The expression of Jagged1 in the developing mammalian heart correlates with cardiovascular disease in Alagille syndrome

Human Molecular Genetics

Volumn 8, Issue 13, 1999, Pages 2443-2449

  Loomes, Kathleen M ^a   Underkoffler, Lara A ^a   Morabito, Justin ^a   Gottlieb, Shoshanna ^a   Piccoli, David A ^a   Spinner, Nancy B ^a   Baldwin, H Scott ^a   Oakey, Rebecca J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALAGILLE SYNDROME; ANIMAL TISSUE; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CARDIOVASCULAR SYSTEM; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION; GENE MUTATION; HEART DEVELOPMENT; HUMAN; HUMAN TISSUE; MAMMAL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA; MAMMALIA; MURINAE;

EID: 0032755346     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/8.13.2443     Document Type: Article

References (33)

1. Li, L., Krantz, I.D., Deng, Y., Genin, A., Banta, A.B., Collins, C.C., Qi, M., Trask, B.J., Kuo, W.L., Cochran, J., Costa, T., Pierpont, M.E.M., Rand, E.B., Piccoli, D.A., Hood, L. and Spinner, N.B. (1997) Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch 1. Nature Genet., 16, 243-251.
2. Oda, T., Elkahloun, A.G., Pike, B.L., Okajima, K., Krantz, I.D., Genin, A., Piccoli, D.A., Meltzer, P.S., Spinner, N.B., Collins, F.S. and Chandrasekharappa, S.C. (1997) Mutations in the human Jagged1 gene are responsible for Alagille syndrome. Nature Genet., 16, 235-242.
3. Artavanis-Tsakonas, S., Matsuno, K. and Fortini, M.E. (1995) Notch signaling. Science, 268, 225-232.
4. Ellisen, L., Bird, J., West, D.C., Soreng, A.L., Reynolds, T.C., Smith, S.D. and Sklar, J. (1991) TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell, 66, 649-661.
5. Joutel, A., Corpechot, C., Ducros, A., Vahedi, K., Chabriat, H., Mouton, P., Alamowitch, S., Domenga, V., Cecillion, M., Marechal, E., Maciazek, J., Vayssierre, C., Cruaud, C., Cabanis, E.-A., Ruchoux, M.M., Weissenbach, J., Bach, J.F., Bousser, M.G. and Tournier-Lasserve, E. (1996) Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature, 383, 707-710.
6. Emerick, K.M., Rand, E.B., Goldmuntz, E., Krantz, I.D., Spinner, N.B. and Piccoli, D.A. (1999) Features of Alagille syndrome in 92 patients: frequency and relation to prognosis. Hepatology, 29, 822-829.
7. Alagille, D., Estrada, A., Hadchouel, M., Gautier, M., Odievre, M. and Dommergues, J.P. (1987) Syndromic paucity of interlobular bile ducts (Alagille syndrome or arteriohepatic dysplasia): review of 80 cases. J. Pediatr., 110, 195-200.
8. Lindsell, C.E., Boulter, J., diSibio, G., Gossler, A. and Weinmaster, G. (1996) Expression patterns of Jagged, Delta1, Notch1, Notch2 and Notch3 genes identify ligand-receptor pairs that may function in neural development. Mol. Cell. Neurosci., 8, 14-27.
9. Bao, Z. and Cepko, C.L. (1997) The expression and function of Notch pathway genes in the developing rat eye. J. Neurosci., 17, 1425-1434.
10. Mitsiadis, T.A., Henrique, D., Thesleff, I. and Lendahl, U. (1997) Mouse serrate (Jagged1): expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor-4. Development, 124, 1473-1483.
11. Lindsell, C.E., Shawber, C.J., Boulter, J. and Weinmaster, G. (1995) Jagged: a mammalian ligand that activates Notch 1. Cell, 80, 909-917.
12. Adam, J., Myat, A., Le Roux, I., Eddison, M., Henrique, D., Ish-Horowicz, D. and Lewis, J. (1998) Cell fate choices and the expression of Notch, Delta and Serrate homologues in the chick inner ear: parallels with Drosophila sense organ development. Development, 125, 4645-4654.
13. Baldwin, H.S., Shen, H.M., Chung, A., Mickanin, C., Trask, T., Yan, H.C., Delisser, H., Albelda, S. and Buck, C.A. (1994) Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD 31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development. Development, 120, 2539-2553.
14. Albelda, S.M., Muller, W.A., Buck, C.A. and Newman, P.J. (1991) Molecular and cellular properties of PECAM-1 (endo-CAM/CD31): a novel vascular cell-cell adhesion molecule. J. Cell Biol., 114, 1059-1068.
15. Buck, C.A., Edelman, J.M., Buck, C.E., Kennedy, G. and Baldwin, H.S. (1996) Expression patterns of adhesion receptors in the developing mouse lung: functional implications. Cell Adhes. Commun., 4, 69-87.
16. Eisenberg, L. and Markwald, R.R. (1995) Molecular regulation of atrioventricular valvuloseptal morphogenesis. Circ. Res., 77, 1-6.
17. Poelmann, R.E., Gittenberger-de Groot, A.C., Mentink, M.M.T., Bokenkamp, R. and Hogers, B. (1993) Development of the cardiac coronary vascular endothelium, studied with antiendothelial antibodies in chicken-quail chimeras. Circ. Res., 73, 559-568.
18. Vargesson, N., Patel, K., Lewis, J. and Tickle, C. (1998) Expression patterns of Notch1, Serrate1, Serrate2 and Delta1 in tissues of the developing chick limb. Mech. Dev., 77, 197-200.
19. Krantz, I.D., Piccoli, D.A. and Spinner, N.B. (1997) Alagille syndrome. J. Med. Genet., 34, 152-157.
20. Conlon, R.A., Reaume, A.G. and Rossant, J. (1995) Notch1 is required for the coordinate segmentation of somites. Development, 121, 1533-1545.
21. Swiatek, P.J., Lindsell, C.E., del Amo, F.F., Weinmaster, G. and Gridley, T. (1994) Notch1 is essential for postimplantation development in mice. Genes Dev., 8, 707-719.
22. Myat, A., Henrique, D., Ish-Horowicz, D. and Lewis, J. (1996) A chick homologue of Serrate and its relationship with Notch and Delta homologues during central neurogenesis. Dev. Biol., 174, 233-247.
23. Xue, Y., Gao, X., Lindsell, C.E., Norton, C.R., Chang, B., Hicks, C., Gendron-Maguire, M., Rand, E.B., Weinmaster, G. and Gridley, T. (1999) Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1. Hum. Mol. Genet., 8, 723-730.
24. Silberbach, M., Lashley, D., Reller, M.D., Kinn, W.F.Jr, Terry, A. and Sunderland, C.O. (1995) Arteriohepatic dysplasia and cardiovascular malformations. Am. Heart J., 130, 1317-1318.
25. Dettman, R.W., Denetclaw, W., Ordahl, C.P. and Bristow, J. (1998) Common epicardial origin of coronary vascular smooth muscle, perivascular fibroblasts and intermyocardial fibroblasts in the avian heart. Dev. Biol., 193, 169-181.
26. Folkman, J. and D'Amore, P.A. (1996) Blood vessel formation: what is its molecular basis? Cell, 87, 1153-1155.
27. Carmeliet, P. and Collen, D. (1997) The genetic analysis of blood vessel formation: role of endothelial verus smooth muscle cells. Trends Cardiovasc. Med., 7, 271-281.
28. Baldwin, H.S. (1998) Molecular determinants of embryonic vascular development. In Polin, R.A. and Fox, W.W. (eds), Fetal and Neonatal Cardiovascular Physiology. Saunders, Philadelphia, PA, pp. 801-813.
29. Zimrin, A.B., Pepper, M.S., MaMahon, A., Nguyen, F., Montesano, R. and Maciag, T. (1996) An antisense oligonucleotide to the Notch ligand Jagged1 enhances fibroblast growth factor-induced angiogenesis in vitro. J. Biol. Chem., 271, 32499-32502.
30. Varnum-Finney, B., Purton, L.E., Yu, M., Brashem-Stein, C., Flowers, D., Staats, S., Moore, K.A., Le Roux, I., Mann, R., Gray, G., Artavanis-Tsakonas, S. and Bernstein, I.D. (1998) The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells. Blood, 11, 4084-4091.
31. Wilkinson, D.G. and Nieto, M.A. (1993) Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts. In Wassarman, P.M. and DePamphilis, M.L. (eds), Methods in Enzymology. Academic Press, London, UK, pp. 361-372.
32. Sassoon, D. and Rosenthal, N. (1993) Detection of messenger RNA by in situ hybridization. In Wassarman, P.M. and DePamphilis, M.L. (eds), Methods in Enzymology. Academic Press, London, UK, pp. 384-406.
33. Harlow, E. and Lane, D. (1988) Antibodies: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 359-420.