Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 1, 2006, Pages 218-223

  Nascimento, N R F ^a,b   Lessa, L M A ^a   Kerntopf, M R ^b   Sousa, C M ^d   Alves, R S ^d   Queiroz, M G R ^d   Price, J ^c   Heimark, D B ^c   Larner, J ^c   Du, X ^e   Brownlee, M ^e   Gow, A ^f   Davis, C ^f   Fonteles, M C ^a,b  

^a STATE UNIVERSITY OF CEARÁ   (Brazil)

^b Instituto de Biomedicina IBIMED   (Brazil)

^c Allomed Pharmaceuticals   (United States)

^d FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^e ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

D chiro inositol; Diabetes; Insulin; Mimetic; NO

Indexed keywords

ACETYLCHOLINE; ADVANCED GLYCATION END PRODUCT; DIBUTYRYL INOSITOL; FERRIC ION; GLUCOSE; HEXOSAMINE; INDOMETACIN; INOSITOL; INSULIN; MONOCLONAL ANTIBODY; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; PINITOL; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; SODIUM NITRATE; SUPEROXIDE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; VASODILATOR AGENT; XANTHINE; XANTHINE OXIDASE;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DIABETES MELLITUS; DOSE RESPONSE; ELECTROSTIMULATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; MESENTERIC ARTERY; NONHUMAN; PENIS; PRIORITY JOURNAL; RABBIT; RAT; VASCULAR DISEASE; VASCULAR ENDOTHELIUM; VASCULAR RING;

ANIMALS; AORTA; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; HYPERGLYCEMIA; HYPERTRIGLYCERIDEMIA; INOSITOL PHOSPHATES; MUSCLE CONTRACTION; NITRIC OXIDE; PROTEIN KINASE C; RABBITS; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 30444434037     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0509779103     Document Type: Article

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