A designed inhibitor of a clc antiporter blocks function through a unique binding mode

Chemistry and Biology

Volumn 19, Issue 11, 2012, Pages 1460-1470

  Howery, Andrew E ^a,b   Elvington, Shelley ^a   Abraham, Sherwin J ^a   Choi, Kee Hyun ^a   Dworschak Simpson, Sierra ^a   Phillips, Sabrina ^c   Ryan, Christopher M ^d   Sanford, R Lea ^e   Almqvist, Jonas ^a   Tran, Kevin ^a   Chew, Thomas A ^a   Zachariae, Ulrich ^f   Andersen, Olaf S ^e   Whitelegge, Julian ^d   Matulef, Kimberly ^c   Du Bois, Justin ^b   Maduke, Merritt C ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

^c UNIVERSITY OF SAN DIEGO   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

^f UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' OCTANAMIDOSTILBENE 2,2' DISULFONATE; ANTIPORTER; CHLORIDE CHANNEL; CHLORIDE CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CARDIOVASCULAR DISEASE; CONCENTRATION (PARAMETERS); DEGENERATIVE DISEASE; INTRACELLULAR SPACE; LIPID COMPOSITION; MOLECULAR WEIGHT; OSTEOPOROSIS; PRIORITY JOURNAL; STOICHIOMETRY; THERMODYNAMICS;

ANTIPORTERS; BINDING SITES; CHLORIDE CHANNELS; ESCHERICHIA COLI PROTEINS; LIPID BILAYERS; MOLECULAR DYNAMICS SIMULATION; MUTATION; STILBENES; SULFONIC ACIDS;

EID: 84868600770     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2012.09.017     Document Type: Article

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