Mechanisms and role of microRNA deregulation in cancer onset and progression

Genetics and Molecular Biology

Volumn 34, Issue 3, 2011, Pages 363-370

  Palmero, Edenir Inês ^a   de Campos, Silvana Gisele P ^a   Campos, Marcelo ^a   de Souza, Naiara C Nogueira ^a   Guerreiro, Ismael Dale C ^a,b   Carvalho, Andre L ^a   Marques, Marcia Maria C ^a  

^a BARRETOS CANCER HOSPITAL   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Cancer; Epigenetic alteration; Genetic alteration; MicroRNA; Therapeutic application

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CHOLESTEROL; DNA DIRECTED RNA POLYMERASE III; LIPOSOME; MICRORNA; MICRORNA 21; PLASMID VECTOR; RNA POLYMERASE II; SHORT HAIRPIN RNA; SINGLE STRANDED RNA; SMALL INTERFERING RNA; VIRUS VECTOR;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; APOPTOSIS; BASE PAIRING; CANCER GENE THERAPY; CANCER GROWTH; CANCER INHIBITION; CANCER RISK; CARCINOGENESIS; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL INVASION; CELL STRESS; DRUG BINDING SITE; EPIGENETICS; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC ASSOCIATION; HUMAN; MALIGNANT NEOPLASTIC DISEASE; MOLECULAR GENETICS; NONHUMAN; NUCLEOTIDE BINDING SITE; PROTEIN LOCALIZATION; REVIEW; RNA INTERFERENCE; RNA STABILITY; SINGLE NUCLEOTIDE POLYMORPHISM; VIRAL GENE DELIVERY SYSTEM;

EID: 80051750488     PISSN: 14154757     EISSN: 16784685     Source Type: Journal    
DOI: 10.1590/S1415-47572011000300001     Document Type: Review

References (49)

1. Ambros V (2003) MicroRNA pathways in flies and worms: growth, death, fat, stress and timming. Cell 13:673-6
2. Arndt GM, Dossey L, Cullen LM, Lai A, Druker R, Eisbacher M, Zhang C, Tran N, Fan H, Hetzlaff K, et al. (2009) Characterization of global microRNA expression reveals oncogenic potential of miR-145 in metastatic colorectal cancer. BMC Cancer 20:374-391
3. Bandres E, Agirre X, Bitarte N, Ramirez N, Zarate R, Roman-Gomez J, Prosper F and Garcia-Foncillas J (2009) Epigenetic regulation of microRNA expression in colorectal cancer. Int J Cancer 125:2737-2743
4. Bartel D (2004) MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116:281-297
5. Bijsterbosch MK, Rump ET, De Vrueh RL, Dorland R, van Veghel R, Tivel KL, Biessen EA, van Berkel TJ and Manoharan M (2000) Modulation of plasma protein binding and in vivo liver cell uptake of phosphorothioate oligodeoxynucleotides by cholesterol conjugation. Nucleic Acids Res 28:2717-2725
6. Blenkiron C and Miska EA (2007) miRNAs in cancer: approaches, aetiology, diagnostics and therapy. Hum Mol Genet 1:106-113
7. Brown BD and Naldini L (2009) Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications. Nat Rev Genet 10:578-585
8. Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, et al. (2002) Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 99:15524-15529
9. Calin GA, Liu CG, Sevignani C, Ferracin M, Felli N, Dumitru CD, Shimizu M, Cimmino A, Zupu S, Dono M, et al. (2004a) MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. Proc Natl Acad Sci USA 101:11755-11760
10. Calin GA, Sevignani C, Dumitru CD, Hyslop T, Noch E, Yendamuri S, Shimizu M, Rattan S, Bullrich F, Negrini M, et al. (2004b) Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 101:2999-3004
11. Calin GA, Cimmino A, Fabbri M, Ferracin M, Wojcik SE, Shimizu M, Taccioli C, Zanesi N, Garzon R, Ageilan RI, et al. (2008) MiR-15a and miR-16-1 cluster functions in human leukemia. Proc Natl Acad Sci USA 105:5166-5171
12. Chan JA, Krichevsky AM and Kosik KS (2005) MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 65:6029-6033
13. Chiosea S, Jelezcova E, Chandran U, Acquafondata M, McHale T, Sobol RW and Dhir H (2009) Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma. Am J Pathol 169:1812-1820
14. Christensen BC, Moyer BJ, Avissar M, Ouellet LG, Plaza SL, McClean MD, Marsit CJ and Kelsey KT (2009) A let-7 microRNA-binding site polymorphism in the KRAS 3' UTR is associated with reduced survival in oral cancers. Carcinogenesis 30:1003-1007
15. Duan R and Pak C JP (2007) Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNA. Hum Mol Genet 16:1124-1131
16. Dykxhoorn DM and Lieberman J (2006) Running interference: Prospects and obstacles to using small interfering RNAs as small molecule drugs. Annu Rev Biomed Eng 8:377-402
17. Ebert MS, Neilson JR and Sharp PA (2007) MicroRNA sponges: Competitive inhibitors of small RNAs in mammalian cells. Nat Methods 4:721-726
18. Esteller M (2008) Epigenetics in cancer. N Engl J Med 358:1148-1159
19. Foekens JA, Sieuwerts AM, Smid M, Look MP, de Weerd V, Boersma AWM, Klijn JG, Wiemer EA and Martens JW (2008) Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer. Proc Natl Acad Sci USA 105:13021-13026
20. Garofalo Mand Croce CM (2010) microRNAs: Master regulators as potential therapeutics in cancer. Annu Rev Pharmacol Toxicol 51:25-43
21. He L, Thomson JM, Hemann MT, Hernando-Monge E, Mu D, Goodson S, Powers S, Cardon-Cardo S, Lowe SW, Hannon GJ, et al. (2005) A microRNA polycistron as a potential human oncogene. Nature 435:828-833
22. Hoffman AE, Zheng T, Yi C, Leaderer D, Weidhaas J, Slack F, Zhang Y, Paranjape T and Zhu Y (2009) microRNA miR-196a-2 and breast cancer: a genetic and epigenetic association study and functional analysis. Cancer Res 69:5970-5977
23. Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reinert KL, Brown D and Slack FJ (2005) RAS is regulated by the let-7 microRNA family. Cell 120:635-647
24. Krützfeldt J, Rajewsky N, Braich R, Rajeev KG, Tuschl T, Manoharan M and Stoffel M (2005) Silencing of microRNAs in vivo with 'antagomirs'. Nature 438:685-689
25. Landi D, Gemignani F, Naccarati A, Pardini B, Vodicka P, Vodickova L, Novotny J, Forsti A, Hemmink K, Canzian F, et al. (2008) Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer. Carcinogenesis 29:579-584
26. Lodygin D, Tarasov V, Epanchintsev A, Berking C, Knyazeva T, Körner H, Knyazev P, Diebold J and Hermeking H (2008) Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer. Cell Cycle 7:2591-2600
27. Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mark RH, Ferrnando AA, et al. (2005) MicroRNA expression profiles classify human cancers. Nature 435:834-838
28. Lu J and Tsoukars A (2009) Imaging individual microRNAs in single mammalian cells in situ. Nucleic Acids Res 37:e100.
29. Ma L, Teruya-Feldstein J and Weinberg RA (2007) Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449:682-688
30. Medina PP and Slack FJ (2008) MicroRNAs and cancer: An overview. Cell Cycle 7:2485-2492
31. Miyoshi K, Miyoshi T and Siomi H (2010) Many ways to generate microRNA-like small RNAs: Non-canonical pathways for microRNA production. Mol Genet Genomics 284:95-103
32. Newman MA, Thomson JM and Hammond SM (2008) Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing. RNA 14:1539-1549
33. O'Donnell KA, Wentzel EA, Zeller KI, Dang CV and Mendell JT (2005) c-Myc-regulated microRNAs modulate E2F1 expression. Nature 435:839-843
34. Qi L, Bart J, Tan LP, Platteel I, Sluis TVD, Huitema S, Harms G, Ful L, Hollema H and Berg A (2009) Expression of miR-21 and its targets (PTEN, PDCD4, TM1) in flat epithelial atypia of the breast in relation to ductal carcinoma in situ and invasive carcinoma. BMC Cancer 9:163-171
35. Saito Y, Liang G, Egger G, Friedman JM, Chuang JC, Coetzee GA and Jones PA (2006) Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 9:435-443
36. Scott GK, Mattie MD, Berger CE, Benz SC and Benz CC (2006) Rapid alteration of microRNA levels by histone deacetylase inhibition. Cancer Res 66:1277-1281
37. Si M, Zhu S, Wu H, Lu Z, Wu F and Mo Y (2007) miR-21-mediated tumor growth. Oncogene 26:2799-2803
38. Soifer HS, Rossi JJ and Saetrom P (2007) MicroRNAs in disease and potential therapeutic applications. Mol Ther 15:2070-2079
39. Soutschek J, Akinc A, Bramlage B, Charisse K, Constien R, Donoghue M, Elbashir S, Geick A, Hadwiger P, Harborth J, et al. (2004) Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432:173-178
40. Sun G, Yan J, Noltner K, Feng J, Li H, Sarkis DA, Sommer SS and Rossi JJ (2009) SNPs in human miRNA genes affect biogenesis and function. RNA 15:1640-1651
41. Tchatchou S, Jung A, Hemminki K, Sutter C, Wappenschmidt B, Bugert P, Weber BH, Niederacher D, Arnold N and Varon-Mateeva R (2009) A variant affecting a putative miRNA target site in estrogen receptor (ESR) 1 is associated with breast cancer risk in premenopausal women. Carcinogenesis 30:59-64
42. Trang P, Weidhaas JB and Slack FJ (2008) MicroRNAs as potential cancer therapeutics. Oncogene 2:S52-S57.
43. Ueda R, Kohanbash G, Sasaki K, Fujita M, Zhu X, Kastenhuber ER, McDonald HA, Potter DM, Hamiltom RL and Lotze MT (2009) Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1. Proc Natl Acad Sci USA 106:10746-10751
44. Vandenboom II TG, Li Y, Philip PA and Sarkar FH (2008) MicroRNA and Cancer: Tiny molecules with major implications. Curr Genomics 9:97-109
45. Viswanathan SR, Powers JT, Einhorn W, Hoshida Y, Ng TL, Toffanin S, O'Sullivan M, Lu J, Philips LA and Lockhart VL (2009) Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet 2009 41:843-848
46. Volinia S, Calin GA, Liu C, Ambs S, Cimmino A, Petrocca F, Visone R, Iorio M, Roldo C, Ferracin M, et al. (2006) A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 103:2257-2261
47. Yang H, Dinney CP, Ye Y, Zhu Y, Grossman HB and Wu X (2008) Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer. Cancer Res 68:2530-2537
48. Zhang X, Chen J, Radcliffe T, Lebrun DP, Tron VA and Feilotter H (2008) An array-based analysis of microRNA expression comparing matched frozen and formalin-fixed paraffinembedded human tissue samples. J Mol Diagn 10:513-519
49. Zhu S, Wu H, Wu F, Nie D, Sheng S and Mo Y (2008) Micro-RNA-21 targets tumor suppressor genes in invasion and metastasis. Cell Res 18:350-359.