Niflumic acid hyperpolarizes smooth muscle cells via calcium-activated potassium channel in spiral modiolar artery of guinea pigs

Acta Pharmacologica Sinica

Volumn 29, Issue 7, 2008, Pages 789-799

  Li, Li ^a,b   Ma, Ke Tao ^b,c   Zhao, Lei ^b   Si, Jun Qiang ^b,c   Zhang, Zhong Shuang ^b   Zhu, He ^b   Li, Jing ^b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHIHEZI UNIVERSITY   (China)

^c WUHAN UNIVERSITY   (China)

Author keywords

Ca2+ activated potassium channels; Cochlea; Hyperpolarizat ion; Niflumic acid; Smooth muscle cells; Spiral modiolar artery

Indexed keywords

(2 CYCLOPENTYL 6,7 DICHLORO 2 METHYL 1 OXO 5 INDANYLOXY)ACETIC ACID; 4 AMINOPYRIDINE; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; APAMIN; BARIUM; CADMIUM CHLORIDE; CALCIUM ACTIVATED POTASSIUM CHANNEL; CHARYBDOTOXIN; CHLORIDE CHANNEL; GLIPIZIDE; IBERIOTOXIN; NIFLUMIC ACID; OUABAIN; TETRYLAMMONIUM; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CELL MEMBRANE STEADY POTENTIAL; COCHLEAR SPIRAL MODIOLAR ARTERY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; EAR ARTERY; GUINEA PIG; HYPERPOLARIZATION; INTRACELLULAR RECORDING; ISOLATED ARTERY; NONHUMAN; SMOOTH MUSCLE FIBER; WHOLE CELL; ANIMAL; ARTERY; CELL MEMBRANE POTENTIAL; DRUG EFFECT; ELECTROPHYSIOLOGY; IN VITRO STUDY; PATCH CLAMP; VASCULAR SMOOTH MUSCLE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTERIES; BARIUM; CHLORIDE CHANNELS; ELECTROPHYSIOLOGY; GUINEA PIGS; MEMBRANE POTENTIALS; MUSCLE, SMOOTH, VASCULAR; NIFLUMIC ACID; OUABAIN; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, CALCIUM-ACTIVATED;

EID: 65849471747     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2008.00803.x     Document Type: Article

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