Bacterial biosynthetic gene clusters encoding the anti-cancer haterumalide class of molecules: Biogenesis of the broad spectrum antifungal and anti-oomycete compound, oocydin A

Journal of Biological Chemistry

Volumn 287, Issue 46, 2012, Pages 39125-39138

  Matilla, Miguel A ^a   Stöckmann, Henning ^a   Leeper, Finian J ^a   Salmond, George P C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; ANTI-FUNGAL; ANTITUMOR PROPERTY; BIOLOGICAL PROPERTIES; BIOSYNTHETIC GENE CLUSTER; BROAD SPECTRUM; CHEMICAL SYNTHESIS; COMPARATIVE GENOMICS; ENTEROBACTERIA; FLAVIN-DEPENDENT; GENE CLUSTERS; GENOME SEQUENCING; HYDROXYMETHYLGLUTARYL; IN-SILICO; MACROLIDES; MULTI-MODULAR; OOMYCETES; PATHOGENIC FUNGI; POLYKETIDE SYNTHASES; SERRATIA; SYNTHASES; SYNTHETIC ROUTES;

AMINO ACIDS; BIOSYNTHESIS; DISEASES; DRUG PRODUCTS; ENCODING (SYMBOLS); FUNGI; HALOGENATION; METABOLITES; MOLECULES; PROTEINS;

GENES;

ANTIFUNGAL AGENT; ANTINEOPLASTIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; OOCYDIN A; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIFUNGAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOGENESIS; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DRUG SCREENING; GENE CLUSTER; GENE DISRUPTION; GENE SYNTHESIS; GENETIC ORGANIZATION; GENOME ANALYSIS; IN VITRO STUDY; MOLECULAR WEIGHT; MUTAGENESIS; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; OOMYCETES; PARASITE VIRULENCE; PLANT PATHOGEN INTERACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SERRATIA MARCESCENS; SERRATIA PLYMUTHICA; TRANSPOSON; WILD TYPE;

ANIMALS; ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS; BIOFILMS; CAENORHABDITIS ELEGANS; CHROMATOGRAPHY, LIQUID; GENOME; LACTONES; MACROLIDES; MASS SPECTROMETRY; MODELS, GENETIC; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; MUTAGENESIS; OOMYCETES; PLASMIDS; POLYKETIDE SYNTHASES; POLYKETIDES; TRANSCRIPTION, GENETIC;

BACTERIA (MICROORGANISMS); DICKEYA; ENTEROBACTERIACEAE; FUNGI; OOMYCETES; SERRATIA;

EID: 84869054540     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.401026     Document Type: Article

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