Application of dissolution/permeation system for evaluation of formulation effect on oral absorption of poorly water-soluble drugs in drug development

Pharmaceutical Research

Volumn 29, Issue 6, 2012, Pages 1485-1494

  Kataoka, Makoto ^a   Sugano, Kiyohiko ^b   Da Costa Mathews, Claudia ^b   Wong, Jing Wen ^b   Jones, Kelly Lane ^b   Masaoka, Yoshie ^a   Sakuma, Shinji ^a   Yamashita, Shinji ^a  

^a SETSUNAN UNIVERSITY   (Japan)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

absorption; dissolution; permeability; solubility; supersaturation

Indexed keywords

BOVINE SERUM ALBUMIN; DANAZOL; DRUG CARRIER; PRANLUKAST;

ANALYTIC METHOD; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DISSOLUTION PERMEATION SYSTEM; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG SOLUBILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MONOLAYER CULTURE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; SELF EMULSIFIED DRUG DELIVERY SYSTEM;

ADMINISTRATION, ORAL; ANIMALS; CACO-2 CELLS; CHEMISTRY, PHARMACEUTICAL; CHROMONES; DANAZOL; DRUG COMPOUNDING; HUMANS; INTESTINAL ABSORPTION; INTESTINES; MALE; PERMEABILITY; RATS; RATS, WISTAR; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL;

EID: 84862639043     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0623-2     Document Type: Article

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