Effects of pH on molecular mechanisms of chitosan-integrin interactions and resulting tight-junction disruptions

Biomaterials

Volumn 34, Issue 3, 2013, Pages 784-793

  Hsu, Li Wen ^a   Ho, Yi Cheng ^b   Chuang, Er Yuan ^a   Chen, Chiung Tong ^c   Juang, Jyuhn Huarng ^d   Su, Fang Yi ^a   Hwang, Shiaw Min ^e   Sung, Hsing Wen ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b VANUNG UNIVERSITY   (Taiwan)

^c NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^d CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^e FOOD INDUSTRY RESEARCH AND DEVELOPMENT INSTITUTE   (Taiwan)

Author keywords

Chitosan; Integrin receptor; Oral drug delivery; Paracellular permeability; Tight junction

Indexed keywords

CACO-2 CELLS; CELL SURFACES; CONFORMATION CHANGE; DIRECT INTERACTIONS; DOWN-REGULATION; EPITHELIAL PERMEABILITY; F-ACTIN; INTEGRIN RECEPTORS; INTEGRINS; MECHANISM OF ACTION; MOLECULAR MECHANISM; ORAL DRUG DELIVERY; PARACELLULAR PERMEABILITY; PERMEATION ENHANCERS; PH-DEPENDENT; POSITIVELY CHARGED; RECEPTOR ACTIVATION; TIGHT JUNCTIONS;

CELL MEMBRANES; CHITOSAN; DRUG DELIVERY; ELECTROSTATIC SEPARATORS; MONOLAYERS; PROTEINS;

PH EFFECTS;

CELL PROTEIN; CHITOSAN; CLDN4 PROTEIN; F ACTIN; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR;

ARTICLE; CELL MEMBRANE PERMEABILITY; CELL PH; CELL STRAIN CACO 2; CELL SURFACE; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; STATIC ELECTRICITY; TIGHT JUNCTION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

ACTINS; CACO-2 CELLS; CHITOSAN; DRUG CARRIERS; HUMANS; HYDROGEN-ION CONCENTRATION; INTEGRIN ALPHAVBETA3; PERMEABILITY; TIGHT JUNCTIONS;

EID: 84868504862     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.09.082     Document Type: Article

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