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Volumn 22, Issue 7, 2003, Pages 1451-1460

Virulence factors of the human opportunistic pathogen Serratia marcescens identified by in vivo screening

Author keywords

Caenorhabditis elegans; Cytotoxicity; Insertional mutagenesis; Iron transport; LPS

Indexed keywords

LIPOPOLYSACCHARIDE; VIRULENCE FACTOR;

EID: 0344091555     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg159     Document Type: Article
Times cited : (309)

References (54)
  • 1
    • 0036164933 scopus 로고    scopus 로고
    • Caenorhabditis elegans as a host for the study of host-pathogen interactions
    • Aballay, A. and Ausubel, F.M. (2002) Caenorhabditis elegans as a host for the study of host-pathogen interactions. Curr. Opin. Microbiol., 5, 97-101.
    • (2002) Curr. Opin. Microbiol. , vol.5 , pp. 97-101
    • Aballay, A.1    Ausubel, F.M.2
  • 2
    • 0033777744 scopus 로고    scopus 로고
    • Shifting trends in bacterial keratitis in south Florida and emerging resistance to fluoroquinolones
    • Alexandrakis, G., Alfonso, E.C. and Miller, D. (2000) Shifting trends in bacterial keratitis in south Florida and emerging resistance to fluoroquinolones. Ophthalmology, 107, 1497-1502.
    • (2000) Ophthalmology , vol.107 , pp. 1497-1502
    • Alexandrakis, G.1    Alfonso, E.C.2    Miller, D.3
  • 4
    • 0026518492 scopus 로고
    • Iron transport systems of Serratia marcescens
    • Angerer, A., Klupp, B. and Braun, V. (1992) Iron transport systems of Serratia marcescens. J. Bacteriol., 174, 1378-1387.
    • (1992) J. Bacteriol. , vol.174 , pp. 1378-1387
    • Angerer, A.1    Klupp, B.2    Braun, V.3
  • 6
    • 0034975764 scopus 로고    scopus 로고
    • Iron uptake mechanisms and their regulation in pathogenic bacteria
    • Braun, V. (2001) Iron uptake mechanisms and their regulation in pathogenic bacteria. Int. J. Med. Microbiol., 291, 67-79.
    • (2001) Int. J. Med. Microbiol. , vol.291 , pp. 67-79
    • Braun, V.1
  • 7
    • 0036216270 scopus 로고    scopus 로고
    • Active transport of iron and siderophore antibiotics
    • Braun, V. and Braun, M. (2002) Active transport of iron and siderophore antibiotics. Curr. Opin. Microbiol., 5, 194-201.
    • (2002) Curr. Opin. Microbiol. , vol.5 , pp. 194-201
    • Braun, V.1    Braun, M.2
  • 10
    • 0036073326 scopus 로고    scopus 로고
    • Diverse bacteria are pathogens of Caenorhabditis elegans
    • Couillault, C. and Ewbank, J.J. (2002) Diverse bacteria are pathogens of Caenorhabditis elegans. Infect. Immun., 70, 4705-4707.
    • (2002) Infect. Immun. , vol.70 , pp. 4705-4707
    • Couillault, C.1    Ewbank, J.J.2
  • 11
    • 0028289692 scopus 로고
    • The Pseudomonas aeruginosa algC gene encodes phosphoglucomutase, required for the synthesis of a complete lipopolysaccharide core
    • Coyne, M.J., Jr, Russell, K.S., Coyle, C.L. and Goldberg, J.B. (1994) The Pseudomonas aeruginosa algC gene encodes phosphoglucomutase, required for the synthesis of a complete lipopolysaccharide core. J. Bacteriol., 176, 3500-3507.
    • (1994) J. Bacteriol. , vol.176 , pp. 3500-3507
    • Coyne M.J., Jr.1    Russell, K.S.2    Coyle, C.L.3    Goldberg, J.B.4
  • 13
    • 0037118055 scopus 로고    scopus 로고
    • Caenorhabditis elegans: Plague bacteria biofilm blocks food intake
    • Darby, C., Hsu, J.W., Ghori, N. and Falkow, S. (2002) Caenorhabditis elegans: plague bacteria biofilm blocks food intake. Nature, 417, 243-244.
    • (2002) Nature , vol.417 , pp. 243-244
    • Darby, C.1    Hsu, J.W.2    Ghori, N.3    Falkow, S.4
  • 14
    • 0035801397 scopus 로고    scopus 로고
    • Folded HasA inhibits its own secretion through its ABC exporter
    • Debarbieux, L. and Wandersman, C. (2001) Folded HasA inhibits its own secretion through its ABC exporter. EMBO J., 20, 4657-4663.
    • (2001) EMBO J. , vol.20 , pp. 4657-4663
    • Debarbieux, L.1    Wandersman, C.2
  • 15
    • 0025195680 scopus 로고
    • Mini-Tn5 transposon derivatives for insertion mutagenesis, promoter probing and chromosomal insertion of cloned DNA in Gram-negative eubacteria
    • de Lorenzo, V., Herrero, M., Jakubzik, U. and Timmis, K.N. (1990) Mini-Tn5 transposon derivatives for insertion mutagenesis, promoter probing and chromosomal insertion of cloned DNA in Gram-negative eubacteria. J. Bacteriol., 172, 6568-6572.
    • (1990) J. Bacteriol. , vol.172 , pp. 6568-6572
    • De Lorenzo, V.1    Herrero, M.2    Jakubzik, U.3    Timmis, K.N.4
  • 16
    • 0036185610 scopus 로고    scopus 로고
    • Tackling both sides of the host-pathogen equation with Caenorhabditis elegans
    • Ewbank, J.J. (2002) Tackling both sides of the host-pathogen equation with Caenorhabditis elegans. Microbes Infect., 4, 247-256.
    • (2002) Microbes Infect. , vol.4 , pp. 247-256
    • Ewbank, J.J.1
  • 17
    • 0001582385 scopus 로고
    • Insect pathogenic properties of Serratia marcescens. Passive and active resistance to insect immunity studied with protease-deficient and phage-resistant mutants
    • Flyg, C. and Xanthopoulos, K.G. (1983) Insect pathogenic properties of Serratia marcescens. Passive and active resistance to insect immunity studied with protease-deficient and phage-resistant mutants. J. Gen. Microbiol., 129, 453-464.
    • (1983) J. Gen. Microbiol. , vol.129 , pp. 453-464
    • Flyg, C.1    Xanthopoulos, K.G.2
  • 18
    • 0019191699 scopus 로고
    • Insect pathogenic properties of Serratia marcescens: Phage-resistant mutants with a decreased resistance to Cecropia immunity and a decreased virulence to Drosophila
    • Flyg, C., Kenne, K. and Boman, H.G. (1980) Insect pathogenic properties of Serratia marcescens: phage-resistant mutants with a decreased resistance to Cecropia immunity and a decreased virulence to Drosophila. J. Gen. Microbiol., 120, 173-181.
    • (1980) J. Gen. Microbiol. , vol.120 , pp. 173-181
    • Flyg, C.1    Kenne, K.2    Boman, H.G.3
  • 19
    • 0036015636 scopus 로고    scopus 로고
    • Characterization of Burkholderia pseudomallei infection and identification of novel virulence factors using a Caenorhabditis elegans host system
    • Gan, Y.H., Chua, K.L., Chua, H.H., Liu, B., Hii, C.S., Chong, H.L. and Tan, P. (2002) Characterization of Burkholderia pseudomallei infection and identification of novel virulence factors using a Caenorhabditis elegans host system. Mol. Microbiol., 44, 1185-1197.
    • (2002) Mol. Microbiol. , vol.44 , pp. 1185-1197
    • Gan, Y.H.1    Chua, K.L.2    Chua, H.H.3    Liu, B.4    Hii, C.S.5    Chong, H.L.6    Tan, P.7
  • 23
    • 0036727002 scopus 로고    scopus 로고
    • Serratia marcescens hemolysin (ShlA) binds artificial membranes and forms pores in a receptor-independent manner
    • Hertle, R. (2002) Serratia marcescens hemolysin (ShlA) binds artificial membranes and forms pores in a receptor-independent manner. J. Membr. Biol., 189, 1-14.
    • (2002) J. Membr. Biol. , vol.189 , pp. 1-14
    • Hertle, R.1
  • 24
    • 0032964320 scopus 로고    scopus 로고
    • Cytotoxic action of Serratia marcescens hemolysin on human epithelial cells
    • Hertle, R., Hilger, M., Weingardt-Kocher, S. and Walev, I. (1999) Cytotoxic action of Serratia marcescens hemolysin on human epithelial cells. Infect. Immun., 67, 817-825.
    • (1999) Infect. Immun. , vol.67 , pp. 817-825
    • Hertle, R.1    Hilger, M.2    Weingardt-Kocher, S.3    Walev, I.4
  • 25
    • 0034035586 scopus 로고    scopus 로고
    • Two-component and phosphorelay signal transduction
    • Hoch, J.A. (2000) Two-component and phosphorelay signal transduction. Curr. Opin. Microbiol., 3, 165-170.
    • (2000) Curr. Opin. Microbiol. , vol.3 , pp. 165-170
    • Hoch, J.A.1
  • 26
    • 0036315595 scopus 로고    scopus 로고
    • Escherichia coli small heat shock proteins, IbpA and IbpB, protect enzymes from inactivation by heat and oxidants
    • Kitagawa, M., Miyakawa, M., Matsumura, Y. and Tsuchido, T, (2002) Escherichia coli small heat shock proteins, IbpA and IbpB, protect enzymes from inactivation by heat and oxidants. Eur. J. Biochem., 269, 2907-2917.
    • (2002) Eur. J. Biochem. , vol.269 , pp. 2907-2917
    • Kitagawa, M.1    Miyakawa, M.2    Matsumura, Y.3    Tsuchido, T.4
  • 27
  • 28
    • 0036241790 scopus 로고    scopus 로고
    • O-antigen structural variation: Mechanisms and possible roles in animal/plant-microbe interactions
    • Lerouge, I. and Vanderleyden, J. (2002) O-antigen structural variation: mechanisms and possible roles in animal/plant-microbe interactions. FEMS Microbiol. Rev., 26, 17-47.
    • (2002) FEMS Microbiol. Rev. , vol.26 , pp. 17-47
    • Lerouge, I.1    Vanderleyden, J.2
  • 30
    • 0024316903 scopus 로고
    • The cell-bound hemolysin of Serratia marcescens contributes to uropathogenicity
    • Marre, R., Hacker, J. and Braun, V. (1989) The cell-bound hemolysin of Serratia marcescens contributes to uropathogenicity. Microb. Pathog., 7, 153-156.
    • (1989) Microb. Pathog. , vol.7 , pp. 153-156
    • Marre, R.1    Hacker, J.2    Braun, V.3
  • 31
    • 0023231674 scopus 로고
    • Cluster of genes controlling synthesis and activation of 2,3-dihydroxybenzoic acid in production of enterobactin in Escherichia coli
    • Nahlik, M.S., Fleming, T.P. and McIntosh, M.A. (1987) Cluster of genes controlling synthesis and activation of 2,3-dihydroxybenzoic acid in production of enterobactin in Escherichia coli. J. Bacteriol., 169, 4163-4170.
    • (1987) J. Bacteriol. , vol.169 , pp. 4163-4170
    • Nahlik, M.S.1    Fleming, T.P.2    McIntosh, M.A.3
  • 32
    • 0026683423 scopus 로고
    • In vitro activation of the Serratia marcescens hemolysin through modification and complementation
    • Ondraczek, R., Hobbie, S. and Braun, V. (1992) In vitro activation of the Serratia marcescens hemolysin through modification and complementation. J. Bacteriol., 174, 5086-5094.
    • (1992) J. Bacteriol. , vol.174 , pp. 5086-5094
    • Ondraczek, R.1    Hobbie, S.2    Braun, V.3
  • 33
    • 0034960639 scopus 로고    scopus 로고
    • Burkholderia pseudomallei kills the nematode Caenorhabditis elegans using an endotoxin-mediated paralysis
    • O'Quinn, A.L., Wiegand, E.M. and Jeddeloh, J.A. (2001) Burkholderia pseudomallei kills the nematode Caenorhabditis elegans using an endotoxin-mediated paralysis. Cell. Microbiol., 3, 381-394.
    • (2001) Cell. Microbiol. , vol.3 , pp. 381-394
    • O'Quinn, A.L.1    Wiegand, E.M.2    Jeddeloh, J.A.3
  • 34
    • 0027728586 scopus 로고
    • The role of O-antigen in susceptibility of Serratia marcescens to non-immune serum
    • Palomar, J., Montilla, R., Fuste, M.C. and Vinas, M. (1993) The role of O-antigen in susceptibility of Serratia marcescens to non-immune serum. Microbios, 76, 189-196.
    • (1993) Microbios , vol.76 , pp. 189-196
    • Palomar, J.1    Montilla, R.2    Fuste, M.C.3    Vinas, M.4
  • 35
    • 0029197109 scopus 로고
    • Serratia marcescens adherence: The effect of O-antigen presence
    • Palomar, J., Leranoz, A.M. and Vinas, M. (1995) Serratia marcescens adherence: the effect of O-antigen presence. Microbios, 81, 107-113.
    • (1995) Microbios , vol.81 , pp. 107-113
    • Palomar, J.1    Leranoz, A.M.2    Vinas, M.3
  • 36
    • 0034971666 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa GacA, a factor in multihost virulence, is also essential for biofilm formation
    • Parkins, M.D., Ceri, H. and Storey, D.G. (2001) Pseudomonas aeruginosa GacA, a factor in multihost virulence, is also essential for biofilm formation. Mol. Microbiol., 40, 1215-1226.
    • (2001) Mol. Microbiol. , vol.40 , pp. 1215-1226
    • Parkins, M.D.1    Ceri, H.2    Storey, D.G.3
  • 37
    • 0023815497 scopus 로고
    • Influence of growth temperature and lipopolysaccharide on hemolytic activity of Serratia marcescens
    • Poole, K. and Braun, V. (1988a) Influence of growth temperature and lipopolysaccharide on hemolytic activity of Serratia marcescens. J. Bacteriol., 170, 5146-5152.
    • (1988) J. Bacteriol. , vol.170 , pp. 5146-5152
    • Poole, K.1    Braun, V.2
  • 38
    • 0023779391 scopus 로고
    • Iron regulation of Serratia marcescens hemolysin gene expression
    • Poole, K. and Braun, V. (1988b) Iron regulation of Serratia marcescens hemolysin gene expression. Infect. Immun., 56, 2967-2971.
    • (1988) Infect. Immun. , vol.56 , pp. 2967-2971
    • Poole, K.1    Braun, V.2
  • 39
    • 0024041282 scopus 로고
    • Molecular characterization of the hemolysin determinant of Serratia marcescens
    • Poole, K., Schiebel, E. and Braun, V. (1988) Molecular characterization of the hemolysin determinant of Serratia marcescens. J. Bacteriol., 170, 3177-3188.
    • (1988) J. Bacteriol. , vol.170 , pp. 3177-3188
    • Poole, K.1    Schiebel, E.2    Braun, V.3
  • 40
    • 0035811018 scopus 로고    scopus 로고
    • A reverse genetic analysis of components of the Toll signalling pathway in Caenorhabditis elegans
    • Pujol, N. et al. (2001) A reverse genetic analysis of components of the Toll signalling pathway in Caenorhabditis elegans. Curr. Biol., 11, 809-821.
    • (2001) Curr. Biol. , vol.11 , pp. 809-821
    • Pujol, N.1
  • 41
    • 0029035765 scopus 로고
    • Common virulence factors for bacterial pathogenicity in plants and animals
    • Rahme, L.G., Stevens, E.J., Wolfort, S.F., Shao, J., Tompkins, R.G. and Ausubel, F.M. (1995) Common virulence factors for bacterial pathogenicity in plants and animals. Science, 268, 1899-1902.
    • (1995) Science , vol.268 , pp. 1899-1902
    • Rahme, L.G.1    Stevens, E.J.2    Wolfort, S.F.3    Shao, J.4    Tompkins, R.G.5    Ausubel, F.M.6
  • 42
    • 0027951939 scopus 로고
    • Buffering capacity of pigmented and nonpigmented strains of Serratia marcescens
    • Rius, N., Sole, M., Francia, A. and Loren, J. (1994) Buffering capacity of pigmented and nonpigmented strains of Serratia marcescens. Appl. Environ. Microbiol., 60, 2152-2154.
    • (1994) Appl. Environ. Microbiol. , vol.60 , pp. 2152-2154
    • Rius, N.1    Sole, M.2    Francia, A.3    Loren, J.4
  • 43
    • 0023472472 scopus 로고
    • Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa
    • Schägger, H. and von Jagow, G. (1987) Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal. Biochem., 166, 368-379.
    • (1987) Anal. Biochem. , vol.166 , pp. 368-379
    • Schägger, H.1    Von Jagow, G.2
  • 44
    • 0024550676 scopus 로고
    • Integration of the Serratia marcescens haemolysin into human erythrocyte membranes
    • Schiebel, E. and Braun, V. (1989) Integration of the Serratia marcescens haemolysin into human erythrocyte membranes. Mol. Microbiol., 3, 445-453.
    • (1989) Mol. Microbiol. , vol.3 , pp. 445-453
    • Schiebel, E.1    Braun, V.2
  • 45
    • 0023127806 scopus 로고
    • Universal chemical assay for the detection and determination of siderophores
    • Schwyn, B. and Neilands, J.B. (1987) Universal chemical assay for the detection and determination of siderophores. Anal. Biochem., 160, 47-56.
    • (1987) Anal. Biochem. , vol.160 , pp. 47-56
    • Schwyn, B.1    Neilands, J.B.2
  • 46
    • 0031946778 scopus 로고    scopus 로고
    • Generation of Escherichia coli O9a serotype, a subtype of E. coli O9, by transfer of the wb* gene cluster of Klebsiella O3 into E. coli via recombination
    • Sugiyama, T., Kido, N., Kato, Y., Koide, N., Yoshida, T. and Yokochi, T. (1998) Generation of Escherichia coli O9a serotype, a subtype of E. coli O9, by transfer of the wb* gene cluster of Klebsiella O3 into E. coli via recombination. J. Bacteriol., 180, 2775-2778.
    • (1998) J. Bacteriol. , vol.180 , pp. 2775-2778
    • Sugiyama, T.1    Kido, N.2    Kato, Y.3    Koide, N.4    Yoshida, T.5    Yokochi, T.6
  • 47
    • 0000182225 scopus 로고
    • Methods
    • Wood. W.B. (ed.). Cold Spring Harbor Laboratory Press, Plainview, NY
    • Sulston, J. and Hodgkin, J. (1988) Methods. In Wood. W.B. (ed.), The Nematode Caenorhabditis elegans. Cold Spring Harbor Laboratory Press, Plainview, NY, pp. 587-606.
    • (1988) The Nematode Caenorhabditis elegans , pp. 587-606
    • Sulston, J.1    Hodgkin, J.2
  • 48
    • 0035260802 scopus 로고    scopus 로고
    • LysR-type transcriptional regulator ChiR is essential for production of all chitinases and a chitin-binding protein, CBP21, in Serratia marcescens 2170
    • Suzuki, K., Uchiyama, T., Suzuki, M., Nikaidou, N., Regue, M. and Watanabe, T. (2001) LysR-type transcriptional regulator ChiR is essential for production of all chitinases and a chitin-binding protein, CBP21, in Serratia marcescens 2170. Biosci. Biotechnol. Biochem., 65, 338-347.
    • (2001) Biosci. Biotechnol. Biochem. , vol.65 , pp. 338-347
    • Suzuki, K.1    Uchiyama, T.2    Suzuki, M.3    Nikaidou, N.4    Regue, M.5    Watanabe, T.6
  • 49
    • 0033965253 scopus 로고    scopus 로고
    • Caenorhabditis elegans: A model genetic host to study Pseudomonas aeruginosa pathogenesis
    • Tan, M.W. and Ausubel, F.M. (2000) Caenorhabditis elegans: a model genetic host to study Pseudomonas aeruginosa pathogenesis. Curr. Opin. Microbiol., 3, 29-34.
    • (2000) Curr. Opin. Microbiol. , vol.3 , pp. 29-34
    • Tan, M.W.1    Ausubel, F.M.2
  • 50
    • 0033515018 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P.aeruginosa virulence factors
    • Tan, M.W., Rahme, L.G., Stemberg, J.A., Tompkins, R.G. and Ausubel, F.M. (1999) Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P.aeruginosa virulence factors. Proc. Natl Acad. Sci. USA, 96, 2408-2413.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 2408-2413
    • Tan, M.W.1    Rahme, L.G.2    Stemberg, J.A.3    Tompkins, R.G.4    Ausubel, F.M.5
  • 51
    • 0034016854 scopus 로고    scopus 로고
    • Biosynthesis of carbapenem antibiotic and prodigiosin pigment in Serratia is under quorum sensing control
    • Thomson, N.R., Crow, M.A., McGowan, S.J., Cox, A. and Salmond, G.P. (2000) Biosynthesis of carbapenem antibiotic and prodigiosin pigment in Serratia is under quorum sensing control. Mol. Microbiol., 36, 539-556.
    • (2000) Mol. Microbiol. , vol.36 , pp. 539-556
    • Thomson, N.R.1    Crow, M.A.2    McGowan, S.J.3    Cox, A.4    Salmond, G.P.5
  • 52
    • 0020055346 scopus 로고
    • A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels
    • Tsai, C.M. and Frasch, C.E. (1982) A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. Anal. Biochem., 119, 115-119.
    • (1982) Anal. Biochem. , vol.119 , pp. 115-119
    • Tsai, C.M.1    Frasch, C.E.2
  • 53
    • 0035159925 scopus 로고    scopus 로고
    • + exchangers (vcgO) perturbs cytoplasmic alkali cation balance at low osmolarity
    • + exchangers (vcgO) perturbs cytoplasmic alkali cation balance at low osmolarity. Microbiology, 147. 3005-3013.
    • (2001) Microbiology , vol.147 , pp. 3005-3013
    • Verkhovskaya, M.L.1    Barquera, B.2    Wikstrom, M.3
  • 54
    • 0035113720 scopus 로고    scopus 로고
    • VibD and VibH are required for late steps in vibriobactin biosynthesis in Vibrio cholerae
    • Wyckoff, E.E., Smith, S.L. and Payne, S.M. (2001) VibD and VibH are required for late steps in vibriobactin biosynthesis in Vibrio cholerae. J. Bacteriol., 183, 1830-1834.
    • (2001) J. Bacteriol. , vol.183 , pp. 1830-1834
    • Wyckoff, E.E.1    Smith, S.L.2    Payne, S.M.3


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