메뉴 건너뛰기




Volumn 122, Issue 18, 2009, Pages 3303-3311

VEGFR2-PLCγ1 axis is essential for endothelial specification of VEGFR2+ vascular progenitor cells

Author keywords

Embryonic stem cells; Endothelial differentiation; PLC 1; VEGFR2

Indexed keywords

PHOSPHOLIPASE C GAMMA1; TYROSINE; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3; HYBRID PROTEIN; MUTANT PROTEIN; PHENYLALANINE; PHOSPHOLIPASE C GAMMA; PHOSPHOTYROSINE;

EID: 70350351129     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.049908     Document Type: Article
Times cited : (41)

References (38)
  • 2
    • 30744432619 scopus 로고    scopus 로고
    • Endothelial cells and VEGF in vascular development
    • Coultas, L., Chawengsaksophak, K. and Rossant, J. (2005). Endothelial cells and VEGF in vascular development. Nature 438, 937-945.
    • (2005) Nature , vol.438 , pp. 937-945
    • Coultas, L.1    Chawengsaksophak, K.2    Rossant, J.3
  • 3
    • 0035947584 scopus 로고    scopus 로고
    • Identification of tyrosine residues in vascular endothelial growth factor receptor-2/FLK-1 involved in activation of phosphatidylinositol 3-kinase and cell proliferation
    • Dayanir, V., Meyer, R. D., Lashkari, K. and Rahimi, N. (2001). Identification of tyrosine residues in vascular endothelial growth factor receptor-2/FLK-1 involved in activation of phosphatidylinositol 3-kinase and cell proliferation. J. Biol. Chem. 276, 17686-17692.
    • (2001) J. Biol. Chem , vol.276 , pp. 17686-17692
    • Dayanir, V.1    Meyer, R.D.2    Lashkari, K.3    Rahimi, N.4
  • 4
    • 0033602091 scopus 로고    scopus 로고
    • Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization
    • Dougher, M. and Terman, B. I. (1999). Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization. Oncogene 18, 1619-1627.
    • (1999) Oncogene , vol.18 , pp. 1619-1627
    • Dougher, M.1    Terman, B.I.2
  • 6
    • 0033522927 scopus 로고    scopus 로고
    • Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner
    • Fujio, Y. and Walsh, K. (1999). Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner. J. Biol. Chem. 274, 16349-16354.
    • (1999) J. Biol. Chem , vol.274 , pp. 16349-16354
    • Fujio, Y.1    Walsh, K.2
  • 7
    • 0029773758 scopus 로고    scopus 로고
    • Modifications of vectors pEF-BOS, pcDNA1 and pcDNA3 result in improved convenience and expression
    • Goldman, L. A., Cutrone, E. C., Kotenko, S. V., Krause, C. D. and Langer, J. A. (1996). Modifications of vectors pEF-BOS, pcDNA1 and pcDNA3 result in improved convenience and expression. Biotechniques 121, 1013-1015.
    • (1996) Biotechniques , vol.121 , pp. 1013-1015
    • Goldman, L.A.1    Cutrone, E.C.2    Kotenko, S.V.3    Krause, C.D.4    Langer, J.A.5
  • 8
    • 0033557571 scopus 로고    scopus 로고
    • Maturation of embryonic stem cells into endothelial cells in an in vitro models of vasculogenesis
    • Hirashima, M., Kataoka, H., Nishikawa, S., Matsuyoshi, N. and Nishikawa, S. (1999). Maturation of embryonic stem cells into endothelial cells in an in vitro models of vasculogenesis. Blood 93, 1253-1263.
    • (1999) Blood , vol.93 , pp. 1253-1263
    • Hirashima, M.1    Kataoka, H.2    Nishikawa, S.3    Matsuyoshi, N.4    Nishikawa, S.5
  • 9
    • 11144318701 scopus 로고    scopus 로고
    • Vascular endothelial growth factor A (VEGF-A) is involved in guidance of VEGF receptor-positive cells to the anterior portion of early embryos
    • Hiratsuka, S., Kataoka, Y., Nakao, K., Nakamura, K., Morikawa, S., Tanaka, S., Katsuki, M., Maru, Y. and Shibuya, M. (2005). Vascular endothelial growth factor A (VEGF-A) is involved in guidance of VEGF receptor-positive cells to the anterior portion of early embryos. Mol. Cell. Biol. 25, 355-363.
    • (2005) Mol. Cell. Biol , vol.25 , pp. 355-363
    • Hiratsuka, S.1    Kataoka, Y.2    Nakao, K.3    Nakamura, K.4    Morikawa, S.5    Tanaka, S.6    Katsuki, M.7    Maru, Y.8    Shibuya, M.9
  • 10
    • 2542455474 scopus 로고    scopus 로고
    • The adaptor protein shb binds to tyros 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration
    • Holmqvist, K., Cross, M. J., Rolny, C., Hägerkvist, R., Rahimi, N., Matsumoto, T., Claesson-Welsh, L. and Welsh, M. (2004). The adaptor protein shb binds to tyros 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration. J. Biol. Chem. 279, 22267-22275.
    • (2004) J. Biol. Chem , vol.279 , pp. 22267-22275
    • Holmqvist, K.1    Cross, M.J.2    Rolny, C.3    Hägerkvist, R.4    Rahimi, N.5    Matsumoto, T.6    Claesson-Welsh, L.7    Welsh, M.8
  • 11
    • 10344247125 scopus 로고    scopus 로고
    • Haemangioblast commitment is initiated in the primitive streak of the mouse embryo
    • Huber, T. L., Kouskoff, V., Fehling, H. J., Palis, J. and Keller, G. (2004). Haemangioblast commitment is initiated in the primitive streak of the mouse embryo. Nature 432, 625-630.
    • (2004) Nature , vol.432 , pp. 625-630
    • Huber, T.L.1    Kouskoff, V.2    Fehling, H.J.3    Palis, J.4    Keller, G.5
  • 12
    • 0032549572 scopus 로고    scopus 로고
    • A recombinant mutant vascular endothelial growth factor-C that has lost vascular endothelial growth factor receptor-2 binding, activation, and vascular permeability activities
    • Joukov, V., Kumar, V., Sorsa, T., Arighi, E., Weich, H., Saksela, O. and Alitalo, K. (1998). A recombinant mutant vascular endothelial growth factor-C that has lost vascular endothelial growth factor receptor-2 binding, activation, and vascular permeability activities. J. Biol. Chem. 273, 6599-6602.
    • (1998) J. Biol. Chem , vol.273 , pp. 6599-6602
    • Joukov, V.1    Kumar, V.2    Sorsa, T.3    Arighi, E.4    Weich, H.5    Saksela, O.6    Alitalo, K.7
  • 13
    • 24944534593 scopus 로고    scopus 로고
    • VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B-PDGFRβ signaling
    • Kano, M. R., Morishita, Y., Iwata, C., Iwasaka, S., Watabe, T., Ouchi, Y., Miyazono, K. and Miyazawa, K. (2005). VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B-PDGFRβ signaling. J. Cell. Sci. 118, 3759-3768.
    • (2005) J. Cell. Sci , vol.118 , pp. 3759-3768
    • Kano, M.R.1    Morishita, Y.2    Iwata, C.3    Iwasaka, S.4    Watabe, T.5    Ouchi, Y.6    Miyazono, K.7    Miyazawa, K.8
  • 15
    • 0034025493 scopus 로고    scopus 로고
    • Eyes wide shut: Protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters
    • Kazanietz, M. G. (2000). Eyes wide shut: protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters. Mol. Carcinogen. 28, 5-11.
    • (2000) Mol. Carcinogen , vol.28 , pp. 5-11
    • Kazanietz, M.G.1
  • 16
    • 0842308307 scopus 로고    scopus 로고
    • Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38
    • Lamalice, L., Houle, F., Jourdan, G. and Huot, J. (2004). Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38. Oncogene 23, 434-445.
    • (2004) Oncogene , vol.23 , pp. 434-445
    • Lamalice, L.1    Houle, F.2    Jourdan, G.3    Huot, J.4
  • 17
    • 33845953426 scopus 로고    scopus 로고
    • Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF
    • Lamalice, L., Houle, F. and Huot, J. (2006). Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF. J. Biol. Chem. 281, 34009-34020.
    • (2006) J. Biol. Chem , vol.281 , pp. 34009-34020
    • Lamalice, L.1    Houle, F.2    Huot, J.3
  • 18
    • 0032831817 scopus 로고    scopus 로고
    • Overexpression of phospholipase C-γ1 suppresses UVC-induced apoptosis through inhibition of c-fos accumulation and c-Jun N-terminal kinase activation in PC12 cells
    • Lee, Y. H., Kim, S., Kim, J., Young Kim, K., Kim, M. J., Ryu, S. H. and Suh, P. (1999). Overexpression of phospholipase C-γ1 suppresses UVC-induced apoptosis through inhibition of c-fos accumulation and c-Jun N-terminal kinase activation in PC12 cells. Biochim. Biophys. Acta 1440, 235-243.
    • (1999) Biochim. Biophys. Acta , vol.1440 , pp. 235-243
    • Lee, Y.H.1    Kim, S.2    Kim, J.3    Young Kim, K.4    Kim, M.J.5    Ryu, S.H.6    Suh, P.7
  • 19
    • 0037088684 scopus 로고    scopus 로고
    • Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice
    • Liao, H. J., Kume, T., McKay, C., Xu, M. J., Ihle, J. N. and Carpenter, G. (2002). Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice. J. Biol. Chem. 277, 9335-9341.
    • (2002) J. Biol. Chem , vol.277 , pp. 9335-9341
    • Liao, H.J.1    Kume, T.2    McKay, C.3    Xu, M.J.4    Ihle, J.N.5    Carpenter, G.6
  • 20
    • 0032478610 scopus 로고    scopus 로고
    • Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C
    • Marais, R., Light, Y., Mason, C., Paterson, H., Olson, M. F. and Marshall, C. J. (1998). Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C. Science 280, 109-112.
    • (1998) Science , vol.280 , pp. 109-112
    • Marais, R.1    Light, Y.2    Mason, C.3    Paterson, H.4    Olson, M.F.5    Marshall, C.J.6
  • 21
    • 26644472432 scopus 로고    scopus 로고
    • An efficient system to establish multiple embryonic stem cell lines carrying an inducible expression unit
    • Masui, S., Shimosato, D., Toyooka, Y., Yagi, R., Takahashi, K. and Niwa, H. (2005). An efficient system to establish multiple embryonic stem cell lines carrying an inducible expression unit. Nucleic. Acids Res. 33, e43.
    • (2005) Nucleic. Acids Res , vol.33
    • Masui, S.1    Shimosato, D.2    Toyooka, Y.3    Yagi, R.4    Takahashi, K.5    Niwa, H.6
  • 24
    • 12844264070 scopus 로고    scopus 로고
    • Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice
    • Sakurai, Y., Ohgimoto, K., Kataoka, Y., Yoshida, N. and Shibuya, M. (2005). Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. Proc. Natl. Acad. Sci. USA 102, 1076-1081.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 1076-1081
    • Sakurai, Y.1    Ohgimoto, K.2    Kataoka, Y.3    Yoshida, N.4    Shibuya, M.5
  • 27
    • 15244341029 scopus 로고    scopus 로고
    • Roles of vascular endothelial growth factor receptor 3 signaling in differentiation of mouse embryonic stem cell-derived vascular progenitor cells into endothelial cells
    • Suzuki, H., Watabe, T., Kato, M., Miyazawa, K. and Miyazono, K. (2005). Roles of vascular endothelial growth factor receptor 3 signaling in differentiation of mouse embryonic stem cell-derived vascular progenitor cells into endothelial cells. Blood 105, 2372-2379.
    • (2005) Blood , vol.105 , pp. 2372-2379
    • Suzuki, H.1    Watabe, T.2    Kato, M.3    Miyazawa, K.4    Miyazono, K.5
  • 28
    • 0031008750 scopus 로고    scopus 로고
    • The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-γ pathway and partially induces mitotic signals in NIH3T3 fibroblasts
    • Takahashi, T. and Shibuya, M. (1997). The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-γ pathway and partially induces mitotic signals in NIH3T3 fibroblasts. Oncogene 14, 2079-2089.
    • (1997) Oncogene , vol.14 , pp. 2079-2089
    • Takahashi, T.1    Shibuya, M.2
  • 29
    • 0033118228 scopus 로고    scopus 로고
    • VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells
    • Takahashi, T., Ueno, H. and Shibuya, M. (1999). VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells. Oncogene 18, 2221-2230.
    • (1999) Oncogene , vol.18 , pp. 2221-2230
    • Takahashi, T.1    Ueno, H.2    Shibuya, M.3
  • 30
    • 0035355472 scopus 로고    scopus 로고
    • A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-γ and DNA synthesis in vascular endothelial cells
    • Takahashi, T., Yamaguchi, S., Chida, K. and Shibuya, M. (2001). A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-γ and DNA synthesis in vascular endothelial cells. EMBO J. 20, 2768-2778.
    • (2001) EMBO J , vol.20 , pp. 2768-2778
    • Takahashi, T.1    Yamaguchi, S.2    Chida, K.3    Shibuya, M.4
  • 33
    • 0035958913 scopus 로고    scopus 로고
    • Oxidative stress-induced phospholipase C-γ1 activation enhances cell survival
    • Wang, X. T., McCullough, K. D., Wang, X. J., Carpenter, G. and Holbrook, N. J. (2001). Oxidative stress-induced phospholipase C-γ1 activation enhances cell survival. J. Biol. Chem. 276, 28364-28371.
    • (2001) J. Biol. Chem , vol.276 , pp. 28364-28371
    • Wang, X.T.1    McCullough, K.D.2    Wang, X.J.3    Carpenter, G.4    Holbrook, N.J.5
  • 34
    • 0347363474 scopus 로고    scopus 로고
    • TGF-β receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells
    • Watabe, T., Nishihara, A., Mishima, K., Yamashita, J., Shimizu, K., Miyazawa, K., Nishikawa, S. and Miyazono, K. (2003). TGF-β receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells. J. Cell Biol. 163, 1303-1311.
    • (2003) J. Cell Biol , vol.163 , pp. 1303-1311
    • Watabe, T.1    Nishihara, A.2    Mishima, K.3    Yamashita, J.4    Shimizu, K.5    Miyazawa, K.6    Nishikawa, S.7    Miyazono, K.8
  • 35
    • 0034051161 scopus 로고    scopus 로고
    • VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor
    • Wu, L. W., Mayo, L, D., Dunbar, J, D., Kessler, K. M., Ozes, O. N., Warren, R. S. and Donner, D. B. (2000). VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor. J. Biol. Chem. 275, 6059-6062.
    • (2000) J. Biol. Chem , vol.275 , pp. 6059-6062
    • Wu, L.W.1    Mayo, L.D.2    Dunbar, J.D.3    Kessler, K.M.4    Ozes, O.N.5    Warren, R.S.6    Donner, D.B.7
  • 38
    • 0035980051 scopus 로고    scopus 로고
    • Tyrosine residues 951 and 1059 of vascular endothelial growth factor receptor-2 (KDR) are essential for vascular permeability factor/vascular endothelial growth factor-induced endothelium migration and proliferation, respectively
    • Zeng, H., Sanyal, S. and Mukhopadhyay, D. (2001). Tyrosine residues 951 and 1059 of vascular endothelial growth factor receptor-2 (KDR) are essential for vascular permeability factor/vascular endothelial growth factor-induced endothelium migration and proliferation, respectively. J. Biol. Chem. 276, 32714-32719.
    • (2001) J. Biol. Chem , vol.276 , pp. 32714-32719
    • Zeng, H.1    Sanyal, S.2    Mukhopadhyay, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.