-
1
-
-
0028328655
-
Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type I insulin-like growth factor receptor
-
Dilling MB, Dias P, Shapiro DN, Germain GS, Johnson RK, Houghton PJ. Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type I insulin-like growth factor receptor. Cancer Res 1994;54:903-7.
-
(1994)
Cancer Res
, vol.54
, pp. 903-907
-
-
Dilling, M.B.1
Dias, P.2
Shapiro, D.N.3
Germain, G.S.4
Johnson, R.K.5
Houghton, P.J.6
-
2
-
-
40449091406
-
Initial testing (stage 1) of the mTOR inhibitor rapamycin by the Pediatric Preclinical Testing Program
-
Houghton PJ, Morton CL, Kolb EA, et al. Initial testing (stage 1) of the mTOR inhibitor rapamycin by the Pediatric Preclinical Testing Program. Pediatr Blood Cancer 2008;50:799-805.
-
(2008)
Pediatr Blood Cancer
, vol.50
, pp. 799-805
-
-
Houghton, P.J.1
Morton, C.L.2
Kolb, E.A.3
-
4
-
-
0036174289
-
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor
-
Guba M, von Breitenbuch P, Steinbauer M, et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med 2002;8:128-35.
-
(2002)
Nat Med
, vol.8
, pp. 128-135
-
-
Guba, M.1
von Breitenbuch, P.2
Steinbauer, M.3
-
5
-
-
34249779568
-
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
-
Hudes G, Carducci M, Tomczak P, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007;356:2271-81.
-
(2007)
N Engl J Med
, vol.356
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
-
6
-
-
48649107474
-
Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
-
Motzer RJ, Escudier B, Oudard S, et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 2008;372:449-56.
-
(2008)
Lancet
, vol.372
, pp. 449-456
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
-
7
-
-
23944481410
-
Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma
-
Witzig TE, Geyer SM, Ghobrial I, et al. Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma. J Clin Oncol 2005;23:5347-56.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5347-5356
-
-
Witzig, T.E.1
Geyer, S.M.2
Ghobrial, I.3
-
8
-
-
36049023679
-
Phase I study of everolimus in pediatric patients with refractory solid tumors
-
Fouladi M, Laningham F, Wu J, et al. Phase I study of everolimus in pediatric patients with refractory solid tumors. J Clin Oncol 2007;25: 4806-12.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4806-4812
-
-
Fouladi, M.1
Laningham, F.2
Wu, J.3
-
9
-
-
20444363122
-
The coordinate regulation of the p53 and mTOR pathways in cells
-
Feng Z, Zhang H, Levine AJ, Jin S. The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci U S A 2005; 102:8204-9.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 8204-8209
-
-
Feng, Z.1
Zhang, H.2
Levine, A.J.3
Jin, S.4
-
10
-
-
36549026878
-
Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53
-
Lee CH, Inoki K, Karbowniczek M, et al. Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. EMBO J 2007;26:4812-23.
-
(2007)
EMBO J
, vol.26
, pp. 4812-4823
-
-
Lee, C.H.1
Inoki, K.2
Karbowniczek, M.3
-
11
-
-
35148875496
-
TOR signaling is a determinant of cell survival in response to DNA damage
-
Shen C, Lancaster CS, Shi B, Guo H, Thimmaiah P, Bjornsti MA. TOR signaling is a determinant of cell survival in response to DNA damage. Mol Cell Biol 2007;27:7007-17.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 7007-7017
-
-
Shen, C.1
Lancaster, C.S.2
Shi, B.3
Guo, H.4
Thimmaiah, P.5
Bjornsti, M.A.6
-
12
-
-
0016836859
-
Proliferation-dependent cytotoxicity of anticancer agents: A review
-
Valeriote F, van Putten L. Proliferation-dependent cytotoxicity of anticancer agents: a review. Cancer Res 1975;35:2619-30.
-
(1975)
Cancer Res
, vol.35
, pp. 2619-2630
-
-
Valeriote, F.1
van Putten, L.2
-
13
-
-
0028925744
-
Rapamycin enhances apoptosis and increases sensitivity to cisplatin in vitro
-
Shi Y, Frankel A, Radvanyi LG, Penn LZ, Miller RG, Mills GB. Rapamycin enhances apoptosis and increases sensitivity to cisplatin in vitro. Cancer Res 1995;55:1982-8.
-
(1995)
Cancer Res
, vol.55
, pp. 1982-1988
-
-
Shi, Y.1
Frankel, A.2
Radvanyi, L.G.3
Penn, L.Z.4
Miller, R.G.5
Mills, G.B.6
-
14
-
-
26844545448
-
Overcoming cisplatin resistance by mTOR inhibitor in lung cancer
-
Wu C, Wangpaichitr M, Feun L, et al. Overcoming cisplatin resistance by mTOR inhibitor in lung cancer. Mol Cancer 2005;4:25.
-
(2005)
Mol Cancer
, vol.4
, pp. 25
-
-
Wu, C.1
Wangpaichitr, M.2
Feun, L.3
-
15
-
-
20244365941
-
The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation
-
Beuvink I, Boulay A, Fumagalli S, et al. The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. Cell 2005;120:747-59.
-
(2005)
Cell
, vol.120
, pp. 747-759
-
-
Beuvink, I.1
Boulay, A.2
Fumagalli, S.3
-
16
-
-
34249799034
-
CCI-779 plus cisplatin is highly effective against human melanoma in a SCID mouse xenotranplantation model
-
Thallinger C, Poeppl W, Pratscher B, et al. CCI-779 plus cisplatin is highly effective against human melanoma in a SCID mouse xenotranplantation model. Pharmacology 2007;79:207-13.
-
(2007)
Pharmacology
, vol.79
, pp. 207-213
-
-
Thallinger, C.1
Poeppl, W.2
Pratscher, B.3
-
17
-
-
0026722491
-
Immunosuppressants FK506 and rapamycin function as reversal agents of the multidrug resistance phenotype
-
Arceci RJ, Stieglitz K, Bierer BE. Immunosuppressants FK506 and rapamycin function as reversal agents of the multidrug resistance phenotype. Blood 1992;80:1528-36.
-
(1992)
Blood
, vol.80
, pp. 1528-1536
-
-
Arceci, R.J.1
Stieglitz, K.2
Bierer, B.E.3
-
18
-
-
34147135644
-
A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations
-
Frgala T, Kalous O, Proffitt RT, Reynolds CP. A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations. Mol Cancer Ther 2007;6:886-97.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 886-897
-
-
Frgala, T.1
Kalous, O.2
Proffitt, R.T.3
Reynolds, C.P.4
-
19
-
-
0023731771
-
Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents
-
Friedman HS, Colvin OM, Skapek SX, et al. Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents. Cancer Res 1988;48: 4189-95.
-
(1988)
Cancer Res
, vol.48
, pp. 4189-4195
-
-
Friedman, H.S.1
Colvin, O.M.2
Skapek, S.X.3
-
20
-
-
31544467339
-
Evaluation of the antitumor efficacy, pharmacokinetics, and pharmacodynamics of the histone deacetylase inhibitor depsipeptide in childhood cancer models in vivo
-
Graham C, Tucker C, Creech J, et al. Evaluation of the antitumor efficacy, pharmacokinetics, and pharmacodynamics of the histone deacetylase inhibitor depsipeptide in childhood cancer models in vivo. Clin Cancer Res 2006;12:223-34.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 223-234
-
-
Graham, C.1
Tucker, C.2
Creech, J.3
-
21
-
-
26444507974
-
In vivo evaluation of ixabepilone (BMS247550), a novel epothilone B derivative, against pediatric cancer models
-
Peterson JK, Tucker C, Favours E, et al. In vivo evaluation of ixabepilone (BMS247550), a novel epothilone B derivative, against pediatric cancer models. Clin Cancer Res 2005;11:6950-8.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 6950-6958
-
-
Peterson, J.K.1
Tucker, C.2
Favours, E.3
-
22
-
-
2342531648
-
Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies
-
Liem NL, Papa RA, Milross CG, et al. Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies. Blood 2004;103:3905-14.
-
(2004)
Blood
, vol.103
, pp. 3905-3914
-
-
Liem, N.L.1
Papa, R.A.2
Milross, C.G.3
-
23
-
-
34447249881
-
The Pediatric Preclinical Testing Program: Description of models and early testing results
-
Houghton PJ, Morton CL, Tucker C, et al. The Pediatric Preclinical Testing Program: description of models and early testing results. Pediatr Blood Cancer 2007;49:928-40.
-
(2007)
Pediatr Blood Cancer
, vol.49
, pp. 928-940
-
-
Houghton, P.J.1
Morton, C.L.2
Tucker, C.3
-
24
-
-
41849114246
-
Initial testing of cisplatin by the Pediatric Preclinical Testing Program
-
Tajbakhsh M, Houghton PJ, Morton CL, et al. Initial testing of cisplatin by the Pediatric Preclinical Testing Program. Pediatr Blood Cancer 2008;50:992-1000.
-
(2008)
Pediatr Blood Cancer
, vol.50
, pp. 992-1000
-
-
Tajbakhsh, M.1
Houghton, P.J.2
Morton, C.L.3
-
25
-
-
0018306685
-
Design and evaluation of combination chemotherapy trials in experimental animal tumor systems
-
Corbett TH, Griswold DP, Jr., Wolpert MK, Venditti JM, Schabel FM, Jr. Design and evaluation of combination chemotherapy trials in experimental animal tumor systems. Cancer Treat Rep 1979;63: 799-801.
-
(1979)
Cancer Treat Rep
, vol.63
, pp. 799-801
-
-
Corbett, T.H.1
Griswold Jr., D.P.2
Wolpert, M.K.3
Venditti, J.M.4
Schabel Jr, F.M.5
-
26
-
-
8444240000
-
Therapeutic synergy of oral taxane BMS-275183 and cetuximab versus human tumor xenografts
-
Rose WC, Wild R. Therapeutic synergy of oral taxane BMS-275183 and cetuximab versus human tumor xenografts. Clin Cancer Res 2004;10:7413-7.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 7413-7417
-
-
Rose, W.C.1
Wild, R.2
-
27
-
-
28544446417
-
Sensitization of human carcinoma cells to alkylating agents by small interfering RNA suppression of 3-alkyladenine-DNA glycosylase
-
Paik J, Duncan T, Lindahl T, Sedgwick B. Sensitization of human carcinoma cells to alkylating agents by small interfering RNA suppression of 3-alkyladenine-DNA glycosylase. Cancer Res 2005;65: 10472-7.
-
(2005)
Cancer Res
, vol.65
, pp. 10472-10477
-
-
Paik, J.1
Duncan, T.2
Lindahl, T.3
Sedgwick, B.4
-
28
-
-
10844296820
-
Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate cancer
-
Rochester MA, Riedemann J, Hellawell GO, Brewster SF, Macaulay VM. Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate cancer. Cancer Gene Ther 2005;12:90-100.
-
(2005)
Cancer Gene Ther
, vol.12
, pp. 90-100
-
-
Rochester, M.A.1
Riedemann, J.2
Hellawell, G.O.3
Brewster, S.F.4
Macaulay, V.M.5
-
29
-
-
37249003222
-
The Bcl-2/Bcl-XL family inhibitor ABT-737 sensitizes ovarian cancer cells to carboplatin
-
Witham J, Valenti MR, De-Haven-Brandon AK, et al. The Bcl-2/Bcl-XL family inhibitor ABT-737 sensitizes ovarian cancer cells to carboplatin. Clin Cancer Res 2007;13:7191-8.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 7191-7198
-
-
Witham, J.1
Valenti, M.R.2
De-Haven-Brandon, A.K.3
-
30
-
-
33749016520
-
A Small-Molecule Inhibitor of Bcl-XL Potentiates the Activity of Cytotoxic Drugs In vitro and In vivo
-
Shoemaker AR, Oleksijew A, Bauch J, et al. A Small-Molecule Inhibitor of Bcl-XL Potentiates the Activity of Cytotoxic Drugs In vitro and In vivo. Cancer Res 2006;66:8731-9.
-
(2006)
Cancer Res
, vol.66
, pp. 8731-8739
-
-
Shoemaker, A.R.1
Oleksijew, A.2
Bauch, J.3
-
31
-
-
33749443714
-
Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance
-
Wei G, Twomey D, Lamb J, et al. Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance. Cancer cell 2006;10:331-42.
-
(2006)
Cancer cell
, vol.10
, pp. 331-342
-
-
Wei, G.1
Twomey, D.2
Lamb, J.3
-
32
-
-
33749335282
-
The Connectivity Map: Using gene-expression signatures to connect small molecules, genes, and disease
-
Lamb J, Crawford ED, Peck D, et al. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science 2006;313:1929-35.
-
(2006)
Science
, vol.313
, pp. 1929-1935
-
-
Lamb, J.1
Crawford, E.D.2
Peck, D.3
-
33
-
-
33846516354
-
Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma
-
Haritunians T, Mori A, O'Kelly J, Luong QT, Giles FJ, Koeffler HP. Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma. Leukemia 2007;21:333-9.
-
(2007)
Leukemia
, vol.21
, pp. 333-339
-
-
Haritunians, T.1
Mori, A.2
O'Kelly, J.3
Luong, Q.T.4
Giles, F.J.5
Koeffler, H.P.6
-
34
-
-
0028227356
-
Efficacy of rapamycin, RS-61443, and cyclophosphamide in the prolongation of survival of discordant pig-to-rabbit cardiac xenografts
-
Yatscoff RW, Wang S, Keenan R, Chackowsky P, Koshal A. Efficacy of rapamycin, RS-61443, and cyclophosphamide in the prolongation of survival of discordant pig-to-rabbit cardiac xenografts. Transplant Proc 1994;26:1271-3.
-
(1994)
Transplant Proc
, vol.26
, pp. 1271-1273
-
-
Yatscoff, R.W.1
Wang, S.2
Keenan, R.3
Chackowsky, P.4
Koshal, A.5
-
35
-
-
73949097151
-
-
Tew KD, P J, Houghton JA. Modulation of glutathione. In: Tew KDH, P J, Houghton JA, editors. Preclinical and Clinical Modulation of Anticancer Drugs. Boca Raton (FL): CRC Press; 1993, p. 13-77.
-
Tew KD, P J, Houghton JA. Modulation of glutathione. In: Tew KDH, P J, Houghton JA, editors. Preclinical and Clinical Modulation of Anticancer Drugs. Boca Raton (FL): CRC Press; 1993, p. 13-77.
-
-
-
-
36
-
-
38549133452
-
Phase 1 trial of O6-benzylguanine and BCNU in children with CNS tumors: A Children's Oncology Group study
-
Adams DM, Zhou T, Berg SL, Bernstein M, Neville K, Blaney SM. Phase 1 trial of O6-benzylguanine and BCNU in children with CNS tumors: a Children's Oncology Group study. Pediatr Blood Cancer 2008;50:549-53.
-
(2008)
Pediatr Blood Cancer
, vol.50
, pp. 549-553
-
-
Adams, D.M.1
Zhou, T.2
Berg, S.L.3
Bernstein, M.4
Neville, K.5
Blaney, S.M.6
-
37
-
-
0036570292
-
Phase II trial of carmustine plus O (6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma
-
Quinn JA, Pluda J, Dolan ME, et al. Phase II trial of carmustine plus O (6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma. J Clin Oncol 2002;20:2277-83.
-
(2002)
J Clin Oncol
, vol.20
, pp. 2277-2283
-
-
Quinn, J.A.1
Pluda, J.2
Dolan, M.E.3
-
38
-
-
34250727606
-
Differential regulation of vascular endothelial growth factor by Akt and mammalian target of rapamycin inhibitors in cell lines derived from childhood solid tumors
-
Kurmasheva RT, Harwood FC, Houghton PJ. Differential regulation of vascular endothelial growth factor by Akt and mammalian target of rapamycin inhibitors in cell lines derived from childhood solid tumors. Mol Cancer Ther 2007;6:1620-8.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 1620-1628
-
-
Kurmasheva, R.T.1
Harwood, F.C.2
Houghton, P.J.3
-
39
-
-
63449098382
-
mTOR inhibitor RAD001 (everolimus) has antiangiogenic/vascular properties distinct from a VEGFR tyrosine kinase inhibitor
-
Lane HA, Wood JM, McSheehy PM, et al. mTOR inhibitor RAD001 (everolimus) has antiangiogenic/vascular properties distinct from a VEGFR tyrosine kinase inhibitor. Clin Cancer Res 2009;15:1612-22.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 1612-1622
-
-
Lane, H.A.1
Wood, J.M.2
McSheehy, P.M.3
|