-
1
-
-
75749139262
-
Activation of the hedgehog signaling pathway in human cancer and the clinical implications
-
Yang, L., Xie, G., Fan, Q., and Xie, J. (2010) Activation of the hedgehog signaling pathway in human cancer and the clinical implications. Oncogene 29, 469-4811
-
(2010)
Oncogene
, vol.29
, pp. 469-4811
-
-
Yang, L.1
Xie, G.2
Fan, Q.3
Xie, J.4
-
2
-
-
39149135552
-
The adventures of Sonic Hedgehog in development and repair.I. Hedgehog signaling in gastrointestinal development and disease
-
Parkin, C. A., and Ingham, P. W. (2008)The adventures of Sonic Hedgehog in development and repair. I. Hedgehog signaling in gastrointestinal development and disease. Am. J. Physiol. Gastrointest. Liver Physiol. 294, G363-3677
-
(2008)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.294
-
-
Parkin, C.A.1
Ingham, P.W.2
-
3
-
-
57049089995
-
Hedgehog signaling in development and cancer
-
Jiang, J., and Hui, C. C. (2008)Hedgehog signaling in development and cancer. Dev. Cell 15, 801-8122
-
(2008)
Dev. Cell
, vol.15
, pp. 801-8122
-
-
Jiang, J.1
Hui, C.C.2
-
4
-
-
0002452569
-
Developmental roles and clinical significance of hedgehog signaling
-
McMahon, A. P., Ingham PW, Tabin CJ (2003) Developmental roles and clinical significance of hedgehog signaling. Curr. Top. Dev. Biol. 53, 1-1144
-
(2003)
Curr. Top. Dev. Biol.
, vol.53
, pp. 1-1144
-
-
McMahon, A.P.1
Ingham, P.W.2
Tabin, C.J.3
-
5
-
-
52649111039
-
Basal cell carcinomas. Attack of the hedgehog
-
Epstein, E. H. (2008)Basal cell carcinomas. Attack of the hedgehog. Nat. Rev. Cancer 8, 743-7544
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 743-7544
-
-
Epstein, E.H.1
-
6
-
-
0025156778
-
The GLI gene encodes a nuclear protein which binds specific sequences in the human genome
-
Kinzler, K. W., and Vogelstein, B. (1990) The GLI gene encodes a nuclear protein which binds specific sequences in the human genome. Mol. Cell. Biol. 10, 634-6422
-
(1990)
Mol. Cell. Biol.
, vol.10
, pp. 634-6422
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
7
-
-
15844381336
-
Human homolog of patched, a candidate gene for the basal cell nevus syndrome
-
Johnson, R. L., Rothman, A. L., Xie, J., Goodrich, L. V., Bare, J. W., Bonifas, J. M., Quinn, A. G., Myers, R. M., Cox, D. R., Epstein, E. H., Jr., and Scott, M. P. (1996)Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 272, 1668-16711
-
(1996)
Science
, vol.272
, pp. 1668-16711
-
-
Johnson, R.L.1
Rothman, A.L.2
Xie, J.3
Goodrich, L.V.4
Bare, J.W.5
Bonifas, J.M.6
Quinn, A.G.7
Myers, R.M.8
Cox, D.R.9
Epstein Jr., E.H.10
Scott, M.P.11
-
8
-
-
15844382075
-
A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities
-
Hahn, H., Christiansen, J., Wicking, C., Zaphiropoulos, P. G., Chidambaram, A., Gerrard, B., Vorechovsky, I., Bale, A. E., Toftgard, R., Dean, M., and Wainwright, B. (1996)A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities. J. Biol. Chem. 271, 12125-121288
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 12125-121288
-
-
Hahn, H.1
Christiansen, J.2
Wicking, C.3
Zaphiropoulos, P.G.4
Chidambaram, A.5
Gerrard, B.6
Vorechovsky, I.7
Bale, A.E.8
Toftgard, R.9
Dean, M.10
Wainwright, B.11
-
9
-
-
15844386165
-
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
-
Hahn, H., Wicking, C., Zaphiropoulous, P. G., Gailani, M. R., Shanley, S., Chidambaram, A., Vorechovsky, I., Holmberg, E., Unden, A. B., Gillies, S., Negus, K., Smyth, I., Pressman, C., Leffell, D. J., Gerrard, B., Goldstein, A. M., Dean, M., Toftgard, R., Chenevix-Trench, G., Wainwright, B., and Bale, A. E. (1996)Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85, 841-8511
-
(1996)
Cell
, vol.85
, pp. 841-8511
-
-
Hahn, H.1
Wicking, C.2
Zaphiropoulous, P.G.3
Gailani, M.R.4
Shanley, S.5
Chidambaram, A.6
Vorechovsky, I.7
Holmberg, E.8
Unden, A.B.9
Gillies, S.10
Negus, K.11
Smyth, I.12
Pressman, C.13
Leffell, D.J.14
Gerrard, B.15
Goldstein, A.M.16
Dean, M.17
Toftgard, R.18
Chenevix-Trench, G.19
Wainwright, B.20
Bale, A.E.21
more..
-
10
-
-
0031837454
-
Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome
-
Hahn, H., Wojnowski, L., Zimmer, A. M., Hall, J., Miller, G., and Zimmer, A. (1998) Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Nat Med 4, 619-6222
-
(1998)
Nat Med
, vol.4
, pp. 619-6222
-
-
Hahn, H.1
Wojnowski, L.2
Zimmer, A.M.3
Hall, J.4
Miller, G.5
Zimmer, A.6
-
11
-
-
0032694528
-
Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice
-
Aszterbaum, M., Epstein, J., Oro, A., Douglas, V., LeBoit, P. E., Scott, M. P., and Epstein, E. H., Jr. (1999)Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. Nat. Med. 5, 1285-12911
-
(1999)
Nat. Med.
, vol.5
, pp. 1285-12911
-
-
Aszterbaum, M.1
Epstein, J.2
Oro, A.3
Douglas, V.4
Leboit, P.E.5
Scott, M.P.6
Epstein Jr., E.H.7
-
12
-
-
5644264887
-
Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis
-
Athar, M., Li, C., Tang, X., Chi, S., Zhang, X., Kim, A. L., Tyring, S. K., Kopelovich, L., Hebert, J., Epstein, E. H., Jr., Bickers, D. R., and Xie, J. (2004) Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis. Cancer Res. 64, 7545-75522
-
(2004)
Cancer Res.
, vol.64
, pp. 7545-75522
-
-
Athar, M.1
Li, C.2
Tang, X.3
Chi, S.4
Zhang, X.5
Kim, A.L.6
Tyring, S.K.7
Kopelovich, L.8
Hebert, J.9
Epstein Jr., E.H.10
Bickers, D.R.11
Xie, J.12
-
13
-
-
0031913524
-
Activating Smoothened mutations in sporadic basal cell carcinoma
-
Xie, J., Murone, M., Luoh, S. M., Ryan, A., Gu, Q., Zhang, C., Bonifas, J. M., Lam, C. W., Hynes, M., Goddard, A., Rosenthal, A., Epstein, E. H., Jr., and de Sauvage, F. J. (1998) Activating Smoothened mutations in sporadic basal cell carcinoma. Nature 391, 90-922
-
(1998)
Nature
, vol.391
, pp. 90-922
-
-
Xie, J.1
Murone, M.2
Luoh, S.M.3
Ryan, A.4
Gu, Q.5
Zhang, C.6
Bonifas, J.M.7
Lam, C.W.8
Hynes, M.9
Goddard, A.10
Rosenthal, A.11
Epstein Jr., E.H.12
De Sauvage, F.J.13
-
14
-
-
19944433687
-
Somatic mutations in the PTCH, SMOH, SUFUH, and TP53 genes in sporadic basal cell carcinomas
-
Reifenberger, J., Wolter, M., Knobbe, C. B., Köhler, B., Schönicke, A., Scharwächter, C., Kumar, K., Blaschke, B., Ruzicka, T., and Reifenberger, G. (2005) Somatic mutations in the PTCH, SMOH, SUFUH, and TP53 genes in sporadic basal cell carcinomas. Br. J. Dermatol. 152, 43-511
-
(2005)
Br. J. Dermatol.
, vol.152
, pp. 43-511
-
-
Reifenberger, J.1
Wolter, M.2
Knobbe, C.B.3
Köhler, B.4
Schönicke, A.5
Scharwächter, C.6
Kumar, K.7
Blaschke, B.8
Ruzicka, T.9
Reifenberger, G.10
-
15
-
-
0032080853
-
Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system
-
Reifenberger, J., Wolter, M., Weber, R. G., Megahed, M., Ruzicka, T., Lichter, P., and Reifenberger, G. (1998) Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res. 58, 1798-18033
-
(1998)
Cancer Res.
, vol.58
, pp. 1798-18033
-
-
Reifenberger, J.1
Wolter, M.2
Weber, R.G.3
Megahed, M.4
Ruzicka, T.5
Lichter, P.6
Reifenberger, G.7
-
16
-
-
31744451535
-
Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway
-
Svärd, J., Heby-Henricson, K., Henricson, K. H., Persson-Lek, M., Rozell, B., Lauth, M., Bergström, A., Ericson, J., Toftgård, R., and Teglund, S. (2006) Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev. Cell 10, 187-1977
-
(2006)
Dev. Cell
, vol.10
, pp. 187-1977
-
-
Svärd, J.1
Heby-Henricson, K.2
Henricson, K.H.3
Persson-Lek, M.4
Rozell, B.5
Lauth, M.6
Bergström, A.7
Ericson, J.8
Toftgård, R.9
Teglund, S.10
-
17
-
-
0030866154
-
Altered neural cell fates and medulloblastoma in mouse patched mutants
-
Goodrich, L. V., Milenković, L., Higgins, K. M., and Scott, M. P. (1997) Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277, 1109-11133
-
(1997)
Science
, vol.277
, pp. 1109-11133
-
-
Goodrich, L.V.1
Milenković, L.2
Higgins, K.M.3
Scott, M.P.4
-
18
-
-
79960935826
-
Hedgehog fights back. Mechanisms of acquired resistance against Smoothened antagonists
-
Metcalfe, C., and de Sauvage, F. J. (2011) Hedgehog fights back. Mechanisms of acquired resistance against Smoothened antagonists. Cancer Res. 71, 5057-50611
-
(2011)
Cancer Res.
, vol.71
, pp. 5057-50611
-
-
Metcalfe, C.1
De Sauvage, F.J.2
-
19
-
-
80955181031
-
The Hedgehog's tale. Developing strategies for targeting cancer
-
Ng, J. M., and Curran, T. (2011) The Hedgehog's tale. Developing strategies for targeting cancer. Nat. Rev. Cancer 11, 493-5011
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 493-5011
-
-
Ng, J.M.1
Curran, T.2
-
20
-
-
0346463039
-
Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1
-
Bigelow, R. L., Chari, N. S., Unden, A. B., Spurgers, K. B., Lee, S., Roop, D. R., Toftgard, R., and McDonnell, T. J. (2004) Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1. J. Biol. Chem. 279, 1197-12055
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 1197-12055
-
-
Bigelow, R.L.1
Chari, N.S.2
Unden, A.B.3
Spurgers, K.B.4
Lee, S.5
Roop, D.R.6
Toftgard, R.7
McDonnell, T.J.8
-
21
-
-
7444247429
-
Activation of the BCL2 promoter in response to Hedgehog/ GLI signal transduction is predominantly mediated by GLI2
-
Regl, G., Kasper, M., Schnidar, H., Eichberger, T., Neill, G. W., Philpott, M. P., Esterbauer, H., Hauser-Kronberger, C., Frischauf, A. M., and Aberger, F. (2004) Activation of the BCL2 promoter in response to Hedgehog/ GLI signal transduction is predominantly mediated by GLI2. Cancer Res. 64, 7724-77311
-
(2004)
Cancer Res.
, vol.64
, pp. 7724-77311
-
-
Regl, G.1
Kasper, M.2
Schnidar, H.3
Eichberger, T.4
Neill, G.W.5
Philpott, M.P.6
Esterbauer, H.7
Hauser-Kronberger, C.8
Frischauf, A.M.9
Aberger, F.10
-
22
-
-
0035979147
-
A role of PDGFR-in basal cell carcinoma proliferation
-
Xie, J., Aszterbaum, M., Zhang, X., Bonifas, J. M., Zachary, C., Epstein, E., and McCormick, F. (2001) A role of PDGFR-in basal cell carcinoma proliferation. Proc. Natl. Acad. Sci. U.S.A. 98, 9255-92599
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 9255-92599
-
-
Xie, J.1
Aszterbaum, M.2
Zhang, X.3
Bonifas, J.M.4
Zachary, C.5
Epstein, E.6
McCormick, F.7
-
23
-
-
1542427154
-
IFN-induces Fas expression and apoptosis in hedgehog pathway-activated BCC cells through inhibiting Ras-Erk signaling
-
Li, C., Chi, S., He, N., Zhang, X., Guicherit, O., Wagner, R., Tyring, S., and Xie, J. (2004) IFN-induces Fas expression and apoptosis in hedgehog pathway-activated BCC cells through inhibiting Ras-Erk signaling. Oncogene 23, 1608-16177
-
(2004)
Oncogene
, vol.23
, pp. 1608-16177
-
-
Li, C.1
Chi, S.2
He, N.3
Zhang, X.4
Guicherit, O.5
Wagner, R.6
Tyring, S.7
Xie, J.8
-
24
-
-
1642633053
-
Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas
-
Leung, C., Lingbeek, M., Shakhova, O., Liu, J., Tanger, E., Saremaslani, P., Van Lohuizen, M., and Marino, S. (2004) Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas. Nature 428, 337-3411
-
(2004)
Nature
, vol.428
, pp. 337-3411
-
-
Leung, C.1
Lingbeek, M.2
Shakhova, O.3
Liu, J.4
Tanger, E.5
Saremaslani, P.6
Van Lohuizen, M.7
Marino, S.8
-
25
-
-
0035734285
-
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer
-
Jonkers, J., Meuwissen, R., van der Gulden, H., Peterse, H., van der Valk, M., Berns, and A. (2001) Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat. Genet. 29, 418-4255
-
(2001)
Nat. Genet.
, vol.29
, pp. 418-4255
-
-
Jonkers, J.1
Meuwissen, R.2
Van Der Gulden, H.3
Peterse, H.4
Van Der Valk, M.5
Berns, A.6
-
26
-
-
0033587776
-
The magical touch. Genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin
-
Vasioukhin, V., Degenstein, L., Wise, B., and Fuchs, E. (1999)The magical touch. Genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Proc. Natl. Acad. Sci. U.S.A. 96, 8551-85566
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 8551-85566
-
-
Vasioukhin, V.1
Degenstein, L.2
Wise, B.3
Fuchs, E.4
-
27
-
-
0030847329
-
Adult mice with targeted mutation of the interleukin-11 receptor (IL11Ra) display normal hematopoiesis
-
Nandurkar, H. H., Robb, L., Tarlinton, D., Barnett, L., Köntgen, F., and Begley, C. G. (1997) Adult mice with targeted mutation of the interleukin-11 receptor (IL11Ra) display normal hematopoiesis. Blood 90, 2148-21599
-
(1997)
Blood
, vol.90
, pp. 2148-21599
-
-
Nandurkar, H.H.1
Robb, L.2
Tarlinton, D.3
Barnett, L.4
Köntgen, F.5
Begley, C.G.6
-
28
-
-
33750543972
-
A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway
-
Mao, J., Ligon, K. L., Rakhlin, E. Y., Thayer, S. P., Bronson, R. T., Rowitch, D., and McMahon, A. P. (2006) A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res. 66, 10171-101788
-
(2006)
Cancer Res.
, vol.66
, pp. 10171-101788
-
-
Mao, J.1
Ligon, K.L.2
Rakhlin, E.Y.3
Thayer, S.P.4
Bronson, R.T.5
Rowitch, D.6
McMahon, A.P.7
-
29
-
-
10744231991
-
Endothelial cells require STAT3 for protection against endotoxin-induced inflammation
-
Kano, A., Wolfgang, M. J., Gao, Q., Jacoby, J., Chai, G. X., Hansen, W., Iwamoto, Y., Pober, J. S., Flavell, R. A., and Fu, X. Y. (2003) Endothelial cells require STAT3 for protection against endotoxin-induced inflammation. J. Exp. Med. 198, 1517-15255
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1517-15255
-
-
Kano, A.1
Wolfgang, M.J.2
Gao, Q.3
Jacoby, J.4
Chai, G.X.5
Hansen, W.6
Iwamoto, Y.7
Pober, J.S.8
Flavell, R.A.9
Fu, X.Y.10
-
30
-
-
0034055649
-
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
-
Park, H. L., Bai, C., Platt, K. A., Matise, M. P., Beeghly, A., Hui, C. C., Nakashima, M., and Joyner, A. L. (2000) Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development 127, 1593-16055
-
(2000)
Development
, vol.127
, pp. 1593-16055
-
-
Park, H.L.1
Bai, C.2
Platt, K.A.3
Matise, M.P.4
Beeghly, A.5
Hui, C.C.6
Nakashima, M.7
Joyner, A.L.8
-
31
-
-
33845967146
-
Suppressing Wnt signaling by the hedgehog pathway through sFRP-1
-
He, J., Sheng, T., Stelter, A. A., Li, C., Zhang, X., Sinha, M., Luxon, B. A., and Xie, J. (2006) Suppressing Wnt signaling by the hedgehog pathway through sFRP-1. J. Biol. Chem. 281, 35598-356022
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 35598-356022
-
-
He, J.1
Sheng, T.2
Stelter, A.A.3
Li, C.4
Zhang, X.5
Sinha, M.6
Luxon, B.A.7
Xie, J.8
-
32
-
-
66449128220
-
Cell type specific applicability of 5-ethynyl-2-deoxyuridine (EdU) for dynamic proliferation assessment in flow cytometry
-
Diermeier-Daucher, S., Clarke, S. T., Hill, D., Vollmann-Zwerenz, A., Bradford, J. A., and Brockhoff, G. (2009)Cell type specific applicability of 5-ethynyl-2-deoxyuridine (EdU) for dynamic proliferation assessment in flow cytometry. Cytometry. 75, 535-5466
-
(2009)
Cytometry.
, vol.75
, pp. 535-5466
-
-
Diermeier-Daucher, S.1
Clarke, S.T.2
Hill, D.3
Vollmann-Zwerenz, A.4
Bradford, J.A.5
Brockhoff, G.6
-
33
-
-
78449258451
-
Requirement of TGF-signaling for SMO-mediated carcinogenesis
-
Fan, Q., He, M., Sheng, T., Zhang, X., Sinha, M., Luxon, B., Zhao, X., and Xie, J. (2010) Requirement of TGF-signaling for SMO-mediated carcinogenesis. J. Biol. Chem. 285, 36570-365766
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 36570-365766
-
-
Fan, Q.1
He, M.2
Sheng, T.3
Zhang, X.4
Sinha, M.5
Luxon, B.6
Zhao, X.7
Xie, J.8
-
34
-
-
84859048012
-
-
Chi, S., Xie, G., Liu, H., Chen, K., Zhang, X., Li, C., and Xie, J. (2012) Cell. Signal. 24, 1222-12288
-
(2012)
Cell
, vol.24
, pp. 1222-12288
-
-
Chi, S.1
Xie, G.2
Liu, H.3
Chen, K.4
Zhang, X.5
Li, C.6
Xie, J.7
-
35
-
-
70350500225
-
STATs in cancer inflammation and immunity. A leading role for STAT3
-
Yu, H., Pardoll, D., and Jove, R. (2009)STATs in cancer inflammation and immunity. A leading role for STAT3. Nat. Rev. Cancer 9, 798-8099
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 798-8099
-
-
Yu, H.1
Pardoll, D.2
Jove, R.3
-
36
-
-
0033198793
-
Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling but does not affect skin morphogenesis
-
Sano, S., Itami, S., Takeda, K., Tarutani, M., Yamaguchi, Y., Miura, H., Yoshikawa, K., Akira, S., and Takeda, J. (1999)Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling but does not affect skin morphogenesis. EMBO J. 18, 4657-46688
-
(1999)
EMBO J.
, vol.18
, pp. 4657-46688
-
-
Sano, S.1
Itami, S.2
Takeda, K.3
Tarutani, M.4
Yamaguchi, Y.5
Miura, H.6
Yoshikawa, K.7
Akira, S.8
Takeda, J.9
-
37
-
-
4444290010
-
Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche
-
Blanpain, C., Lowry, W. E., Geoghegan, A., Polak, L., and Fuchs, E. (2004) Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell 118, 635-6488
-
(2004)
Cell
, vol.118
, pp. 635-6488
-
-
Blanpain, C.1
Lowry, W.E.2
Geoghegan, A.3
Polak, L.4
Fuchs, E.5
-
38
-
-
77949360959
-
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin
-
Snippert, H. J., Haegebarth, A., Kasper, M., Jaks, V., van Es, J. H., Barker, N., van de Wetering, M., van den Born, M., Begthel, H., Vries, R. G., Stange, D. E., Toftgård, R., and Clevers, H. (2010) Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science 327, 1385-13899
-
(2010)
Science
, vol.327
, pp. 1385-13899
-
-
Snippert, H.J.1
Haegebarth, A.2
Kasper, M.3
Jaks, V.4
Van Es, J.H.5
Barker, N.6
Van De Wetering, M.7
Van Den Born, M.8
Begthel, H.9
Vries, R.G.10
Stange, D.E.11
Toftgård, R.12
Clevers, H.13
-
39
-
-
61349100687
-
Myeloid-derived suppressor cells as regulators of the immune system
-
Gabrilovich, D. I., and Nagaraj, S. (2009)Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol. 9, 162-1744
-
(2009)
Nat. Rev. Immunol.
, vol.9
, pp. 162-1744
-
-
Gabrilovich, D.I.1
Nagaraj, S.2
-
40
-
-
0034676267
-
Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts. Role of activated STAT3 signaling
-
Sinibaldi, D., Wharton, W., Turkson, J., Bowman, T., Pledger, W. J., and Jove, R. (2000) Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts. Role of activated STAT3 signaling. Oncogene 19, 5419-54277
-
(2000)
Oncogene
, vol.19
, pp. 5419-54277
-
-
Sinibaldi, D.1
Wharton, W.2
Turkson, J.3
Bowman, T.4
Pledger, W.J.5
Jove, R.6
-
41
-
-
78751520029
-
Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance
-
Dijkgraaf, G. J., Alicke, B., Weinmann, L., Januario, T., West, K., Modrusan, Z., Burdick, D., Goldsmith, R., Robarge, K., Sutherlin, D., Scales, S. J., Gould, S. E., Yauch, R. L., and de Sauvage, F. J. (2011) Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance. Cancer Res. 71, 435-4444
-
(2011)
Cancer Res.
, vol.71
, pp. 435-4444
-
-
Dijkgraaf, G.J.1
Alicke, B.2
Weinmann, L.3
Januario, T.4
West, K.5
Modrusan, Z.6
Burdick, D.7
Goldsmith, R.8
Robarge, K.9
Sutherlin, D.10
Scales, S.J.11
Gould, S.E.12
Yauch, R.L.13
De Sauvage, F.J.14
-
42
-
-
52649172153
-
Survivin: Key regulator of mitosis and apoptosis and novel target for cancer therapeutics
-
Mita, A. C., Mita, M. M., Nawrocki, S. T., and Giles, F. J. (2008)Survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics. Clin. Cancer Res. 14, 5000-50055
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 5000-50055
-
-
Mita, A.C.1
Mita, M.M.2
Nawrocki, S.T.3
Giles, F.J.4
-
43
-
-
0031793127
-
Heat shock protein 70 kDa. Molecular biology, biochemistry, and physiology
-
Kiang, J. G., and Tsokos, G. C. (1998) Heat shock protein 70 kDa. Molecular biology, biochemistry, and physiology. Pharmacol. Ther. 80, 183-2011
-
(1998)
Pharmacol. Ther.
, vol.80
, pp. 183-2011
-
-
Kiang, J.G.1
Tsokos, G.C.2
-
44
-
-
0034352334
-
Regulation of Bcl-xL. A little bit of this and a little bit of STAT
-
Grad, J. M., Zeng, X. R., and Boise, L. H. (2000) Regulation of Bcl-xL. A little bit of this and a little bit of STAT. Curr. Opin. Oncol. 12, 543-5499
-
(2000)
Curr. Opin. Oncol.
, vol.12
, pp. 543-5499
-
-
Grad, J.M.1
Zeng, X.R.2
Boise, L.H.3
-
45
-
-
78649744885
-
More than a sidekick. The IL-6 family cytokine IL-11 links inflammation to cancer
-
Putoczki, T., and Ernst, M. (2010) More than a sidekick. The IL-6 family cytokine IL-11 links inflammation to cancer. J. Leukocyte Biol. 88, 1109-11177
-
(2010)
J. Leukocyte Biol.
, vol.88
, pp. 1109-11177
-
-
Putoczki, T.1
Ernst, M.2
-
46
-
-
71849098081
-
Identification of the transforming activity of Indian hedgehog by retroviral expression screening
-
Hatanaka, H., Takada, S., Tsukui, M., Choi, Y. L., Kurashina, K., Soda, M., Yamashita, Y., Haruta, H., Hamada, T., Tamada, K., Hosoya, Y., Sata, N., Nagai, H., Yasuda, Y., Sugano, K., and Mano, H. (2010) Identification of the transforming activity of Indian hedgehog by retroviral expression screening. Cancer Sci. 101, 60-644
-
(2010)
Cancer Sci.
, vol.101
, pp. 60-644
-
-
Hatanaka, H.1
Takada, S.2
Tsukui, M.3
Choi, Y.L.4
Kurashina, K.5
Soda, M.6
Yamashita, Y.7
Haruta, H.8
Hamada, T.9
Tamada, K.10
Hosoya, Y.11
Sata, N.12
Nagai, H.13
Yasuda, Y.14
Sugano, K.15
Mano, H.16
-
47
-
-
77649258546
-
Identification of the cell lineage at the origin of basal cell carcinoma
-
Youssef, K. K., Van Keymeulen, A., Lapouge, G., Beck, B., Michaux, C., Achouri, Y., Sotiropoulou, P. A., and Blanpain, C. (2010) Identification of the cell lineage at the origin of basal cell carcinoma. Nat. Cell Biol. 12, 299-3055
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 299-3055
-
-
Youssef, K.K.1
Van Keymeulen, A.2
Lapouge, G.3
Beck, B.4
Michaux, C.5
Achouri, Y.6
Sotiropoulou, P.A.7
Blanpain, C.8
-
48
-
-
79955508675
-
Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations
-
Grachtchouk, M., Pero, J., Yang, S. H., Ermilov, A. N., Michael, L. E., Wang, A., Wilbert, D., Patel, R. M., Ferris, J., Diener, J., Allen, M., Lim, S., Syu, L. J., Verhaegen, M., and Dlugosz, A. A. (2011) Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations. J. Clin. Invest. 121, 1768-17811
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 1768-17811
-
-
Grachtchouk, M.1
Pero, J.2
Yang, S.H.3
Ermilov, A.N.4
Michael, L.E.5
Wang, A.6
Wilbert, D.7
Patel, R.M.8
Ferris, J.9
Diener, J.10
Allen, M.11
Lim, S.12
Syu, L.J.13
Verhaegen, M.14
Dlugosz, A.A.15
-
49
-
-
78651467232
-
Basal cell carcinomas arise from hair follicle stem cells in ptch1(-) mice
-
Wang, G. Y., Wang, J., Mancianti, M. L., and Epstein, E. H., Jr. (2011) Basal cell carcinomas arise from hair follicle stem cells in Ptch1(-/-) mice. Cancer Cell 19, 114-1244
-
(2011)
Cancer Cell
, vol.19
, pp. 114-1244
-
-
Wang, G.Y.1
Wang, J.2
Mancianti, M.L.3
Epstein Jr., E.H.4
-
50
-
-
66049102512
-
Hedgehog signaling is dispensable for adult hematopoietic stem cell function
-
Gao, J., Graves, S., Koch, U., Liu, S., Jankovic, V., Buonamici, S., El Andaloussi, A., Nimer, S. D., Kee, B. L., Taichman, R., Radtke, F., and Aifantis, I. (2009)Hedgehog signaling is dispensable for adult hematopoietic stem cell function. Cell Stem Cell 4, 548-5588
-
(2009)
Cell Stem Cell
, vol.4
, pp. 548-5588
-
-
Gao, J.1
Graves, S.2
Koch, U.3
Liu, S.4
Jankovic, V.5
Buonamici, S.6
El Andaloussi, A.7
Nimer, S.D.8
Kee, B.L.9
Taichman, R.10
Radtke, F.11
Aifantis, I.12
-
51
-
-
66049085125
-
Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis
-
Hofmann, I., Stover, E. H., Cullen, D. E., Mao, J., Morgan, K. J., Lee, B. H., Kharas, M. G., Miller, P. G., Cornejo, M. G., Okabe, R., Armstrong, S. A., Ghilardi, N., Gould, S., de Sauvage, F. J., McMahon, A. P., and Gilliland, D. G. (2009)Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis. Cell Stem Cell 4, 559-5677
-
(2009)
Cell Stem Cell
, vol.4
, pp. 559-5677
-
-
Hofmann, I.1
Stover, E.H.2
Cullen, D.E.3
Mao, J.4
Morgan, K.J.5
Lee, B.H.6
Kharas, M.G.7
Miller, P.G.8
Cornejo, M.G.9
Okabe, R.10
Armstrong, S.A.11
Ghilardi, N.12
Gould, S.13
De Sauvage, F.J.14
McMahon, A.P.15
Gilliland, D.G.16
-
52
-
-
34547897027
-
Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis
-
Kim, D. J., Chan, K. S., Sano, S., and Digiovanni, J. (2007) Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis. Mol. Carcinog. 46, 725-7311
-
(2007)
Mol. Carcinog.
, vol.46
, pp. 725-7311
-
-
Kim, D.J.1
Chan, K.S.2
Sano, S.3
Digiovanni, J.4
-
53
-
-
0035144809
-
Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate carcinoma
-
Campbell, C. L., Jiang, Z., Savarese, D. M., and Savarese, T. M. (2001) Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate carcinoma. Am J. Pathol. 158, 25-322
-
(2001)
Am J. Pathol.
, vol.158
, pp. 25-322
-
-
Campbell, C.L.1
Jiang, Z.2
Savarese, D.M.3
Savarese, T.M.4
-
54
-
-
1642475187
-
Combinatorial screenings in patients. The interleukin-11 receptoras a candidate target in the progression of human prostate cancer
-
Zurita, A. J., Troncoso, P., Cardó-Vila, M., Logothetis, C. J., Pasqualini, R., and Arap, W. (2004) Combinatorial screenings in patients. The interleukin-11 receptoras a candidate target in the progression of human prostate cancer. Cancer Res. 64, 435-4399
-
(2004)
Cancer Res.
, vol.64
, pp. 435-4399
-
-
Zurita, A.J.1
Troncoso, P.2
Cardó-Vila, M.3
Logothetis, C.J.4
Pasqualini, R.5
Arap, W.6
-
55
-
-
62449095801
-
The interleukin-11 receptoras a candidate ligand-directed target in osteosarcoma. Consistent data from cell lines, orthotopic models, and human tumor samples
-
Lewis, V. O., Ozawa, M. G., Deavers, M. T., Wang, G., Shintani, T., Arap, W., and Pasqualini, R. (2009)The interleukin-11 receptoras a candidate ligand-directed target in osteosarcoma. Consistent data from cell lines, orthotopic models, and human tumor samples. Cancer Res. 69, 1995-19999
-
(2009)
Cancer Res.
, vol.69
, pp. 1995-19999
-
-
Lewis, V.O.1
Ozawa, M.G.2
Deavers, M.T.3
Wang, G.4
Shintani, T.5
Arap, W.6
Pasqualini, R.7
-
56
-
-
34247855977
-
Expression of interleukin-11 (IL-11) and IL-11 receptorin human gastric carcinoma and IL-11 up-regulates the invasive activity of human gastric carcinoma cells
-
Nakayama, T., Yoshizaki, A., Izumida, S., Suehiro, T., Miura, S., Uemura, T., Yakata, Y., Shichijo, K., Yamashita, S., and Sekin, I. (2007) Expression of interleukin-11 (IL-11) and IL-11 receptorin human gastric carcinoma and IL-11 up-regulates the invasive activity of human gastric carcinoma cells. Int. J. Oncol. 30, 825-8333
-
(2007)
Int. J. Oncol.
, vol.30
, pp. 825-8333
-
-
Nakayama, T.1
Yoshizaki, A.2
Izumida, S.3
Suehiro, T.4
Miura, S.5
Uemura, T.6
Yakata, Y.7
Shichijo, K.8
Yamashita, S.9
Sekin, I.10
-
57
-
-
43049096401
-
STAT3 and STAT1 mediate IL-11-dependent and inflammationassociated gastric tumorigenesis in gp130 receptor mutant mice
-
Ernst, M., Najdovska, M., Grail, D., Lundgren-May, T., Buchert, M., Tye, H., Matthews, V. B., Armes, J., Bhathal, P. S., Hughes, N. R., Marcusson, E. G., Karras, J. G., Na, S., Sedgwick, J. D., Hertzog, P. J., and Jenkins, B. J. (2008)STAT3 and STAT1 mediate IL-11-dependent and inflammationassociated gastric tumorigenesis in gp130 receptor mutant mice. J. Clin. Invest. 118, 1727-17388
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 1727-17388
-
-
Ernst, M.1
Najdovska, M.2
Grail, D.3
Lundgren-May, T.4
Buchert, M.5
Tye, H.6
Matthews, V.B.7
Armes, J.8
Bhathal, P.S.9
Hughes, N.R.10
Marcusson, E.G.11
Karras, J.G.12
Na, S.13
Sedgwick, J.D.14
Hertzog, P.J.15
Jenkins, B.J.16
-
58
-
-
4944239032
-
Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis
-
Chan, K. S., Sano, S., Kiguchi, K., Anders, J., Komazawa, N., Takeda, J., and DiGiovanni, J. (2004) Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis. J. Clin. Invest. 114, 720-7288
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 720-7288
-
-
Chan, K.S.1
Sano, S.2
Kiguchi, K.3
Anders, J.4
Komazawa, N.5
Takeda, J.6
Digiovanni, J.7
-
59
-
-
1942538505
-
Epidermal growth factor receptormediated activation of Stat3 during multistage skin carcinogenesis
-
Chan, K. S., Carbajal, S., Kiguchi, K., Clifford, J., Sano, S., and DiGiovanni, J. (2004) Epidermal growth factor receptormediated activation of Stat3 during multistage skin carcinogenesis. Cancer Res. 64, 2382-23899
-
(2004)
Cancer Res.
, vol.64
, pp. 2382-23899
-
-
Chan, K.S.1
Carbajal, S.2
Kiguchi, K.3
Clifford, J.4
Sano, S.5
Digiovanni, J.6
|