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Volumn 42, Issue 3, 2012, Pages 243-257

Oncogenesis recapitulates embryogenesis via the hypoxia pathway: Morphoproteomics and biomedical analytics provide proof of concept and therapeutic options

Author keywords

Biomedical analytics; Embryogenesis; Hypoxia; Morphoproteomics; Oncogenesis

Indexed keywords

CELECOXIB; DOXORUBICIN; MELATONIN; METFORMIN; TEMOZOLOMIDE; VALPROIC ACID;

EID: 84868654237     PISSN: 00917370     EISSN: 15508080     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (13)

References (97)
  • 3
    • 0011691451 scopus 로고
    • An Experimental Comparison of Transplanted Tumor and a Transplanted Normal Tissue Capable of Growth
    • Rous P. An Experimental Comparison of Transplanted Tumor and a Transplanted Normal Tissue Capable of Growth. The Journal of experimental medicine 1910; 12: 344-366.
    • (1910) The Journal of experimental medicine , vol.12 , pp. 344-366
    • Rous, P.1
  • 4
    • 84868671212 scopus 로고
    • The Relations of Embryonic Tissue and Tumor in Mixed Grafts
    • Rous P. The Relations of Embryonic Tissue and Tumor in Mixed Grafts. The Journal of experimental medicine 1911; 13: 239-247.
    • (1911) The Journal of experimental medicine , vol.13 , pp. 239-247
    • Rous, P.1
  • 5
    • 0024708518 scopus 로고
    • The distribution of secondary growths in cancer of the breast
    • Paget S. The distribution of secondary growths in cancer of the breast. 1889. Cancer Metastasis Rev 1989; 8: 98-101.
    • (1989) 1989 Cancer Metastasis Rev , vol.8 , pp. 98-101
    • Paget, S.1
  • 7
    • 20544477463 scopus 로고    scopus 로고
    • Morphoproteomics: exposing protein circuitries in tumors to identify potential therapeutic targets in cancer patients
    • Brown RE. Morphoproteomics: exposing protein circuitries in tumors to identify potential therapeutic targets in cancer patients. Expert Rev Proteomics. 2005; 2(3):337-348.
    • (2005) Expert Rev Proteomics , vol.2 , Issue.3 , pp. 337-348
    • Brown, R.E.1
  • 8
    • 64849109415 scopus 로고    scopus 로고
    • Morphogenomics and morphoproteomics: a role for anatomic pathology in personalized medicine
    • Brown RE. Morphogenomics and morphoproteomics: a role for anatomic pathology in personalized medicine. Arch Pathol Lab Med. 2009; 133(4):568-579.
    • (2009) Arch Pathol Lab Med , vol.133 , Issue.4 , pp. 568-579
    • Brown, R.E.1
  • 11
    • 34047095297 scopus 로고    scopus 로고
    • The two TORCs and Akt
    • Bhaskar PT, Hay N. The two TORCs and Akt. Dev Cell. 2007;12:487-502.
    • (2007) Dev Cell , vol.12 , pp. 487-502
    • Bhaskar, P.T.1    Hay, N.2
  • 12
    • 52949137425 scopus 로고    scopus 로고
    • Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1
    • Rosner M, Hengstschläger M. Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1. Hum Mol Genet. 2008; 17(19):2934-2948.
    • (2008) Hum Mol Genet , vol.17 , Issue.19 , pp. 2934-2948
    • Rosner, M.1    Hengstschläger, M.2
  • 14
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictormTOR complex
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictormTOR complex. Science. 2005; 307(5712):1098-1101.
    • (2005) Science , vol.307 , Issue.5712 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 15
    • 37549048521 scopus 로고    scopus 로고
    • mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor
    • Masri J, Bernath A, Martin J, Jo O.D., Vartanian R., Funk A. & Gera J. mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor. Cancer Res. 2007;67:11712-11720.
    • (2007) Cancer Res , vol.67 , pp. 11712-11720
    • Masri, J.1    Bernath, A.2    Martin, J.3    Jo, O.D.4    Vartanian, R.5    Funk, A.6    Gera, J.7
  • 17
    • 58049216350 scopus 로고    scopus 로고
    • Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2
    • Toschi A, Lee E, Gadir N, Ohh M, Foster DA. Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2. J Biol Chem. 2008;283:34495-34499.
    • (2008) J Biol Chem , vol.283 , pp. 34495-34499
    • Toschi, A.1    Lee, E.2    Gadir, N.3    Ohh, M.4    Foster, D.A.5
  • 18
    • 51649096739 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells
    • Niu G, Briggs J, Deng J, Fu X.M, Tang S.F. & Li J. Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells. Mol Cancer Res. 2008;6:1099-1105.
    • (2008) Mol Cancer Res , vol.6 , pp. 1099-1105
    • Niu, G.1    Briggs, J.2    Deng, J.3    Fu, X.M.4    Tang, S.F.5    Li, J.6
  • 20
    • 72449173021 scopus 로고    scopus 로고
    • Notch signal activates hypoxia pathway through HES1-dependent SRC/signal transducers and activators of transcription 3 pathway
    • Lee JH, Suk J, Park J, Kim SB, Kwak SS, Kim JW, Lee CH, Byun B, Ahn JK, Joe CO. Notch signal activates hypoxia pathway through HES1-dependent SRC/signal transducers and activators of transcription 3 pathway. Mol Cancer Res. 2009;7:1663-1671.
    • (2009) Mol Cancer Res , vol.7 , pp. 1663-1671
    • Lee, J.H.1    Suk, J.2    Park, J.3    Kim, S.B.4    Kwak, S.S.5    Kim, J.W.6    Lee, C.H.7    Byun, B.8    Ahn, J.K.9    Joe, C.O.10
  • 21
    • 33751203592 scopus 로고    scopus 로고
    • Morphoproteomic demonstration of constitutive nuclear factor-kappaB activation in glioblastoma multiforme with genomic correlates and therapeutic implications
    • Brown RE, Law A. Morphoproteomic demonstration of constitutive nuclear factor-kappaB activation in glioblastoma multiforme with genomic correlates and therapeutic implications. Ann Clin Lab Sci. 2006;36:421-426.
    • (2006) Ann Clin Lab Sci , vol.36 , pp. 421-426
    • Brown, R.E.1    Law, A.2
  • 23
    • 47149099173 scopus 로고    scopus 로고
    • The cross-talk between NF-kappaB and HIF-1: further evidence for a significant liaison
    • Gorlach A, Bonello S. The cross-talk between NF-kappaB and HIF-1: further evidence for a significant liaison. Biochem J. 2008;412:e17-19.
    • (2008) Biochem J , vol.412
    • Gorlach, A.1    Bonello, S.2
  • 25
    • 80054762435 scopus 로고    scopus 로고
    • Hypoxia-inhibited dualspecificity phosphatase-2 expression in endometriotic cells regulates cyclooxygenase-2 expression
    • Wu MH, Lin SC, Hsiao KY, Tsai SJ. Hypoxia-inhibited dualspecificity phosphatase-2 expression in endometriotic cells regulates cyclooxygenase-2 expression. J Pathol. 2011;225:390-400.
    • (2011) J Pathol , vol.225 , pp. 390-400
    • Wu, M.H.1    Lin, S.C.2    Hsiao, K.Y.3    Tsai, S.J.4
  • 27
    • 44449113872 scopus 로고    scopus 로고
    • Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer
    • Kitajima Y, Ide T, Ohtsuka T, Miyazaki K. Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer. Cancer Sci. 2008;99:1341-1347.
    • (2008) Cancer Sci , vol.99 , pp. 1341-1347
    • Kitajima, Y.1    Ide, T.2    Ohtsuka, T.3    Miyazaki, K.4
  • 31
    • 54849405345 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor-A and mRNA stability factor HuR in human astrocytic tumors
    • Ido K, Nakagawa T, Sakuma T, Takeuchi H, Sato K, Kubota T. Expression of vascular endothelial growth factor-A and mRNA stability factor HuR in human astrocytic tumors. Neuropathology. 2008;28:604-611.
    • (2008) Neuropathology , vol.28 , pp. 604-611
    • Ido, K.1    Nakagawa, T.2    Sakuma, T.3    Takeuchi, H.4    Sato, K.5    Kubota, T.6
  • 32
    • 64549154509 scopus 로고    scopus 로고
    • Downregulation of SPARC expression inhibits cell migration and invasion in malignant gliomas
    • Seno T, Harada H, Kohno S, Teraoka M, Inoue A, Ohnishi T. Downregulation of SPARC expression inhibits cell migration and invasion in malignant gliomas. Int J Oncol. 2009;34:707-715.
    • (2009) Int J Oncol , vol.34 , pp. 707-715
    • Seno, T.1    Harada, H.2    Kohno, S.3    Teraoka, M.4    Inoue, A.5    Ohnishi, T.6
  • 36
    • 77950231070 scopus 로고    scopus 로고
    • CD44 attenuates activation of the hippo signaling pathway and is a prime therapeutic target for glioblastoma
    • Xu Y, Stamenkovic I, Yu Q. CD44 attenuates activation of the hippo signaling pathway and is a prime therapeutic target for glioblastoma. Cancer Res 2010;70:2455-2464.
    • (2010) Cancer Res , vol.70 , pp. 2455-2464
    • Xu, Y.1    Stamenkovic, I.2    Yu, Q.3
  • 39
    • 81455142965 scopus 로고    scopus 로고
    • The three-layer concentric model of glioblastoma: cancer stem cells, microenvironmental regulation, and therapeutic implications
    • Persano L, Rampazzo E, Della Puppa A, Pistollato F, Basso G. The three-layer concentric model of glioblastoma: cancer stem cells, microenvironmental regulation, and therapeutic implications. ScientificWorld Journal 2011;11:1829-1841.
    • (2011) ScientificWorld Journal , vol.11 , pp. 1829-1841
    • Persano, L.1    Rampazzo, E.2    Della Puppa, A.3    Pistollato, F.4    Basso, G.5
  • 40
    • 79251591038 scopus 로고    scopus 로고
    • Glioblastoma, cancer stem cells and hypoxia
    • Bar EE. Glioblastoma, cancer stem cells and hypoxia. Brain Pathol. 2011;21:119-129.
    • (2011) Brain Pathol , vol.21 , pp. 119-129
    • Bar, E.E.1
  • 41
    • 0031680014 scopus 로고    scopus 로고
    • A cellular model that recapitulates major pathogenic steps of Huntington's disease
    • Lunkes A, Mandel JL. A cellular model that recapitulates major pathogenic steps of Huntington's disease. Human molecular genetics 1998; 7: 1355-61.
    • (1998) Human molecular genetics , vol.7 , pp. 1355-1361
    • Lunkes, A.1    Mandel, J.L.2
  • 42
    • 75149154666 scopus 로고    scopus 로고
    • HIF prolyl hydroxylase inhibitors prevent neuronal death induced by mitochondrial toxins: therapeutic implications for Huntington's disease and Alzheimer's disease
    • Niatsetskaya Z, Basso M, Speer RE, McConoughey SJ, Coppola G, Ma TC, Ratan RR. HIF prolyl hydroxylase inhibitors prevent neuronal death induced by mitochondrial toxins: therapeutic implications for Huntington's disease and Alzheimer's disease. Antioxidants & redox signaling 2010; 12: 435-443.
    • (2010) Antioxidants & redox signaling , vol.12 , pp. 435-443
    • Niatsetskaya, Z.1    Basso, M.2    Speer, R.E.3    McConoughey, S.J.4    Coppola, G.5    Ma, T.C.6    Ratan, R.R.7
  • 44
    • 84857852626 scopus 로고    scopus 로고
    • Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFalpha)-induced apoptosis through SIRT1 inhibition
    • Dixit D, Sharma V, Ghosh S, Mehta VS, Sen E. Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFalpha)-induced apoptosis through SIRT1 inhibition. Cell Death Dis 2012; 3: e271.
    • (2012) Cell Death Dis , vol.3
    • Dixit, D.1    Sharma, V.2    Ghosh, S.3    Mehta, V.S.4    Sen, E.5
  • 49
    • 77955770568 scopus 로고    scopus 로고
    • Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells
    • Zakikhani M, Blouin MJ, Piura E, Pollak MN. Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells. Breast Cancer Res Treat 2010; 123:271-279.
    • (2010) Breast Cancer Res Treat , vol.123 , pp. 271-279
    • Zakikhani, M.1    Blouin, M.J.2    Piura, E.3    Pollak, M.N.4
  • 50
    • 0023768544 scopus 로고
    • The expression of insulin-like growth factor I and insulin-like growth factor II genes in the human fetal and adult brain and in glioma
    • Sandberg AC, Engberg C, Lake M, von Holst H, Sara VR. The expression of insulin-like growth factor I and insulin-like growth factor II genes in the human fetal and adult brain and in glioma. Neurosci Lett. 1988;93:114-119.
    • (1988) Neurosci Lett , vol.93 , pp. 114-119
    • Sandberg, A.C.1    Engberg, C.2    Lake, M.3    von Holst, H.4    Sara, V.R.5
  • 51
    • 0023854380 scopus 로고
    • Expression of two types of receptor for insulinlike growth factors in human malignant glioma
    • Gammeltoft S, Ballotti R, Kowalski A, Westermark B, Van Obberghen E. Expression of two types of receptor for insulinlike growth factors in human malignant glioma. Cancer Res. 1988;48:1233-1237.
    • (1988) Cancer Res , vol.48 , pp. 1233-1237
    • Gammeltoft, S.1    Ballotti, R.2    Kowalski, A.3    Westermark, B.4    Van Obberghen, E.5
  • 53
    • 33947320145 scopus 로고    scopus 로고
    • Insulin-like growth factor type I biology and targeting in malignant gliomas
    • Trojan J, Cloix JF, Ardourel MY, Chatel M, Anthony DD. Insulin-like growth factor type I biology and targeting in malignant gliomas. Neuroscience. 2007;145:795-811.
    • (2007) Neuroscience , vol.145 , pp. 795-811
    • Trojan, J.1    Cloix, J.F.2    Ardourel, M.Y.3    Chatel, M.4    Anthony, D.D.5
  • 55
    • 42549145434 scopus 로고    scopus 로고
    • Cell proliferation and migration in glioblastoma multiforme cell lines are influenced by insulin-like growth factor I in vitro
    • Schlenska-Lange A, Knupfer H, Lange TJ, Kiess W, Knupfer M. Cell proliferation and migration in glioblastoma multiforme cell lines are influenced by insulin-like growth factor I in vitro. Anticancer Res. 2008;28:1055-1060.
    • (2008) Anticancer Res , vol.28 , pp. 1055-1060
    • Schlenska-Lange, A.1    Knupfer, H.2    Lange, T.J.3    Kiess, W.4    Knupfer, M.5
  • 58
    • 1842861743 scopus 로고    scopus 로고
    • Human neuroblastoma cells exposed to hypoxia: induction of genes associated with growth, survival, and aggressive behavior
    • Jogi A, Vallon-Christersson J, Holmquist L, Axelson H, Borg A, Pahlman S. Human neuroblastoma cells exposed to hypoxia: induction of genes associated with growth, survival, and aggressive behavior. Exp Cell Res. 2004;295:469-487.
    • (2004) Exp Cell Res , vol.295 , pp. 469-487
    • Jogi, A.1    Vallon-Christersson, J.2    Holmquist, L.3    Axelson, H.4    Borg, A.5    Pahlman, S.6
  • 59
    • 77953912455 scopus 로고    scopus 로고
    • The IGFR1 inhibitor NVP-AEW541 disrupts a pro-survival and pro-angiogenic IGF-STAT3-HIF1 pathway in human glioblastoma cells
    • Gariboldi MB, Ravizza R, Monti E. The IGFR1 inhibitor NVP-AEW541 disrupts a pro-survival and pro-angiogenic IGF-STAT3-HIF1 pathway in human glioblastoma cells. Biochem Pharmacol. 2010;80:455-462.
    • (2010) Biochem Pharmacol , vol.80 , pp. 455-462
    • Gariboldi, M.B.1    Ravizza, R.2    Monti, E.3
  • 60
    • 84862908866 scopus 로고    scopus 로고
    • Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers
    • Deng XS, Wang S, Deng A, Liu B, Edgerton SM, Lind SE, Wahdan-Alaswad R, Thor AD. Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers. Cell Cycle 2012: 15; 11: 367-376.
    • (2012) Cell Cycle , vol.15 , Issue.11 , pp. 367-376
    • Deng, X.S.1    Wang, S.2    Deng, A.3    Liu, B.4    Edgerton, S.M.5    Lind, S.E.6    Wahdan-Alaswad, R.7    Thor, A.D.8
  • 62
    • 79952391694 scopus 로고    scopus 로고
    • Tubular injury in a rat model of type 2 diabetes is prevented by metformin: a possible role of HIF-1alpha expression and oxygen metabolism
    • Takiyama Y, Harumi T, Watanabe J, Fujita Y, Honjo J, Shimizu N, Makino Y, Haneda M. Tubular injury in a rat model of type 2 diabetes is prevented by metformin: a possible role of HIF-1alpha expression and oxygen metabolism. Diabetes 2011;60:981-992.
    • (2011) Diabetes , vol.60 , pp. 981-992
    • Takiyama, Y.1    Harumi, T.2    Watanabe, J.3    Fujita, Y.4    Honjo, J.5    Shimizu, N.6    Makino, Y.7    Haneda, M.8
  • 63
    • 70350236538 scopus 로고    scopus 로고
    • Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission
    • Hirsch HA, Iliopoulos D, Tsichlis PN, Struhl K. Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission. Cancer Res. 2009:69:7507-7511.
    • (2009) Cancer Res , vol.69 , pp. 7507-7511
    • Hirsch, H.A.1    Iliopoulos, D.2    Tsichlis, P.N.3    Struhl, K.4
  • 64
    • 84876699946 scopus 로고    scopus 로고
    • Metformin: A Rising Star to Fight The Epithelial Mesenchymal Transition in Oncology
    • [Epub ahead of print]
    • Barriere G, Tartary M, Rigaud M. Metformin: A Rising Star to Fight The Epithelial Mesenchymal Transition in Oncology. Anticancer Agents Med Chem Jun 18.2012 [Epub ahead of print].
    • Anticancer Agents Med Chem Jun 18. 2012.
    • Barriere, G.1    Tartary, M.2    Rigaud, M.3
  • 66
    • 80054015235 scopus 로고    scopus 로고
    • Can the therapeutic effects of temozolomide be potentiated by stimulating AMP-activated protein kinase with olanzepine and metformin?
    • Kast RE, Karpel-Massler G, Halatsch ME. Can the therapeutic effects of temozolomide be potentiated by stimulating AMP-activated protein kinase with olanzepine and metformin? Br J Pharmacol. 2011;164:1393-1396.
    • (2011) Br J Pharmacol , vol.164 , pp. 1393-1396
    • Kast, R.E.1    Karpel-Massler, G.2    Halatsch, M.E.3
  • 67
    • 34247850849 scopus 로고    scopus 로고
    • Regulation of the HIF-1alpha stability by histone deacetylases
    • Kim SH, Jeong JW, Park JA et al. Regulation of the HIF-1alpha stability by histone deacetylases. Oncol Rep. 2007;17:647-651.
    • (2007) Oncol Rep , vol.17 , pp. 647-651
    • Kim, S.H.1    Jeong, J.W.2    Park, J.A.3
  • 68
    • 0031763892 scopus 로고    scopus 로고
    • Valproic acid inhibits proliferation and changes expression of CD44 and CD56 of malignant glioma cells in vitro
    • Knupfer MM, Hernaiz-Driever P, Poppenborg H, Wolff JE, Cinatl J. Valproic acid inhibits proliferation and changes expression of CD44 and CD56 of malignant glioma cells in vitro. Anticancer Res. 1998;18:3585-3589.
    • (1998) Anticancer Res , vol.18 , pp. 3585-3589
    • Knupfer, M.M.1    Hernaiz-Driever, P.2    Poppenborg, H.3    Wolff, J.E.4    Cinatl, J.5
  • 69
    • 28844473025 scopus 로고    scopus 로고
    • Novel targets for valproic acid: up-regulation of melatonin receptors and neurotrophic factors in C6 glioma cells
    • Castro LM, Gallant M, Niles LP. Novel targets for valproic acid: up-regulation of melatonin receptors and neurotrophic factors in C6 glioma cells. J Neurochem. 2005; 95(5):1227-1236.
    • (2005) J Neurochem , vol.95 , Issue.5 , pp. 1227-1236
    • Castro, L.M.1    Gallant, M.2    Niles, L.P.3
  • 70
    • 47549105492 scopus 로고    scopus 로고
    • Clinically relevant concentrations of valproic acid modulate melatonin MT (1) receptor HDAC and MeCP2 mRNA expression in C6 glioma cells
    • Kim B, Rincón Castro LM, Jawed S, Lee JW, Seo JH, Jung BK, Bae MK, Kim KW. Clinically relevant concentrations of valproic acid modulate melatonin MT (1) receptor, HDAC and MeCP2 mRNA expression in C6 glioma cells. Eur J Pharmacol. 2008; 589:45-48.
    • (2008) Eur J Pharmacol , vol.589 , pp. 45-48
    • Kim, B.1    Rincón Castro, L.M.2    Jawed, S.3    Lee, J.W.4    Seo, J.H.5    Jung, B.K.6    Bae, M.K.7    Kim, K.W.8
  • 74
    • 70350355240 scopus 로고    scopus 로고
    • Regulation of vascularization by hypoxia-inducible factor 1
    • Semenza GL. Regulation of vascularization by hypoxia-inducible factor 1. Ann N Y Acad Sci. 2009;1177:2-8.
    • (2009) Ann N Y Acad Sci , vol.1177 , pp. 2-8
    • Semenza, G.L.1
  • 75
    • 34249981734 scopus 로고    scopus 로고
    • Cisplatin and doxorubicin repress Vascular Endothelial Growth Factor expression and differentially down-regulate Hypoxia-inducible Factor I activity in human ovarian cancer cells
    • Duyndam MC, van Berkel MP, Dorsman JC, Rockx DA, Pinedo HM, Boven E. Cisplatin and doxorubicin repress Vascular Endothelial Growth Factor expression and differentially down-regulate Hypoxia-inducible Factor I activity in human ovarian cancer cells. Biochem Pharmacol. 2007;74:191-201.
    • (2007) Biochem Pharmacol , vol.74 , pp. 191-201
    • Duyndam, M.C.1    van Berkel, M.P.2    Dorsman, J.C.3    Rockx, D.A.4    Pinedo, H.M.5    Boven, E.6
  • 76
    • 0033380652 scopus 로고    scopus 로고
    • DNA topoisomerase II-alpha as a proliferation marker in astrocytic neoplasms of the central nervous system: correlation with MIB1 expression and patient survival
    • Holden JA, Townsend JJ. DNA topoisomerase II-alpha as a proliferation marker in astrocytic neoplasms of the central nervous system: correlation with MIB1 expression and patient survival. Mod Pathol. 1999;12:1094-1100.
    • (1999) Mod Pathol , vol.12 , pp. 1094-1100
    • Holden, J.A.1    Townsend, J.J.2
  • 77
    • 35448999681 scopus 로고    scopus 로고
    • Valproic acid induces p21 and topoisomerase-II (alpha/beta) expression and synergistically enhances etoposide cytotoxicity in human glioblastoma cell lines
    • Das CM, Aguilera D, Vasquez H, Prasad P, Zhang M, Wolff JE, Gopalakrishnan V. Valproic acid induces p21 and topoisomerase-II (alpha/beta) expression and synergistically enhances etoposide cytotoxicity in human glioblastoma cell lines. J Neurooncol. 2007;85:159-170.
    • (2007) J Neurooncol , vol.85 , pp. 159-170
    • Das, C.M.1    Aguilera, D.2    Vasquez, H.3    Prasad, P.4    Zhang, M.5    Wolff, J.E.6    Gopalakrishnan, V.7
  • 78
    • 79958254773 scopus 로고    scopus 로고
    • Chemosensitization of glioblastoma cells by the histone deacetylase inhibitor MS275
    • Bangert A, Hacker S, Cristofanon S, Debatin KM, Fulda S. Chemosensitization of glioblastoma cells by the histone deacetylase inhibitor MS275. Anticancer Drugs 2011;22:494-499.
    • (2011) Anticancer Drugs , vol.22 , pp. 494-499
    • Bangert, A.1    Hacker, S.2    Cristofanon, S.3    Debatin, K.M.4    Fulda, S.5
  • 79
    • 79955490053 scopus 로고    scopus 로고
    • Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types
    • Iliopoulos D, Hirsch HA, Struhl K. Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types. Cancer Res. 2011;71:3196-3201.
    • (2011) Cancer Res , vol.71 , pp. 3196-3201
    • Iliopoulos, D.1    Hirsch, H.A.2    Struhl, K.3
  • 80
    • 29644448240 scopus 로고    scopus 로고
    • Prevention of doxorubicin-induced cardiotoxicity by melatonin
    • Oz E, Erbas D, Surucu HS, Duzgun E. Prevention of doxorubicin-induced cardiotoxicity by melatonin. Mol Cell Biochem. 2006;282:31-37.
    • (2006) Mol Cell Biochem , vol.282 , pp. 31-37
    • Oz, E.1    Erbas, D.2    Surucu, H.S.3    Duzgun, E.4
  • 82
    • 39149091686 scopus 로고    scopus 로고
    • Melatonin modulates the expression of VEGF and HIF-1 alpha induced by CoCl2 in cultured cancer cells
    • Dai M, Cui P, Yu M, Han J, Li H, Xiu R. Melatonin modulates the expression of VEGF and HIF-1 alpha induced by CoCl2 in cultured cancer cells. J Pineal Res. 2008; 44:121-126.
    • (2008) J Pineal Res , vol.44 , pp. 121-126
    • Dai, M.1    Cui, P.2    Yu, M.3    Han, J.4    Li, H.5    Xiu, R.6
  • 83
    • 64649100878 scopus 로고    scopus 로고
    • Melatonin downregulates HIF-1 alpha expression through inhibition of protein translation in prostate cancer cells
    • Park JW, Hwang MS, Suh SI, Baek WK. Melatonin downregulates HIF-1 alpha expression through inhibition of protein translation in prostate cancer cells. J Pineal Res. 2009; 46:415-421.
    • (2009) J Pineal Res , vol.46 , pp. 415-421
    • Park, J.W.1    Hwang, M.S.2    Suh, S.I.3    Baek, W.K.4
  • 84
    • 75149158379 scopus 로고    scopus 로고
    • Melatonin suppresses tumor angiogenesis by inhibiting HIF-1alpha stabilization under hypoxia
    • Park SY, Jang WJ, Yi EY, Jang JY, Jung Y, Jeong JW, Kim YJ. Melatonin suppresses tumor angiogenesis by inhibiting HIF-1alpha stabilization under hypoxia. J Pineal Res. 2010; 48:178-184.
    • (2010) J Pineal Res , vol.48 , pp. 178-184
    • Park, S.Y.1    Jang, W.J.2    Yi, E.Y.3    Jang, J.Y.4    Jung, Y.5    Jeong, J.W.6    Kim, Y.J.7
  • 85
    • 0030025155 scopus 로고    scopus 로고
    • Increased survival time in brain glioblastomas by a radioneuroendocrine strategy with radiotherapy plus melatonin compared to radiotherapy alone
    • Lissoni P, Meregalli S, Nosetto L, Tancini G, Fossati V, Maestroni G. Increased survival time in brain glioblastomas by a radioneuroendocrine strategy with radiotherapy plus melatonin compared to radiotherapy alone. Oncology. 1996; 53:43-46.
    • (1996) Oncology , vol.53 , pp. 43-46
    • Lissoni, P.1    Meregalli, S.2    Nosetto, L.3    Tancini, G.4    Fossati, V.5    Maestroni, G.6
  • 86
    • 84862299740 scopus 로고    scopus 로고
    • The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: a meta-analysis of randomized controlled trials
    • Wang YM, Jin BZ, Ai F, Duan CH, Lu YZ, Dong TF, Fu QL. The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: a meta-analysis of randomized controlled trials. Cancer Chemother. Pharmacol. 2012;69:1213-1220.
    • (2012) Cancer Chemother. Pharmacol. , vol.69 , pp. 1213-1220
    • Wang, Y.M.1    Jin, B.Z.2    Ai, F.3    Duan, C.H.4    Lu, Y.Z.5    Dong, T.F.6    Fu, Q.L.7
  • 87
    • 84866145762 scopus 로고    scopus 로고
    • Celecoxib inactivates epithelial-mesenchymal transition stimulated by hypoxia and/or epidermal growth factor in colon cancer cells
    • [Epub ahead of print]
    • Bocca C, Bozzo F, Cannito S, Parola M, Miglietta A. Celecoxib inactivates epithelial-mesenchymal transition stimulated by hypoxia and/or epidermal growth factor in colon cancer cells. Mol Carcinog.2011: Aug31 [Epub ahead of print].
    • Mol Carcinog. 2011: Aug31.
    • Bocca, C.1    Bozzo, F.2    Cannito, S.3    Parola, M.4    Miglietta, A.5
  • 88
    • 83055194567 scopus 로고    scopus 로고
    • The nonsteroidal anti-inflammatory drug celecoxib suppresses the growth and induces apoptosis of human glioblastoma cells via the NFkappaB pathway
    • Sareddy GR, Geeviman K, Ramulu C, Babu PP. The nonsteroidal anti-inflammatory drug celecoxib suppresses the growth and induces apoptosis of human glioblastoma cells via the NFkappaB pathway. J Neurooncol.2012: 106:99-109.
    • (2012) J Neurooncol , vol.106 , pp. 99-109
    • Sareddy, G.R.1    Geeviman, K.2    Ramulu, C.3    Babu, P.P.4
  • 89
    • 79952275286 scopus 로고    scopus 로고
    • Celecoxib and radioresistant glioblastoma-derived CD133+ cells: improvement in radiotherapeutic effects
    • Ma HI, Chiou SH, Hueng DY et al. Celecoxib and radioresistant glioblastoma-derived CD133+ cells: improvement in radiotherapeutic effects. Laboratory investigation. J Neurosurg. 2011; 114:651-662.
    • (2011) Laboratory investigation. J Neurosurg. , vol.114 , pp. 651-662
    • Ma, H.I.1    Chiou, S.H.2    Hueng, D.Y.3
  • 91
    • 75149117810 scopus 로고    scopus 로고
    • Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions
    • Forristal CE, Wright KL, Hanley NA, Oreffo RO, Houghton FD. Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions. Reproduction 2010; 139: 85-97.
    • (2010) Reproduction , vol.139 , pp. 85-97
    • Forristal, C.E.1    Wright, K.L.2    Hanley, N.A.3    Oreffo, R.O.4    Houghton, F.D.5
  • 92
    • 50649085287 scopus 로고    scopus 로고
    • Activation of hypoxic response in human embryonic stem cell-derived embryoid bodies
    • Cameron CM, Harding F, Hu WS, Kaufman DS. Activation of hypoxic response in human embryonic stem cell-derived embryoid bodies. Exp Biol Med (Maywood) 2008 Aug; 233: 1044-1057.
    • (2008) Exp Biol Med (Maywood) , vol.233 , pp. 1044-1057
    • Cameron, C.M.1    Harding, F.2    Hu, W.S.3    Kaufman, D.S.4
  • 93
    • 77951953778 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: from molecular mechanisms, redox regulation to implications in human health and disease
    • Cannito S, Novo E, di Bonzo LV, Busletta C, Colombatto S, Parola M. Epithelial-mesenchymal transition: from molecular mechanisms, redox regulation to implications in human health and disease. Antioxid Redox Signal. 2010; 12: 1383-1430.
    • (2010) Antioxid Redox Signal , vol.12 , pp. 1383-1430
    • Cannito, S.1    Novo, E.2    di Bonzo, L.V.3    Busletta, C.4    Colombatto, S.5    Parola, M.6
  • 96
    • 84859385707 scopus 로고    scopus 로고
    • Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma
    • Hu YL, Delay M, Jahangiri A, Molinaro AM, Rose SD, Carbonell WS, Aghi MK. Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma. Cancer Res 2012;72:1773-1783.
    • (2012) Cancer Res , vol.72 , pp. 1773-1783
    • Hu, Y.L.1    Delay, M.2    Jahangiri, A.3    Molinaro, A.M.4    Rose, S.D.5    Carbonell, W.S.6    Aghi, M.K.7
  • 97
    • 81955161113 scopus 로고    scopus 로고
    • [Anti-angiogenic strategies in glioblastoma]
    • Guillamo JS. [Anti-angiogenic strategies in glioblastoma]. Rev Neurol (Paris) 2011;167:662-667.
    • (2011) Rev Neurol (Paris) , vol.167 , pp. 662-667
    • Guillamo, J.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.