메뉴 건너뛰기




Volumn 70, Issue 11, 2010, Pages 4634-4643

Autotaxin promotes cancer invasion via the lysophosphatidic acid receptor 4: Participation of the cyclic AMP/EPAC/Rac1 signaling pathway in invadopodia formation

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPORTER; AUTOTAXIN; CYCLIC AMP; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CYCLIC AMP; LYSOPHOSPHATIDIC ACID RECEPTOR; LYSOPHOSPHATIDIC ACID RECEPTOR 4; RAC1 PROTEIN; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

EID: 77953159888     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-3813     Document Type: Article
Times cited : (60)

References (50)
  • 1
    • 0026787698 scopus 로고
    • Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein
    • Stracke ML, Krutzsch HC, Unsworth EJ, et al. Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein. J Biol Chem 1992;267:2524-2529
    • (1992) J Biol Chem , vol.267 , pp. 2524-2529
    • Stracke, M.L.1    Krutzsch, H.C.2    Unsworth, E.J.3
  • 2
    • 33745221886 scopus 로고    scopus 로고
    • Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid
    • Kishi Y, Okudaira S, Tanaka M, et al. Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid. J Biol Chem 2006;281:17492-17500
    • (2006) J Biol Chem , vol.281 , pp. 17492-17500
    • Kishi, Y.1    Okudaira, S.2    Tanaka, M.3
  • 3
    • 0036456916 scopus 로고    scopus 로고
    • Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells
    • Yang SY, Lee J, Park CG, et al. Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells. Clin Exp Metastasis 2002;19:603-8.4.
    • (2002) Clin Exp Metastasis , vol.19
    • Yang, S.Y.1    Lee, J.2    Park, C.G.3
  • 5
    • 33947307364 scopus 로고    scopus 로고
    • Peritoneal fluids from patients with certain gynecologic tumor contain elevated levels of bioactive lysophospholipase D activity
    • Tokumura A, Kume T, Fukuzawa K, et al. Peritoneal fluids from patients with certain gynecologic tumor contain elevated levels of bioactive lysophospholipase D activity. Life Sci 2007;80:1641-1649
    • (2007) Life Sci , vol.80 , pp. 1641-1649
    • Tokumura, A.1    Kume, T.2    Fukuzawa, K.3
  • 6
    • 58149290244 scopus 로고    scopus 로고
    • Stimulatory role of lysophosphatidic acid in cyclooxygenase-2 induction by synovial fluid of patients with rheumatoid arthritis in fibroblast-like synovial cells
    • Nochi H, Tomura H, Tobo M, et al. Stimulatory role of lysophosphatidic acid in cyclooxygenase-2 induction by synovial fluid of patients with rheumatoid arthritis in fibroblast-like synovial cells. J Immunol 2008;181:5111-5119
    • (2008) J Immunol , vol.181 , pp. 5111-5119
    • Nochi, H.1    Tomura, H.2    Tobo, M.3
  • 7
    • 13644249767 scopus 로고    scopus 로고
    • Identification of autotaxin as a neurite retraction-inducing factor of PC12 cells in cerebrospinal fluid and its possible sources
    • Sato K, Malchinkhuu E, Muraki T, et al. Identification of autotaxin as a neurite retraction-inducing factor of PC12 cells in cerebrospinal fluid and its possible sources. J Neurochem 2005;92:904-914
    • (2005) J Neurochem , vol.92 , pp. 904-914
    • Sato, K.1    Malchinkhuu, E.2    Muraki, T.3
  • 8
    • 27144527959 scopus 로고    scopus 로고
    • Production of lysophosphatidic acid in blister fluid: Involvement of a lysophospholipase D activity
    • Mazereeuw-Hautier J, Gres S, Fanguin M, et al. Production of lysophosphatidic acid in blister fluid: involvement of a lysophospholipase D activity. J Invest Dermatol 2005;125:421-427
    • (2005) J Invest Dermatol , vol.125 , pp. 421-427
    • Mazereeuw-Hautier, J.1    Gres, S.2    Fanguin, M.3
  • 9
    • 0034642507 scopus 로고    scopus 로고
    • Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells
    • Nam SW, Clair T, Campo CK, Lee HY, Liotta LA, Stracke ML. Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells. Oncogene 2000;19:241-247 (Pubitemid 30077220)
    • (2000) Oncogene , vol.19 , Issue.2 , pp. 241-247
    • Nam, S.W.1    Clair, T.2    Campo, C.K.3    Lee, H.Y.4    Liotta, L.A.5    Stracke, M.L.6
  • 11
    • 1542359873 scopus 로고    scopus 로고
    • Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production
    • Umezu-Goto M, Kishi Y, Taira A, et al. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. J Cell Biol 2002;158:227-233
    • (2002) J Cell Biol , vol.158 , pp. 227-233
    • Umezu-Goto, M.1    Kishi, Y.2    Taira, A.3
  • 12
    • 33745466418 scopus 로고    scopus 로고
    • Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development
    • van Meeteren LA, Ruurs P, Stortelers C, et al. Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development. Mol Cell Biol 2006;26:5015-5022
    • (2006) Mol Cell Biol , vol.26 , pp. 5015-5022
    • Van Meeteren, L.A.1    Ruurs, P.2    Stortelers, C.3
  • 14
    • 17144460494 scopus 로고    scopus 로고
    • Critical role of lysophospholipids in the pathophysiology, diagnosis, and management of ovarian cancer
    • Mills GB, Eder A, Fang X, et al. Critical role of lysophospholipids in the pathophysiology, diagnosis, and management of ovarian cancer. Cancer Treat Res 2002;107:259-283
    • (2002) Cancer Treat Res , vol.107 , pp. 259-283
    • Mills, G.B.1    Eder, A.2    Fang, X.3
  • 15
    • 14844284989 scopus 로고    scopus 로고
    • Lipid phosphate phosphatases and related proteins: Signaling functions in development, cell division, and cancer
    • Brindley DN. Lipid phosphate phosphatases and related proteins: signaling functions in development, cell division, and cancer. J Cell Biochem 2004;92:900-912
    • (2004) J Cell Biochem , vol.92 , pp. 900-912
    • Brindley, D.N.1
  • 16
    • 33747685338 scopus 로고    scopus 로고
    • GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5
    • Lee CW, Rivera R, Gardell S, Dubin AE, Chun J. GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5. J Biol Chem 2006;281:23589-23597
    • (2006) J Biol Chem , vol.281 , pp. 23589-23597
    • Lee, C.W.1    Rivera, R.2    Gardell, S.3    Dubin, A.E.4    Chun, J.5
  • 17
    • 0038152846 scopus 로고    scopus 로고
    • Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the edg family
    • Noguchi K, Ishii S, Shimizu T. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the edg family. J Biol Chem 2003;278:25600-25606
    • (2003) J Biol Chem , vol.278 , pp. 25600-25606
    • Noguchi, K.1    Ishii, S.2    Shimizu, T.3
  • 18
    • 34948889998 scopus 로고    scopus 로고
    • The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor
    • Tabata K, Baba K, Shiraishi A, Ito M, Fujita N. The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor. Biochem Biophys Res Commun 2007;363:861-866
    • (2007) Biochem Biophys Res Commun , vol.363 , pp. 861-866
    • Tabata, K.1    Baba, K.2    Shiraishi, A.3    Ito, M.4    Fujita, N.5
  • 20
    • 65649132676 scopus 로고    scopus 로고
    • Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases
    • Liu S, Umezu-Goto M, Murph M, et al. Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases. Cancer Cell 2009;15:539-550
    • (2009) Cancer Cell , vol.15 , pp. 539-550
    • Liu, S.1    Umezu-Goto, M.2    Murph, M.3
  • 21
    • 67650458524 scopus 로고    scopus 로고
    • Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo
    • Zhang H, Xu X, Gajewiak J, et al. Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo. Cancer Res 2009;69:5441-5449
    • (2009) Cancer Res , vol.69 , pp. 5441-5449
    • Zhang, H.1    Xu, X.2    Gajewiak, J.3
  • 22
    • 13444301091 scopus 로고    scopus 로고
    • Molecular mechanisms of invadopodium formation: The role of the N-WASP-Arp2/3 complex pathway and cofilin
    • Yamaguchi H, Lorenz M, Kempiak S, et al. Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin. J Cell Biol 2005;168:441-452
    • (2005) J Cell Biol , vol.168 , pp. 441-452
    • Yamaguchi, H.1    Lorenz, M.2    Kempiak, S.3
  • 23
    • 0345059766 scopus 로고    scopus 로고
    • Intravital imaging of cell movement in tumours
    • Condeelis J, Segall JE. Intravital imaging of cell movement in tumours. Nat Rev Cancer 2003;3:921-930 (Pubitemid 37500177)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.12 , pp. 921-930
    • Condeelis, J.1    Segall, J.E.2
  • 24
    • 3543114271 scopus 로고    scopus 로고
    • Foot and mouth: Podosomes, invadopodia and circular dorsal ruffles
    • Buccione R, Orth JD, McNiven MA. Foot and mouth: podosomes, invadopodia and circular dorsal ruffles. Nat Rev Mol Cell Biol 2004; 5:647-657
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 647-657
    • Buccione, R.1    Orth, J.D.2    McNiven, M.A.3
  • 26
    • 65549106079 scopus 로고    scopus 로고
    • ADP-ribosylation factor 6 regulates tumorigenic and invasive properties in vivo
    • Muralidharan-Chari V, Hoover H, Clancy J, et al. ADP-ribosylation factor 6 regulates tumorigenic and invasive properties in vivo. Cancer Res 2009;69:2201-2209
    • (2009) Cancer Res , vol.69 , pp. 2201-2209
    • Muralidharan-Chari, V.1    Hoover, H.2    Clancy, J.3
  • 27
    • 50849085178 scopus 로고    scopus 로고
    • Extracellular matrix rigidity promotes invadopodia activity
    • Alexander NR, Branch KM, Parekh A, et al. Extracellular matrix rigidity promotes invadopodia activity. Curr Biol 2008;18:1295-1299
    • (2008) Curr Biol , vol.18 , pp. 1295-1299
    • Alexander, N.R.1    Branch, K.M.2    Parekh, A.3
  • 28
    • 33645507413 scopus 로고    scopus 로고
    • Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: Defining the stages of invadopodia formation and function
    • Artym VV, Zhang Y, Seillier-Moiseiwitsch F, Yamada KM, Mueller SC. Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function. Cancer Res 2006;66:3034-3043
    • (2006) Cancer Res , vol.66 , pp. 3034-3043
    • Artym, V.V.1    Zhang, Y.2    Seillier-Moiseiwitsch, F.3    Yamada, K.M.4    Mueller, S.C.5
  • 29
    • 0027169767 scopus 로고
    • A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples
    • 536-537
    • Chomczynski P. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. BioTechniques 1993;15:532-4, 536-537
    • (1993) BioTechniques , vol.15 , pp. 532-534
    • Chomczynski, P.1
  • 30
    • 0035823510 scopus 로고    scopus 로고
    • Cross-talk between the p42/p44 MAP kinase and smad pathways in transforming growth factor β1-induced furin gene transactivation
    • Blanchette F, Rivard N, Rudd P, Grondin F, Attisano L, Dubois CM. Cross-talk between the p42/p44 MAP kinase and smad pathways in transforming growth factor β1-induced furin gene transactivation. J Biol Chem 2001;276:33986-33994
    • (2001) J Biol Chem , vol.276 , pp. 33986-33994
    • Blanchette, F.1    Rivard, N.2    Rudd, P.3    Grondin, F.4    Attisano, L.5    Dubois, C.M.6
  • 31
    • 33751257756 scopus 로고    scopus 로고
    • Actin dynamics at sites of extracellular matrix degradation
    • Baldassarre M, Ayala I, Beznoussenko G, et al. Actin dynamics at sites of extracellular matrix degradation. Eur J Cell Biol 2006;85: 1217-1231
    • (2006) Eur J Cell Biol , vol.85 , pp. 1217-1231
    • Baldassarre, M.1    Ayala, I.2    Beznoussenko, G.3
  • 32
    • 33748948921 scopus 로고    scopus 로고
    • Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: A link to integrin function
    • Carragher NO, Walker SM, Scott Carragher LA, et al. Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function. Oncogene 2006; 25:5726-5740
    • (2006) Oncogene , vol.25 , pp. 5726-5740
    • Carragher, N.O.1    Walker, S.M.2    Scott Carragher, L.A.3
  • 34
    • 0030015892 scopus 로고    scopus 로고
    • Mechanism of action of cholera toxin & other toxins
    • Ganguly NK, Kaur T. Mechanism of action of cholera toxin & other toxins. Indian J Med Res 1996;104:28-37.
    • (1996) Indian J Med Res , vol.104 , pp. 28-37
    • Ganguly, N.K.1    Kaur, T.2
  • 35
    • 47549108691 scopus 로고    scopus 로고
    • Epac and PKA: A tale of two intracellular cAMP receptors
    • Shanghai
    • Cheng X, Ji Z, Tsalkova T, Mei F. Epac and PKA: a tale of two intracellular cAMP receptors. Acta Biochim Biophys Sin (Shanghai) 2008; 40:651-662
    • (2008) Acta Biochim Biophys Sin , vol.40 , pp. 651-662
    • Cheng, X.1    Ji, Z.2    Tsalkova, T.3    Mei, F.4
  • 36
    • 0142024483 scopus 로고    scopus 로고
    • Rap1 GTPase: Functions, regulation, and malignancy
    • Hattori M, Minato N. Rap1 GTPase: functions, regulation, and malignancy. J Biochem 2003;134:479-484
    • (2003) J Biochem , vol.134 , pp. 479-484
    • Hattori, M.1    Minato, N.2
  • 37
    • 64049095782 scopus 로고    scopus 로고
    • Involvement of rac and rho signaling in cancer cell motility in 3D substrates
    • Yamazaki D, Kurisu S, Takenawa T. Involvement of rac and rho signaling in cancer cell motility in 3D substrates. Oncogene 2009;28: 1570-1583
    • (2009) Oncogene , vol.28 , pp. 1570-1583
    • Yamazaki, D.1    Kurisu, S.2    Takenawa, T.3
  • 38
    • 70350451708 scopus 로고    scopus 로고
    • A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27(kip1) and regulates RhoA activation, actin remodeling, and matrigel invasion
    • Hoshino D, Tomari T, Nagano M, et al. A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27(kip1) and regulates RhoA activation, actin remodeling, and matrigel invasion. J Biol Chem 2009;284:27315-27326
    • (2009) J Biol Chem , vol.284 , pp. 27315-27326
    • Hoshino, D.1    Tomari, T.2    Nagano, M.3
  • 39
    • 2342437623 scopus 로고    scopus 로고
    • Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1
    • Hama K, Aoki J, Fukaya M, et al. Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1. J Biol Chem 2004;279:17634-17639
    • (2004) J Biol Chem , vol.279 , pp. 17634-17639
    • Hama, K.1    Aoki, J.2    Fukaya, M.3
  • 40
    • 33947529532 scopus 로고    scopus 로고
    • LPA(4)/GPR23 is a lysophosphatidic acid (LPA) receptor utilizing G(s)-, G(q)/G(i)-mediated calcium signaling and G(12/13)-mediated rho activation
    • Lee CW, Rivera R, Dubin AE, Chun J. LPA(4)/GPR23 is a lysophosphatidic acid (LPA) receptor utilizing G(s)-, G(q)/G(i)-mediated calcium signaling and G(12/13)-mediated rho activation. J Biol Chem 2007; 282:4310-4317
    • (2007) J Biol Chem , vol.282 , pp. 4310-4317
    • Lee, C.W.1    Rivera, R.2    Dubin, A.E.3    Chun, J.4
  • 41
    • 59449091267 scopus 로고    scopus 로고
    • Role of LPA4/p2y9/GPR23 in negative regulation of cell motility
    • Lee Z, Cheng CT, Zhang H, et al. Role of LPA4/p2y9/GPR23 in negative regulation of cell motility. Mol Biol Cell 2008;19:5435-5445
    • (2008) Mol Biol Cell , vol.19 , pp. 5435-5445
    • Lee, Z.1    Cheng, C.T.2    Zhang, H.3
  • 42
    • 56649105158 scopus 로고    scopus 로고
    • In vitro genetic screen identifies a cooperative role for LPA signaling and c-myc in cell transformation
    • Taghavi P, Verhoeven E, Jacobs JJ, et al. In vitro genetic screen identifies a cooperative role for LPA signaling and c-myc in cell transformation. Oncogene 2008;27:6806-6816
    • (2008) Oncogene , vol.27 , pp. 6806-6816
    • Taghavi, P.1    Verhoeven, E.2    Jacobs, J.J.3
  • 43
    • 2342533007 scopus 로고    scopus 로고
    • Attenuation by cyclic phosphatidic acid of peritoneal metastasis of azoxymethane-induced intestinal cancers in Wistar rats
    • Ishihara R, Tatsuta M, Iishi H, et al. Attenuation by cyclic phosphatidic acid of peritoneal metastasis of azoxymethane-induced intestinal cancers in Wistar rats. Int J Cancer 2004; 110:188-193
    • (2004) Int J Cancer , vol.110 , pp. 188-193
    • Ishihara, R.1    Tatsuta, M.2    Iishi, H.3
  • 44
    • 0016683582 scopus 로고
    • Cyclic AMP modulates microvillus formation and agglutinability in transformed and normal mouse fibroblasts
    • Willingham MC, Pastan I. Cyclic AMP modulates microvillus formation and agglutinability in transformed and normal mouse fibroblasts. Proc Natl Acad Sci U S A 1975;72:1263-1267
    • (1975) Proc Natl Acad Sci U S A , vol.72 , pp. 1263-1267
    • Willingham, M.C.1    Pastan, I.2
  • 45
    • 15044359236 scopus 로고    scopus 로고
    • Linking rap to cell adhesion
    • Bos JL. Linking rap to cell adhesion. Curr Opin Cell Biol 2005;17: 123-128
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 123-128
    • Bos, J.L.1
  • 46
    • 0025853849 scopus 로고
    • Cellular invasion into matrix beads: Localization of β1 integrins and fibronectin to the invadopodia
    • Mueller SC, Chen WT. Cellular invasion into matrix beads: localization of β1 integrins and fibronectin to the invadopodia. J Cell Sci 1991;99:213-225
    • (1991) J Cell Sci , vol.99 , pp. 213-225
    • Mueller, S.C.1    Chen, W.T.2
  • 47
    • 44149106107 scopus 로고    scopus 로고
    • cAMP induced rac 1-mediated cytoskeletal reorganization in microvascular endothelium
    • Baumer Y, Drenckhahn D, Waschke J. cAMP induced rac 1-mediated cytoskeletal reorganization in microvascular endothelium. Histochem Cell Biol 2008;129:765-778
    • (2008) Histochem Cell Biol , vol.129 , pp. 765-778
    • Baumer, Y.1    Drenckhahn, D.2    Waschke, J.3
  • 49
    • 0030613761 scopus 로고    scopus 로고
    • Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
    • Daaka Y, Luttrell LM, Lefkowitz RJ. Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A. Nature 1997;390:88-91.
    • (1997) Nature , vol.390 , pp. 88-91
    • Daaka, Y.1    Luttrell, L.M.2    Lefkowitz, R.J.3
  • 50
    • 35448989224 scopus 로고    scopus 로고
    • Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression
    • Murph M, Mills GB. Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression. Expert Rev Mol Med 2007;9:1-18.
    • (2007) Expert Rev Mol Med , vol.9 , pp. 1-18
    • Murph, M.1    Mills, G.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.