메뉴 건너뛰기




Volumn 26, Issue 6, 2012, Pages 554-561

Epigenetic mechanisms in the pathogenesis of diabetic foot ulcers

Author keywords

Diabetes; Diabetic complications; Foot ulcer; MicroRNA; Vascular endothelial cells

Indexed keywords

ACETYLATION; DIABETIC FOOT; ENDOTHELIUM CELL; EPIGENETICS; GLYCEMIC CONTROL; HISTONE MODIFICATION; HUMAN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN METHYLATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; REVIEW; WOUND HEALING IMPAIRMENT;

EID: 84868647173     PISSN: 10568727     EISSN: 1873460X     Source Type: Journal    
DOI: 10.1016/j.jdiacomp.2012.05.015     Document Type: Review
Times cited : (27)

References (97)
  • 1
    • 79959209876 scopus 로고    scopus 로고
    • Long-term administration of the histone deacetylase inhibitor vorinostat attenuates renal injury in experimental diabetes through an endothelial nitric oxide synthase-dependent mechanism
    • A. Advani, Q. Huang, K. Thai, S.L. Advani, K.E. White, D.J. Kelly, D.A. Yuen, K.A. Connelly, P.A. Marsden, and R.E. Gilbert Long-term administration of the histone deacetylase inhibitor vorinostat attenuates renal injury in experimental diabetes through an endothelial nitric oxide synthase-dependent mechanism The American Journal of Pathology 178 2011 2205 2214
    • (2011) The American Journal of Pathology , vol.178 , pp. 2205-2214
    • Advani, A.1    Huang, Q.2    Thai, K.3    Advani, S.L.4    White, K.E.5    Kelly, D.J.6    Yuen, D.A.7    Connelly, K.A.8    Marsden, P.A.9    Gilbert, R.E.10
  • 2
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • D.P. Bartel MicroRNAs: genomics, biogenesis, mechanism, and function Cell 116 2004 281 297
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 3
    • 12144284499 scopus 로고    scopus 로고
    • Reducing the incidence of foot ulceration and amputation in diabetes
    • C.L. Bartus, and D.J. Margolis Reducing the incidence of foot ulceration and amputation in diabetes Current Diabetes Reports 4 2004 413 418
    • (2004) Current Diabetes Reports , vol.4 , pp. 413-418
    • Bartus, C.L.1    Margolis, D.J.2
  • 4
    • 1442352339 scopus 로고    scopus 로고
    • Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: Peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach
    • H. Bays, L. Mandarino, and R.A. DeFronzo Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach The Journal of Clinical Endocrinology and Metabolism 89 2004 463 478
    • (2004) The Journal of Clinical Endocrinology and Metabolism , vol.89 , pp. 463-478
    • Bays, H.1    Mandarino, L.2    Defronzo, R.A.3
  • 8
    • 0036122494 scopus 로고    scopus 로고
    • Functional divergence between histone deacetylases in fission yeast by distinct cellular localization and in vivo specificity
    • P. Bjerling, R.A. Silverstein, G. Thon, A. Caudy, S. Grewal, and K. Ekwall Functional divergence between histone deacetylases in fission yeast by distinct cellular localization and in vivo specificity Molecular and Cellular Biology 22 2002 2170 2181
    • (2002) Molecular and Cellular Biology , vol.22 , pp. 2170-2181
    • Bjerling, P.1    Silverstein, R.A.2    Thon, G.3    Caudy, A.4    Grewal, S.5    Ekwall, K.6
  • 13
    • 0033595590 scopus 로고    scopus 로고
    • Nuclear factor kappaB activity is essential for matrix metalloproteinase-1 and -3 upregulation in rabbit dermal fibroblasts
    • M. Bond, A.H. Baker, and A.C. Newby Nuclear factor kappaB activity is essential for matrix metalloproteinase-1 and -3 upregulation in rabbit dermal fibroblasts Biochemical and Biophysical Research Communications 264 1999 561 567
    • (1999) Biochemical and Biophysical Research Communications , vol.264 , pp. 561-567
    • Bond, M.1    Baker, A.H.2    Newby, A.C.3
  • 14
  • 16
    • 20044376702 scopus 로고    scopus 로고
    • The pathobiology of diabetic complications: A unifying mechanism
    • M. Brownlee The pathobiology of diabetic complications: a unifying mechanism Diabetes 54 2005 1615 1625
    • (2005) Diabetes , vol.54 , pp. 1615-1625
    • Brownlee, M.1
  • 18
    • 9444296528 scopus 로고    scopus 로고
    • Hyperglycemia regulates hypoxia-inducible factor-1alpha protein stability and function
    • S.B. Catrina, K. Okamoto, T. Pereira, K. Brismar, and L. Poellinger Hyperglycemia regulates hypoxia-inducible factor-1alpha protein stability and function Diabetes 53 2004 3226 3232
    • (2004) Diabetes , vol.53 , pp. 3226-3232
    • Catrina, S.B.1    Okamoto, K.2    Pereira, T.3    Brismar, K.4    Poellinger, L.5
  • 20
    • 10944251346 scopus 로고    scopus 로고
    • The DP-1 transcription factor is required for keratinocyte growth and epidermal stratification
    • W.Y. Chang, D.M. Bryce, S.J. D'Souza, and L. Dagnino The DP-1 transcription factor is required for keratinocyte growth and epidermal stratification The Journal of Biological Chemistry 279 2004 51343 51353
    • (2004) The Journal of Biological Chemistry , vol.279 , pp. 51343-51353
    • Chang, W.Y.1    Bryce, D.M.2    D'Souza, S.J.3    Dagnino, L.4
  • 22
    • 27744547290 scopus 로고    scopus 로고
    • Maintenance and regulation of DNA methylation patterns in mammals
    • Z.X. Chen, and A.D. Riggs Maintenance and regulation of DNA methylation patterns in mammals Biochemistry and Cell Biology 83 2005 438 448
    • (2005) Biochemistry and Cell Biology , vol.83 , pp. 438-448
    • Chen, Z.X.1    Riggs, A.D.2
  • 27
    • 0023641117 scopus 로고
    • Progression of incipient diabetic retinopathy during good glycemic control
    • R.L. Engerman, and T.S. Kern Progression of incipient diabetic retinopathy during good glycemic control Diabetes 36 1987 808 812
    • (1987) Diabetes , vol.36 , pp. 808-812
    • Engerman, R.L.1    Kern, T.S.2
  • 28
    • 80755152827 scopus 로고    scopus 로고
    • MiR-146a-mediated extracellular matrix protein production in chronic diabetes complications
    • B. Feng, S. Chen, K. McArthur, Y. Wu, S. Sen, Q. Ding, R.D. Feldman, and S. Chakrabarti miR-146a-mediated extracellular matrix protein production in chronic diabetes complications Diabetes 60 2011 2975 2984
    • (2011) Diabetes , vol.60 , pp. 2975-2984
    • Feng, B.1    Chen, S.2    McArthur, K.3    Wu, Y.4    Sen, S.5    Ding, Q.6    Feldman, R.D.7    Chakrabarti, S.8
  • 29
    • 78349297565 scopus 로고    scopus 로고
    • Oxidative stress and diabetic complications
    • F. Giacco, and M. Brownlee Oxidative stress and diabetic complications Circulation Research 107 2010 1058 1070
    • (2010) Circulation Research , vol.107 , pp. 1058-1070
    • Giacco, F.1    Brownlee, M.2
  • 31
    • 0035933864 scopus 로고    scopus 로고
    • Transforming growth factor-beta- and tumor necrosis factor-alpha-mediated induction and proteolytic activation of MMP-9 in human skin
    • Y.P. Han, T.L. Tuan, M. Hughes, H. Wu, and W.L. Garner Transforming growth factor-beta- and tumor necrosis factor-alpha-mediated induction and proteolytic activation of MMP-9 in human skin The Journal of Biological Chemistry 276 2001 22341 22350
    • (2001) The Journal of Biological Chemistry , vol.276 , pp. 22341-22350
    • Han, Y.P.1    Tuan, T.L.2    Hughes, M.3    Wu, H.4    Garner, W.L.5
  • 32
    • 0035156633 scopus 로고    scopus 로고
    • TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP
    • Y.P. Han, T.L. Tuan, H. Wu, M. Hughes, and W.L. Garner TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP Journal of Cell Science 114 2001 131 139
    • (2001) Journal of Cell Science , vol.114 , pp. 131-139
    • Han, Y.P.1    Tuan, T.L.2    Wu, H.3    Hughes, M.4    Garner, W.L.5
  • 33
    • 79957463780 scopus 로고    scopus 로고
    • Epigenetic modifications: Basic mechanisms and role in cardiovascular disease
    • D.E. Handy, R. Castro, and J. Loscalzo Epigenetic modifications: basic mechanisms and role in cardiovascular disease Circulation 123 2011 2145 2156
    • (2011) Circulation , vol.123 , pp. 2145-2156
    • Handy, D.E.1    Castro, R.2    Loscalzo, J.3
  • 37
    • 80052102044 scopus 로고    scopus 로고
    • Diabetes complications: The microRNA perspective
    • P. Kantharidis, B. Wang, R.M. Carew, and H.Y. Lan Diabetes complications: the microRNA perspective Diabetes 60 2011 1832 1837
    • (2011) Diabetes , vol.60 , pp. 1832-1837
    • Kantharidis, P.1    Wang, B.2    Carew, R.M.3    Lan, H.Y.4
  • 39
    • 0035985832 scopus 로고    scopus 로고
    • Influence of transforming growth factor-alpha on expression of matrix metalloproteinase-2, matrix metalloproteinase-9, and epidermal growth factor receptor gene in the mouse blastocysts
    • J.H. Kim, S.H. Hong, H.Y. Nah, J.Y. Lee, H.D. Chae, C.H. Kim, B.M. Kang, and I.H. Bae Influence of transforming growth factor-alpha on expression of matrix metalloproteinase-2, matrix metalloproteinase-9, and epidermal growth factor receptor gene in the mouse blastocysts Journal of Assisted Reproduction and Genetics 19 2002 232 239
    • (2002) Journal of Assisted Reproduction and Genetics , vol.19 , pp. 232-239
    • Kim, J.H.1    Hong, S.H.2    Nah, H.Y.3    Lee, J.Y.4    Chae, H.D.5    Kim, C.H.6    Kang, B.M.7    Bae, I.H.8
  • 41
    • 0346969838 scopus 로고    scopus 로고
    • Acute cutaneous barrier disruption activates epidermal p44/42 and p38 mitogen-activated protein kinases in human and hairless guinea pig skin
    • H. Kobayashi, S. Aiba, Y. Yoshino, and H. Tagami Acute cutaneous barrier disruption activates epidermal p44/42 and p38 mitogen-activated protein kinases in human and hairless guinea pig skin Experimental Dermatology 12 2003 734 746
    • (2003) Experimental Dermatology , vol.12 , pp. 734-746
    • Kobayashi, H.1    Aiba, S.2    Yoshino, Y.3    Tagami, H.4
  • 42
    • 79960108626 scopus 로고    scopus 로고
    • The methylation hypothesis: Do epigenetic chromatin modifications play a role in epileptogenesis?
    • K. Kobow, and I. Blumcke The methylation hypothesis: do epigenetic chromatin modifications play a role in epileptogenesis? Epilepsia 52 Suppl. 4 2011 15 19
    • (2011) Epilepsia , vol.52 , Issue.SUPPL. 4 , pp. 15-19
    • Kobow, K.1    Blumcke, I.2
  • 43
    • 34447632218 scopus 로고    scopus 로고
    • Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis
    • A. Kuehbacher, C. Urbich, A.M. Zeiher, and S. Dimmeler Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis Circulation Research 101 2007 59 68
    • (2007) Circulation Research , vol.101 , pp. 59-68
    • Kuehbacher, A.1    Urbich, C.2    Zeiher, A.M.3    Dimmeler, S.4
  • 46
    • 55549140173 scopus 로고    scopus 로고
    • Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation
    • Y. Li, M.A. Reddy, F. Miao, N. Shanmugam, J.K. Yee, D. Hawkins, B. Ren, and R. Natarajan Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation The Journal of Biological Chemistry 283 2008 26771 26781
    • (2008) The Journal of Biological Chemistry , vol.283 , pp. 26771-26781
    • Li, Y.1    Reddy, M.A.2    Miao, F.3    Shanmugam, N.4    Yee, J.K.5    Hawkins, D.6    Ren, B.7    Natarajan, R.8
  • 48
    • 64549119604 scopus 로고    scopus 로고
    • Increased matrix metalloproteinase-9 predicts poor wound healing in diabetic foot ulcers
    • Y. Liu, D. Min, T. Bolton, V. Nube, S.M. Twigg, D.K. Yue, and S.V. McLennan Increased matrix metalloproteinase-9 predicts poor wound healing in diabetic foot ulcers Diabetes Care 32 2009 117 119
    • (2009) Diabetes Care , vol.32 , pp. 117-119
    • Liu, Y.1    Min, D.2    Bolton, T.3    Nube, V.4    Twigg, S.M.5    Yue, D.K.6    McLennan, S.V.7
  • 49
    • 0032882084 scopus 로고    scopus 로고
    • Low phagocytic activity of resident peritoneal macrophages in diabetic mice: Relevance to the formation of advanced glycation end products
    • B.F. Liu, S. Miyata, H. Kojima, A. Uriuhara, H. Kusunoki, K. Suzuki, and M. Kasuga Low phagocytic activity of resident peritoneal macrophages in diabetic mice: relevance to the formation of advanced glycation end products Diabetes 48 1999 2074 2082
    • (1999) Diabetes , vol.48 , pp. 2074-2082
    • Liu, B.F.1    Miyata, S.2    Kojima, H.3    Uriuhara, A.4    Kusunoki, H.5    Suzuki, K.6    Kasuga, M.7
  • 53
    • 0027768570 scopus 로고
    • Cytokine regulation of metalloproteinase gene expression
    • A. Mauviel Cytokine regulation of metalloproteinase gene expression Journal of Cellular Biochemistry 53 1993 288 295
    • (1993) Journal of Cellular Biochemistry , vol.53 , pp. 288-295
    • Mauviel, A.1
  • 54
    • 0029916877 scopus 로고    scopus 로고
    • Cell-specific induction of distinct oncogenes of the Jun family is responsible for differential regulation of collagenase gene expression by transforming growth factor-beta in fibroblasts and keratinocytes
    • A. Mauviel, K.Y. Chung, A. Agarwal, K. Tamai, and J. Uitto Cell-specific induction of distinct oncogenes of the Jun family is responsible for differential regulation of collagenase gene expression by transforming growth factor-beta in fibroblasts and keratinocytes The Journal of Biological Chemistry 271 1996 10917 10923
    • (1996) The Journal of Biological Chemistry , vol.271 , pp. 10917-10923
    • Mauviel, A.1    Chung, K.Y.2    Agarwal, A.3    Tamai, K.4    Uitto, J.5
  • 55
    • 0031873178 scopus 로고    scopus 로고
    • Epidermal growth factor (EGF)- and scatter factor/hepatocyte growth factor (SF/HGF)-mediated keratinocyte migration is coincident with induction of matrix metalloproteinase (MMP)-9
    • L.J. McCawley, P. O'Brien, and L.G. Hudson Epidermal growth factor (EGF)- and scatter factor/hepatocyte growth factor (SF/HGF)-mediated keratinocyte migration is coincident with induction of matrix metalloproteinase (MMP)-9 Journal of Cellular Physiology 176 1998 255 265
    • (1998) Journal of Cellular Physiology , vol.176 , pp. 255-265
    • McCawley, L.J.1    O'Brien, P.2    Hudson, L.G.3
  • 56
    • 80053300866 scopus 로고    scopus 로고
    • Dysregulation of monocyte/macrophage phenotype in wounds of diabetic mice
    • R. Mirza, and T.J. Koh Dysregulation of monocyte/macrophage phenotype in wounds of diabetic mice Cytokine 2011
    • (2011) Cytokine
    • Mirza, R.1    Koh, T.J.2
  • 57
    • 33845709215 scopus 로고    scopus 로고
    • Multiple mechanisms are involved in regulating the expression of the developmental timing regulator lin-28 in Caenorhabditis elegans
    • K. Morita, and M. Han Multiple mechanisms are involved in regulating the expression of the developmental timing regulator lin-28 in Caenorhabditis elegans The EMBO Journal 25 2006 5794 5804
    • (2006) The EMBO Journal , vol.25 , pp. 5794-5804
    • Morita, K.1    Han, M.2
  • 59
    • 41749096554 scopus 로고    scopus 로고
    • Matrix metalloproteinases and diabetic foot ulcers: The ratio of MMP-1 to TIMP-1 is a predictor of wound healing
    • M. Muller, C. Trocme, B. Lardy, F. Morel, S. Halimi, and P.Y. Benhamou Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healing Diabetic Medicine 25 2008 419 426
    • (2008) Diabetic Medicine , vol.25 , pp. 419-426
    • Muller, M.1    Trocme, C.2    Lardy, B.3    Morel, F.4    Halimi, S.5    Benhamou, P.Y.6
  • 61
    • 0035212224 scopus 로고    scopus 로고
    • A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: Identification of new loci with evidence of interactions
    • J. Nerup, and F. Pociot A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: identification of new loci with evidence of interactions The American Journal of Human Genetics 69 2001 1301 1313
    • (2001) The American Journal of Human Genetics , vol.69 , pp. 1301-1313
    • Nerup, J.1    Pociot, F.2
  • 67
    • 80052100218 scopus 로고    scopus 로고
    • Epigenetics and diabetes risk: Not just for imprinting anymore?
    • T.I. Pollin Epigenetics and diabetes risk: not just for imprinting anymore? Diabetes 60 2011 1859 1860
    • (2011) Diabetes , vol.60 , pp. 1859-1860
    • Pollin, T.I.1
  • 68
    • 0026285191 scopus 로고
    • Collagenase production at the border of granulation tissue in a healing wound: Macrophage and mesenchymal collagenase production in vivo
    • B.H. Porras-Reyes, H.C. Blair, J.J. Jeffrey, and T.A. Mustoe Collagenase production at the border of granulation tissue in a healing wound: macrophage and mesenchymal collagenase production in vivo Connective Tissue Research 27 1991 63 71
    • (1991) Connective Tissue Research , vol.27 , pp. 63-71
    • Porras-Reyes, B.H.1    Blair, H.C.2    Jeffrey, J.J.3    Mustoe, T.A.4
  • 70
    • 79953326953 scopus 로고    scopus 로고
    • DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation
    • Y. Qian, Y.S. Jung, and X. Chen DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation The Journal of Biological Chemistry 286 2011 12033 12041
    • (2011) The Journal of Biological Chemistry , vol.286 , pp. 12033-12041
    • Qian, Y.1    Jung, Y.S.2    Chen, X.3
  • 73
    • 79960104144 scopus 로고    scopus 로고
    • MicroRNAs in development and disease
    • D. Sayed, and M. Abdellatif MicroRNAs in development and disease Physiological Reviews 91 2010 827 887
    • (2010) Physiological Reviews , vol.91 , pp. 827-887
    • Sayed, D.1    Abdellatif, M.2
  • 76
    • 40749106180 scopus 로고    scopus 로고
    • Evidence for the involvement of miRNA in redox regulated angiogenic response of human microvascular endothelial cells
    • S. Shilo, S. Roy, S. Khanna, and C.K. Sen Evidence for the involvement of miRNA in redox regulated angiogenic response of human microvascular endothelial cells Arteriosclerosis, Thrombosis, and Vascular Biology 28 2008 471 477
    • (2008) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.28 , pp. 471-477
    • Shilo, S.1    Roy, S.2    Khanna, S.3    Sen, C.K.4
  • 78
    • 0027761345 scopus 로고
    • Localization of mRNAs representing collagenase and TIMP in sections of healing human burn wounds
    • G.P. Stricklin, L. Li, V. Jancic, B.A. Wenczak, and L.B. Nanney Localization of mRNAs representing collagenase and TIMP in sections of healing human burn wounds The American Journal of Pathology 143 1993 1657 1666
    • (1993) The American Journal of Pathology , vol.143 , pp. 1657-1666
    • Stricklin, G.P.1    Li, L.2    Jancic, V.3    Wenczak, B.A.4    Nanney, L.B.5
  • 79
    • 73949113629 scopus 로고    scopus 로고
    • Cutting edge: TNF-induced microRNAs regulate TNF-induced expression of E-selectin and intercellular adhesion molecule-1 on human endothelial cells: Feedback control of inflammation
    • Y. Suarez, C. Wang, T.D. Manes, and J.S. Pober Cutting edge: TNF-induced microRNAs regulate TNF-induced expression of E-selectin and intercellular adhesion molecule-1 on human endothelial cells: feedback control of inflammation The Journal of Immunology 184 2010 21 25
    • (2010) The Journal of Immunology , vol.184 , pp. 21-25
    • Suarez, Y.1    Wang, C.2    Manes, T.D.3    Pober, J.S.4
  • 80
    • 0142087597 scopus 로고    scopus 로고
    • Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: The Epidemiology of Diabetes Interventions and Complications (EDIC) study
    • Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: the Epidemiology of Diabetes Interventions and Complications (EDIC) study Journal of the American Medical Association 290 2003 2159 2167
    • (2003) Journal of the American Medical Association , vol.290 , pp. 2159-2167
  • 82
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group The New England Journal of Medicine 329 1993 977 986
    • (1993) The New England Journal of Medicine , vol.329 , pp. 977-986
  • 83
    • 77952061606 scopus 로고    scopus 로고
    • Experimental intrauterine growth restriction induces alterations in DNA methylation and gene expression in pancreatic islets of rats
    • R.F. Thompson, M.J. Fazzari, H. Niu, N. Barzilai, R.A. Simmons, and J.M. Greally Experimental intrauterine growth restriction induces alterations in DNA methylation and gene expression in pancreatic islets of rats The Journal of Biological Chemistry 285 2010 15111 15118
    • (2010) The Journal of Biological Chemistry , vol.285 , pp. 15111-15118
    • Thompson, R.F.1    Fazzari, M.J.2    Niu, H.3    Barzilai, N.4    Simmons, R.A.5    Greally, J.M.6
  • 85
    • 0023726231 scopus 로고
    • Deactivation of macrophages by transforming growth factor-beta
    • S. Tsunawaki, M. Sporn, A. Ding, and C. Nathan Deactivation of macrophages by transforming growth factor-beta Nature 334 1988 260 262
    • (1988) Nature , vol.334 , pp. 260-262
    • Tsunawaki, S.1    Sporn, M.2    Ding, A.3    Nathan, C.4
  • 87
    • 78049294740 scopus 로고    scopus 로고
    • Enhanced levels of microRNA-125b in vascular smooth muscle cells of diabetic db/db mice lead to increased inflammatory gene expression by targeting the histone methyltransferase Suv39h1
    • L.M. Villeneuve, M. Kato, M.A. Reddy, M. Wang, L. Lanting, and R. Natarajan Enhanced levels of microRNA-125b in vascular smooth muscle cells of diabetic db/db mice lead to increased inflammatory gene expression by targeting the histone methyltransferase Suv39h1 Diabetes 59 2010 2904 2915
    • (2010) Diabetes , vol.59 , pp. 2904-2915
    • Villeneuve, L.M.1    Kato, M.2    Reddy, M.A.3    Wang, M.4    Lanting, L.5    Natarajan, R.6
  • 88
    • 0035063182 scopus 로고    scopus 로고
    • Transcriptional control at regulatory checkpoints by histone deacetylases: Molecular connections between cancer and chromatin
    • P.A. Wade Transcriptional control at regulatory checkpoints by histone deacetylases: molecular connections between cancer and chromatin Human Molecular Genetics 10 2001 693 698
    • (2001) Human Molecular Genetics , vol.10 , pp. 693-698
    • Wade, P.A.1
  • 89
    • 2442684104 scopus 로고    scopus 로고
    • An evaluation of new criteria for CpG islands in the human genome as gene markers
    • Y. Wang, and F.C. Leung An evaluation of new criteria for CpG islands in the human genome as gene markers Bioinformatics 20 2004 1170 1177
    • (2004) Bioinformatics , vol.20 , pp. 1170-1177
    • Wang, Y.1    Leung, F.C.2
  • 91
    • 59049099131 scopus 로고    scopus 로고
    • When wound healing goes awry. A review of normal and abnormal wound healing, scar pathophysiology, and therapeutics
    • S.A. Watkins, and J.H. Zippin When wound healing goes awry. A review of normal and abnormal wound healing, scar pathophysiology, and therapeutics Journal of Drugs in Dermatology 7 2008 997 1005
    • (2008) Journal of Drugs in Dermatology , vol.7 , pp. 997-1005
    • Watkins, S.A.1    Zippin, J.H.2
  • 95
    • 0032530673 scopus 로고    scopus 로고
    • Differential regulation of monocyte matrix metalloproteinase and TIMP-1 production by TNF-alpha, granulocyte-macrophage CSF, and IL-1 beta through prostaglandin-dependent and -independent mechanisms
    • Y. Zhang, K. McCluskey, K. Fujii, and L.M. Wahl Differential regulation of monocyte matrix metalloproteinase and TIMP-1 production by TNF-alpha, granulocyte-macrophage CSF, and IL-1 beta through prostaglandin-dependent and -independent mechanisms The Journal of Immunology 161 1998 3071 3076
    • (1998) The Journal of Immunology , vol.161 , pp. 3071-3076
    • Zhang, Y.1    McCluskey, K.2    Fujii, K.3    Wahl, L.M.4
  • 97
    • 79953183375 scopus 로고    scopus 로고
    • Epigenetic changes in mitochondrial superoxide dismutase in the retina and the development of diabetic retinopathy
    • Q. Zhong, and R.A. Kowluru Epigenetic changes in mitochondrial superoxide dismutase in the retina and the development of diabetic retinopathy Diabetes 60 2011 1304 1313
    • (2011) Diabetes , vol.60 , pp. 1304-1313
    • Zhong, Q.1    Kowluru, R.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.