Hypoxia-inhibited dual-specificity phosphatase-2 expression in endometriotic cells regulates cyclooxygenase-2 expression

Journal of Pathology

Volumn 225, Issue 3, 2011, Pages 390-400

  Wu, Meng Hsing ^a   Lin, Shih Chieh ^a   Hsiao, Kuei Yang ^a   Tsai, Shaw Jenq ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

cyclooxygenase 2; dual specificity phosphatase; endometriosis; ERK; hypoxia

Indexed keywords

CYCLOOXYGENASE 2; DUAL SPECIFICITY PHOSPHATASE 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROSTAGLANDIN E2; PYRUVATE DEHYDROGENASE KINASE;

ADULT; ARTICLE; BINDING SITE; ENDOMETRIOSIS; ENDOMETRIUM CELL; FEMALE; HUMAN; HUMAN CELL; HYPOXIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STROMA CELL; UPREGULATION;

CELL HYPOXIA; CYCLOOXYGENASE 2; DNA METHYLATION; DOWN-REGULATION; DUAL SPECIFICITY PHOSPHATASE 2; ENDOMETRIOSIS; ENDOMETRIUM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTERLEUKIN-1BETA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RNA, MESSENGER; STROMAL CELLS; UP-REGULATION;

EID: 80054762435     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2963     Document Type: Article

References (33)

1. Simoens S, Hummelshoj L, D'Hooghe T,. Endometriosis: cost estimates and methodological perspective. Hum Reprod Update 2007; 13: 395-404. (Pubitemid 47062831)
2. Sampson JA,. Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol 1927; 14: 422-425.
3. Buchweitz O, Staebler A, Wulfing P, et al., COX-2 overexpression in peritoneal lesions is correlated with non-menstrual chronic pelvic pain. Eur J Obstet Gynecol Reprod Biol 2006; 124: 216-221. (Pubitemid 43143082)
4. Wu MH, Sun HS, Lin CC, et al., Distinct mechanisms regulate cyclooxygenase-1 and -2 in peritoneal macrophages of women with and without endometriosis. Mol Hum Reprod 2002; 8: 1103-1110. (Pubitemid 36032848)
5. Wu MH, Wang CA, Lin CC, et al., Distinct regulation of cyclooxygenase-2 by interleukin-1β in normal and endometriotic stromal cells. J Clin Endocrinol Metab 2005; 90: 286-295.
6. Tsai SJ, Wu MH, Lin CC, et al., Regulation of steroidogenic acute regulatory protein expression and progesterone production in endometriotic stromal cells. J Clin Endocrinol Metab 2001; 86: 5765-5773.
7. Sun HS, Hsiao KY, Hsu CC, et al., Transactivation of steroidogenic acute regulatory protein in human endometriotic stromal cells is mediated by the prostaglandin EP2 receptor. Endocrinology 2003; 144: 3934-3942. (Pubitemid 37088748)
8. Hsu CC, Lu CW, Huang BM, et al., Cyclic adenosine 3′,5′- monophosphate response element-binding protein and CCAAT/enhancer-binding protein mediate prostaglandin E2-induced steroidogenic acute regulatory protein expression in endometriotic stromal cells. Am J Pathol 2008; 173: 433-441.
9. Noble LS, Takayama K, Zeitoun KM, et al., Prostaglandin E2 stimulates aromatase expression in endometriosis-derived stromal cells. J Clin Endocrinol Metab 1997; 82: 600-606. (Pubitemid 27068636)
10. Chuang PC, Sun HS, Chen TM, et al., Prostaglandin E2 induces fibroblast growth factor 9 via EP3-dependent protein kinase Cδ and Elk-1 signaling. Mol Cell Biol 2006; 26: 8281-8292. (Pubitemid 44748564)
11. Laschke MW, Elitzsch A, Scheuer C, et al., Selective cyclo-oxygenase-2 inhibition induces regression of autologous endometrial grafts by down-regulation of vascular endothelial growth factor-mediated angiogenesis and stimulation of caspase-3-dependent apoptosis. Fertil Steril 2007; 87: 163-171. (Pubitemid 46013870)
12. Wu MH, Shoji Y, Wu MC, et al., Suppression of matrix metalloproteinase-9 by prostaglandin E(2) in peritoneal macrophage is associated with severity of endometriosis. Am J Pathol 2005; 167: 1061-1069. (Pubitemid 41416258)
13. Chuang PC, Lin YJ, Wu MH, et al., Inhibition of CD36-dependent phagocytosis by prostaglandin E2 contributes to the development of endometriosis. Am J Pathol 2010; 176: 850-860.
14. Wu MH, Lu CW, Chuang PC, et al., Prostaglandin E2: the master of endometriosis? Exp Biol Med (Maywood) 2010; 235: 668-677.
15. Carli C, Metz CN, Al-Abed Y, et al., Up-regulation of cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic cells by macrophage migration inhibitory factor: involvement of novel kinase signaling pathways. Endocrinology 2009; 150: 3128-3137.
16. Tamura M, Sebastian S, Yang S, et al., Interleukin-1β elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinases 1 and 2. J Clin Endocrinol Metab 2002; 87: 3263-3273. (Pubitemid 34816375)
17. Murk W, Atabekoglu CS, Cakmak H, et al., Extracellularly signal-regulated kinase activity in the human endometrium: possible roles in the pathogenesis of endometriosis. J Clin Endocrinol Metab 2008; 93: 3532-3540.
18. Wu Y, Kajdacsy-Balla A, Strawn E, et al., Transcriptional characterizations of differences between eutopic and ectopic endometrium. Endocrinology 2006; 147: 232-246. (Pubitemid 43004277)
19. Owens DM, Keyse SM,. Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases. Oncogene 2007; 26: 3203-3213. (Pubitemid 46763015)
20. Rohan PJ, Davis P, Moskaluk CA, et al., PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. Science 1993; 259: 1763-1766. (Pubitemid 23114665)
21. Zhang Q, Muller M, Chen CH, et al., New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding. J Mol Biol 2005; 354: 777-788. (Pubitemid 41735501)
22. Wing L-YC, Chuang P-C, Wu M-H, et al., Expression and mitogenic effect of fibroblast growth factor-9 in human endometriotic implant is regulated by aberrant production of estrogen. J Clin Endocrinol Metab 2003; 88: 5547-5554. (Pubitemid 37452768)
23. Chuang PC, Wu MH, Shoji Y, et al., Downregulation of CD36 results in reduced phagocytic ability of peritoneal macrophages of women with endometriosis. J Pathol 2009; 219: 232-241.
24. Lin SC, Chien CW, Lee JC, et al., Suppression of dual specificity phosphatase-2 by hypoxia increases chemoresistance and malignancy in human cancer cells. J Clin Invest 2011; 121: 1905-1916.
25. Wu MH, Chen KF, Lin SC, et al., Aberrant expression of leptin in human endometriotic stromal cells is induced by elevated levels of hypoxia inducible factor-1 α. Am J Pathol 2007; 170: 590-598.
26. Lang R, Hammer M, Mages J,. DUSP meet immunology: dual specificity MAPK phosphatases in control of the inflammatory response. J Immunol 2006; 177: 7497-7504. (Pubitemid 44846262)
27. Yin Y, Liu YX, Jin YJ, et al., PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression. Nature 2003; 422: 527-531. (Pubitemid 36433648)
28. Wu J, Jin YJ, Calaf GM, et al., PAC1 is a direct transcription target of E2F-1 in apoptotic signaling. Oncogene 2007; 26: 6526-6535. (Pubitemid 47530605)
29. Veillat V, Carli C, Metz CN, et al., Macrophage migration inhibitory factor elicits an angiogenic phenotype in human ectopic endometrial cells and triggers the production of major angiogenic factors via CD44, CD74, and MAPK signaling pathways. J Clin Endocrinol Metab 2010; 95: E403-412.
30. Ngo C, Nicco C, Leconte M, et al., Protein kinase inhibitors can control the progression of endometriosis in vitro and in vivo. J Pathol 2010; 222: 148-157.
31. Wu MH, Chuang PC, Chen SM, et al., Increased leptin expression in endometriosis cells is associated with endometrial stromal cell proliferation and leptin gene upregulation. Mol Hum Reprod 2002; 8: 456-464.
32. Richard DE, Berra E, Gothie E, et al., p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1. J Biol Chem 1999; 274: 32631-32637. (Pubitemid 129535289)
33. Bulun SE, Zeitoun KM, Takayama K, et al., Molecular basis for treating endometriosis with aromatase inhibitors. Hum Reprod Update 2000; 6: 413-418.