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Volumn 1831, Issue 1, 2013, Pages 33-41

Current progress in non-Edg family LPA receptor research

Author keywords

GPR23 p2y9; GPR92 GPR93; LPA4; LPA5; LPA6; p2y5

Indexed keywords

1 OLEOYL 2 O METHYL RAC GLYCEROPHSOPHOTHIONATE; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDIC ACID 5; LYSOPHOSPHATIDIC ACID RECEPTOR; MESSENGER RNA; UNCLASSIFIED DRUG;

EID: 84868514597     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2012.08.003     Document Type: Review
Times cited : (73)

References (110)
  • 2
    • 0037077199 scopus 로고    scopus 로고
    • Multiple mechanisms linked to platelet activation result in lysophosphatidic acid and sphingosine 1-phosphate generation in blood
    • T. Sano, D. Baker, T. Virag, A. Wada, Y. Yatomi, T. Kobayashi, Y. Igarashi, and G. Tigyi Multiple mechanisms linked to platelet activation result in lysophosphatidic acid and sphingosine 1-phosphate generation in blood J. Biol. Chem. 277 2002 21197 21206
    • (2002) J. Biol. Chem. , vol.277 , pp. 21197-21206
    • Sano, T.1    Baker, D.2    Virag, T.3    Wada, A.4    Yatomi, Y.5    Kobayashi, T.6    Igarashi, Y.7    Tigyi, G.8
  • 4
    • 0037125239 scopus 로고    scopus 로고
    • Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors
    • K. Hama, K. Bandoh, Y. Kakehi, J. Aoki, and H. Arai Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors FEBS Lett. 523 2002 187 192
    • (2002) FEBS Lett. , vol.523 , pp. 187-192
    • Hama, K.1    Bandoh, K.2    Kakehi, Y.3    Aoki, J.4    Arai, H.5
  • 6
    • 49949098676 scopus 로고    scopus 로고
    • Two pathways for lysophosphatidic acid production
    • J. Aoki, A. Inoue, and S. Okudaira Two pathways for lysophosphatidic acid production Biochim. Biophys. Acta 1781 2008 513 518
    • (2008) Biochim. Biophys. Acta , vol.1781 , pp. 513-518
    • Aoki, J.1    Inoue, A.2    Okudaira, S.3
  • 8
    • 33748757239 scopus 로고    scopus 로고
    • Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid
    • M. Tanaka, S. Okudaira, Y. Kishi, R. Ohkawa, S. Iseki, M. Ota, S. Noji, Y. Yatomi, J. Aoki, and H. Arai Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid J. Biol. Chem. 281 2006 25822 25830
    • (2006) J. Biol. Chem. , vol.281 , pp. 25822-25830
    • Tanaka, M.1    Okudaira, S.2    Kishi, Y.3    Ohkawa, R.4    Iseki, S.5    Ota, M.6    Noji, S.7    Yatomi, Y.8    Aoki, J.9    Arai, H.10
  • 9
    • 80054938937 scopus 로고    scopus 로고
    • LPA-producing enzyme PA-PLAalpha regulates hair follicle development by modulating EGFR signalling
    • A. Inoue, N. Arima, J. Ishiguro, G.D. Prestwich, H. Arai, and J. Aoki LPA-producing enzyme PA-PLAalpha regulates hair follicle development by modulating EGFR signalling EMBO J. 30 2011 4248 4260
    • (2011) EMBO J. , vol.30 , pp. 4248-4260
    • Inoue, A.1    Arima, N.2    Ishiguro, J.3    Prestwich, G.D.4    Arai, H.5    Aoki, J.6
  • 10
    • 78650141494 scopus 로고    scopus 로고
    • International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature
    • J. Chun, T. Hla, K.R. Lynch, S. Spiegel, and W.H. Moolenaar International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature Pharmacol. Rev. 62 2010 579 587
    • (2010) Pharmacol. Rev. , vol.62 , pp. 579-587
    • Chun, J.1    Hla, T.2    Lynch, K.R.3    Spiegel, S.4    Moolenaar, W.H.5
  • 15
    • 0036786445 scopus 로고    scopus 로고
    • Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2)
    • J.J. Contos, I. Ishii, N. Fukushima, M.A. Kingsbury, X. Ye, S. Kawamura, J.H. Brown, and J. Chun Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2) Mol. Cell. Biol. 22 2002 6921 6929
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 6921-6929
    • Contos, J.J.1    Ishii, I.2    Fukushima, N.3    Kingsbury, M.A.4    Ye, X.5    Kawamura, S.6    Brown, J.H.7    Chun, J.8
  • 16
    • 0020285599 scopus 로고
    • Human platelet aggregation induced by 1-alkyl-lysophosphatidic acid and its analogs: A new group of phospholipid mediators?
    • M.F. Simon, H. Chap, and L. Douste-Blazy Human platelet aggregation induced by 1-alkyl-lysophosphatidic acid and its analogs: a new group of phospholipid mediators? Biochem. Biophys. Res. Commun. 108 1982 1743 1750
    • (1982) Biochem. Biophys. Res. Commun. , vol.108 , pp. 1743-1750
    • Simon, M.F.1    Chap, H.2    Douste-Blazy, L.3
  • 18
    • 0036683314 scopus 로고    scopus 로고
    • Human platelets respond differentially to lysophosphatidic acids having a highly unsaturated fatty acyl group and alkyl ether-linked lysophosphatidic acids
    • A. Tokumura, J. Sinomiya, S. Kishimoto, T. Tanaka, K. Kogure, T. Sugiura, K. Satouchi, K. Waku, and K. Fukuzawa Human platelets respond differentially to lysophosphatidic acids having a highly unsaturated fatty acyl group and alkyl ether-linked lysophosphatidic acids Biochem. J. 365 2002 617 628
    • (2002) Biochem. J. , vol.365 , pp. 617-628
    • Tokumura, A.1    Sinomiya, J.2    Kishimoto, S.3    Tanaka, T.4    Kogure, K.5    Sugiura, T.6    Satouchi, K.7    Waku, K.8    Fukuzawa, K.9
  • 19
    • 0038152846 scopus 로고    scopus 로고
    • Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family
    • K. Noguchi, S. Ishii, and T. Shimizu Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family J. Biol. Chem. 278 2003 25600 25606
    • (2003) J. Biol. Chem. , vol.278 , pp. 25600-25606
    • Noguchi, K.1    Ishii, S.2    Shimizu, T.3
  • 22
    • 70349756906 scopus 로고    scopus 로고
    • P2Y5 is a G(alpha)i, G(alpha)12/13 G protein-coupled receptor activated by lysophosphatidic acid that reduces intestinal cell adhesion
    • M. Lee, S. Choi, G. Hallden, S.J. Yo, D. Schichnes, and G.W. Aponte P2Y5 is a G(alpha)i, G(alpha)12/13 G protein-coupled receptor activated by lysophosphatidic acid that reduces intestinal cell adhesion Am. J. Physiol. Gastrointest. Liver Physiol. 297 2009 G641 G654
    • (2009) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.297
    • Lee, M.1    Choi, S.2    Hallden, G.3    Yo, S.J.4    Schichnes, D.5    Aponte, G.W.6
  • 24
    • 80052229808 scopus 로고    scopus 로고
    • Non-Edg family LPA receptors: The cutting edge of LPA research
    • K. Yanagida, and S. Ishii Non-Edg family LPA receptors: the cutting edge of LPA research J. Biochem. 150 2011 223 232
    • (2011) J. Biochem. , vol.150 , pp. 223-232
    • Yanagida, K.1    Ishii, S.2
  • 25
    • 0029836932 scopus 로고    scopus 로고
    • Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex
    • J.H. Hecht, J.A. Weiner, S.R. Post, and J. Chun Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex J. Cell Biol. 135 1996 1071 1083
    • (1996) J. Cell Biol. , vol.135 , pp. 1071-1083
    • Hecht, J.H.1    Weiner, J.A.2    Post, S.R.3    Chun, J.4
  • 26
    • 0024190129 scopus 로고    scopus 로고
    • Fossil squamata from the San-Jose formation, early eocene, San-Juan Basin, New-Mexico
    • R.M. Sullivan, and S.G. Lucas Fossil squamata from the San-Jose formation, early eocene, San-Juan Basin, New-Mexico J. Paleontol. 62 1998 631
    • (1998) J. Paleontol. , vol.62 , pp. 631
    • Sullivan, R.M.1    Lucas, S.G.2
  • 28
    • 33747685338 scopus 로고    scopus 로고
    • GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5
    • C.W. Lee, R. Rivera, S. Gardell, A.E. Dubin, and J. Chun GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5 J. Biol. Chem. 281 2006 23589 23597
    • (2006) J. Biol. Chem. , vol.281 , pp. 23589-23597
    • Lee, C.W.1    Rivera, R.2    Gardell, S.3    Dubin, A.E.4    Chun, J.5
  • 30
    • 34948889998 scopus 로고    scopus 로고
    • The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor
    • K. Tabata, K. Baba, A. Shiraishi, M. Ito, and N. Fujita The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor Biochem. Biophys. Res. Commun. 363 2007 861 866
    • (2007) Biochem. Biophys. Res. Commun. , vol.363 , pp. 861-866
    • Tabata, K.1    Baba, K.2    Shiraishi, A.3    Ito, M.4    Fujita, N.5
  • 31
    • 44149111549 scopus 로고    scopus 로고
    • Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor
    • M. Murakami, A. Shiraishi, K. Tabata, and N. Fujita Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor Biochem. Biophys. Res. Commun. 371 2008 707 712
    • (2008) Biochem. Biophys. Res. Commun. , vol.371 , pp. 707-712
    • Murakami, M.1    Shiraishi, A.2    Tabata, K.3    Fujita, N.4
  • 33
    • 0029077406 scopus 로고
    • A family of phospholipid autacoids: occurrence, metabolism and bioactions
    • A. Tokumura A family of phospholipid autacoids: occurrence, metabolism and bioactions Prog. Lipid Res. 34 1995 151 184
    • (1995) Prog. Lipid Res. , vol.34 , pp. 151-184
    • Tokumura, A.1
  • 34
    • 0034726004 scopus 로고    scopus 로고
    • Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors
    • K. Bandoh, J. Aoki, A. Taira, M. Tsujimoto, H. Arai, and K. Inoue Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors FEBS Lett. 478 2000 159 165
    • (2000) FEBS Lett. , vol.478 , pp. 159-165
    • Bandoh, K.1    Aoki, J.2    Taira, A.3    Tsujimoto, M.4    Arai, H.5    Inoue, K.6
  • 35
    • 70449549949 scopus 로고
    • Intestine-stimulating activity of various phosphatides and glycolipids
    • W. Vogt Intestine-stimulating activity of various phosphatides and glycolipids Naunyn Schmiedebergs Arch. Exp. Pathol. Pharmakol. 240 1960 134 139
    • (1960) Naunyn Schmiedebergs Arch. Exp. Pathol. Pharmakol. , vol.240 , pp. 134-139
    • Vogt, W.1
  • 36
    • 0018172397 scopus 로고
    • Effects of synthetic and natural lysophosphatidic acids on the arterial blood pressure of different animal species
    • A. Tokumura, K. Fukuzawa, and H. Tsukatani Effects of synthetic and natural lysophosphatidic acids on the arterial blood pressure of different animal species Lipids 13 1978 572 574
    • (1978) Lipids , vol.13 , pp. 572-574
    • Tokumura, A.1    Fukuzawa, K.2    Tsukatani, H.3
  • 37
    • 42649146229 scopus 로고    scopus 로고
    • Gene expression profiling for the identification of G-protein coupled receptors in human platelets
    • S. Amisten, O.O. Braun, A. Bengtsson, and D. Erlinge Gene expression profiling for the identification of G-protein coupled receptors in human platelets Thromb. Res. 122 2008 47 57
    • (2008) Thromb. Res. , vol.122 , pp. 47-57
    • Amisten, S.1    Braun, O.O.2    Bengtsson, A.3    Erlinge, D.4
  • 40
    • 79952842711 scopus 로고    scopus 로고
    • GPR92/LPA5 lysophosphatidate receptor mediates megakaryocytic cell shape change induced by human atherosclerotic plaques
    • A.L. Khandoga, D. Pandey, U. Welsch, R. Brandl, and W. Siess GPR92/LPA5 lysophosphatidate receptor mediates megakaryocytic cell shape change induced by human atherosclerotic plaques Cardiovasc. Res. 90 2011 157 164
    • (2011) Cardiovasc. Res. , vol.90 , pp. 157-164
    • Khandoga, A.L.1    Pandey, D.2    Welsch, U.3    Brandl, R.4    Siess, W.5
  • 41
    • 84855351712 scopus 로고    scopus 로고
    • Congenital hair loss disorders: rare, but not too rare
    • Y. Shimomura Congenital hair loss disorders: rare, but not too rare J. Dermatol. 39 2012 3 10
    • (2012) J. Dermatol. , vol.39 , pp. 3-10
    • Shimomura, Y.1
  • 43
    • 0028340689 scopus 로고
    • Biochemical characterization of the interaction of lipid phosphoric acids with human platelets: comparison with platelet activating factor
    • T. Sugiura, A. Tokumura, L. Gregory, T. Nouchi, S.T. Weintraub, and D.J. Hanahan Biochemical characterization of the interaction of lipid phosphoric acids with human platelets: comparison with platelet activating factor Arch. Biochem. Biophys. 311 1994 358 368
    • (1994) Arch. Biochem. Biophys. , vol.311 , pp. 358-368
    • Sugiura, T.1    Tokumura, A.2    Gregory, L.3    Nouchi, T.4    Weintraub, S.T.5    Hanahan, D.J.6
  • 44
    • 0035206909 scopus 로고    scopus 로고
    • Activity of 2-substituted lysophosphatidic acid (LPA) analogs at LPA receptors: discovery of a LPA1/LPA3 receptor antagonist
    • C.E. Heise, W.L. Santos, A.M. Schreihofer, B.H. Heasley, Y.V. Mukhin, T.L. Macdonald, and K.R. Lynch Activity of 2-substituted lysophosphatidic acid (LPA) analogs at LPA receptors: discovery of a LPA1/LPA3 receptor antagonist Mol. Pharmacol. 60 2001 1173 1180
    • (2001) Mol. Pharmacol. , vol.60 , pp. 1173-1180
    • Heise, C.E.1    Santos, W.L.2    Schreihofer, A.M.3    Heasley, B.H.4    Mukhin, Y.V.5    Macdonald, T.L.6    Lynch, K.R.7
  • 45
    • 2342626086 scopus 로고    scopus 로고
    • Initial structure-activity relationships of lysophosphatidic acid receptor antagonists: discovery of a high-affinity LPA1/LPA3 receptor antagonist
    • B.H. Heasley, R. Jarosz, K.R. Lynch, and T.L. Macdonald Initial structure-activity relationships of lysophosphatidic acid receptor antagonists: discovery of a high-affinity LPA1/LPA3 receptor antagonist Bioorg. Med. Chem. Lett. 14 2004 2735 2740
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 2735-2740
    • Heasley, B.H.1    Jarosz, R.2    Lynch, K.R.3    Macdonald, T.L.4
  • 46
    • 2942532893 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of phosphonic and thiophosphoric acid derivatives of lysophosphatidic acid
    • W.L. Santos, B.H. Heasley, R. Jarosz, K.M. Carter, K.R. Lynch, and T.L. Macdonald Synthesis and biological evaluation of phosphonic and thiophosphoric acid derivatives of lysophosphatidic acid Bioorg. Med. Chem. Lett. 14 2004 3473 3476
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 3473-3476
    • Santos, W.L.1    Heasley, B.H.2    Jarosz, R.3    Carter, K.M.4    Lynch, K.R.5    Macdonald, T.L.6
  • 47
    • 3042640422 scopus 로고    scopus 로고
    • A novel series of 2-pyridyl-containing compounds as lysophosphatidic acid receptor antagonists: development of a nonhydrolyzable LPA3 receptor-selective antagonist
    • B.H. Heasley, R. Jarosz, K.M. Carter, S.J. Van, K.R. Lynch, and T.L. Macdonald A novel series of 2-pyridyl-containing compounds as lysophosphatidic acid receptor antagonists: development of a nonhydrolyzable LPA3 receptor-selective antagonist Bioorg. Med. Chem. Lett. 14 2004 4069 4074
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 4069-4074
    • Heasley, B.H.1    Jarosz, R.2    Carter, K.M.3    Van, S.J.4    Lynch, K.R.5    Macdonald, T.L.6
  • 48
    • 0346366461 scopus 로고    scopus 로고
    • Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity
    • L. Qian, Y. Xu, Y. Hasegawa, J. Aoki, G.B. Mills, and G.D. Prestwich Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity J. Med. Chem. 46 2003 5575 5578
    • (2003) J. Med. Chem. , vol.46 , pp. 5575-5578
    • Qian, L.1    Xu, Y.2    Hasegawa, Y.3    Aoki, J.4    Mills, G.B.5    Prestwich, G.D.6
  • 51
  • 52
    • 26844556056 scopus 로고    scopus 로고
    • IL-4 regulates MEK expression required for lysophosphatidic acid-mediated chemokine generation by human mast cells
    • D.A. Lin, and J.A. Boyce IL-4 regulates MEK expression required for lysophosphatidic acid-mediated chemokine generation by human mast cells J. Immunol. 175 2005 5430 5438
    • (2005) J. Immunol. , vol.175 , pp. 5430-5438
    • Lin, D.A.1    Boyce, J.A.2
  • 53
    • 36248947897 scopus 로고    scopus 로고
    • Lysophosphatidic acid decreases the nuclear localization and cellular abundance of the p53 tumor suppressor in A549 lung carcinoma cells
    • M.M. Murph, J. Hurst-Kennedy, V. Newton, D.N. Brindley, and H. Radhakrishna Lysophosphatidic acid decreases the nuclear localization and cellular abundance of the p53 tumor suppressor in A549 lung carcinoma cells Mol. Cancer Res. 5 2007 1201 1211
    • (2007) Mol. Cancer Res. , vol.5 , pp. 1201-1211
    • Murph, M.M.1    Hurst-Kennedy, J.2    Newton, V.3    Brindley, D.N.4    Radhakrishna, H.5
  • 55
    • 77955663998 scopus 로고    scopus 로고
    • The role of lysophosphatidic acid receptors in phenotypic modulation of vascular smooth muscle cells
    • Z. Zhou, J. Niu, and Z. Zhang The role of lysophosphatidic acid receptors in phenotypic modulation of vascular smooth muscle cells Mol. Biol. Rep. 37 2010 2675 2686
    • (2010) Mol. Biol. Rep. , vol.37 , pp. 2675-2686
    • Zhou, Z.1    Niu, J.2    Zhang, Z.3
  • 56
    • 70350719132 scopus 로고    scopus 로고
    • The synergistic effects of lysophosphatidic acid receptor agonists and calcitriol on MG63 osteoblast maturation at titanium and hydroxyapatite surfaces
    • J.P. Mansell, M. Barbour, C. Moore, M. Nowghani, M. Pabbruwe, T. Sjostrom, and A.W. Blom The synergistic effects of lysophosphatidic acid receptor agonists and calcitriol on MG63 osteoblast maturation at titanium and hydroxyapatite surfaces Biomaterials 31 2010 199 206
    • (2010) Biomaterials , vol.31 , pp. 199-206
    • Mansell, J.P.1    Barbour, M.2    Moore, C.3    Nowghani, M.4    Pabbruwe, M.5    Sjostrom, T.6    Blom, A.W.7
  • 57
    • 79955069231 scopus 로고    scopus 로고
    • Lysophosphatidic acid presynaptically blocks NO uptake during electric field stimulation-induced relaxation via LPA(1) receptor in cat lower esophageal sphincter
    • J.W. Lee, C.H. Kim, Y.Y. Wang, X.M. Yan, and U.D. Sohn Lysophosphatidic acid presynaptically blocks NO uptake during electric field stimulation-induced relaxation via LPA(1) receptor in cat lower esophageal sphincter Arch. Pharm. Res. 34 2011 169 176
    • (2011) Arch. Pharm. Res. , vol.34 , pp. 169-176
    • Lee, J.W.1    Kim, C.H.2    Wang, Y.Y.3    Yan, X.M.4    Sohn, U.D.5
  • 60
    • 33751410796 scopus 로고    scopus 로고
    • Farnesyl phosphates are endogenous ligands of lysophosphatidic acid receptors: inhibition of LPA GPCR and activation of PPARs
    • K. Liliom, T. Tsukahara, R. Tsukahara, M. Zelman-Femiak, E. Swiezewska, and G. Tigyi Farnesyl phosphates are endogenous ligands of lysophosphatidic acid receptors: inhibition of LPA GPCR and activation of PPARs Biochim. Biophys. Acta 1761 2006 1506 1514
    • (2006) Biochim. Biophys. Acta , vol.1761 , pp. 1506-1514
    • Liliom, K.1    Tsukahara, T.2    Tsukahara, R.3    Zelman-Femiak, M.4    Swiezewska, E.5    Tigyi, G.6
  • 63
    • 33947529532 scopus 로고    scopus 로고
    • LPA(4)/GPR23 is a lysophosphatidic acid (LPA) receptor utilizing G(s)-, G(q)/G(i)-mediated calcium signaling and G(12/13)-mediated Rho activation
    • C.W. Lee, R. Rivera, A.E. Dubin, and J. Chun LPA(4)/GPR23 is a lysophosphatidic acid (LPA) receptor utilizing G(s)-, G(q)/G(i)-mediated calcium signaling and G(12/13)-mediated Rho activation J. Biol. Chem. 282 2007 4310 4317
    • (2007) J. Biol. Chem. , vol.282 , pp. 4310-4317
    • Lee, C.W.1    Rivera, R.2    Dubin, A.E.3    Chun, J.4
  • 65
    • 0036597808 scopus 로고    scopus 로고
    • The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities
    • Y. Takuwa, N. Takuwa, and N. Sugimoto The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities J. Biochem. 131 2002 767 771
    • (2002) J. Biochem. , vol.131 , pp. 767-771
    • Takuwa, Y.1    Takuwa, N.2    Sugimoto, N.3
  • 66
    • 34247173599 scopus 로고    scopus 로고
    • LPA4/p2y9/GPR23 mediates rho-dependent morphological changes in a rat neuronal cell line
    • K. Yanagida, S. Ishii, F. Hamano, K. Noguchi, and T. Shimizu LPA4/p2y9/GPR23 mediates rho-dependent morphological changes in a rat neuronal cell line J. Biol. Chem. 282 2007 5814 5824
    • (2007) J. Biol. Chem. , vol.282 , pp. 5814-5824
    • Yanagida, K.1    Ishii, S.2    Hamano, F.3    Noguchi, K.4    Shimizu, T.5
  • 69
    • 0031015426 scopus 로고    scopus 로고
    • Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency
    • S. Offermanns, V. Mancino, J.P. Revel, and M.I. Simon Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency Science 275 1997 533 536
    • (1997) Science , vol.275 , pp. 533-536
    • Offermanns, S.1    Mancino, V.2    Revel, J.P.3    Simon, M.I.4
  • 72
    • 77953159888 scopus 로고    scopus 로고
    • Autotaxin promotes cancer invasion via the lysophosphatidic acid receptor 4: participation of the cyclic AMP/EPAC/Rac1 signaling pathway in invadopodia formation
    • K. Harper, D. Arsenault, S. Boulay-Jean, A. Lauzier, F. Lucien, and C.M. Dubois Autotaxin promotes cancer invasion via the lysophosphatidic acid receptor 4: participation of the cyclic AMP/EPAC/Rac1 signaling pathway in invadopodia formation Cancer Res. 70 2010 4634 4643
    • (2010) Cancer Res. , vol.70 , pp. 4634-4643
    • Harper, K.1    Arsenault, D.2    Boulay-Jean, S.3    Lauzier, A.4    Lucien, F.5    Dubois, C.M.6
  • 74
    • 0030613761 scopus 로고    scopus 로고
    • Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A
    • Y. Daaka, L.M. Luttrell, and R.J. Lefkowitz Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A Nature 390 1997 88 91
    • (1997) Nature , vol.390 , pp. 88-91
    • Daaka, Y.1    Luttrell, L.M.2    Lefkowitz, R.J.3
  • 75
    • 33646394319 scopus 로고    scopus 로고
    • Gs and Gi coupling of adrenomedullin in adult rat ventricular myocytes
    • S. Mittra, and J.P. Bourreau Gs and Gi coupling of adrenomedullin in adult rat ventricular myocytes Am. J. Physiol. Heart Circ. Physiol. 290 2006 H1842 H1847
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.290
    • Mittra, S.1    Bourreau, J.P.2
  • 76
    • 83355173005 scopus 로고    scopus 로고
    • LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor
    • M. Jongsma, E. Matas-Rico, A. Rzadkowski, K. Jalink, and W.H. Moolenaar LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor PLoS One 6 2012 e29260
    • (2012) PLoS One , vol.6 , pp. 29260
    • Jongsma, M.1    Matas-Rico, E.2    Rzadkowski, A.3    Jalink, K.4    Moolenaar, W.H.5
  • 78
    • 79953157141 scopus 로고    scopus 로고
    • LPA5 is abundantly expressed by human mast cells and important for lysophosphatidic acid induced MIP-1beta release
    • A. Lundequist, and J.A. Boyce LPA5 is abundantly expressed by human mast cells and important for lysophosphatidic acid induced MIP-1beta release PLoS One 6 2011 e18192
    • (2011) PLoS One , vol.6 , pp. 18192
    • Lundequist, A.1    Boyce, J.A.2
  • 79
    • 70450270609 scopus 로고    scopus 로고
    • Autotaxin/lysophospholipase D-mediated lysophosphatidic acid signaling is required to form distinctive large lysosomes in the visceral endoderm cells of the mouse yolk sac
    • S. Koike, K. Keino-Masu, T. Ohto, F. Sugiyama, S. Takahashi, and M. Masu Autotaxin/lysophospholipase D-mediated lysophosphatidic acid signaling is required to form distinctive large lysosomes in the visceral endoderm cells of the mouse yolk sac J. Biol. Chem. 284 2009 33561 33570
    • (2009) J. Biol. Chem. , vol.284 , pp. 33561-33570
    • Koike, S.1    Keino-Masu, K.2    Ohto, T.3    Sugiyama, F.4    Takahashi, S.5    Masu, M.6
  • 81
    • 34447306925 scopus 로고    scopus 로고
    • Functional invalidation of the autotaxin gene by a single amino acid mutation in mouse is lethal
    • G. Ferry, A. Giganti, F. Coge, F. Bertaux, K. Thiam, and J.A. Boutin Functional invalidation of the autotaxin gene by a single amino acid mutation in mouse is lethal FEBS Lett. 581 2007 3572 3578
    • (2007) FEBS Lett. , vol.581 , pp. 3572-3578
    • Ferry, G.1    Giganti, A.2    Coge, F.3    Bertaux, F.4    Thiam, K.5    Boutin, J.A.6
  • 83
    • 48749098088 scopus 로고    scopus 로고
    • Age-dependent loss of sperm production in mice via impaired lysophosphatidic acid signaling
    • X. Ye, M.K. Skinner, G. Kennedy, and J. Chun Age-dependent loss of sperm production in mice via impaired lysophosphatidic acid signaling Biol. Reprod. 79 2008 328 336
    • (2008) Biol. Reprod. , vol.79 , pp. 328-336
    • Ye, X.1    Skinner, M.K.2    Kennedy, G.3    Chun, J.4
  • 85
    • 54049091540 scopus 로고    scopus 로고
    • LPA1 is essential for lymphatic vessel development in zebrafish
    • S.J. Lee, T.H. Chan, T.C. Chen, B.K. Liao, P.P. Hwang, and H. Lee LPA1 is essential for lymphatic vessel development in zebrafish FASEB J. 22 2008 3706 3715
    • (2008) FASEB J. , vol.22 , pp. 3706-3715
    • Lee, S.J.1    Chan, T.H.2    Chen, T.C.3    Liao, B.K.4    Hwang, P.P.5    Lee, H.6
  • 87
    • 84856966242 scopus 로고    scopus 로고
    • The emerging role of lysophosphatidic acid (LPA) in skeletal biology
    • J. Blackburn, and J.P. Mansell The emerging role of lysophosphatidic acid (LPA) in skeletal biology Bone 50 2012 756 762
    • (2012) Bone , vol.50 , pp. 756-762
    • Blackburn, J.1    Mansell, J.P.2
  • 88
    • 10244227889 scopus 로고    scopus 로고
    • Lysophosphatidic acid accelerates the development of human mast cells
    • S. Bagga, K.S. Price, D.A. Lin, D.S. Friend, K.F. Austen, and J.A. Boyce Lysophosphatidic acid accelerates the development of human mast cells Blood 104 2004 4080 4087
    • (2004) Blood , vol.104 , pp. 4080-4087
    • Bagga, S.1    Price, K.S.2    Lin, D.A.3    Friend, D.S.4    Austen, K.F.5    Boyce, J.A.6
  • 89
    • 31544450736 scopus 로고    scopus 로고
    • Lysophosphatidic acid (LPA) induces plasma exudation and histamine release in mice via LPA receptors
    • T. Hashimoto, H. Ohata, and K. Honda Lysophosphatidic acid (LPA) induces plasma exudation and histamine release in mice via LPA receptors J. Pharmacol. Sci. 100 2006 82 87
    • (2006) J. Pharmacol. Sci. , vol.100 , pp. 82-87
    • Hashimoto, T.1    Ohata, H.2    Honda, K.3
  • 90
    • 27144494614 scopus 로고    scopus 로고
    • Lysophosphatidic acid induces histamine release from mast cells and skin fragments
    • T. Hashimoto, H. Ohata, K. Momose, and K. Honda Lysophosphatidic acid induces histamine release from mast cells and skin fragments Pharmacology 75 2005 13 20
    • (2005) Pharmacology , vol.75 , pp. 13-20
    • Hashimoto, T.1    Ohata, H.2    Momose, K.3    Honda, K.4
  • 91
    • 4043072745 scopus 로고    scopus 로고
    • Itch-scratch responses induced by lysophosphatidic acid in mice
    • T. Hashimoto, H. Ohata, and K. Momose Itch-scratch responses induced by lysophosphatidic acid in mice Pharmacology 72 2004 51 56
    • (2004) Pharmacology , vol.72 , pp. 51-56
    • Hashimoto, T.1    Ohata, H.2    Momose, K.3
  • 92
    • 35748982943 scopus 로고    scopus 로고
    • Submucosal connective tissue-type mast cells contribute to the production of lysophosphatidic acid (LPA) in the gastrointestinal tract through the secretion of autotaxin (ATX)/lysophospholipase D (lysoPLD)
    • K. Mori, J. Kitayama, J. Aoki, Y. Kishi, D. Shida, H. Yamashita, H. Arai, and H. Nagawa Submucosal connective tissue-type mast cells contribute to the production of lysophosphatidic acid (LPA) in the gastrointestinal tract through the secretion of autotaxin (ATX)/lysophospholipase D (lysoPLD) Virchows Arch. 451 2007 47 56
    • (2007) Virchows Arch. , vol.451 , pp. 47-56
    • Mori, K.1    Kitayama, J.2    Aoki, J.3    Kishi, Y.4    Shida, D.5    Yamashita, H.6    Arai, H.7    Nagawa, H.8
  • 93
  • 95
    • 0042887042 scopus 로고    scopus 로고
    • The emerging role of lysophosphatidic acid in cancer
    • G.B. Mills, and W.H. Moolenaar The emerging role of lysophosphatidic acid in cancer Nat. Rev. Cancer 3 2003 582 591
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 582-591
    • Mills, G.B.1    Moolenaar, W.H.2
  • 96
  • 97
    • 69549117128 scopus 로고    scopus 로고
    • Evaluating dual activity LPA receptor pan-antagonist/autotaxin inhibitors as anti-cancer agents in vivo using engineered human tumors
    • X. Xu, G. Yang, H. Zhang, and G.D. Prestwich Evaluating dual activity LPA receptor pan-antagonist/autotaxin inhibitors as anti-cancer agents in vivo using engineered human tumors Prostaglandins Other Lipid Mediat. 89 2009 140 146
    • (2009) Prostaglandins Other Lipid Mediat. , vol.89 , pp. 140-146
    • Xu, X.1    Yang, G.2    Zhang, H.3    Prestwich, G.D.4
  • 102
    • 80051543064 scopus 로고    scopus 로고
    • Lysophosphatidic acid as the initiator of neuropathic pain
    • H. Ueda Lysophosphatidic acid as the initiator of neuropathic pain Biol. Pharm. Bull. 34 2011 1154 1158
    • (2011) Biol. Pharm. Bull. , vol.34 , pp. 1154-1158
    • Ueda, H.1
  • 103
    • 41749103337 scopus 로고    scopus 로고
    • Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain
    • M. Inoue, L. Ma, J. Aoki, J. Chun, and H. Ueda Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain Mol. Pain 4 2008 6
    • (2008) Mol. Pain , vol.4 , pp. 6
    • Inoue, M.1    Ma, L.2    Aoki, J.3    Chun, J.4    Ueda, H.5
  • 104
    • 3142685946 scopus 로고    scopus 로고
    • Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling
    • M. Inoue, M.H. Rashid, R. Fujita, J.J. Contos, J. Chun, and H. Ueda Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling Nat. Med. 10 2004 712 718
    • (2004) Nat. Med. , vol.10 , pp. 712-718
    • Inoue, M.1    Rashid, M.H.2    Fujita, R.3    Contos, J.J.4    Chun, J.5    Ueda, H.6
  • 105
    • 75549089548 scopus 로고    scopus 로고
    • Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain
    • L. Ma, H. Uchida, J. Nagai, M. Inoue, J. Chun, J. Aoki, and H. Ueda Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain Mol. Pain 5 2009 64
    • (2009) Mol. Pain , vol.5 , pp. 64
    • Ma, L.1    Uchida, H.2    Nagai, J.3    Inoue, M.4    Chun, J.5    Aoki, J.6    Ueda, H.7
  • 106
    • 84861218222 scopus 로고    scopus 로고
    • Targeted deletion of LPA5 identifies novel roles for LPA signaling in the development of neuropathic pain
    • M.E. Lin, R.R. Rivera, and J. Chun Targeted deletion of LPA5 identifies novel roles for LPA signaling in the development of neuropathic pain J. Biol. Chem. 287 2012 17608 17617
    • (2012) J. Biol. Chem. , vol.287 , pp. 17608-17617
    • Lin, M.E.1    Rivera, R.R.2    Chun, J.3
  • 107
    • 0041833766 scopus 로고    scopus 로고
    • Phosphatidic acid has a potential to promote hair growth in vitro and in vivo, and activates mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in hair epithelial cells
    • T. Takahashi, A. Kamimura, T. Hamazono-Matsuoka, and S. Honda Phosphatidic acid has a potential to promote hair growth in vitro and in vivo, and activates mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in hair epithelial cells J. Invest. Dermatol. 121 2003 448 456
    • (2003) J. Invest. Dermatol. , vol.121 , pp. 448-456
    • Takahashi, T.1    Kamimura, A.2    Hamazono-Matsuoka, T.3    Honda, S.4
  • 109
    • 39749127117 scopus 로고    scopus 로고
    • Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair
    • Y. Shimomura, M. Wajid, Y. Ishii, L. Shapiro, L. Petukhova, D. Gordon, and A.M. Christiano Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair Nat. Genet. 40 2008 335 339
    • (2008) Nat. Genet. , vol.40 , pp. 335-339
    • Shimomura, Y.1    Wajid, M.2    Ishii, Y.3    Shapiro, L.4    Petukhova, L.5    Gordon, D.6    Christiano, A.M.7
  • 110
    • 77955293300 scopus 로고    scopus 로고
    • Genetic mapping of a novel hypotrichosis locus to chromosome 7p21.3-p22.3 in a Pakistani family and screening of the candidate genes
    • S. Basit, G. Ali, N. Wasif, M. Ansar, and W. Ahmad Genetic mapping of a novel hypotrichosis locus to chromosome 7p21.3-p22.3 in a Pakistani family and screening of the candidate genes Hum. Genet. 128 2010 213 220
    • (2010) Hum. Genet. , vol.128 , pp. 213-220
    • Basit, S.1    Ali, G.2    Wasif, N.3    Ansar, M.4    Ahmad, W.5


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