Vascular endothelial growth factor (VEGF) receptor-2 tyrosine 1175 signaling controls VEGF-induced von Willebrand factor release from endothelial cells via phospholipase C-γ1- and protein kinase A-dependent pathways

Journal of Biological Chemistry

Volumn 284, Issue 35, 2009, Pages 23217-23224

  Xiong, Yan ^a   Huo, Yingqing ^a   Chen, Chao ^a   Zeng, Huiyan ^b   Lu, Xiaofan ^a   Wei, Chaoliang ^a   Ruan, Changgeng ^c   Zhang, Xiaoyu ^a   Hu, Zhenqian ^a   Shibuya, Masabumi ^d   Luo, Jincai ^a  

^a PEKING UNIVERSITY   (China)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Affiliated Hospital of Soochow University   (China)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

C TERMINUS; CALCIUM SIGNALING; INTERLEUKIN-6; KINASE A; MEDIATED SIGNALING PATHWAYS; PHOSPHOLIPASE C; PROTEIN KINASE A; SIGNALING PATHWAYS; SINGLE MUTATION; THERAPEUTIC TARGETS; TYROSINE RESIDUES; VASCULAR ENDOTHELIAL GROWTH FACTOR; VASCULOGENESIS; VEGFR-2; VON WILLEBRAND FACTOR; WEIBEL-PALADE BODIES;

AMINO ACIDS; BIOACTIVITY; CALCIUM; PATHOLOGY; PEPTIDES; PIGMENTS; SELF ASSEMBLY; SIGNALING;

ENDOTHELIAL CELLS;

CALCIUM; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; INTERLEUKIN 6; PHOSPHOLIPASE C GAMMA1; TYROSINE; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VON WILLEBRAND FACTOR;

ARTICLE; CALCIUM SIGNALING; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOTHELIUM CELL; ENZYME ACTIVATION; EXOCYTOSIS; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; WEIBEL PALADE BODY;

CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENDOTHELIUM, VASCULAR; HUMANS; PHOSPHOLIPASE C GAMMA; SIGNAL TRANSDUCTION; TYROSINE; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; VON WILLEBRAND FACTOR;

EID: 69949112647     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.019679     Document Type: Article

References (44)

1. Ferrara, N., Gerber, H. P., and LeCouter, J. (2003) Nat. Med. 9, 669-676
2. Shibuya, M., and Claesson-Welsh, L. (2006) Exp. Cell Res. 312, 549-560
3. Rahimi, N. (2006) Exp. Eye Res. 83, 1005-1016
4. Kowanetz, M., and Ferrara, N. (2006) Clin. Cancer Res. 12, 5018-5022
5. Leung, D. W., Cachianes, G., Kuang, W. J., Goeddel, D. V., and Ferrara, N. (1989) Science 246, 1306-1309
6. Detmar, M., Brown, L. F., Schön, M. P., Elicker, B. M., Velasco, P., Richard, L., Fukumura, D., Monsky, W., Claffey, K. P., and Jain, R. K. (1998) J. Invest. Dermatol. 111, 1-6
7. Xia, Y. P., Li, B., Hylton, D., Detmar, M., Yancopoulos, G. D., and Rudge, J. S. (2003) Blood 102, 161-168
8. Reinders, M. E., Sho, M., Izawa, A., Wang, P., Mukhopadhyay, D., Koss, K. E., Geehan, C. S., Luster, A. D., Sayegh, M. H., and Briscoe, D. M. (2003) J. Clin. Invest. 112, 1655-1665
9. Yano, K., Liaw, P. C., Mullington, J. M., Shih, S. C., Okada, H., Bodyak, N., Kang, P. M., Toltl, L., Belikoff, B., Buras, J., Simms, B. T., Mizgerd, J. P., Carmeliet, P., Karumanchi, S. A., and Aird, W. C. (2006) J. Exp. Med. 203, 1447-1458
10. Bhushan, M., McLaughlin, B., Weiss, J. B., and Griffiths, C. E. (1999) Br. J. Dermatol. 141, 1054-1060
11. Brown, L. F., Harrist, T. J., Yeo, K. T., Ståhle-Bäckdahl, M., Jackman, R. W., Berse, B., Tognazzi, K., Dvorak, H. F., and Detmar, M. (1995) J. Invest. Dermatol. 104, 744-749
12. Murakami, M., Iwai, S., Hiratsuka, S., Yamauchi, M., Nakamura, K., Iwakura, Y., and Shibuya, M. (2006) Blood 108, 1849-1856
13. van der Flier, M., van Leeuwen, H. J., van Kessel, K. P., Kimpen, J. L., Hoepelman, A. I., and Geelen, S. P. (2005) Shock 23, 35-38
14. Pickkers, P., Sprong, T., Eijk, L., Hoeven, H., Smits, P., and Deuren, M. (2005) Shock 24, 508-512
15. Sawano, A., Iwai, S., Sakurai, Y., Ito, M., Shitara, K., Nakahata, T., and Shibuya, M. (2001) Blood 97, 785-791
16. Wagner, D. D. (1993) Thromb. Haemost. 70, 105-110
17. Babich, V., Meli, A., Knipe, L., Dempster, J. E., Skehel, P., Hannah, M. J., and Carter, T. (2008) Blood 111, 5282-5290
18. Rondaij, M. G., Bierings, R., Kragt, A., van Mourik, J. A., and Voorberg, J. (2006) Arterioscler. Thromb. Vasc. Biol. 26, 1002-1007
19. Sadler, J. E., Mancuso, D. J., Randi, A. M., Tuley, E. A., and Westfield, L. A. (1991) Ann. N. Y. Acad. Sci. 614, 114-124
20. Matsushita, K., Yamakuchi, M., Morrell, C. N., Ozaki, M., O'Rourke, B., Irani, K., and Lowenstein, C. J. (2005) Blood 105, 207-214
21. Berger, R., Lin, D. I., Nieto, M., Sicinska, E., Garraway, L. A., Adams, H., Signoretti, S., Hahn, W. C., and Loda, M. (2006) Cancer Res. 66, 5723-5728
22. Zhou, Q. S., Zhao, Y. M., Xu, C. S., Yu, Z. Y., Yao, D. Y., Gao, Y. M., and Ruan, C. G. (1992) Thromb. Res. 68, 109-118
23. Zeng, H., Dvorak, H. F., and Mukhopadhyay, D. (2001) J. Biol. Chem. 276, 26969-26979
24. LeCouter, J., Moritz, D. R., Li, B., Phillips, G. L., Liang, X. H., Gerber, H. P., Hillan, K. J., and Ferrara, N. (2003) Science 299, 890-893
25. Takahashi, T., Yamaguchi, S., Chida, K., and Shibuya, M. (2001) EMBO J. 20, 2768-2778
26. Patterson, R. L., van Rossum, D. B., Ford, D. L., Hurt, K. J., Bae, S. S., Suh, P. G., Kurosaki, T., Snyder, S. H., and Gill, D. L. (2002) Cell 111, 529-541
27. Wilsher, N. E., Court, W. J., Ruddle, R., Newbatt, Y. M., Aherne, W., Sheldrake, P. W., Jones, N. P., Katan, M., Eccles, S. A., and Raynaud, F. I. (2007) Drug Metab. Dispos. 35, 1017-1022
28. Wong, R., Fabian, L., Forer, A., and Brill, J. A. (2007) BMC Cell Biol. 8, 15-24
29. Carew, M. A., Paleolog, E. M., and Pearson, J. D. (1992) Biochem. J. 286, 631-635
30. Bodnar, R. J., Yates, C. C., and Wells, A. (2006) Circ. Res. 98, 617-625
31. Mirzapoiazova, T., Kolosova, I., Usatyuk, P. V., Natarajan, V., and Verin, A. D. (2006) Am. J. Physiol. Lung Cell. Mol. Physiol. 291, L718-L724
32. Desloges, N., Rahaus, M., and Wolff, M. H. (2008) Med. Microbiol. Immunol. 197, 353-360
33. Mahadev, K., Wu, X., Donnelly, S., Ouedraogo, R., Eckhart, A. D., and Goldstein, B. J. (2008) Cardiovasc. Res. 78, 376-384
34. Matsumoto, T., Bohman, S., Dixelius, J., Berge, T., Dimberg, A., Magnusson, P., Wang, L., Wikner, C., Qi, J. H., Wernstedt, C., Wu, J., Bruheim, S., Mugishima, H., Mukhopadhyay, D., Spurkland, A., and Claesson-Welsh, L. (2005) EMBO J. 24, 2342-2353
35. Wu, L. W., Mayo, L. D., Dunbar, J. D., Kessler, K. M., Baerwald, M. R., Jaffe, E. A., Wang, D., Warren, R. S., and Donner, D. B. (2000) J. Biol. Chem. 275, 5096-5103
36. Meyer, R. D., Dayanir, V., Majnoun, F., and Rahimi, N. (2002) J. Biol. Chem. 277, 27081-27087
37. Brockington, A., Lewis, C., Wharton, S., and Shaw, P. J. (2004) Neuropathol. Appl. Neurobiol. 30, 427-446
38. Weis, S., Cui, J., Barnes, L., and Cheresh, D. (2004) J. Cell Biol. 167, 223-229
39. Fukuhara, S., Sakurai, A., Sano, H., Yamagishi, A., Somekawa, S., Takakura, N., Saito, Y., Kangawa, K., and Mochizuki, N. (2005) Mol. Cell. Biol. 25, 136-146
40. Legrain, P., and Selig, L. (2000) FEBS Lett. 480, 32-36
41. Sakurai, Y., Ohgimoto, K., Kataoka, Y., Yoshida, N., and Shibuya, M. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 1076-1081
42. Zeng, H., Zhao, D., and Mukhopadhyay, D. (2002) J. Biol. Chem. 277, 46791-46798
43. Ma, Y., Pitson, S., Hercus, T., Murphy, J., Lopez, A., and Woodcock, J. (2005) J. Biol. Chem. 280, 26011-26017
44. Lorenzi, O., Frieden, M., Villemin, P., Fournier, M., Foti, M., and Vischer, U. M. (2008) J. Thromb. Haemost. 11, 1962-1969