS; LETTER; MOUSE; NONHUMAN; PERCUTANEOUS CORONARY INTERVENTION; PROTEIN BINDING; PROTEIN CONFORMATION; RAT; SHEAR STRESS; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE PRESERVATION; THROMBOSIS;

APOPTOSIS; BLOOD PLATELETS; CALCIMYCIN; CASPASE 3; COAGULANTS; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMANS; IONOPHORES; PEPTIDES; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; THROMBIN; TYROSINE;

EID: 73149096959     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2009.012708     Document Type: Letter

References (12)

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