Characterization and optimization of AMG 517 Supersaturatable Self-Emulsifying Drug Delivery System (S-SEDDS) for improved oral absorption

Journal of Pharmaceutical Sciences

Volumn 98, Issue 2, 2009, Pages 516-528

  Gao, Ping ^a,b   Akrami, Anna ^a   Alvarez, Francisco ^a   Hu, Jack ^a   Li, Lan ^a   Ma, Chandra ^a   Surapaneni, Sekhar ^a  

^a AMGEN INC   (United States)

^b ABBOTT LABORATORIES   (United States)

Author keywords

Absorption; Bioavailability; In vitro models; Microemulsion; Oral drug delivery; Pharmacokinetics; Polymers; Precipitation; Supersaturation

Indexed keywords

AMG 517; ANALGESIC AGENT; HYDROXYPROPYLMETHYLCELLULOSE; MACROGOL 400; OCTANOIN; POLYSORBATE 80; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; BENZOTHIAZOLE DERIVATIVE; DRUG CARRIER; DRUG DERIVATIVE; EXCIPIENT; LIPID; METHYLCELLULOSE; N (4 (6 (4 TRIFLUOROMETHYLPHENYL)PYRIMIDIN 4 YLOXY)BENZOTHIAZOL 2 YL)ACETAMIDE; N-(4-(6-(4-TRIFLUOROMETHYLPHENYL)PYRIMIDIN-4-YLOXY)BENZOTHIAZOL-2-YL)ACETAMIDE; POLYSORBATE; PYRIMIDINE DERIVATIVE; SOLVENT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG SOLUBILITY; EXCIPIENT COMPATIBILITY; MALE; MICROEMULSION; MONKEY; NONHUMAN; PRECIPITATION; SUPERSATURATABLE SELF EMULSIFYING DRUG DELIVERY SYSTEM; ANIMAL; BIOAVAILABILITY; CHEMISTRY; CRYSTALLIZATION; DRUG FORMULATION; EMULSION; INTESTINE ABSORPTION; KINETICS; MACACA; ORAL DRUG ADMINISTRATION; PARTICLE SIZE; SOLUBILITY;

ADMINISTRATION, ORAL; ANIMALS; BENZOTHIAZOLES; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DRUG CARRIERS; DRUG COMPOUNDING; EMULSIONS; EXCIPIENTS; INTESTINAL ABSORPTION; KINETICS; LIPIDS; MACACA FASCICULARIS; MALE; METHYLCELLULOSE; PARTICLE SIZE; POLYSORBATES; PRECIPITATION; PYRIMIDINES; SOLUBILITY; SOLVENTS;

EID: 59849110173     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21451     Document Type: Article

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